Potential conflict of interest: Nothing to report.
Steatohepatitis/Metabolic Liver Disease
Hepatic cannabinoid-1 receptors mediate diet-induced insulin resistance by increasing de novo synthesis of long-chain ceramides
Version of Record online: 18 NOV 2013
© 2013 by the American Association for the Study of Liver Diseases
Volume 59, Issue 1, pages 143–153, January 2014
How to Cite
Cinar, R., Godlewski, G., Liu, J., Tam, J., Jourdan, T., Mukhopadhyay, B., Harvey-White, J. and Kunos, G. (2014), Hepatic cannabinoid-1 receptors mediate diet-induced insulin resistance by increasing de novo synthesis of long-chain ceramides. Hepatology, 59: 143–153. doi: 10.1002/hep.26606
- Issue online: 20 DEC 2013
- Version of Record online: 18 NOV 2013
- Accepted manuscript online: 5 JUL 2013 11:21PM EST
- Manuscript Accepted: 20 JUN 2013
- Manuscript Received: 17 MAR 2013
- Intramural funds from the National Institute on Alcohol Abuse and Alcoholism
- National Institutes of Health
Additional Supporting Information may be found in the online version of this article.
|hep26606-sup-0001-suppfig1.tif||589K||Supporting Information Figure 1. Peripheral CB1R blockade reversed HFD-induced elevation of the long-chain ceramides in muscle (A), fat (B), serum (C) and levels of palmitic acid in serum (D). *P<0.05 relative to Vehicle-STD; #P<0.05 relative to Vehicle-HFD.|
|hep26606-sup-0002-suppfig2.tif||304K||Supporting Information Figure 2. Effects of chronic blockade of CB1R or SPT on glycemic control in DIO mice. Treatment with JD5037 or myriocin was as described in Fig. 1. Effects of the two compounds on body weight (A), adiposity index (B), hepatic TG (C), and on the gene expression of CD36 (D) are shown. Data represent mean ± SEM from 5-6 mice/group,|
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