Potential conflicts of interest: Drs. Ishimoto, Lanaspa, and Johnson have patent applications with the University of Colorado related to the inhibition of fructokinase and its isoforms for the treatment of metabolic disorders including NAFLD. Dr. Johnson is author of two lay books on the topic of fructose and metabolic syndrome, including The Sugar Fix (Rodale, 2008) and The Fat Switch (Mercola.com, 2012), and has received grants from Amway.
Steatohepatitis/Metabolic Liver Disease
High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase
Article first published online: 8 OCT 2013
© 2013 by the American Association for the Study of Liver Diseases
Volume 58, Issue 5, pages 1632–1643, November 2013
How to Cite
Ishimoto, T., Lanaspa, M. A., Rivard, C. J., Roncal-Jimenez, C. A., Orlicky, D. J., Cicerchi, C., McMahan, R. H., Abdelmalek, M. F., Rosen, H. R., Jackman, M. R., MacLean, P. S., Diggle, C. P., Asipu, A., Inaba, S., Kosugi, T., Sato, W., Maruyama, S., Sánchez-Lozada, L. G., Sautin, Y. Y., Hill, J. O., Bonthron, D. T. and Johnson, R. J. (2013), High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase. Hepatology, 58: 1632–1643. doi: 10.1002/hep.26594
Supported by startup funds to Dr. Richard Johnson from the Department of Medicine at the University of Colorado Denver, and by grants from the NIH (DK-038088) and Diabetes UK (RD04/0002833).
- Issue published online: 30 OCT 2013
- Article first published online: 8 OCT 2013
- Accepted manuscript online: 28 JUN 2013 02:29PM EST
- Manuscript Accepted: 17 JUN 2013
- Manuscript Revised: 1 MAY 2013
- Manuscript Received: 1 FEB 2013
Additional Supporting Information may be found in the online version of this article.
|hep26594-sup-0001-supptbl1.doc||39K||Supporting Table 1. Nutrient profile of diets|
|hep26594-sup-0002-supptbl2.doc||45K||Supporting Table 2. Fatty Acid Profiles of LFD, HFD and HFHSD|
|hep26594-sup-0003-supptbl3.doc||24K||Supporting Table 3. Biochemical analysis of mice given ad libitum LFD, HFD and HFHSD for 15 weeks.|
|hep26594-sup-0004-supptbl4.doc||34K||Supporting Table 4. Nutrient profile of normal chow with 15% fructose water, 30% fructose water, or tap water|
|hep26594-sup-0005-suppfig1.tif||6533K||Supporting Information Figure 1.|
|hep26594-sup-0006-suppfig2.tif||9725K||Supporting Information Figure 2.|
|hep26594-sup-0007-suppfig3.tif||1656K||Supporting Information Figure 3.|
|hep26594-sup-0008-suppfig4.tif||489K||Supporting Information Figure 4.|
|hep26594-sup-0009-suppfig5.tif||9110K||Supporting Information Figure 5.|
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