• 1
    Krawitt EL. Autoimmune hepatitis. N Engl J Med 1996; 334: 897903.
  • 2
    Berg PA, Klein R, Lindenborn-Fotinos J. ATPase associated antigen (M2): marker antigen for serological diagnosis of primary biliary cirrhosis. Lancet 1982; 2: 14231426.
  • 3
    Golding PL, Brown R, Mason AMS, Taylor E. “Sicca complex” in liver disease. Br Med J 1970; 4: 340342.
  • 4
    Gulp KS, Duffy J, Fleming CR, Baldus WP, Dickson ER. Autoimmune associations in primary biliary cirrhosis [Abstract]. Gastroenterology 1980; 79: 1011.
  • 5
    Alarcon-Segovia D, Diaz-Jouanen E, Fishbein E. Features of Sjögren's syndrome in primary biliary cirrhosis. Ann Intern Med 1973; 79: 3136.
  • 6
    Crowe JP, Christensen E, Butler J, Wheeler P, Doniach D, Keenan J, Williams R. Primary biliary cirrhosis: the prevalence of hypothyroidism and its relationship to thyroid autoantibodies and sicca syndrome. Gastroenterology 1980; 78: 14371441.
  • 7
    Tsianos EV, Hofnagle JH, Fox PC, Alspaugh M, Jones EA, Schafer DF, Moutsopoulos HM. Sjögren's syndrome in patients with primary biliary cirrhosis. Hepatology 1990; 11: 730734.
  • 8
    Webb J. Sjögren's syndrome: clinical and laboratory features. Aust N Z J Med 1978; 8: 124129.
  • 9
    Czaja AJ, Nishioka M, Morshed SA, Hachiya T. Patterns of nuclear immunofluorescence and reactivities to nuclear antigens in autoimmune hepatitis. Gastroenterology 1994; 107: 200207.
  • 10
    Dörner T, Held C, Trebeljahr G, Lukowsky A, Yamamoto K, Hiepe F. Serological characteristics in primary biliary cirrhosis associated with sicca syndrome. Scand J Gastroenterol 1994; 29: 655660.
  • 11
    Peek R, Pruijn GJ, van Venrooij WJ. Epitope specificity determines the ability of anti-Ro52 autoantibodies to precipitate Ro ribonucleoprotein particles. J Immunol 1994; 153: 43214329.
  • 12
    Frank MB, Itoh K, McCubbin V. Epitope mapping of the 52-kD Ro/SSA autoantigen. Clin Exp Immunol 1994; 95: 390396.
  • 13
    Buyon JP, Slade SG, Reveille JD, Hamel JC, Chan EK. Autoantibody responses to the “native” 52-kDa SS-A/Ro protein in neonatal lupus syndromes, systemic lupus erythematosus, and Sjogren's syndrome. J Immunol 1994; 152: 36753684.
  • 14
    Ricchiuti V, Briand JP, Meyer O, Isenberg DA, Pruijn G, Muller S. Epitope mapping with synthetic peptides of 52-kD SSA/Ro protein reveals heterogeneous antibody profiles in human autoimmune sera. Clin Exp Immunol 1994; 95: 397407.
  • 15
    Bozic B, Pruijn GJ, Rozman B, van Venrooij WJ. Sera from patients with rheumatic diseases recognize different epitope regions on the 52-kD Ro/SS-A protein. Clin Exp Immunol 1993; 94: 227235.
  • 16
    McCauliffe DP, Yin H, Wang LX, Lucas L. Autoimmune sera react with multiple epitopes on recombinant 52 and 60 kDa Ro(SSA) proteins. J Rheumatol 1994; 21: 10731080.
  • 17
    Kato T, Sasakawa H, Suzuki S, Shirako M, Tashiro F, Nishioka K, Yamamoto K. Autoepitopes of the 52-kd SS-A/Ro molecule. Arthritis Rheum 1995; 38: 990998.
  • 18
    Dörner T, Feist E, Wagenmann A, Kato T, Yamamoto K, Nishioka K, Burmester GR, et al. Sera from different autoimmune diseases preferentially recognize B-cell epitopes present on the central region of the antigen. J Rheumatol 1996; 23: 462469.
  • 19
    Vitali C, Bombardieri S, Moutsopoulos HM, Balestrieri G, Bencivelli W, Bernstein RM, Bjerrum KB, et al. Preliminary criteria for the classification of Sjögren's syndrome. Results of an ECC prospective concerted action. Arthritis Rheum 1993; 36: 340347.
