Potential conflict of interest: Nothing to report.
Liver Failure/Cirrhosis/Portal Hypertension
Human and experimental evidence supporting a role for osteopontin in alcoholic hepatitis
Article first published online: 19 AUG 2013
© 2013 by the American Association for the Study of Liver Diseases
Volume 58, Issue 5, pages 1742–1756, November 2013
How to Cite
Morales-Ibanez, O., Domínguez, M., Ki, S. H., Marcos, M., Chaves, J. F., Nguyen-Khac, E., Houchi, H., Affò, S., Sancho-Bru, P., Altamirano, J., Michelena, J., García-Pagán, J. C., Abraldes, J. G., Arroyo, V., Caballería, J., Laso, F.-J., Gao, B. and Bataller, R. (2013), Human and experimental evidence supporting a role for osteopontin in alcoholic hepatitis. Hepatology, 58: 1742–1756. doi: 10.1002/hep.26521
This work was supported by grants from the Instituto de Salud Carlos III (FIS PI080237 and FIS PS09/01164; to R.B. and J.C., respectively). S.A. received a grant from IDIBAPS. P.S.-B. received grants from Instituto Carlos III, Miguel Servet (CP11/00071), and from the European Commission (within its FP7 Cooperation Program) and the European Cosmetics Association (COLIPA; °HeMiBio-HEALTH-F5-2010-266777). J.A. received a grant from Fundación Banco Bilbao Vizcaya Argentaria.
- Issue published online: 30 OCT 2013
- Article first published online: 19 AUG 2013
- Accepted manuscript online: 31 MAY 2013 08:44AM EST
- Manuscript Accepted: 10 MAY 2013
- Manuscript Received: 17 AUG 2012
Additional Supporting Information may be found in the online version of this article.
|hep26521-sup-0001-suppfig1.tif||107K||Supplementary Figure 1. AUROC graph showing that a value of 112 fold expression was identified as the cut-off value with best sensitivity and specificity to define patients with low and high OPN gene expression (P<0.05), and AUROC graph showing that a value of 240 ng/ml was identified as the cut-off value with best sensitivity and specificity to define patients with low and high OPN serum levels (P<0.05).|
|hep26521-sup-0002-suppfig2.tif||386K||Supplementary Figure 2. Correlation between OPN hepatic gene expression and hepatic gene expression of members of the family of CXC chemokines in patients with AH (P<0.05).|
|hep26521-sup-0003-supptab1.doc||32K||Supplemmentary Table 1. Clinical, Analytical and Hepatic Hemodynamic Characteristics of Patients with Alcoholic Hepatitis (AH) (n=100) included in the genetic studies.|
Please note: Wiley Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.