• 1
    Nakamura T, Nawa K, Ichiara A. Partial purification and characterization of hepatocyte growth factor from serum of hepatec-tomized rats. Biochem Biophys Res Commun 1984; 122: 14501459.
  • 2
    Russell WE, McGowan JA, Bucher NLR. Partial characterization of a hepatocyte growth factor from rat platelets. J Cell Physiol 1984; 119: 183190.
  • 3
    Nakamura T, Teramoto H, Ichiara A. Purification of a growth factor rat platelets for mature parenchymal hepatocytes in primary cultures. Proc Natl Acad Sci U S A 1986; 83: 64896493.
  • 4
    Nakamura T, Nishizawa T, Hagiya M, Seki T, Shimonishi M, Sugimura A, Tashiro K. et al. Molecular cloning and expression of human hepatocyte growth factor. Nature 1989; 342: 440443.
  • 5
    Michalopoulos G, Cianciulli HD, Novotny RA, Kligerman AD, Strom SC, Jirtle RL. Liver regeneration studies with rat hepatocytes in primary culture. Cancer Res 1982; 42: 46734682.
  • 6
    Gómez-Lechón MJ, Castell JV, Guillén MI, O'Connor E, Nakamura T, Fabra R, Trullenque R. Effects of hepatocyte growth factor on the growth and metabolism of human hepatocytes in primary culture. Hepatology 1995; 21: 12481254.
  • 7
    Matsumoto K, Nakamura T. Roles of HGF as a pleitropic factor in organ regeneration. In: GoldbergID, RosenEM. eds. Hepatocyte growth factor-scatter (HGF-SF) and the C-met receptor. Basel, Switzerland: Birkghauser Verlag, 1993: 225249.
  • 8
    Matsumoto K, Nakamura T. Hepatocyte growth factor: molecular structure and implications for a central role in liver regeneration. J Gastroenterol Hepatol 1991; 6: 509519.
  • 9
    Gohda E, Tsubouchi H, Nakayama H, Hirano S, Sakiyama O, Takahashi K, Miyazaki H. et al. Purification and partial characterization of hepatocyte growth factor from plasma of a patient with hepatic failure. J Clin Invest 1988; 81: 414419.
  • 10
    Selden C, Johnstone R, Darby H, Gupta S, Hodgson HJF. Human serum does contain a high molecular weight hepatocyte growth factor: studies pre- and post-hepatic resection. Biochem Biophys Res Commun 1986; 139: 361366.
  • 11
    Asami O, Ihara I, Shimidzu N, Shimizu S, Tomita Y, Ichihara A, Nakamura T. Purification and characterization of hepatocyte growth factor from injured liver of carbon tetrachloride-treated rats. J Biochem 1991; 109: 813.
  • 12
    Shimizu I, Ichihara A, Nakamura T. Hepatocyte growth factor in ascites from patients with cirrhosis. J Biochem 1991; 109: 1418.
  • 13
    Kinoshita Y, Tashiro K, Nakamura T. Marked increase of HGF mRNA in non-parenchymal liver cells of rats treated with hepatotoxins. Biochem Biophys Res Commun 1989; 165: 12291234.
  • 14
    Maher JJ. Cell-specific expression of hepatocyte growth factor in liver. Upregulation in sinusoidal endothelial cells after carbon tetrachloride. J Clin Invest 1993; 91: 22442252.
  • 15
    Rubin SJ, Chan AML, Bottaro DP, Burgess WH, Taylor WG, Cech AC, Hirschfield CVW. et al. A broad spectrum human lung fibroblasts-derived mitogen is a variant of hepatocyte growth factor. Proc Natl Acad Sci U S A 1991; 88: 415419.
  • 16
    Yanagita K, Nagaike M, Ishibashi H, Niho Y, Matsumoto K, Nakamura T. Lung may have an endocrine function producing hepatocyte growth factor in response to injury of distal organs. Biochem Biophys Res Commun 1992; 182: 802809.
  • 17
    Igawa T, Matsumoto K, Kanda S, Saito Y, Nakamura T. Hepatocyte growth factor may function as a renotropic factor for regeneration in rats with acute renal injury. Am J Physiol 1993; 265: F61F69.
  • 18
    Matsumoto K, Nakamura T. Hepatocyte growth factor: molecular structure, roles in liver regeneration and other biological functions. Crit Rev Oncog 1992; 3: 2754.
  • 19
    Boros P, Miller CM. Hepatocyte growth factor: a multifunctional cytokine. Lancet 1995; 345: 293295.
  • 20
    Gómez-Lechón MJ, López P, Donato T, Montoya A, Larrauri A, Gimenez P, Trullenque R. et al. Culture human hepatocytes from small surgical liver biopsies. Biochemical characterization and comparison with in vivo. In Vitro Cell Dev Biol 1990; 26: 6774.
