• 1
    Bates TE, Williams SR, Kauppinen RA, Godian DG. Observation of cerebral metabolites in an animal model of acute liver failure in vivo: 1H and 31P nuclear magnetic resonance study. J Neurochem 1989; 53: 102110.
  • 2
    Butterworth RF. Hepatic encephalopathy. In: AriasIM, BoyerJL, FaustoN, JakobyWB, SchachterDA, ShafritzDA, eds. The liver: biology and pathobiology. Ed 3. New York: Raven, 1994: 11931208.
  • 3
    Monaghan DT, Bridges RJ, Cotman CW. The excitatory amino acid receptors: their classes, pharmacology, and distinct properties in the function of the central nervous system. Annu Rev Pharmacol Toxicol 1989; 29: 365402.
  • 4
    Gallo V, Russell JT. Excitatory amino acid receptors in glia: different subtypes for distinct functions? J Neurosci Res 1995; 42: 18.
  • 5
    de Knegt RJ, Schalm SW, van der Rijt CCD, Fekkes D, Dalm E, Hekking-Weyma I. Extracellular brain glutamate during acute liver failure and during acute hyperammonemia simulating acute liver failure: an experimental study based on in vivo brain dialysis. J Hepatol 1994; 20: 1926.
  • 6
    Bosman DK, Deutz NEP, Maas MAW, van Eijk HMH, Smit JJH, de Haan JG, Chamuleau RAFM. Amino acid release from cerebral cortex in experimental acute liver failure, studied by in vivo microdialysis. J Neurochem 1992; 59: 591599.
  • 7
    Michalak A, Rose C, Butterworth J, Butterworth RF. Extracellular concentrations of neuroactive amino acids and glutamate (NMDA) receptors in frontal cortex of rats with experimental acute liver failure. Hepatology 1996; 24: 908913.
  • 8
    Swain M, Butterworth RF, Blei AT. Ammonia and related amino acids in the pathogenesis of brain edema in acute ischemic liver failure in rats. Hepatology 1992; 15: 449453.
  • 9
    Moroni F, Mannaioni G, Cherici G, Leonardi P, Carlà V, Lombardi G. Excitatory amino acid neurotransmission and ammonia toxicity. In: CapocacciaL, MerliM, RiggioO, eds. Advances in hepatic encephalopathy and metabolic nitrogen exchange. Boca Raton, FL: CRC, 1995: 130139.
  • 10
    Fan P, Szerb JC. Effects of ammonium ions on synaptic transmission and on responses to quisqualate and N-methyl-D-aspartate in hippocampal CA1 pyramidal neurons in vitro. Brain Res 1993; 632: 225231.
  • 11
    Hawkins LM, Beaver KM, Jane DE, Taylor PM, Sunter DC, Roberts PJ. Characterization of the pharmacology and regional distribution of (S)-[3H]−5-fluorowillardiine binding in rat brain. Br J Pharmacol 1995; 116: 20332039.
  • 12
    Lee SH, Fisher B. Portacaval shunt in the rat. Surgery 1961; 50: 668672.
  • 13
    Rao VLR, Audet R, Therrien G, Butterworth RF. Tissue-specific alterations of binding sites for peripheral-type benzodiazepine receptor ligand [3H]PK11195 in rats following portacaval anastomosis. Dig Dis Sci 1994; 39: 10551063.
  • 14
    Sakurai SY, Penney JB, Young AB. Regionally distinct N-methyl-D-aspartate receptors distinguished by quantitative autoradiography of [3H] MK-801 binding in rat brain. J Neurochem 1993; 60: 13441353.
  • 15
    Magnusson KR, Cotman CW. Age-related changes in excitatory amino acid receptors in two mouse strains. Neurobiol Aging 1993; 14: 197206.
