Additional Supporting Information may be found in the online version of this article.

hep26606-sup-0001-suppfig1.tif589KSupporting Information Figure 1. Peripheral CB1R blockade reversed HFD-induced elevation of the long-chain ceramides in muscle (A), fat (B), serum (C) and levels of palmitic acid in serum (D). *P<0.05 relative to Vehicle-STD; #P<0.05 relative to Vehicle-HFD.
hep26606-sup-0002-suppfig2.tif304KSupporting Information Figure 2. Effects of chronic blockade of CB1R or SPT on glycemic control in DIO mice. Treatment with JD5037 or myriocin was as described in Fig. 1. Effects of the two compounds on body weight (A), adiposity index (B), hepatic TG (C), and on the gene expression of CD36 (D) are shown. Data represent mean ± SEM from 5-6 mice/group,
hep26606-sup-0003-suppinfo.doc118KSupporting Information

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