Potential conflict of interest: Nothing to report.
Overactivation of the TGF-β pathway confers a mesenchymal-like phenotype and CXCR4-dependent migratory properties to liver tumor cells
Article first published online: 11 OCT 2013
© 2013 by the American Association for the Study of Liver Diseases
Volume 58, Issue 6, pages 2032–2044, December 2013
How to Cite
Bertran, E., Crosas-Molist, E., Sancho, P., Caja, L., Lopez-Luque, J., Navarro, E., Egea, G., Lastra, R., Serrano, T., Ramos, E. and Fabregat, I. (2013), Overactivation of the TGF-β pathway confers a mesenchymal-like phenotype and CXCR4-dependent migratory properties to liver tumor cells. Hepatology, 58: 2032–2044. doi: 10.1002/hep.26597
- Issue published online: 26 NOV 2013
- Article first published online: 11 OCT 2013
- Accepted manuscript online: 28 JUN 2013 01:42PM EST
- Manuscript Accepted: 15 JUN 2013
- Manuscript Received: 4 FEB 2013
- Ministry of Economy and Competitiveness (MECC), Spain . Grant Numbers: BFU2009-07219 , BFU2012-35538 , ISCIII-RTICC RD06/0020
- AGAUR-Generalitat de Catalunya . Grant Number: 2009SGR-312
- E.C-M. was the recipient of a predoctoral fellowship from the FPU program, Ministry of Education, Culture and Sport, Spain
Additional Supporting Information may be found in the online version of this article.
|hep26597-sup-0001-suppfig1.tif||4300K||Supporting Fig. 1. Overactivation of the TGF-β pathway in HCC cells that show a mesenchymal-like phenotype. Correlation with higher production of TGF-β. (Complement to Fig. 1).|
|hep26597-sup-0002-suppfig2.tif||1253K||Supporting Fig. 2. CXCL12 increases the migratory capacity of SNU449 cells, whereas has no effect on HepG2 cells. (Complement to Fig. 2).|
|hep26597-sup-0003-suppfig3.tif||4767K||Supporting Fig. 3. Stable silencing of TGFBRI in PLC/PRF/5 induces reorganization of the cytoskeleton and attenuates expression and asymmetric distribution of CXCR4. (Complement to Fig. 3).|
|hep26597-sup-0004-suppfig4.tif||951K||Supporting Fig. 4. Effect of pharmacological inhibition of TGFBR1 kinase in the mesenchymal HCC cell lines. (Complement to Fig. 4).|
|hep26597-sup-0005-suppfig5.tif||4171K||Supporting Fig. 5. DEN treatment was used to induce HCC in mice. (Complement to Fig. 5).|
|hep26597-sup-0006-suppfig6.tif||12580K||Supporting Fig. 6. Higher expression of both TGFB1 and CXCR4 in tumor tissues correlates with differentiation stages III/IV (less differentiated phenotype) and a cirrhotic background in HCC patients. (Complement to Fig. 6).|
|hep26597-sup-0009-supptab1.doc||37K||Supplementary Table 1. Molecular characteristics of the human HCC cell lines used in this study.|
Please note: Wiley Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.