• 1
    Choo QL, Richman KH, Han JH, Berger K, Lee C, Dong C, Gallegos C, et al. Genetic organization and diversity of the hepatitis C virus. Proc Natl Acad Sci U S A 1991; 88: 24512455.
  • 2
    Bukh J, Purcell RH, Miller RH. At least 12 genotypes of hepatitis C virus predicted sequence analysis of the putative E1 gene of isolates collected worldwide. Proc Natl Acad Sci U S A 1993; 90: 82348238.
  • 3
    Weiner AJ, Brauer MJ, Rosenblatt J, Richman KH, Tung J, Crawford K, Bonino F, et al. Variable and hypervariable domains are found in the regions of HCV corresponding to the flavivirus envelope and NS1 proteins and the pestivirus envelope glycoproteins. Virology 1991; 180: 842848.
  • 4
    Bukh J, Miller RH, Purcell RH. Genetic heterogeneity of hepatitis C virus: Quasispecies and genotype. Semin Liv Dis 1995; 15: 4163.
  • 5
    Martell M, Esteban JI, Quer J, Genesca J, Weiner A, Esteban R, Guardia J, et al. Hepatitis C virus (HCV) circulates as a population of different but closely related genome: quasispecies nature of HCV genome distribution. JVirol 1992; 66: 32253229.
  • 6
    Okada S, Akahane Y, Suzuki H, Okamoto H, Mishiro S. The degree of variability in the amino terminal region of the E2/NS1 protein of hepatitis C virus correlates with responsiveness to interferon therapy in viremic patients. Hepatology 1992; 16: 619624.
  • 7
    Enomoto N, Sato C, Marumo F. Hepatitis C virus remaining after interferon treatment has the variation in the hypervariable region of envelope 2 gene. J Hepatol 1994; 20: 252261.
  • 8
    Enomoto N, Kurosaki M, Tanaka Y, Marumo F, Sato C. Fluctuation of hepatitis C virus quasispecies in persistent infection and interferon treatment revealed by single-strand conformation polymorphism analysis. J Hepatol 1994; 75: 136169.
  • 9
    Kanazawa Y, Hayashi N, Mita E, Hagiwara M, Kasahara A, Fusamoto H, Kamada T. Influence of viral quasispecies on effectiveness of interferon therapy in chronic hepatitis C patients. Hepatology 1994; 20: 11211132.
  • 10
    Moribe T, Hayashi N, Kanazawa Y, Mita E, Fusamoto H, Negi M, Kane-shige T, et al. Hepatitis C viral complexity detected by single-strand conformation polymorphism and response to interferon therapy. Gastroenterology 1995; 108: 789795.
  • 11
    Koizumi K, Enomoto N, Kurosaki M, Murakami T, Izumi N, Maruo F, Sato C. Diversity of quasispecies in various disease stages chronic hepatitis C virus infection and its significance in interferon treatment. Hepatology 1995; 22: 3035.
  • 12
    Orita M, Iwahana H, Kanazawa H, Hayashi K, Sekiya. Detection of poly-morpism of human DNA by gel electrophoresis as single strand conformation polymorphisms. Proc Natl Acad Sci U S A 1989; 86: 27662770.
  • 13
    Orita M, Suzuki Y, Sekiya T, Hayashi K. Rapid sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction. Genomics 1989; 5: 874879.
  • 14
    Enomoto N, Sakuma I, Asahina Y, Kurosaki M, Murakami T, Yamamoto C, Izumi N, et al. Comparison of full-length sequence of interferon-sensitive and resistant hepatitis C virus Ib sensitivity to interferon is conferred by amino acid substitutions in the NS5A region. J Clin Invest 1995; 96: 224230.
  • 15
    Enomoto N, Sakuma I, Asahina Y, Kurosaki M, Murakami T, Yamamoto C, Ogura Y, et al. Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus Ib infection. N Engl J Med 1996; 334: 7781.
  • 16
    Desmet VJ, Gerber M, Hoofnagle JH, Manns M, Sheuer PJ. Classification of chronic hepatitis: diagnosis, grading and staging. Hepatology 1994; 19: 15131520.
  • 17
    Shindo M, Arai K, Sokawa Y, Okuno T. Hepatic hepatitis C virus RNA as a predictor of a long-term response to interferon alpha therapy. Ann Intern Med 1995; 122: 586591.
  • 18
    Okamoto H, Okada S, Sugiyama Y, Yotsumoto S, Tanaka T, Yoshizawa H, Tsuda F, et al. The 5′-terminal sequence of the hepatitis C virus genome. Jpn Exp Med 1990; 60: 167177.
  • 19
    Okamoto H, Sugiyama Y, Okada S, Kurai K, Akahane Y, Sugai Tanaka T, et al. Typing hepatitis C virus by polymerase chain reaction with type-specific primers: application to clinical surveys and tracing infectious sources. Gen Virol 1992; 73: 67379.
  • 20
    Hijikata M, Kato N, Tsuyama M, Nakagawa M, Ohkoshi S, Shimotohno K. Hypervariable region in the putative glycoprotein of hepatitis C virus. Biochem Biophys Res Commun 1991; 175: 220228.
  • 21
    Kato N, Ootsuyama Y, Tanaka T, Nakagawa M, Muraiso K, Ohkoshi S, Hijikata M, et al. Marked sequence diversity in the putative envelope proteins of hepatitis C viruses. Virus Res 1992; 22: 107123.
  • 22
    Shindo M, Arai K, Sokawa Y, Okuno T. The virological and histological states of anti-HCV-positive subjects with normal liver biochemical values. Hepatology 1995; 22: 418425.
  • 23
    Nakazawa T, Kato N, Ohkoshi S, Shibuya A, Shimotohno K. Charaterization of the 5′ noncoding and structural region of the hepatitis C virus genome from patients with non-A, non-B hepatitis responding differently to interferon treatment. J Hepatology 1994; 20: 623629.