• 1
    Rosser BG, Gores GJ. Liver cell necrosis: cellular mechanisms and clinical implications. Gastroenterology 1995; 108: 252275.
  • 2
    Clavien P-A, Harvey PRC, Strasberg SM. Preservation and reperfusion injuries in liver allografts. Transplantation 1992; 53: 957978.
  • 3
    Thurman RG, Bunzendahl HR, Lemasters JJ. Role of sinusoidal lining cells in hepatic reperfusion in Jury following cold storage and transplanta-tion. Semin Liver Dis 1993; 13: 93100.
  • 4
    Thurman RG, Marzi I, Seitz G, Thies J, LeMasters JJ, Zimmerman F. Hepatic reperfusion in Jury following orthotopic liver transplantation in the rat. Transplantation 1988; 46: 502506.
  • 5
    Marotto ME, Thurman RG, LeMasters JJ. Early midzonal cell death dur-ing low-flow hypoxia in the isolated, perfused rat liver: protection by allo-purinol. Hepatology 1988; 8: 585590.
  • 6
    Jaeschke HR, Farhood A. Neutrophil and Kupffer cell-induced oxidant stress and ischemia-reperfusion in Jury in the rat liver. Am J Physiol 1991; 260: 355362.
  • 7
    Rao PN, Liu T, Suyder JT, Platt JL, Starzl TE. Reperfusion in Jury following cold ischemia activates rat liver Kupffer cells. Transplant Proc 1991; 23: 666669.
  • 8
    Attalla SL, Toledo-Pereyra LH, Mackenzie GH, Caderna JP. Influence of oxygen-derived free radical scavengers on ischemic livers. Transplantation 1985; 40: 584590.
  • 9
    Colletti LM, Remick DG, Burtch GD, Kunkel SL, Strieter RM, Campbell DA. Role of tumor necrosis factor-α in the pathophysiological alterations after ischemia/reperfusion in Jury in the rat. J Clin Invest 1990; 85: 19361943.
  • 10
    Zhou W, McCollum MO, Levine BD, Olson MS. Inflammation and platelet-activating factor production during hepatic ischemia/reperfusion. Hepatology 1992; 16: 12361240.
  • 11
    Post S, Reutsch M, Palma P, Gonzalez AP, Otto G, Menger MD. Effect of Carolina rinse solution on Kupffer cell activation after reperfusion in rat liver transplantation. Transplant Proc 1992; 24: 2703.
  • 12
    Gao W, Yakei Y, Marzi I, Lindert KA, Caldwell-Kenkel JC, Currin RT, Tanaka Y, et al. Carolina rinse solution-A new strategy to increase survival time after orthotopic liver transplantation in the rat. Transplantation 1991; 52: 417424.
  • 13
    Rymsa B, Becker HD, Lauchart W, de Groot HR. Hypoxia/reoxygenation injury in the liver: Kupffer cells are much more vulnerable to reoxygena-tion than to hypoxia. Res Commun Chem Pathol Pharmacol 1990; 68: 263266.
  • 14
    Rymsa B, Wang J, de Groot HR. O 2-release by activated Kupffer cells upon hypoxia-reoxygenation. Am J Physiol 1991; 261: 602607.
  • 15
    Shiratori Y, Kiriyama HR, Fukushi Y, Nagura T, Takada HR, Hai K, Kamii K Modulation of ischemia-reperfusion induced hepatic injury by Kupffer cells. Dig Dis Sci 1994; 39: 12651272.
  • 16
    Jaeschke HR, Bautista AP, Spolarics Z, Spitzer JJ. Superoxide generation by Kupffer cells and priming of neutrophils during reperfusion after hepatic ischemia. Free Radic Res Commun 1991; 15: 277284.
  • 17
    Caldwell-Kenkel JC, Currin RT, Tanaka Y, Thurman RG, Lemasters JJ. Reperfusion injury to endothelial cells following cold ischemic storage of rat livers. Hepatology 1989; 10: 292299.
  • 18
    Caldwell-Kenkel JC, Currin RT, Tanaka Y, Thurman RG, Lemasters JJ. Kupffer cell activation and endothelial cell damage after storage of rat livers: effects of reperfusion. Hepatology 1991; 13: 8395.
  • 19
    Morgan GR, Sanabria JR, Clavien P-A, Phillips MJ, Edwards C, Harvey PRC, Strasberg SM. Correlation of donor nutritional status with sinusoidalining cell viability and liver function in the rat. Transplantation 1991; 51: 11761183.
  • 20
    McKeown CMB, Edwards V, Phillips MJ, Harvey PRC, Petrunka CN, Strasberg SM. Sinusoidal lining cell damage: the critical injury in cold preservation of liver allografts in the rat. Transplantation 1988; 46: 178191.
