• 1
    Marzolo MP, Rigotti A, Nervi F. Secretion of biliary lipids from the hepatocyte. Hepatology 1990; 12: 134S142S.
  • 2
    Havel RJ, Hamilton RL. Hepatocytic lipoprotein receptors and intracellular lipoprotein catabolism. Hepatology 1988; 8: 16891704.
  • 3
    Cooper AD. Role of the liver in the degradation of lipoproteins. Gastroenterology 1985; 88: 192205.
  • 4
    Turley SD, Dietschy JM. The metabolism and excretion of cholesterol by the liver. In: AriasIM, JacobyH, PopperD, SchachterD, SchafritzDA. eds. The liver: biology and pathology. New York: Raven, 1988: 617641.
  • 5
    Packard CJ, Shepherd J. The hepatobiliary axis and lipoprotein metabolism: effects of bile acid sequestrants and ileal bypass surgery. J Lipid Res 1982; 23: 10811099.
  • 6
    Beg ZH, Stonik JA, Brewer HB Jr. Modulation of the enzymic activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase by multiple kinase systems involving reversible phosphorylation: a review. Metabolism 1987; 36: 900917.
  • 7
    Goldstein JL, Brown MS. The low density lipoprotein pathway and its relation to atherosclerosis. Annu Rev Biochem 1977; 46: 897930.
  • 8
    Myant NB, Mitropooulos KA. Cholesterol 7α-hydroxylase. J Lipid Res 1977; 18: 135153.
  • 9
    Goodwin CD, Cooper BW, Margolis S. Rat liver cholesterol 7α-hydroxylase. Modulation of enzyme activity by changes in phosphorylation state. J Biol Chem 1982; 257: 44694472.
  • 10
    Suckling KE, Stange EF. Role of acyl-CoA: cholesterol acyltransferase in cellular cholesterol metabolism. J Lipid Res 1985; 26: 647671.
  • 11
    Sinclair HM. Essential fatty acids in perspective human nutrition. Clin Nutr 1984; 38C: 245260.
  • 12
    Brown MS, Goldstein JL, Dietschy JM. Active and inactive forms of 3-hydroxy-3-methylglutaryl coenzyme A reductase in the liver of the rat. J Biol Chem 1979; 254: 51445149.
  • 13
    Levy E, Thibault L, Garofalo C, Messier M, Lepage G, Ronco N, Roy CC. Combined (n-3 and n-6) essential fatty acid deficiency is a potent modulator of plasma lipids, lipoprotein composition, and lipolytic enzymes. J Lipid Res 1990; 31: 20092017.
  • 14
    Folch JM, Lees M, Sloane Stanley GH. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 1957; 226: 497509.
  • 15
    Gavino GR, Levy E, Gavino VC. Essential fatty acid deficiency lowers the activity of the acetylated low density lipoprotein receptor of rat peritoneal macrophages. Biochem Cell Biol 1992; 70: 224227.
  • 16
    Levy E, Garofalo C, Thibault L, Dionne S, Daoust L, Lepage G, Roy CC. Intraluminal and intracellular phases of fat absorption are impaired in essential fatty acid deficiency. Am J Physiol 1992; 262: G319G326.
  • 17
    Feingold KR, Wiley MH, Moser AH, Lear SR, Siperstein MD. Activation of HMG-CoA reductase by microsomal phosphatase. J Lipid Res 1983; 24: 290296.
  • 18
    Erickson SK, Shrewsbury MA, Brooks C, Meyer DJ. Rat liver acyl-coenzyme Axholesterol acyltransferase: its regulation in vivo and some properties in vitro. J Lipid Res 1980; 21: 930941.
  • 19
    Goodwin CD, Cooper BW, Margolis S. Rat liver cholesterol 7α-hydroxylase. Modulation of enzyme activity by changes in phosphorylation state. J Biol Chem 1982; 257: 44694472.
  • 20
    Muller W, Psched P. An improved freeze-fracturing procedure preventing contamination artefacts, at fracturing temperatures below 163 k in an unmodified balzers unit. Mikroscopie 1981; 39: 143.
  • 21
    Levy E, Lepage G, Bendayan M, Ronco N, Thibault L, Galéano N, Smith L. et al. Relationship of decreased hepatic lipase activity and lipoprotein abnormalities to essential fatty acid deficiency in cystic fibrosis patients. J Lipid Res 1989; 30: 11971209.
  • 22
    Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951; 193: 265275.
  • 23
    Bartlett GR. Phosphorus assay in column chromatography. J Biol Chem 1959; 234: 466468.
  • 24
    Yousef IM, Barnwell S, Gratton F, Tuchweber B, Weber A, Roy CC. Liver cell membrane solubilization may control maximum secretory rate of cholic acid in the rat. Am J Physiol 1987; 252: G84G91.
  • 25
    Pieters MN, Schouten D, Bakkeren HF, Esbch B, Brouwer A, Knook DL, van Berkel TJC. Selective uptake of cholesteryl esters from apolipoprotein-E-free high-density lipoproteins by rat parenchymal cells in vivo is efficiently coupled to bile acid synthesis. Biochem J 1991; 280: 359365.
  • 26
    Bravo E, Cantafora A, Argiolas L. Hepatic uptake and metabolism of free cholesterol from different lipoprotein classes: an in vivo study in the rat. Biochim Biophys Acta 1989; 1003: 315320.
  • 27
    Schwartz CC, Halloran LG, Vlahcevic ZR, Gregory DH, Swell L. Preferential utilization of free cholesterol from high-density lipoproteins for biliary cholesterol secretion in man. Science 1978; 200: 6264.
  • 28
    Scobey MW, Johnson FL, Rudel LL. Delivery of high-density lipoprotein free and esterified cholesterol to bile by the perfused monkey liver. Am J Physiol 1989; 257: G644G652.
  • 29
    Turley SD, Dietschy JM. The contribution of newly synthesized cholesterol to biliary cholesterol in the rat. J Biol Chem 1981; 256: 24382446.
  • 30
    Sinensky M, Logel J. Inhibition of degradation of 3-hydroxy-3-methylglutaryl coenzyme A by mevinolin. J Biol Chem 1983; 258: 85478549.
  • 31
    Clarke CF, Edwards PA, Lan SF. Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase mRNA levels in rat liver. Proc Natl Acad Sci U S A 1983; 80: 33053308.
  • 32
    Finkel RS, Volpe JJ. A potential role for phospholipids in the regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in cultured C-6 glial cells. Effects of N1N-dimethylethanolamine. Biochim Biophys Acta 1979; 572: 461471.
  • 33
    Sipat AB, Sabine JR. Membrane-mediated control of hepatic β-hydroxy-β-methylglutaryl-coenzyme A reductase. Biochem J 1981; 194: 889893.
  • 34
    Spector AA, Kaduce TL, Dane RW. Effect of dietary fat saturation on acyl coenzyme A: cholesterol acyltransferase activity of rat liver microsomes. J Lipid Res 1980; 21: 169179.
  • 35
    Russell DW, Setchell KD. Bile acid biosynthesis. Biochemistry 1992; 31: 47374749.
  • 36
    Horton JD, Cuthbert JA, Spady DK. Regulation of hepatic 7α-hydroxylase expression by dietary psyllium in the hamster. J Clin Invest 1994; 93: 20842092.
  • 37
    Spector AA, Yorek MA. Membrane lipid composition and cellular function. J Lipid Res 1985; 26: 10151035.