Potential conflicts of interest: Drs. Ishimoto, Lanaspa, and Johnson have patent applications with the University of Colorado related to the inhibition of fructokinase and its isoforms for the treatment of metabolic disorders including NAFLD. Dr. Johnson is author of two lay books on the topic of fructose and metabolic syndrome, including The Sugar Fix (Rodale, 2008) and The Fat Switch (Mercola.com, 2012), and has received grants from Amway.
Steatohepatitis/Metabolic Liver Disease
High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase
Version of Record online: 8 OCT 2013
© 2013 by the American Association for the Study of Liver Diseases
Volume 58, Issue 5, pages 1632–1643, November 2013
How to Cite
Ishimoto, T., Lanaspa, M. A., Rivard, C. J., Roncal-Jimenez, C. A., Orlicky, D. J., Cicerchi, C., McMahan, R. H., Abdelmalek, M. F., Rosen, H. R., Jackman, M. R., MacLean, P. S., Diggle, C. P., Asipu, A., Inaba, S., Kosugi, T., Sato, W., Maruyama, S., Sánchez-Lozada, L. G., Sautin, Y. Y., Hill, J. O., Bonthron, D. T. and Johnson, R. J. (2013), High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase. Hepatology, 58: 1632–1643. doi: 10.1002/hep.26594
Supported by startup funds to Dr. Richard Johnson from the Department of Medicine at the University of Colorado Denver, and by grants from the NIH (DK-038088) and Diabetes UK (RD04/0002833).
- Issue online: 30 OCT 2013
- Version of Record online: 8 OCT 2013
- Accepted manuscript online: 28 JUN 2013 02:29PM EST
- Manuscript Accepted: 17 JUN 2013
- Manuscript Revised: 1 MAY 2013
- Manuscript Received: 1 FEB 2013
- 31Investigating alterations in hepatic ATP levels following fructose and fructose+glucose ingestion: a simple non-invasive technique to assess liver function using 31P MRS. Proc Int Soc Magn Reson Med 2012;20:1369., , , , , , et al.