Potential conflict of interest: Nothing to report.
Article first published online: 8 NOV 2013
© 2013 by the American Association for the Study of Liver Diseases
Volume 59, Issue 1, page 352, January 2014
How to Cite
Bacchi, E., Negri, C., Targher, G., Lanza, M., Schena, F. and Moghetti, P. (2014), Reply. Hepatology, 59: 352. doi: 10.1002/hep.26475
- Issue published online: 20 DEC 2013
- Article first published online: 8 NOV 2013
- Accepted manuscript online: 20 MAY 2013 02:26PM EST
- Manuscript Accepted: 13 APR 2013
- Manuscript Received: 10 APR 2013
We thank Pesta and Burtscher for their comments on our study. In this article, we have demonstrated, for the first time, that 4 months of resistance (RES) or aerobic (AER) training are equally effective in reducing hepatic fat content among sedentary type 2 diabetes subjects with nonalcoholic fatty liver disease (NAFLD). This study was a subproject of the RAED2 Study, a randomized, controlled trial aimed at comparing the metabolic effects of RES and AER training in diabetic patients.
Pesta and Burtscher hypothesized that in untrained overweight/obese subjects with little experience in exercise, RES training would be unable to induce the specific adaptations characteristic of this exercise modality, and that this, in turn, might explain why the results of AER and RES training were similar.
We agree that, in untrained subjects, there may be some overlap between the effects of AER and RES training, and that the full-blown effects of these different exercise modalities can be only appreciated when sustained high-intensity training is performed, as occurs in athletes. Nonetheless, the latter would not be an appropriate model for assessing the effects of these training modalities on hepatic fat accumulation of sedentary subjects with type 2 diabetes, which was the aim of our study.
Moreover, as reported previously, in our study, peak oxygen uptake improved after training in both groups, but to a greater extent in the AER group, whereas increased strength was found only in the RES group. In addition, lean mass of the limbs significantly increased in the RES group, but not in the AER group. These findings clearly indicate that the stimulus was quite different between the two protocols.
These differences were guaranteed through a careful supervision of exercise sessions as well as a progressive increase of workload. In particular, as concerns the RES group, workload was gradually increased to 70%-80% 1-RM, with the weight being adjusted approximately every 2 weeks to match the progress of the subjects.
With regard to baseline data, there were not statistically significant differences between groups.
Overall, most type 2 diabetes patients are sedentary and have no experience with exercise programs. The clinical message that we were able to give is that exercise alone can provide benefit for NAFLD management in these patients, and that, after 4 months of training, RES exercise is as effective as AER exercise in reducing hepatic fat content in these subjects. Future research should address this important issue in the long term.
Elisabetta Bacchi, Ph.D.1
Carlo Negri, M.D.1
Giovanni Targher, M.D.1
Massimo Lanza, M.Sc.2
Federico Schena, M.D., Ph.D.2
Paolo Moghetti, M.D., Ph.D.1
1Unit of Endocrinology, Diabetes and Metabolism Department of Medicine
2Neurological, Neuropsychological, Morphological and Movement Sciences University of Verona Verona, Italy