• 1
    Witt-Sullivan H, Heathcote, EJL, Cauch K, Blendis L, Ghent C, Katz A, Milner K, et al. The demography of primary biliary cirrhosis in Ontario Canada. Hepatology 1990; 12: 98105.
  • 2
    Bernstein JE, Swift R. Relief of intractable pruritus with naloxone. Arch Dermatol 1979; 115: 13661367.
  • 3
    Thronton JR, Dean H, Losowsky MS. Is ascites caused by impaired hepatic inactivation of blood borne endogenous opioid peptides? Gut 1988; 268: 11671172.
  • 4
    Thornton JR, Losowsky MS. Methionine enkephalin is increased in plasma and urine in acute liver disease and is present in bile and urine. J Hepatol 1989; 8: 5359.
  • 5
    Swain MG, Rothman RB, Xu H, Vergalla J, Bergasa NY, Jones EA. Endogenous opiods accumulate in plasma in a rat model of acute cholestasis. Gastroenterology 1992; 103: 630634.
  • 6
    Bergasa NY, Ailing DW, Vergalla J, Jones AE. Cholestasis in the male rat is associated with naxloxone-reversible antinocicep-tion. J Hepatol 1994; 20: 8590.
  • 7
    Rapoport SI, Klee WA, Pettigrew KD, Ohno K. Entry of opioid peptides into the central nervous system. Science 1980; 207: 8486.
  • 8
    Bergasa NV, Thomas DA, Vergalla J, Turner ML, Jones EA. Plasma from patients with the pruritus of cholestasis induces opioid receptor-mediated scratching in monkeys. Life Sci 1993; 53: 12531257.
  • 9
    Bergasa NV, Rothman RB, Vergalla J, Xu H, Swain MG, Jones AE. Central μ-opiod receptors are down-regulated in a rat model of cholestasis. J Hepatol 1992; 15: 220224.
  • 10
    Thornton JR, Losowsky MS. Opioid peptides and primary biliary cirrhosis. BMJ 1988; 297: 15011506.
  • 11
    Levi FA, Zidani R, Vannetzel J-M, Perpoint B, Focan C, Faggiuolo R, Chollet P, et al. Chronomodulated versus fixed-infusion-rate delivery of ambulatory chemotherapy with oxaliplatin, fluorouracil, and folinic acid (leucovorin) in patients with colorectal cancer metastases: a randomized multi-institutional trial. J Natl Cancer Inst 1994; 268: 16081617.
  • 12
    Swain MG, Mogiakou MA, Bergasa NV, Chronsos GP. Facilitation of ACTH and cortisol responses to cortico-trophin releasing hormone (CRH) in patients with primary biliary cirrhosis (PBC). Hepatol 1994; 268: 146A.
  • 13
    Morley JE, Levine AS. Stress-induced eating is mediated through endogenous opiates. Science 1980; 209: 12591260.
  • 14
    Swain MG, Marie M. Defective Corticotropin-releasing hormone mediated neurcendocrine and behavioral responses in cholestatic rats: Implications for cholestatic liver disease-related sickness behaviour. Hepatology 1995; 22: 15601564.
  • 15
    Swain MG. Alterations in Hypothalamic μ-opiate receptor-mediated responses but not methionine enkephalin or proenkephalin messenger RNA levels in rats with acute cholestasis. Hepatology 1994; 20: 700705.