Potential conflict of interest: Nothing to report.
Liver Failure/Cirrhosis/Portal Hypertension
Coffee, alcohol and other beverages in relation to cirrhosis mortality: The Singapore Chinese Health Study
Article first published online: 24 JUN 2014
© 2014 by the American Association for the Study of Liver Diseases
Volume 60, Issue 2, pages 661–669, August 2014
How to Cite
Goh, G. B.-B., Chow, W.-C., Wang, R., Yuan, J.-M. and Koh, W.-P. (2014), Coffee, alcohol and other beverages in relation to cirrhosis mortality: The Singapore Chinese Health Study. Hepatology, 60: 661–669. doi: 10.1002/hep.27054
Supported by the National Institutes of Health, USA (NCI R01 CA55069, R35 CA53890, R01 CA80205, and R01 CA144034).
- Issue published online: 22 JUL 2014
- Article first published online: 24 JUN 2014
- Accepted manuscript online: 6 FEB 2014 05:16AM EST
- Manuscript Accepted: 3 FEB 2014
- Manuscript Received: 1 AUG 2013
Limited experimental and epidemiologic data suggest that coffee may reduce hepatic damage in chronic liver disease. The association between consumption of coffee and other beverages and risk of cirrhosis mortality was evaluated in the Singapore Chinese Health Study. This is a prospective population-based cohort of 63,275 middle-aged and older Chinese subjects who provided data on diet, lifestyle, and medical histories through in-person interviews using a structured questionnaire at enrollment between 1993 and 1998. Mortality from cirrhosis in the cohort was ascertained through linkage analysis with nationwide death registry. After a mean follow-up of 14.7 years, 114 subjects died from cirrhosis; 33 of them from viral hepatitis B (29%), two from hepatitis C (2%), and 14 from alcohol-related cirrhosis (12%). Compared to nondrinkers, daily alcohol drinkers had a strong dose-dependent positive association between amount of alcohol and risk of cirrhosis mortality. Conversely, there was a strong dose-dependent inverse association between coffee intake and risk of nonviral hepatitis-related cirrhosis mortality (P for trend = 0.014). Compared to non-daily coffee drinkers, those who drank two or more cups per day had a 66% reduction in mortality risk (hazard ratio [HR] = 0.34, 95% confidence interval [CI] = 0.14-0.81). However, coffee intake was not associated with hepatitis B-related cirrhosis mortality. The inverse relationship between caffeine intake and nonviral hepatitis-related cirrhosis mortality became null after adjustment for coffee drinking. The consumption of black tea, green tea, fruit juices, or soft drinks was not associated with risk of cirrhosis death. Conclusion: This study demonstrates the protective effect of coffee on nonviral hepatitis-related cirrhosis mortality, and provides further impetus to evaluate coffee as a potential therapeutic agent in patients with cirrhosis. (Hepatology 2014;60:661–669)