  • 21
    Bissell DM, Guzelian PS. Phenotypic stability of adult rat hepatocytes in primary monolayer culture. Ann N Y Acad Sci 1980; 349: 8598.
  • 22
    Kleinman HK, McGarvey ML, Hassell JR, Star VL, Canon FB, Laurie GW, Martin GR. Basement niembrane complexes with biological activity. Biochemistry 1986; 25: 312318.
  • 23
    Zahlten RN, Hagler HK, Nejtek ME, Day CJ. Morphological characteriza-tion of Kupffer and endothelial cells of rat liver isolated by counterflow elutriation. Gastroenterology 1978; 75: 8087.
  • 24
    Shaw RG, Johnson AR, Schulz WW, Zahlten RN, Combes B. Sinusoidal endothelial cells froni normal guinea pig liver: isolation, culture and char-acterization. Hepatology 1984; 4: 591602.
  • 25
    Wisse E. Observations on the fine structure and peroxidase cytocheniistry of normal rat liver Kupffer cells. J Ultrastructure Res 1974; 46: 393426.
  • 26
    Jauregui HO, Hayner NT, Driscoll JL, Williams-Holland R, Lipsky MH, Galletti PM. Trypan blue uptake and lactate dehydrogenase release in adult rat hepatocytes, freshly isolated cells, cell Suspension and primary monolayer cultures. In Vitro 1981; 17: 11001110.
  • 27
    Freshney RI. Measurement of cytotoxicity and viability. In: FreshneyRI, ed. Culture of animal cells. A manual of basic technique. Ed 2. New York: Liss, 1987: 245256.
  • 28
    Johnston RB, Godzik CA, Cohn ZA. Increased Superoxide anion production by immunologically activated and chemically elicited macrophages. J Exp Med 1978; 148: 115127.
  • 29
    Zar JH. Two factor analysis of variance. In: McElroyWD, SwansonCP, eds. Biostatistical analysis. New Jersey: Prentice-Hall, Inc., 1974: 163170.
  • 30
    Jaeschke HR, Farhood A, Bautista AP, Spolarics Z, Spitzer JJ. Comple-ment activates Kupffer cells and neutrophils during reperfusion after he-patic ischemia. Am J Physiol 1993; 264: 801809.
  • 31
    Lindert KA, Caldwell-Kenkel JC, Nukina S, Lemasters JJ, Thurman RG. Activation of Kupffer cells on reperfusion following hypoxia: particle phagocytosis in a low-flow, reflow model. Am J Physiol 1992; 262: 345350.
  • 32
    Rauen U, Haussen M, Lauchart W, Becker HD, de Groot HR. Energy dependent injury to cultured sinusoidal endothelial cells of the rat liver in UW solution. Transplantation 1993; 55: 469473.
  • 33
    Fujii Y, Johnson ME, Gores GJ. Mitochondrial dysfunction during anoxia/ reoxygenation injury of liver sinusoidal endothelial cells. Hepatology 1994; 20: 177185.
  • 34
    Herman B, Nieminen A, Gores GJ, LeMasters JJ. Irreversible injury in anoxic hepatocytes precipitated by an abrupt increase in plasma mem-brane permeability. FASEB J 1988; 2: 146151.
  • 35
    Kobayashi S, Clemens MG. The critical extracellular free [Ca2+] for rat hepatocytes during reoxygenation. Circ Shock 1988; 24: 263264.
  • 36
    Berger M, Hagler HR, Parsons B, Reynolds R. In vitro hepatocellular degeneration and necrosis: a sequential morphologic analysis [Abstract]. Gastroenterology 1985; 88: 1650.
  • 37
    Berger ML, Reynolds RC, Hagler HK, Bellotto D, Parsons D, Mulligan KJ, Buja LM. Anoxic hepatocyte injury: role of reversible changes in elemental content and distribution. Hepatology 1989; 9: 219228.
  • 38
    Caraceni P, Gasbarrini A, Van Thiel DH, Borle AB. Oxygen free radical formation by rat hepatocytes during postanoxic reoxygenation: scavenging effect of albumin. Am J Physiol 1994; 266: 451458.
  • 39
    de Groot HR, Littauer A. Reoxygenation injury in isolated hepatocytes. Cell death precedes conversion of xanthine oxidase. Biochem Biophys Res Commun 1988; 155: 278282.
  • 40
    Rieder HR, Ramadori G, Meyer zum Buschenfelde KH. Guinea pig Kupffer cells can be activated in vitro to an enhanced Superoxide response. 1. Comparison with peritoneal macrophages. J Hepatol 1988; 7: 338344.