  • 20
    Ludwig J, Dickson ER, McDonald GS. Staging of chronic nonsuppurative destructive cholangitis (syndrome of primary biliary cirrhosis). Virchows Arch A Pathol Pathol Anat 1978; 379: 103112.
  • 21
    Dorner T, Chaoui R, Feist E, Göldner B, Yamamoto K, Hiepe F. Significantly increased maternal and fetal autoantibody levels to 52 kD Ro(SS-A) and La(SS-B) in complete congenital heart block. J Autoimmun 1995; 8: 675684.
  • 22
    Kohsaka H, Yamamoto K, Fuji H, Miura H, Miyasaka N, Nishioka K, Miyamoto T. Fine epitope mapping of the human SS-B/La protein. Identification of a distinct autoepitope homologous to a viral gag protein. J Clin Invest 1990; 85: 15661574.
  • 23
    Yamamoto K, Miura H, Moroi Y, Yoshinoia S, Goto M, Nishioka K, Miyamoto T. Isolation and characterization of a complementary DNA expressing Ul small nuclear ribonucleoprotein C polypeptide. J Immunol 1988; 140: 311317.
  • 24
    Okubo M, Yamamoto K, Kato T, Matsuura N, Nishimaki T, Kasukawa R, Ito K, et al. Detection and epitope analysis of autoantigen-reactive T cells to the U1-small nuclear ribonucleoprotein A protein in autoimmune disease patients. J Immunol 1993; 151: 11081115.
  • 25
    Bernstein RM, Neuberger JM, Bunn CC, Callender ME, Hughes GRV, Williams R. Diversity of autoantibodies in primary biliary cirrhosis and chronic active hepatitis. Clin Exp Immunol 1984; 55: 553560.
  • 26
    Hansen BU, Lindgren S, Erikson S, Henricsson V, Larsson A, Manthorpe R, Warfvinge G. Clinical and immunological features of Sjogren's syndrome in patients with primary biliary cirrhosis with emphasis on focal sialadenitis. Acta Med Scand 1988; 224: 611619.
  • 27
    Lozano F, Pares A, Borche L, Plana M, Gallart T, Rodes J, Vives J. Autoantibodies against nuclear envelope-associated proteins in primary biliary cirrhosis. Hepatology 1988; 8: 930938.
  • 28
    Hirakata M, Akizuki M, Miyachi K, Matsushima H, Okano T, Homma M. Coexistence of CREST syndrome and primary biliary cirrhosis. Serological studies of two cases. J Rheumatol 1988; 15: 11661170.
  • 29
    Worman HJ, Courvalin JC. Autoantibodies against nuclear envelope proteins in liver disease. Hepatology 1991; 14: 12691279.
  • 30
    Chan EK, Hamel JC, Buyon JP, Tan EM. Molecular definition and sequence motifs of the 52-kD component of human SS-A/Ro autoantigen. J Clin Invest 1991; 87: 6876.
  • 31
    Itoh K, Itoh Y, Frank MB. Protein heterogeneity in the human Ro/SSA ribonucleoproteins. The 52- and 60-kD Ro/SSA autoantigens are encoded by separate genes. J Clin Invest 1991; 87: 177186.
  • 32
    Namekawa T, Kuroda K, Kato T, Yamamoto K, Murata H, Sakamaki T, Nishioka K, et al. Identification of Ro(SSA) 52 kDa reactive T cells in labial glands from patients with Sjogren's syndrome. J Rheumatol 1995; 22: 10921099.
  • 33
    Slobbe RL, Pluk W, Van Venroij WJ, Prujin GJM. Ro ribonucleoprotein assembly in vitro. Identification of RNA-protein and protein-protein interactions. J Mol Biol 1992; 227: 361366.
  • 34
    Gordon T, Topfer F, Keech C, Reynolds P, Chen W, Rischmueller M, McCluskey J. How does autoimmunity to La and Ro initiate and spread? Autoimmunity 1994; 18: 8792.
  • 35
    Casciola-Rosen LA, Anhalt G, Rosen A. Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. J Exp Med 1994; 179: 13171330.
  • 36
    Van de Water J, Turchany J, Leung PSC, Lake J, Munoz S, Surh CD, Coppel R, et al. Molecular mimickry in primary biliary cirrhosis. J Clin Invest 1993; 91: 26532664.