  • 21
    Castell JV, Gómez-Lechón MJ, David M, Fabra R, Trullenque R, Heinrich PC. Acute-phase response of human hepatocytes: regulation of acute-phase protein synthesis by interleukin-6. Hepatology 1990; 12: 11791186.
  • 22
    Chomczynski P, Sacchi N. Anal Biochem 1987; 162: 156159.
  • 23
    Sambrook J, Fritsch EF, Maniatis T. Molecular cloning. A laboratory manual. 2nd ed. Cold Spring Harbor, NY: Cold Spring Habor Laboratory, 1989: 7: 17. 87.
  • 24
    Kushner I, Mackiewicz A. Acute phase proteins as disease markers. Dis Markers 1987; 5: 111.
  • 25
    Castell JV, Gómez-Lechón MJ, David M, Hirano T, Kishimoto T, Heinrich PC. Recombinant human interleukin 6 (IL-6/BSF-2/HSF) regulates the synthesis of acute-phase proteins in human hepatocytes. FEES Lett 1988; 232: 347350.
  • 26
    Castell JV, Gómez-Lechón MJ, David M, Andus T, Geiger T, Trullenque R, Fabra R. et al. Interleukin 6 is the major regulator of acute phase protein synthesis in adult human hepatocytes. FEES Lett 1989; 242: 237239.
  • 27
    Raynes JG, Bevan S. Inhibition of the acute-phase response in a human hepatoma cell line. Agents Actions 1993; 38: C66C68.
  • 28
    Loyer P, Llyin G, Abdel-Razzak Z, Banchereau J, Dezier JF, Campion JP, Guguen-Guillouzo C. et al. Interleukin 4 inhibits the production of some acute-phase proteins by human hepatocytes in primary culture. FEES Lett 1993; 336: 215220.
  • 29
    Baumann H, Richards C, Gauldie J. Interaction among hepatocyte-stimulating factors, interleukin 1, and glucocorticoids for regulation of acute phase plasma proteins in human hepatoma (HepG2) cells. J Immunol 1987; 139: 41224128.
  • 30
    Richards CD, Gauldie J. Xenobiotics and inflammation. Induction of inflammation: cytokines and acute-phase proteins. In: SchookL, LaskinDL. eds. San Diego: Academic Press, 1994: 7196.
  • 31
    Heinrich PC, Castell JV, Andus T. Interleukin 6 and the acutephase response. Biochem J 1990; 265: 621636.
  • 32
    Hack CE, de Groot ER, Felt-Bersuma RJ, Nuijens JH, Srack Van Schijndel RJM, Eerenberg-Belmer AJM, Thijs LG. et al. Increased plasma levels of interleukin-6 in sepsis. Blood 1989; 74: 17041710.
  • 33
    Sun Y, Tokushige K, Isono E, Yamauchi K, Obata H. Elevated serum interleukin 6 levels in patients with acute-hepatitis. J Clin Immunol 1992; 12: 197200.
  • 34
    Byl B, Roucloux I, Crusiaux A, Dupont E, Devière J. Tumor necrosis factor α and interleukin 6 plasma levels in infected cirrhotic patients. Gastroenterology 1993; 104: 14921497.
  • 35
    Guillén MI, Blanes M, Gómez-Lechón MJ, Castell JV. Cytokine signalling during myocardial infarction: sequential appearance of IL-1β and IL-6. Am J Physiol 1995; 269: R229R235.
  • 36
    Matsunami H, Kawasaki S, Ishizone S, Hashikura Y, Ikegami T, Makuuchi M, Kawarasaki H. et al. Serial changes of h-HGF and IL-6 in living-related donor liver transplantation with special reference to their relationship to intraoperative portal blood flow. Transplant Proc 1992; 24: 19711972.
  • 37
    Sehgal PB. Interleukin-6: a regulator of plasma protein gene expression in hepatic and non-hepatic tissues. Mol Biol Med 1990; 7: 117130.
  • 38
    Baumann H, Morella KK, Jahreis GP, Marinkovic S. Distinct regulation of the interleukin-1 and interleukin-6 response elements of the rat haptoglobin gene in rat and human hepatoma cells. Mol Cell Biol 1990; 10: 59675976.
  • 39
    Björneboe M. Serum protein variations in the course of chronic hepatitis. Acta Med Scand 1948; 206: 392398.
  • 40
    Stein SF, Harker LA. Kinetic and functional studies of platelets, fibrinogen and plasminogen in patients with hepatic cirrhosis. J Lab Clin Med 1982; 99: 217230.
  • 41
    Paramo JA, Rocha E. Hemostasis in advanced liver disease. Semin Thromb Hemost 1993; 19: 184190.