Additional Supporting Information may be found in the online version of this article.

hep26514-sup-0001-suppfig1.tif3752KSupporting Figure S1. 5-Aza-CdR/PBA treatment does not alter the levels of HNF4α, C/EBPα, and other related signaling molecules. HepG2 cells were treated with 3 uM 5-Aza-CdR and 3 mM PBA for 48 hours and the cell lysates were obtained for SDS-PAGE and Western blotting analysis using indicated antibodies. (Panel A) Representative western blots for HNF4α, C/EBPα and related molecules. (Panel B) Representative western blots for other signaling molecules.
hep26514-sup-0002-suppfig2.tif2608KSupporting Figure S2. Representative western blots showing baseline levels of PPARγ, RXRα, N-CoR, SMRT, SUV39H1, and H3K9 di-methyl and tri-methyl histone in human primary hepatocytes (HH) and HCC cell lines (HepG2, Huh7 and Hep3B).
hep26514-sup-0003-suppfig3.tif2360KSupporting Figure S3. Subcellular localization of HBX and PPARγ in HepG2 cells transiently transfected with HBX expression vector or control vector. The cells were treated with 15-d-PGJ2 or DMSO for 24 hours. Cytosolic and nuclear fractions were obtained for Western blotting using indicated antibodies. Whereas HBX is detected in both cytoplasmic and nuclear fractions, PPARγ is detected only in nuclear fraction. Loading controls include β-tubulin for cytoplasmic protein and PARP for nuclear protein.
hep26514-sup-0004-suppinfo.docx36KSupporting Information.

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