Potential conflict of interest: Nothing to report.
Liver Failure/Cirrhosis/Portal Hypertension
Human and experimental evidence supporting a role for osteopontin in alcoholic hepatitis
Version of Record online: 19 AUG 2013
© 2013 by the American Association for the Study of Liver Diseases
Volume 58, Issue 5, pages 1742–1756, November 2013
How to Cite
Morales-Ibanez, O., Domínguez, M., Ki, S. H., Marcos, M., Chaves, J. F., Nguyen-Khac, E., Houchi, H., Affò, S., Sancho-Bru, P., Altamirano, J., Michelena, J., García-Pagán, J. C., Abraldes, J. G., Arroyo, V., Caballería, J., Laso, F.-J., Gao, B. and Bataller, R. (2013), Human and experimental evidence supporting a role for osteopontin in alcoholic hepatitis. Hepatology, 58: 1742–1756. doi: 10.1002/hep.26521
This work was supported by grants from the Instituto de Salud Carlos III (FIS PI080237 and FIS PS09/01164; to R.B. and J.C., respectively). S.A. received a grant from IDIBAPS. P.S.-B. received grants from Instituto Carlos III, Miguel Servet (CP11/00071), and from the European Commission (within its FP7 Cooperation Program) and the European Cosmetics Association (COLIPA; °HeMiBio-HEALTH-F5-2010-266777). J.A. received a grant from Fundación Banco Bilbao Vizcaya Argentaria.
- Issue online: 30 OCT 2013
- Version of Record online: 19 AUG 2013
- Accepted manuscript online: 31 MAY 2013 08:44AM EST
- Manuscript Accepted: 10 MAY 2013
- Manuscript Received: 17 AUG 2012
Additional Supporting Information may be found in the online version of this article.
|hep26521-sup-0001-suppfig1.tif||107K||Supplementary Figure 1. AUROC graph showing that a value of 112 fold expression was identified as the cut-off value with best sensitivity and specificity to define patients with low and high OPN gene expression (P<0.05), and AUROC graph showing that a value of 240 ng/ml was identified as the cut-off value with best sensitivity and specificity to define patients with low and high OPN serum levels (P<0.05).|
|hep26521-sup-0002-suppfig2.tif||386K||Supplementary Figure 2. Correlation between OPN hepatic gene expression and hepatic gene expression of members of the family of CXC chemokines in patients with AH (P<0.05).|
|hep26521-sup-0003-supptab1.doc||32K||Supplemmentary Table 1. Clinical, Analytical and Hepatic Hemodynamic Characteristics of Patients with Alcoholic Hepatitis (AH) (n=100) included in the genetic studies.|
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