Original Article

You have full text access to this OnlineOpen article

Endothelin induced contractility of stellate cells from normal and cirrhotic rat liver: implications for regulation of portal pressure and resistance

  1. D C Rockey,
  2. R A Weisiger

Article first published online: 30 DEC 2003

DOI: 10.1002/hep.510240137

Issue

Hepatology

Hepatology

Volume 24, Issue 1, pages 233–240, July 1996

Additional Information

How to Cite

Rockey, D. C. and Weisiger, R. A. (1996), Endothelin induced contractility of stellate cells from normal and cirrhotic rat liver: implications for regulation of portal pressure and resistance. Hepatology, 24: 233–240. doi: 10.1002/hep.510240137

Author Information

  1. Liver Center, Department of Medicine, University of California, San Francisco, USA

Publication History

  1. Issue published online: 30 DEC 2003
  2. Article first published online: 30 DEC 2003

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

Get PDF (1153K)

References

  • 1
    Yanagisawa M, Kurihara H, Kimura S. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 1988; 332: 411–415.
  • 2
    Rubanyi GM, Parker Bothelho LH. Endothelins. FASEB J 1991; 5: 2713–2720.
  • 3
    Sumner MJ, Cannon TR, Mundin JW, White DG, Watts IS. Endothelin ET-A and ET-B receptors mediate vascular smooth muscle contraction. Br J Pharmacol 1992; 107: 858–860.
  • 4
    Clozel M, Gray GA, Breu V, Loftier B, Osterwalder R. The endothelin ET-B receptor mediates both vasodilation and vasoconstriction in vivo. Biochem Biophys Res Comm 1992; 186: 867–873.
  • 5
    Gandhi CR, Stephenson K, Olson MS. Endothelin, a potent peptide agonist in the liver. J Biol Chem 1990; 265: 17432–17435.
  • 6
    Okumura S, Takei Y, Kawano S, Nagano K, Masuda E, Goto M, Tsuji S. et al. Vasoactive effect of endothelin-1 on rat liver in vivo. Hepatology 1994; 19: 155–161.
  • 7
    Yu PC, Kuo JS, Lin HC, Yang MCM. Effects of endothelin in portal hypertensive rats. Clin Sci 1992; 83: 165–170
  • 8
    Oshita M, Yoshiyuki T, Kawano S, Yoshihara H, Hijoka T, Goto F, Masuda E. et al. Roles of endothelin-1 and nitric oxide in the mechanism of ethanolinduced vasoconstrcition in rat liver. J Clin Invest 1993; 91: 1337–1342.
  • 9
    Housset C, Rockey DC, Bissell DM. Endothelin receptors in rat liver: lipocytes as a contractile target for endothelin-1. Proc Natl Acad Sci USA 1993; 90: 9266–9270.
  • 10
    Gondo K, Ueno T, Sakamoto M, Sakisaka S, Sata M, Tanikawa K. The endothelin-1 binding site in rat liver tissue: light- and electron-microscopic autoradiographic studies. Gastroenterology 1993; 104: 1745–1749.
  • 11
    Oda M, Kaneko H, Suematsu M, Suzuki H, Kazemoto S, Honda K, Yonei Y, et al. A new aspect of the hepatic microvasculature: electron-microscopic evidence for the presence of Ito cells around portal and hepatic venules as pericytes. In: MessmerK, MengerMD, eds. Liver niicrocirculation and hepatobiliary function. Basel: Karger, 1993: 25–39.
  • 12
    Shepro D, Morel NML. Pericyte physiology. FASEB J 1993; 7: 1031–1038.
  • 13
    Kawada N, Klein H, Decker K. Eicosanoid-niediated contractility of hepatic stellate cells. Biochem J 1992; 285: 367–371.
  • 14
    Pinzani M, Failli P, Ruocco C, Casini A, Milani S, Baldi E, Giotto A. et al. Fat-storing cells as liver-specific pericytes. J Clin Invest 1992; 90: 642–646.
  • 15
    Rockey DC. Characterization of endothelin receptors mediating rat hepatic stellate cell contraction. Biochem Biophys Res Comm 1995; 207: 725–731.
