These authors contributed equally to this work.
Autoimmune, Cholestatic and Biliary Disease
Conjugated bilirubin triggers anemia by inducing erythrocyte death
Version of Record online: 24 NOV 2014
© 2014 The Authors. Hepatology published by Wiley Periodicals, Inc., on behalf of the American Association for the Study of Liver Diseases.
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Volume 61, Issue 1, pages 275–284, January 2015
How to Cite
Lang, E., Gatidis, S., Freise, N. F., Bock, H., Kubitz, R., Lauermann, C., Orth, H. M., Klindt, C., Schuier, M., Keitel, V., Reich, M., Liu, G., Schmidt, S., Xu, H. C., Qadri, S. M., Herebian, D., Pandyra, A. A., Mayatepek, E., Gulbins, E., Lang, F., Häussinger, D., Lang, K. S., Föller, M. and Lang, P. A. (2015), Conjugated bilirubin triggers anemia by inducing erythrocyte death. Hepatology, 61: 275–284. doi: 10.1002/hep.27338
Potential conflict of interest: Nothing to report.
Supported by the Alexander von Humboldt Foundation (SKA2010) and the German Research Council (DFG: KFOR217, SFB974, FO 695/1-1, LA2558/4-1, RTG1949).
- Issue online: 29 DEC 2014
- Version of Record online: 24 NOV 2014
- Accepted manuscript online: 28 JUL 2014 03:50AM EST
- Manuscript Accepted: 24 JUL 2014
- Manuscript Received: 13 APR 2014
Additional Supporting Information may be found at onlinelibrary.wiley.com/doi/10.1002/hep.27338/suppinfo.
Supporting Table 1. Clinical parameters of outpatients suffering from liver disease.
Clinical parameters of 113 outpatients suffering from liver disease are displayed. Individual parameters represent the mean ± SEM.
Supporting Fig. 1: Mice suffer from anemia following bile duct ligation.
(A+B) Mice with ligated bile duct (BDL) were compared to sham controls. (A) Red blood cell count and (B) hemoglobin concentration is shown as a function of bilirubin concentrations of individual BDL mice and sham controls 21 days post operation (n=24).
Supporting Fig. 2: Correlations between red blood cell count and liver enzymes in patients suffering from liver disease.
Red blood cell counts from 41 patients with liver disease as a function of plasma concentration of (A) γ-GT (n=40), (B) ALT (n=41), and (C) AST (n=41) are shown.
Supporting Fig. 3: Correlation of erythrocyte and reticulocyte number with bilirubin plasma levels in outpatients suffering from liver disease.
Blood samples were collected from 113 patients suffering from liver disease. Erythrocyte counts (n = 113) (A) and absolute reticulocyte counts (n = 98) (B) as a function of bilirubin plasma level are shown.
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