• 1
    Cooper EH, Bedford AJ, Kenny TE. Cell death in normal and malignant tissues. Adv Cancer Res 1975; 21: 59120.
  • 2
    Wright NA. The tissue kinetics of cell loss. In: BowenID, LockshinRA, eds. Cell Death in Biology and Pathology. London, New York: Chapman and Hall, 1981: 171207.
  • 3
    Wyllie AH. The biology of cell death in tumors. Anticancer Res 1985; 5: 131136.
  • 4
    Sarraf CE, Bowen ID. Kinetic studies on a murine sarcoma and an analysis of apoptosis. Br J Cancer 1986; 54: 989998.
  • 5
    Moore JV. Death of cells and necrosis of tumours. In: PottenCS, ed. Perspectives on Mammalian Cell Death. New York: Oxford University Press, 1987: 295325.
  • 6
    Michalopoulos GK. Liver regeneration and growth factors: old puzzles and new perspectives. Lab Invest 1992; 67: 413415.
  • 7
    Oberhammer FA, Pavelka M, Sharma S, Tiefenbacher R, Purchio AF, Bursch W, Schulte-Hermann R. Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor β. Proc Natl Acad Sci U S A 1992; 89: 54085412.
  • 8
    Fausto N, Webber EM. Mechanisms of growth regulation in liver regeneration and hepatic carcinogenesis. In: BoyerJL, OcknerRK, eds. Progress in Liver Diseases. Philadelphia, Saunders, 1993: 115137.
  • 9
    Nagy P, Bisgaard HC, Thorgeirsson SS. Expression of hepatic transcriptional factors during liver development and oval cell differentiation. J Cell Biol 1994; 126: 223233.
  • 10
    Grasl-Kraupp B, Bursch W, Ruttkay-Nedecky B, Wagner A, Lauer B, Schulte-Hermann R. Food restriction eliminates preneoplastic cells through apoptosis and antagonizes carcinogenesis in rat liver. Proc Natl Acad Sci U S A 1994; 91: 99969999.
  • 11
    Schulte-Hermann R, Bursch W, Grasl-Kraupp B. Active cell death (apoptosis) in liver biology and disease. In: BoyerJL, OcknerRK, eds. Progress in Liver Diseases. Philadelphia, Saunders, 1995: 135.
  • 12
    Okuda K, Kojiro M, Okuda H. Neoplasms of the liver. In: SchiffL, SchiffER, eds. Diseases of the Liver. Philadelphia, Lippincott, 1993: 12361296.
  • 13
    Pitot HC, Dragan YP. Facts and theories concerning the mechanisms of carcinogenesis. FASEB J 1991; 5: 22802286.
  • 14
    Bursch W, Lauer B, Timmermann-Trosiener I, Barthel G, Schuppler J, Schulte-Hermann R. Controlled cell death (apoptosis) of normal and putative preneoplastic cells in rat liver following withdrawal of tumor promoters. Carcinogenesis 1984; 5: 453458.
  • 15
    Schulte-Hermann R, Timmermann-Trosiener I, Barthel G, Bursch W. DNA synthesis, apoptosis, and phenotype expression as determinants of growth of altered foci in rat liver during phenobarbital promotion. Cancer Res 1990; 50: 51275135.
  • 16
    Lake BG. Mechanisms of hepatocarcinogenicity of peroxisome-proliferat-ing drugs and chemicals. Annu Rev Pharmacol Toxicol 1995; 35: 483507.
  • 17
    Issemann I, Green S. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 1990; 347: 645650.
  • 18
    Moody DE, Reddy JK. Morphometric analysis of the ultrastructural changes in rat liver induced by the peroxisome proliferator SaH 42–348. J Cell Biol 1976; 71: 768780.
  • 19
    Greaves P, Irisarri E, Monro AM. Hepatic foci of cellular and enzymatic alteration and nodules in rats treated with clofibrate or diethylnitrosamine followed by phenobarbital: their rate of onset and their reversibility. J Natl Cancer Inst 1986; 76: 475484.
  • 20
    Marsnian DS, Popp JA. Biological potential of basophilic hepatocellular foci and hepatic adenoma induced by the peroxisonie proliferator, Wy-14,643. Carcinogenesis 1994; 15: 111117.
  • 21
    Kraupp-Grasl B, Huber W, Taper H, Schulte-Hermann R. Increased susceptibility of aged rats to hepatocarcinogenesis by the peroxisonie proliferator nafenopin and the possible involvement of altered liver foci occurring spontaneously. Cancer Res 1991; 51: 666671.
  • 22
    Schulte-Hermann R. Two-stage control of cell proliferation induced in rat liver by alpha-hexachlorocyclohexane. Cancer Res 1977; 37: 166171.