  • 16
    Bosman DK, Chamuleau RAFM, Bovée WMMJ, van Dijk JE, Deutz EP. The glutamate hypothesis studied by brain dialysis and 1H-NMR spectroscopy in cerebral cortex of the rat during acute hepatic encephalopathy. In: BengtssonF, JeppsonB, AlmdalT, VilstrupH, eds. Progress in hepatic encephalopathy and metabolic nitrogen exchange. Boca Raton, FL: CRC, 1991: 197209.
  • 17
    Swain MS, Bergeron M, Audet R, Blei AT, Butterworth RF. Monitoring of neurotransmitter amino acids by means of an indwelling cisterna magna catheter. A comparison of two rodent models of fulminant hepatic failure. Hepatology 1992; 16: 10281035.
  • 18
    Record CO, Buxton B, Chase R, Curzon G, Murray-Lyon IM, Williams R. Plasma and brain amino acids in fulminant hepatic failure and their relationship to hepatic encephalopathy. Eur J Clin Invest 1976; 6: 387394.
  • 19
    Zimmerman C, Ferenci P, Pifl C, Yurdaydin C, Ebner J, Lassmann H, Roth E, Hortnagle H. Hepatic encephalopathy in thioacetamide-induced acute liver failure in rats: characterization of an improved model and study of amino-acidergic neurotransmission. Hepatology 1989; 9: 594601.
  • 20
    Huo Z, Neary JT, Petito CK, Norenberg MD. The glutamate transporter GLT-1 is down-regulated in hyperammonemic and acute liver failure [Abstract]. Soc Neurosci Abs 1995; 21: 108A.
  • 21
    Knecht K, Michalak A, Rose C, Butterworth RF. Decreased glutamate transporter [GLT-1] gene expression in brain in acute liver failure [Abstract]. Hepatology 1996; 24: 486A.
  • 22
    Oppong KNW, Bartlett K, Record CO, Al Mardini H. Synaptosomal glutamate transport in thioacetamide-induced hepatic encephalopathy in the rat. Hepatology 1995; 22: 553558.
  • 23
    Watanabe A, Fujiwara M, Shiota T, Tsuji T. Amino acid neurotransmitters and their receptors in the brain synaptosomes of acute hepatic failure rats. Biochem Med Metab Biol 1988; 40: 247252.
  • 24
    Ferenci P, Pappas SC, Munson PJ, Henson K, Jones EA. Changes in the status of neurotransmitter receptors in a rabbit model of hepatic encephalopathy. Hepatology 1984; 4: 186191.
  • 25
    de Knegt RJ, Kornhuber J, Schalm SW, Rusche K, Riederer P, Tan J. Binding of the ligand [3H]MK-801 to the MK-801 binding site of the N-methyl-D-aspartate receptor during experimental encephalopathy from acute liver failure and from acute hyperammonemia in the rabbit. Metab Brain Dis 1993; 8: 8194.
  • 26
    Rao VLR, Agrawal AK, Murthy CRK. Ammonia-induced alterations in glutamate and muscimol binding to cerebellar synaptic membranes. Neurosci Lett 1991; 130: 251254.
  • 27
    Peterson C, Héroux M, Lavoie J, Butterworth RF. Loss of [3H]-kainate and of NMDA-displaceable [3H]-glutamate binding sites in brain in thiamine deficiency: results of a quantitative autoradiographic study. Neurochem Res 1995; 20: 11551160.
  • 28
    Muller T, Moller T, Berger T, Schnitzer J, Kettenmann H. Calcium entry through kainate receptors and resulting potassium-channel blockade in Bergmann glial cells. Science 1992; 256: 15631566.
  • 29
    Jabs R, Kirchhoff F, Kettenmann H, Steinhauser C. Kainate activates Ca2+-permeable glutamate receptors and blocks voltage-gated K+ currents in glial cells of mouse hippocampal slices. Pfugers Arch 1994; 426: 310319.
  • 30
    Seifert G, Steinhauser C. Glial cells in the mouse hippocampus express AMPA receptors with an intermediate Ca2+ permeability. Eur J Neurosci 1995; 7: 18721884.