• 1
    Lotze MT, Flickinger JC, Carr BI. Hepatobiliary neoplasms. In: DevitaVTJr, HellmanS, BosenbergSTJr, eds. Cancer: principle and practice of oncology. 4th ed. Philadelphia: Lippincott, 1993: 883914.
  • 2
    Ng IOL, Ng MMG, Lai ECS, Fan ST. Better survival in female patients with hepatocellular carcinoma: possible causes from a pathologic approach. Cancer 1995; 75: 1822.
  • 3
    Toh YC. Physiological and biochemical review of sex differences and carcinogenesis with particular references to the liver. Adv Cancer Res 1973; 18: 155209.
  • 4
    Yamamoto RS, Weisburger EK. The role of hormones on digestive and urinary tract carcinogenesis. Recent Prog Hormone Res 1977; 33: 617653.
  • 5
    Cantarow A. Endocrinological aspects of liver disease. Acta Un Int Cancer 1957; 13: 740760.
  • 6
    Reuber MD, Firminger HI. Effect of progesterone and diethylstil-bestrol on hepatic carcinogenesis and cirrhosis in A × C rats fed N-2-Fluorenyldiacetamide. J Natl Cancer Inst 1962; 29: 933943.
  • 7
    Rumsfeld HW Jr, Miller WL Jr, Baumann CA. A sex difference in the development of liver tumors in rats fed 3′-methyl-4-di-methylaminoazobenzene or 4′-fluoro-4-dimethylaminoazoben-zene. Cancer Res 1951; 11: 814819.
  • 8
    Katayama S, Ohmori T, Maeura Y, Croci T, Williams GM. Early stages of N-2-fluorenylacetamide-induced hepatocarcinogenesis in male and female rats and effect of gonadectomy on liver neoplastic conversion and neoplastic development. J Natl Cancer Inst 1984; 73: 141149.
  • 9
    Hendrich S, Leveston AO, Pitot HC. Ovariectomy promotes the growth of altered hepatic foci after withdrawal and reintroduction of phenobarbital during hepatocarcinogenesis in rats. Eur J Cancer Prev 1992; 1: 407414.
  • 10
    Lucier GW, Tritscher A, Goldsworthy T, Foley J, Clark G, Goldstein J, Maronpot R. Ovarian hormones enhance 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated increases in cell proliferation and preneoplastic foci in a two-stage model for rat hepatocarcinogenesis. Cancer Res 1991; 51: 13911397.
  • 11
    Firminger HI, Reuber MD. Influence of adrenocortical, androgenic, and anabolic hormones on the development of carcinoma and cirrhosis of the liver in A × C rats fed JV-2-fluorenyldiacetamide. J Natl Cancer Inst 1961; 27: 559595.
  • 12
    Wanless IR, Medline A. Role of estrogens as promoters of hepatic neoplasia. Lab Invest 1982; 46: 313320.
  • 13
    Lupulescu A. Estrogen use and cancer risk: a review. Exp Clin Endocrinol 1993; 101: 204214.
  • 14
    Yager JD, Zurlo J, Ni N. Sex hormones and tumor promotion in liver. Proc Soc Exp Biol Med 1991; 198: 667674.
  • 15
    Yager JD, Campbell HA, Longnecker DS, Roebuck BD, Benoit MC. Enhancement of hepatocarcinogenesis in female rats by ethinyl estradiol and mestranol but not estradiol. Cancer Res 1984; 44: 38623869.
  • 16
    Solt D, Farber E. New principle for the analysis of chemical carcinogenesis. Nature 1976; 263: 702703.
  • 17
    Blanck A, Hansson T, Eriksson LC. Gustafsson J-Å. On mechanisms of sex differences in chemical carcinogenesis: effects of implantation of ectopic pituitary grafts on the early stages of liver carcinogenesis in the rat. Carcinogenesis 1984; 5: 12571262.
  • 18
    Blanck A, Hansson T, Gustafsson J-Å, Eriksson LC. Pituitary grafts modify sex differences in liver tumor formation in the rat following initiation with diethylnitrosamine and different promotion regimens. Carcinogenesis 1986; 7: 981985.
  • 19
    Porsch Hällström I, Svensson D, Blanck A. Sex-differentiated deoxycholic acid promotion of rat liver carcinogenesis is under pituitary control. Carcinogenesis 1991; 12: 20352040.
  • 20
    Porsch Hällström I, Liao D-Z, Gustafsson J-Å, Blanck A. Ectopic pituitary grafts modify the response of male rats to sex differentiated promotion of diethylnitrosamine-initiated hepatic lesions with a choline-deficient diet. Carcinogenesis 1994; 15: 921925.