  • 23
    Saltykow SA. The determination of the size distribution of particles in opaque material from a measurement of the size distributions of their sections. In: EliasH, ed. Proceedings of the Second International Congress for Stereology. Berlin: Springer, 1967: 163173.
  • 24
    Bursch W, Taper HS, Lauer B, Schulte-Hermann R. Quantitative histological and histochemical studies on the occurrence and stages of controlled cell death (apoptosis) during regression of rat liver hyperplasia. Virchows ArchB 1985; 50: 153166.
  • 25
    Luebeck EG, Grasl-Kraupp B, Timmermann-Trosiener I, Bursch W, Schulte-Hermann R, Moolgavkar SH. Growth kinetics of enzyme-altered liver foci in rats treated with phenobarbital or alpha-hexachlorocyclohexane. Toxicol Appl Pharm 1995; 130: 304315.
  • 26
    Edmondson HA, Steiner PE. Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. Cancer 1954; 7: 462503.
  • 27
    Weidner N, Moore DH II, Vartanian R. Correlation of Ki-67 antigen expression with mitotic figure index and tumor grade in breast carcinomas using the novel “paraffin”-reactive MIB1 antibody. Hum Pathol 1994; 25: 337342.
  • 28
    Ogasawara J, Watanabe-Fukunaga R, Adachi M, Matsuzawa A, Kasugal T, Kitamura Y, Itoh N, et al. Lethal effect of the anti-fas antibody in mice. Nature 1993; 364: 806809.
  • 29
    Szende B, Zalatnai A, Schally AV. Programmed cell death (apoptosis) in pancreatic cancers of hamsters after treatment with analogs of both luteinizing hormone-releasing hormone and somatostatin. Proc Natl Acad Sci U S A 1989; 86: 16431647.
  • 30
    Bursch W, Liehr JG, Sirbasku D, Putz B, Taper H, Schulte-Hermann R. Control of cell death (apoptosis) by diethylstilbestrol in an estrogen-dependent kidney tumor. Carcinogenesis 1991; 12: 855860.
  • 31
    Tenniswood MP, Guenette RS, Lakins J, Mooibroek M, Wong P, Welsh JE. Active cell death in hormone-dependent tissue. Cancer Metast Rev 1992; 77: 197220.
  • 32
    Prehn RT. The inhibition of tumor growth by tumor mass. Cancer Res 1991; 51: 24.
  • 33
    Moolgavkar SH, Luebeck EG, de Gunst M, Port RE, Schwarz M. Quantitative analysis of enzyme-altered foci in rat hepatocarcinogenesis experiments I: single agent regimen. Carcinogenesis 1990; 11: 12711278.
  • 34
    Schulte-Hermann R, Ohde G, Schuppler J, Timmermann-Trosiener I. Enhanced proliferation of putative preneoplastic cells in rat liver following treatment with the tumor promoters phenobarbital, hexachlorocyclohexane, steroid compounds, and nafenopin. Cancer Res 1981; 41: 25562562.
  • 35
    Müllauer L, Grasl-Kraupp B, Bursch W, Schulte-Hermann R. Transforming growth factor β–induced cell death in preneoplastic foci of rat liver and sensitization by the antiestrogen tamoxifen. Hepatology 1996; 23: 840847.
  • 36
    Sato Y, Fujiwara K, Nakagawa S, Kanishima S, Ohta Y, Oka Y, Hayashi S, et al. A case of spontaneous regression of hepatocellular carcinoma with bone metastasis. Cancer 1985; 56: 667671.
  • 37
    Gaffey MJ, Joyce JP, Carlson GS, Esteban JM. Spontaneous regression of hepatocellular carcinoma. Cancer 1989; 65: 27792783.
  • 38
    Suzuki M, Okazaki N, Yoshino M, Yoshida T. Spontaneous regression of a hepatocellular carcinoma–a case report. Hepatogastroenterology 1989; 36: 160163.
  • 39
    Farrell GC, Joshua DE, Uren RF, Baird PJ, Perkins KW, Kronenberg H. Androgen-induced hepatoma. Lancet 1975; i: 430432.
  • 40
    Edmondson HA, Reynolds TB, Henderson B, Benton B. Regression of liver cell adenoma associated with oral contraceptives. Ann Intern Med 1977; 86: 180182.
  • 41
    Buhler H, Pirovino M, Akovbiantz A, Altorfer J, Weitzel M, Maranta E, Schmid M. Regression of liver cell adenoma. A follow up study of three consecutive patients after discontinuation of oral contraceptive use. Gastroenterology 1982; 82: 775782.
  • 42
    Huggins C. Endocrine-induced regression of cancers. Cancer Res 1967; 27: 19251930.