These authors contributed equally.
First experience of high-intensity focused ultrasound combined with transcatheter arterial embolization as local control for hepatoblastoma
Article first published online: 8 NOV 2013
© 2013 by the American Association for the Study of Liver Diseases
Volume 59, Issue 1, pages 170–177, January 2014
How to Cite
Wang, S., Yang, C., Zhang, J., Kong, X.-r., Zhu, H., Wu, F. and Wang, Z. (2014), First experience of high-intensity focused ultrasound combined with transcatheter arterial embolization as local control for hepatoblastoma. Hepatology, 59: 170–177. doi: 10.1002/hep.26595
Potential conflict of interest: Nothing to report.
- Issue published online: 20 DEC 2013
- Article first published online: 8 NOV 2013
- Accepted manuscript online: 28 JUN 2013 02:29PM EST
- Manuscript Accepted: 18 JUN 2013
- Manuscript Received: 15 JUN 2012
The purpose of this study was to assess the effectiveness of high-intensity focused ultrasound (HIFU) combined with transarterial chemoembolization (TACE) in treating pediatric hepatoblastoma. Twelve patients with initially unresectable hepatoblastoma were enrolled in the study. All patients received chemotherapy, TACE, and HIFU ablation. Follow-up materials were obtained in all patients. The tumor response, survival rate, and complications were analyzed. Complete ablation was achieved in 10 patients (83.3%), and the alpha-fetoprotein level was also decreased to normal in these patients. The mean follow-up time was 13.3 ± 1.8 months (range, 2-25 months). At the end of follow-up, two patients died from tumor progression, the other 10 patients were alive. One patient was found to have lung metastasis after HIFU and had an operation to remove the lesion. The median survival time was 14 months, and the 1- and 2-year survival rates were 91.7% and 83.3%, respectively. Complications included fever, transient impairment of hepatic function, and mild malformation of ribs. Conclusion: HIFU combined with TACE is a safe and promising method with a low rate of severe complications. As a noninvasive approach, it may provide a novel local therapy for patients with unresectable hepatoblastoma. (Hepatology 2014;58:170–177)