Potential conflict of interest: Dr. Hoffman is a consultant for Sobi, Regeneron, and Novartis. He advises, is on the speakers' bureau for, and received grants from Novartis and Sobi.
Steatohepatitis/Metabolic Liver Disease
NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice
Article first published online: 30 JAN 2014
© 2014 by the American Association for the Study of Liver Diseases
Volume 59, Issue 3, pages 898–910, March 2014
How to Cite
Wree, A., Eguchi, A., McGeough, M. D., Pena, C. A., Johnson, C. D., Canbay, A., Hoffman, H. M. and Feldstein, A. E. (2014), NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice. Hepatology, 59: 898–910. doi: 10.1002/hep.26592
The work was funded by the National Institutes of Health (DK076852 and DK082451 [to A.E.F.] and AI52430 [to H.M.H.]) and the German Research Foundation (DFG grant no. 173/2-1; to A.W.). The monoclonal alpha-tubulin antibody, developed by J. Frankel and E.M. Nelsen, was obtained from the Developmental Studies Hybridoma Bank developed under the auspices of the Eunice Kennedy Shriver National Institute of Child Health and Human Development and maintained by the Department of Biology at The University of Iowa (Iowa City, IA).
See Editorial on Page 761
- Issue published online: 25 FEB 2014
- Article first published online: 30 JAN 2014
- Accepted manuscript online: 28 JUN 2013 02:29PM EST
- Manuscript Accepted: 14 JUN 2013
- Manuscript Received: 8 JAN 2013
Additional Supporting Information may be found in the online version of this article.
|hep26592-sup-0001-supptable.doc||47K||Supplemental Table 2. Sequences of primers used for quantitative PCR.|
|hep26592-sup-0002-suppfig.tif||2627K||Supplemental Information Figure.|
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