Additional Supporting Information may be found in the online version of this article.

hep26525-sup-0001-suppfig1.tif12390KSupplementary Figure 1. CD73 localization in hepatocytes after DDC treatment. Immunofluorescence analysis of Flag-CD73 (green) and different organelle markers (red) in DDC-treated hepatocytes.
hep26525-sup-0002-suppfig2.tif8648KSupplementary Figure 2. A. Serum analysis for ALT levels in control and DDC-treated WT and CD73-/- mice. B. Liver sections from C3H mice after 3 months DDC treatment were stained with antibodies to CD73 (green) and p62 (red). There is no significant co-localization between the two signals. Scale bars=50μm. C. Liver sections from WT and CD73-/- mice were stained with the designated antibodies. The K8/K18 filament organization is similar between WT and CD73-/- mice under basal conditions. Scale bar=50μm. D. Extensive porphyria (dark brown deposits marked by arrows) is observed in WT and CD73-/- mice after DDC treatment. Also shown is K8/K18 immunofluorescence (red) of the sections. Scale bar=100μm.
hep26525-sup-0003-supptable1.tif586KSupporting Table 1.
hep26525-sup-0004-supptable2.tif463KSupporting Table 2.
hep26525-sup-0005-supptable3.tif465KSupporting Table 3.

Please note: Wiley Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.