Vitamin D levels in patients with chronic hepatitis B

Authors


  • Potential conflict of interest: Nothing to report.

To the Editor:

We read with interest the article by Farnik et al.[1] regarding the low vitamin D levels in patients with chronic hepatitis B virus (HBV). A remarkable finding was the inverse relationship between serum vitamin D levels and HBV viral load.

A previous study in patients with chronic hepatitis C had also shown that necroinflammatory activity as well fibrosis scores were independently linked to low vitamin D levels.[2] Because of small cohort size, the researchers could not show an association between serum vitamin D levels and fibrosis scores. However, considering that necroinflammatory activity was not included in statistical analysis in this study; we would like to point out that high necroinflammatory activity may also explain the low vitamin D levels in patients with HBV. Before drawing a definitive conclusion, more details ought to be presented about this important issue.

  • Cumali Efe, M.D.1

  • Tugrul Purnak, M.D.1

  • Ersan Ozaslan, M.D.2

  • 1Department of Gastroenterology Hacettepe University Ankara, Turkey

  • 2Department of Gastroenterology Numune Research and Education Hospital Ankara, Turkey

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