These authors contributed equally to this study.
Steatohepatitis/Metabolic Liver Disease
Hepatic-specific lipin-1 deficiency exacerbates experimental alcohol-induced steatohepatitis in mice
Version of Record online: 17 OCT 2013
© 2013 by the American Association for the Study of Liver Diseases
Volume 58, Issue 6, pages 1953–1963, December 2013
How to Cite
Hu, M., Yin, H., Mitra, M. S., Liang, X., Ajmo, J. M., Nadra, K., Chrast, R., Finck, B. N. and You, M. (2013), Hepatic-specific lipin-1 deficiency exacerbates experimental alcohol-induced steatohepatitis in mice. Hepatology, 58: 1953–1963. doi: 10.1002/hep.26589
Potential conflict of interest: Nothing to report.
Supported by the National Institute on Alcoholism and Alcohol Abuse (grants AA015951 and AA013623 to M.Y. and AA021228 to B.F.) and the National Institute of Diabetes and Digestive and Kidney Diseases (grant DK078187 to B.F.).
- Issue online: 26 NOV 2013
- Version of Record online: 17 OCT 2013
- Accepted manuscript online: 20 JUN 2013 10:08AM EST
- Manuscript Accepted: 12 JUN 2013
- Manuscript Received: 5 APR 2013
Additional Supporting Information may be found in the online version of this article.
|hep26589-sup-0002-suppfig1.tif||119K||Supporting Figure 1. Liver-specific deletion of lipin-1 exacerbates alcoholic fatty liver in mice. Wild-type (WT) or lipin-1LKO (LKO) mice were pair-fed either a control LF diet or an ethanol-containing diet for 4-wks. (A) Relative mRNA levels of hepatic fibronectin and CD68. (B) Relative protein levels of PGC-1α. Results are expressed as means±SEM (n=4-11 mice). Means without a common letter differ, p< 0.05|
|hep26589-sup-0003-suppfig2.tif||119K||Supporting Figure 2. Mice were fed as described in Fig.1. (A) Plasma level of LCN-2. (B) Circulating level of SAA-1. Results are expressed as means±SEM (n=4-11 mice). Means without a common letter differ, p< 0.05|
|hep26589-sup-0004-suppfig3.tif||144K||Supporting Figure 3. Mice were fed as described in Fig.1. (A) Relative mRNA levels of hepatic FAS, SCD1 and GPAT1. (B) Relative mRNA levels of hepatic CD36, ApoB, MTP and c-Met. Results are expressed as means±SEM (n=4-11 mice). Means without a common letter differ, p< 0.05|
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