Potential conflict of interest: Nothing to report.
Overactivation of the TGF-β pathway confers a mesenchymal-like phenotype and CXCR4-dependent migratory properties to liver tumor cells
Article first published online: 11 OCT 2013
© 2013 by the American Association for the Study of Liver Diseases
Volume 58, Issue 6, pages 2032–2044, December 2013
How to Cite
Bertran, E., Crosas-Molist, E., Sancho, P., Caja, L., Lopez-Luque, J., Navarro, E., Egea, G., Lastra, R., Serrano, T., Ramos, E. and Fabregat, I. (2013), Overactivation of the TGF-β pathway confers a mesenchymal-like phenotype and CXCR4-dependent migratory properties to liver tumor cells. Hepatology, 58: 2032–2044. doi: 10.1002/hep.26597
- Issue published online: 26 NOV 2013
- Article first published online: 11 OCT 2013
- Accepted manuscript online: 28 JUN 2013 01:42PM EST
- Manuscript Accepted: 15 JUN 2013
- Manuscript Received: 4 FEB 2013
- Ministry of Economy and Competitiveness (MECC), Spain . Grant Numbers: BFU2009-07219 , BFU2012-35538 , ISCIII-RTICC RD06/0020
- AGAUR-Generalitat de Catalunya . Grant Number: 2009SGR-312
- E.C-M. was the recipient of a predoctoral fellowship from the FPU program, Ministry of Education, Culture and Sport, Spain
Additional Supporting Information may be found in the online version of this article.
|hep26597-sup-0001-suppfig1.tif||4300K||Supporting Fig. 1. Overactivation of the TGF-β pathway in HCC cells that show a mesenchymal-like phenotype. Correlation with higher production of TGF-β. (Complement to Fig. 1).|
|hep26597-sup-0002-suppfig2.tif||1253K||Supporting Fig. 2. CXCL12 increases the migratory capacity of SNU449 cells, whereas has no effect on HepG2 cells. (Complement to Fig. 2).|
|hep26597-sup-0003-suppfig3.tif||4767K||Supporting Fig. 3. Stable silencing of TGFBRI in PLC/PRF/5 induces reorganization of the cytoskeleton and attenuates expression and asymmetric distribution of CXCR4. (Complement to Fig. 3).|
|hep26597-sup-0004-suppfig4.tif||951K||Supporting Fig. 4. Effect of pharmacological inhibition of TGFBR1 kinase in the mesenchymal HCC cell lines. (Complement to Fig. 4).|
|hep26597-sup-0005-suppfig5.tif||4171K||Supporting Fig. 5. DEN treatment was used to induce HCC in mice. (Complement to Fig. 5).|
|hep26597-sup-0006-suppfig6.tif||12580K||Supporting Fig. 6. Higher expression of both TGFB1 and CXCR4 in tumor tissues correlates with differentiation stages III/IV (less differentiated phenotype) and a cirrhotic background in HCC patients. (Complement to Fig. 6).|
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