Additional Supporting Information may be found in the online version of this article.

hep26564-sup-0001-suppfig1.tif2078KSupplemental Figure 1. Absence of anti-INH antibodies in samples from patients before starting INH treatment or after treatment with INH in the absence of significant liver injury compared with sera without anti-INH antibodies from patients with INH-induced liver failure. Lysozyme (L) or INH-modified lysozyme (L-INH) was loaded on a western blot, and serum from patients diluted 1:400 was used as primary antibody. #4-0 = serum from a patient at baseline (ALT = 23), #4-5 = serum from the same patient at revisit number 5 from initiation of INH treatment and a small increase in ALT (ALT = 49). Likewise, #10-0 was from a patient before treatment (ALT = 12) and #10-5 was the same patient at revisit number 5 (ALT = 15); #11-0 was before treatment (ALT = 11) and #11-5 was at revisit number 5 (ALT = 24); #27-0 was before treatment (ALT = 15) and #27-1 was at revisit number 1 (ALT = 16). ALF-6, ALF-11, ALF-5, and ALF-16 are samples from patients with INH-induced liver failure who tested negative for anti-INH antibodies by ELISA. In these blots, the contrast was adjusted to a maximum to show the background and illustrate that there were no bands that could be attributed to anti-INH antibodies. 257×233mm (150 × 150 DPI)
hep26564-sup-0002-suppfig2.tif7072KSupplemental Figure 2. ALT, bilirubin and international normalized ration (INR) for patients who had liver failure due to INH as a function of days after initial hospitalization. In Y-axis, values are expressed as upper limit of normal (ULN); the upper limit of normal for each parameter was considered to be: 40 U/L for ALT, 1.2 mg/dL for bilirubin and 1.5 for INR. A) Patients who had anti-INH antibodies. B) Patients negative for anti-INH antibodies.427×483mm (150 × 150 DPI)

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