  • 16
    Friedman SL. The cellular basis of hepatic fibrosis. N Engl J Med 1993; 328: 1828–1835.
  • 17
    Tanaka Y, Nouchi T, Yamane M, Irie T, Miyakawa H, Sato C, Marumo F. Phenotypic modulation in lipocytes in experimental liver fibrosis. J Pathol 1991; 164: 273–278.
    Direct Link:
  • 18
    Irle C, Kocher O, Gabbiani G. Contractility of myofibroblasts during experimental liver cirrhosis. J Submicrosc Cytol Pathol 1980; 12: 209–217.
  • 19
    Proctor E, Chatamra K. High yield micronodular cirrhosis in the rat. Gastroenterology 1982; 83: 1183–1190.
  • 20
    Clozel M, Breu V, Gray GA, Kalina B, Loffler BM, Burrik K, Cassal JM. et al. Pharmacological characterization of bosentan, a new potent orally active nonpeptide endothelin receptor antagonist. J Pharmacol Exp Ther 1994; 270: 228–235.
  • 21
    Brissot P, Wright TL, Ma WL, Weisiger RA. Efficient clearance of nontransferrin-bound iron by rat liver: Implications for hepatic iron loading in iron overload states. J Clin Invest 1985; 76: 1463–1470.
  • 22
    Knook DL, Sleyster EC. Separation of Kupffer and endothelial cells of the rat liver by centrifugal elutriation. Exp Cell Res 1981; 99: 444–449.
  • 23
    Rockey DC, Boyles JK, Gabbiani G, Friedman SL. Rat hepatic lipocytes express smooth muscle actin upon activation in vivo and in culture. J Submicrosc Cytol Pathol 1992; 24: 193–203.
  • 24
    Mak KM, Leo MA, Lieber CS. Alcoholic liver injury in baboons: transformation of lipocytes to transititional cells. Gastrenterology 1984; 87: 188–200.
  • 25
    Oda M, Azuma T, Watanabe N. Regulatory mechanism of hepatic microcirculation: Involvement of the contraction and dilatation of sinusoids and sinusoidal fenestrae. Prog Appl Microcirc 1990; 127: 103–128.
  • 26
    Greenway CV, Lautt WW. Hepatic Circulation. In: WoodJD ed. Handbook of physiology: the gastrointestinal system, motility and circulation. Bethesda: American Physiological Society, 1989: 1519–1564.
  • 27
    MacPhee PJ, Schmidt EE, Groom AC. Organization and flow in the liver niicrocirculation. In: MessmerK, MengerMD. eds. Liver niicrocirculation and hepatobiliary function. Basel: Karger, 1993: 25–39.
  • 28
    Cousineau D, Goresky CA, Rose CP. Blood flow and norepinephrine effects on liver vascular and extravascular volumes. Am J Physiol 1983; 244: H495–H504.
  • 29
    McCuskey RS. A dynamic and static study of hepatic arterioles and hepatic sphincters. Am J Anat 1966; 119: 455–478.
    Direct Link:
  • 30
    Suematsu M, Oda M, Suzuki H, Kaneko H, Watanable N, Fususho T, Masushige S. et al. Intravital and electron microscopic observation of Ito cells in rat hepatic circulation. Microvasc Res 1993; 46: 1–44.
  • 31
    Zhang JX, Pegoli WJ, Clemens MG. Endothelin-1 induces direct constriction of hepatic sinusoids. Am J Physiol 1994; 266: G624–G632.
  • 32
    Bauer M, Zhang JX, Bauer I, Clemens MG. ET-1 induced alterations of hepatic niicrocirculation: sinusoidal and extras in us oidal sites of action. Am J Physiol 1994; 267: G143–G149.
  • 33
    Zhang JX, Pegoli WJ, Clemens MG. Vessel- and target cell-specific actions of endothelin-1 and endothelin-3 in rat liver. Am J Physiol 1995; 266: G269–G277.
  • 34
    Ballardini GM, Fallini G, Biagini FB, Bianchi Pisi E. Desmin and actin in the identification of Ito cells and in monitoring their evolution to myofibroblasts in experimental liver fibrosis. Virchows Archiv B Cell Pathol 1988; 56: 45–49.
Get PDF (1153K)