  • 21
    Edén S. Age and sex related differences in episodic growth hormone secretion in the rat. Endocrinology 1979; 105: 555560.
  • 22
    Jansson J-O, Edén S, Isaksson O. Sexual dimorphism in the control of growth hormone secretion. Endocr Rev 1985; 6: 128150.
  • 23
    Blanck A, Eriksson LC, Gustafsson J-Å, Porsch Hällström I. Sex-differentiated and growth-hormone-regulated mitoinhibition in rat liver during treatment with 2-acetylaminofluorene and partial hepatecomy in the resistant hepatocyte model. Carcinogenesis 1991; 12: 12591264.
  • 24
    Gu J-R. Molecular aspects of human hepatic carcinogenesis. Carcinogenesis 1988; 9: 697703.
  • 25
    Nagy P, Evarts RP, Marsden E, Roach J, Thorgeirsson SS. Cellular distribution of c-myc transcripts during chemical hepatocarcinogenesis in rats. Cancer Res 1988; 48: 55225527.
  • 26
    Porsch Hällström I, Gustafsson J-Å, Blanck A. Effects of growth hormone on the expression of c-myc and c-fos during early stages of sex-differentiated rat liver carcinogenesis in the resistant hepatocyte model. Carcinogenesis 1989; 12: 23392343.
  • 27
    Porsch Hällström I, Blanck A, Eriksson LC. Gustafsson J-Å. Expression of the c-myc, c-fos and c-rasHa protooncogenes during sex-differentiated rat liver carcinogenesis in the resistant hepatocyte model. Carcinogenesis 1989; 10: 17931800.
  • 28
    Jansson J-O, Ekberg S, Isaksson OGP, Edén S. Influence of gonadal steroids on age- and sex-related secretory patterns of growth hormone in the rat. Endocrinology 1984; 114: 12871294.
  • 29
    Jansson J-O, Frohman LA. Inhibitory effect of the ovaries on neonatal androgen imprinting of growth hormone secretion in female rats. Endocrinology 1987; 121: 14171423.
  • 30
    Clark RG, Carlsson LMS. Robinson ICAF. Growth hormone secretory profiles in conscious female rats. J Endocr 1987; 114: 399407.
  • 31
    Södersten P, Eneroth P, Pettersson A. Episodic secretion of luteinizing hormone and androgen in male rats. J Endocrinol 1983; 97: 145153.
  • 32
    Durnam DM, Palmiter RP. A practical approach for quantifying specific mRNA by solution hybridization. Anal Biochem 1983; 131: 385393.
  • 33
    Blanck A, Porsch Hällström I, Svensson D, Mode A, Eriksson LC. Gustafsson J-Å. Increased expression of the female-predominant cytochrome P450 2C12 in liver nodules from male Wistar rats. Carcinogenesis 1993; 14: 755759.
  • 34
    Dannan GA, Guengerich FP, Waxman DJ. Hormonal regulation of rat liver microsomal enzymes: role of gonadal steroids in programming, maintenance and suppression of delta-4-steroid 5-alpha-reductase, flavin-containing monooxygenase and sex-specific cytochromes p450. J Biol Chem 1986; 261: 1072810735.
  • 35
    Waxman DJ. Interactions of hepatic cytochromes p450 with steroid hormones. Biochem Pharmacol 1988; 37: 7184.
  • 36
    Bandiera S, Dworschak C. Effects of testosterone and estrogen on hepatic levels of cytochromes P450 2C7 and P450 2C11 in the rat. Arch Biochem Biophys 1992; 296: 286295.
  • 37
    Pak RCK, Tsim KWK, Cheng CHK. Pubertal gonadal hormones in modulating the testosterone dependency of hepatic aryl hydrocarbon hydroxylase in female rats. Pharmacology 1984; 29: 121127.
  • 38
    Cadario BJ, Bellward GD, Bandiera S, Chang TKH, Ko WWW, Lemieux E, Pak RCK. Imprinting of hepatic microsomal cytochrome P450 enzyme activities and cytochrome P-450IIC11 by peripubertal administration of testosterone in female rats. Mol Pharmacol 1992; 41: 981988.
  • 39
    Porsch Hällström I, Gustafsson J-Å, Blanck A. Hypothalamo-pituitary regulation of the c-myc gene in rat liver. J Mol Endocrinol 1990; 5: 267274.
  • 40
    Dixon WJ, Massey FJ Jr. Introduction to statistical analysis. New York: McGraw-Hill, 1983: 394397.