Article

You have full text access to this OnlineOpen article

Chronic viral hepatitis induced by hepatitis C but not hepatitis B virus infection correlates with increased liver angiogenesis

  1. R. Mazzanti,
  2. L. Messerini,
  3. L. Monsacchi,
  4. G. Buzzelli,
  5. A. L. Zignego,
  6. M. Foschi,
  7. M. Monti,
  8. G. Laffi,
  9. L. Morbidelli,
  10. O. Fantappié,
  11. F. Bartoloni Saint Omer,
  12. M. Ziche

Article first published online: 30 DEC 2003

DOI: 10.1002/hep.510250142

Issue

Hepatology

Hepatology

Volume 25, Issue 1, pages 229–234, January 1997

Additional Information

How to Cite

Mazzanti, R., Messerini, L., Monsacchi, L., Buzzelli, G., Zignego, A. L., Foschi, M., Monti, M., Laffi, G., Morbidelli, L., Fantappié, O., Omer, F. B. S. and Ziche, M. (1997), Chronic viral hepatitis induced by hepatitis C but not hepatitis B virus infection correlates with increased liver angiogenesis. Hepatology, 25: 229–234. doi: 10.1002/hep.510250142

Author Information

  1. Institute of Internal Medicine, University of Florence, Italy

Publication History

  1. Issue published online: 30 DEC 2003
  2. Article first published online: 30 DEC 2003

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

Get PDF (1325K)

References

  • 1
    Bartoloni Saint Omer F, Giannini FA, Napoli P. Hepatocellular carcinoma and cirrhosis: a review of their relative incidence in a 25 year period in the Florence area. Hepatogastroenterology 1984; 31: 215–217.
  • 2
    Colombo M, De Franchis R, Del Ninno E, Sangiovanni A, DeFazio C, Tommasini M, Donato MF, et al. Hepatocellular carcinoma in Italian patients. N Engl J Med 1991; 325: 675–680.
  • 3
    Gentilini P, Melani L, Riccardi D, Casini Raggi V, Romanelli RG. Hepatocellular carcinoma and viral cirrhosis. HEPATOLOGY 1994; 20: 764–765.
  • 4
    Villa E, Baldini GM, Pasquinelli O, Melegari M, Cariani E, Di Chirico G, Manenti F. Risk factors for hepatocellular carcinoma in Italy. Male sex, hepatitis B virus, non A non B infection, and alcohol. Cancer 1988; 62: 611–615.
    Direct Link:
  • 5
    Caporaso N, Romano M, Marmo R, De Sio I, Morisco F, Minerva A, Coltorti M. Hepatitis C virus infection is an additive risk factor for development of hepatocellular carcinoma in patients with cirrhosis. J Hepatol 1991; 12: 367–371.
  • 6
    Takano S, Yokosuka O, Imazeki F, Tagawa M, Omata M. Incidence of hepatocellular carcinoma in chronic hepatitis B and C: a prospective study of 251 patients. HEPATOLOGY 1995; 21: 650–655.
    Direct Link:
  • 7
    Okuda K. Hepatocellular carcinoma: recent progress. HEPATOLOGY 1992; 15: 848–863.
    Direct Link:
  • 8
    Zhang X-K, Egan JO, Huang D-P, Sun Z-L, Chien VKY, Chiu JF. Hepatitis B virus DNA integration and expression of an Erb B-like gene in human hepatocellular carcinoma. Biochem Biophys Res Commun 1992; 188: 344–351.
  • 9
    Paterlini P, Driss F, Nalpas B, Pisi E, Franco D, Berthelot P, Brechot C. Persistence of hepatitis B and hepatitis C viral genomes in primary liver cancers from HBsAg-negative patients: a study of a low-endemic area. HEPATOLOGY 1993; 17: 20–29.
    Direct Link:
  • 10
    Paterlini P, Poussin K, Kew M, Franco D, Brechot C. Selective accumulation of the X transcript of hepatitis B virus in patients negative for hepatitis B surface antigen with hepatocellular carcinoma. HEPATOLOGY 1995; 21: 313–321.
  • 11
    Simonetti RG, Cammà C, Fiorello F, Cottone M, Rapicetta M, Marino L, Fiorentino G, et al. Hepatitis C virus infection as a risk factor for hepatocellular carcinoma in patients with cirrhosis. Ann Intern Med 1992; 116: 97–102.
  • 12
    De Mitri MS, Poussin K, Baccarini P, Pontisso P, D'Errico A, Simon N, Grigioni W, et al. HCV-associated liver cancer without cirrhosis. Lancet 1995; 345: 413–415.
  • 13
    Ziche M, Gullino PM. Angiogenesis and neoplastic progression in vitro. Monogr Natl Cancer Inst 1982; 69: 483–487.
  • 14
    Gullino PM, Ziche M, Alessandri G. Gangliosides, copper ions and angiogenic capacity of adult tissues. Cancer Metastasis Rev 1990; 9: 239–251.
  • 15
    Folkman J, Shing Y. Angiogenesis. J Biol Chem 1992; 267: 10931–10934.
  • 16
    Kock AE, Polverini PJ, Kunkel SL, Harlow SA, Di Pietro LA, Elner VM, Elner SG, Strieter RM. Interleukin-8:as a macrophage-derived mediator of angiogenesis. Science 1992; 258: 1798–1801.
  • 17
    Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med 1995; 1: 27–31.
  • 18
    Garcìa-Monzòn C, Sànchez-Madrid F, Garcìa-Buey L, Garcìa-Arroyo A, Garcìa-Sanchez A, Moreno-Otero R. Vascular adhesion molecule expression in viral chronic hepatitis: evidence of neoangiogenesis in portal tracts. Gastroenterology 1995; 108: 231–241.
  • 19
    Knodell RG, Ishac KG, Black WC, Chen TS, Craig R, Kaplowitz N, Kier-man TW, et al. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. HEPATOLOGY 1981; 5: 431–435.
    Direct Link:
  • 20
    Desmet VJ, Gerber MA, Hoofnagle JH, Manns M, Scheuer PJ. Classification of chronic hepatitis: diagnosis, grading and staging. HEPATOLOGY 1994; 19: 1513–1520.
    Direct Link:
  • 21
    Gentilini P, Mazzanti R, Foschi M, Bartoloni Saint Omer F, Messerini L. Comparative analysis of histologic features of HBV and HCV related chronic active hepatitis [Abstract]. HEPATOLOGY 1991; 14: 69A.
  • 22
    Zignego AL, Foschi M, Laffi G, Monti M, Careccia G, Romanelli RG, De Majo E, et al. “Inapparent” hepatitis B virus infection and hepatitis C virus replication in alcoholic subjects with and without liver disease. HEPATOLOGY 1994; 19: 577–582.
    Direct Link:
  • 23
    Ramani P, Bradley NJ, Fletcher CDM. QB-END/10, a new monoclonal antibody to endothelium: assessment of its diagnostic utility in paraffin sections. Histopathology 1990; 17: 237–242.
    Direct Link:
  • 24
    Weidner N, Semple JP, Welch WH, Folkman J. Tumor angiogenesis and metastasis. Correlation in invasive breast carcinoma. N Engl J Med 1991; 324: 1–8.
  • 25
    Fox SB, Leek RD, Weeks MP, Whitehouse RM, Gatter KC, Harris AL. Quantitation and prognostic value of breast cancer angiogenesis: comparison of microvessel density, chalkley count, and computer image analysis. J Pathol 1995; 177: 275–283.
    Direct Link:
  • 26
    Gimbrone MA, Cotran RS, Folkman J. Human vascular endothelial cells in culture. J Cell Biol 1974; 60: 673–684.
  • 27
    Ziche M, Morbidelli L, Masini E, Amerini S, Granger HJ, Maggi CA, Geppetti P, et al. Nitric oxide mediates angiogenesis in vivo and endothelial cell growth and migration in vitro promoted by substance P. J Clin Invest 1994; 94: 2036–2044.
  • 28
    Folkman J. Clinical applications of research on angiogenesis. N Engl J Med 1995; 333: 1757–1763.
  • 29
    Ferrara N. Missing link in angiogenesis. Nature 1995; 376: 467.
  • 30
    Koch AE, Halloran MM, Haskell CJ, Shah MR, Polverini PJ. Angiogenesis mediated by soluble forms of E-selectin and vascular adhesion molecule-1. Nature 1995; 376: 517–519.
  • 31
    O'Reilly MS, Holmgren L, Shing Y, Chen C, Rosenthal RA, Moses M, Lane WS, et al. Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell 1994; 79: 315–328.
  • 32
    Shanahan F, O'Sullivan GC. Angiostatin: candidate for molecule of the year. Gastroenterology 1995; 108: 1946–1948.
  • 33
    Bertoletti A, D'Elios MM, De Carli M, Zignego AL, Durazzo M, Boni C, Missale G, et al. Different cytokine profiles of intrahepatic T cells in chronic hepatitis B and hepatitis C virus infections. Gastroenterology, in press.
  • 34
    Cassani F, Muratori L, Manotti P, Lenzi M, Fusconi M, Ballardini G, Selleri L, et al. Serum autoantibodies and the diagnosis of type-1 autoimmune hepatitis in Italy: a reappraisal at the light of hepatitis C virus infection. Gut 1993; 33: 1260–1263.
  • 35
    Agnello V, Chung RT, Kaplan LM. A role for hepatitis C virus infection in type II cryoglobulinemia. N Engl J Med 1992; 327: 1490–1495.
  • 36
    Ferri C, La Civita L, Monti M, Longobardo G, Pasero G, Zignego AL. Can type C hepatitis be complicated by B-cell malignant lymphoma? Lancet 1995; 346: 1426–1427.
  • 37
    Zignego AL, De Carli M, Monti M, Careccia G, La Villa G, Giannini C, Del Prete G, et al. Hepatitis C virus infection of mononuclear cells from peripheral blood and liver infiltrate in chronically infected subjects. J Med Virol 1995; 47: 58–64.
    Direct Link:
  • 38
    Schnittler HJ, Manner F, Drenckhahn D, Klenk HD, Feldmann H. Replication of Marbourg virus in human endothelial cells. J Clin Invest 1993; 91: 1301–1309.
Get PDF (1325K)