• 1
    Cooper J, Rettke SR, Ludwig J, Ayalon A, Sterioff S, Wiesner RH, Krom RAF. UW solution improves duration and quality of clinical liver preservation. Transplant Proc 1990; 22: 477479.
  • 2
    Caldwell-Kenkel JC, Currin RT, Tanaka Y, Thurman RG, Lemasters JJ. Kupffer cell activation and endothelial cell damage after storage of rat livers: effects of reperfusion. Hepatology 1991; 13: 8395.
  • 3
    Thurman RG, Marzi I, Seitz G, Thies J, Lemasters JJ, Zimmerman F. Hepatic reperfusion injury following orthotopic liver transplantation in the rat. Transplantation 1988; 46: 502506.
  • 4
    Howard TK, Klintmalm GBG, Cofer JB, Husberg BS, Goldstein RM, Gonwa TA. The influence of preservation injury on rejection in the hepatic transplant recipient. Transplantation 1990; 49: 103107.
  • 5
    Furukawa H, Todo S, Imventarza O, Casavilla A, Wu YM, Scotti-Foglieni C, Bruznick B, et al. Effect of cold ischemia time on the early outcome of human hepatic allografts preserved with UW solution. Transplantation 1991; 51: 10001004.
  • 6
    Caldwell-Kenkel JC, Currin RT, Tanaka Y, Thurman RG, Lemasters JJ. Reperfusion injury to endothelial cells following cold ischemic storage of rat livers. Hepatology 1989; 10: 292299.
  • 7
    Colletti LM, Remick DG, Burtch GD, Kunkel SL, Strieter RM, Campbell DA. Role of tumor necrosis factor-α in the pathophysiological alterations after ischemia/reperfusion injury in the rat. J Clin Invest 1990; 85: 1936–1943.
  • 8
    Marzi I, Cowper K, Takei Y, Lindert K, Lemasters JJ, Thurman RG. Methyl palmitate prevents Kupffer cell activation and improves survival after orthotopic liver transplantation in the rat. Transplant Int 1991; 4: 215220.
  • 9
    Currin RT, Reinstein LJ, Lichtman SN, Thurman RG, Lemasters JJ. Inhibition of tumor necrosis factor release from cultured rat Kupffer cells by agents that reduce graft failure from storage injury. Transplant Proc 1993; 25: 16311632.
  • 10
    Takei Y, Marzi I, Kauffman FC, Currin RT, Lemasters JJ, Thurman RG. Increase in survival time of liver transplants by protease inhibitors and a calcium channel blocker, nisoldipine. Transplantation 1990; 50: 1420.
  • 11
    Savier E, Shedlofsky SI, Swim AT, Lemasters JJ, Thurman RG. The calcium channel blocker nisoldipine minimizes the release of tumor necrosis factor and interleukin-6 following rat liver transplantation. Transplant Int 1992; 5: S398S402.
  • 12
    Bachman S, Caldwell-Kenkel JC, Currin RT, Lichtman SN, Steffen R, Thurman RG, Lemasters JJ. Protection by pentoxifylline against graft failure from storage injury after orthotopic liver transplantation. Transplant Int 1992; 5: S345S350.
  • 13
    Brenner DA, O'Hara M, Angel P, Chojkier M, Karin M. Prolonged activation of jun and collagenase genes by tumor necrosis factor α. Nature 1989; 337: 661663.
  • 14
    Lowenthal JW, Ballard DW, Bogerd H, Böhnlein E, Greene WC. Tumor necrosis factor-α activation of the IL-2 receptor-α gene involves the induction of KB-specific DNA binding proteins. J Immunol 1989; 142: 31213128.
  • 15
    Westwick JK, Weitzel C, Minden A, Karin M, Brenner DA. Tumor necrosis factor α stimulates AP-1 activity through prolonged activation of c-Jun kinase. J Biol Chem 1994; 269: 2639626401.
  • 16
    Alvarez E, Northwood IC, Gonzalez FA, Latour DA, Seth A, Abate C, Curran T, et al. Pro-leu-ser/thr-pro is a consensus primary sequence for substrate protein phosphorylation. J Biol Chem 1991; 266: 1527715285.
  • 17
    Derijard B, Hibi M, Wu I-H, Barret T, Su B, Deng T, Karin M, et al. JNK-1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 1994; 76: 10251037.
  • 18
    Hibi M, Lin A, Smeal T, Minden A, Karin M. Identification of an oncoprotein- and UV-responsive protein kinase that binds to and potentiates the c-Jun activation domain. Genes Dev 1993; 7: 21352148.
  • 19
    Minden A, Lin A, Smeal T, Derijard B, Cobb M, Davis R, Karin M. c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases. Mol Cell Biol 1994; 14: 66836688.
  • 20
    Gupta S, Campbell D, Derijard B, Davis RJ. Transcription factor ATF2 regulation by the JNK signal transduction pathway. Science 1995; 267: 389393.
  • 21
    van Dam H, Duyndam M, Rottier R, Bosch A, de Vries-Smits L, Herrlich P, Zantema A, et al. Heterodimer formation of cJun and ATF-2 is responsible for induction of c-jun by the 243 amino acid adenovirus E1A protein. EMBO J 1993; 12: 479487.
  • 22
    Hai T, Curran T. Cross-family dimerization of transcription factors Fos/ Jun and ATF/CREB alters DNA binding specificity. Proc Natl Acad Sci US A 1991; 88: 37203724.
  • 23
    Halazonetis TD, Georgopoulos K, Greenberg ME, Leder P. c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities. Cell 1988; 55: 917924.
  • 24
    Han J, Lee J-D, Bibbs L, Ulevitch RJ. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 1994; 265: 808811.
  • 25
    Raingeaud J, Gupta S, Rogers JS, Dickens M, Han J, Ulevitch RJ, Davis RJ. Pro-inflammatory cytokines and environmental stress cause p38 mitogenactivated protein kinase activation by dual phosphorylation on tyrosine and threonine. J Biol Chem 1995; 270: 74207426.
  • 26
    Boulton TG, Nye SH, Robbins DJ, Ip NY, Radziejewska E, Morgenbesser SD, DePinho RA, et al. ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Cell 1991; 65: 663665.
  • 27
    Gille H, Sharrocks AD, Shaw PE. Phosphorylation of transcription factor p62-TCF by MAP kinase stimulated ternary complex formation at the c-fos promoter. Nature 1992; 358: 414417.
  • 28
    Xia Z, Dickens M, Raingeaud J, Davis RJ, Greenberg ME. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 1995; 270: 13261331.
  • 29
    Verheij M, Bose R, Lin XH, Yao B, Jarvis WD, Grant S, Birrer MJ, et al. Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature 1996; 380: 7579.
  • 30
    Sawai H, Okazaki T, Yamamoto H, Okano H, Takeda Y, Tashima M, Sawada H, et al. Requirement of AP-1 for cer amide-induced apoptosis in human leukemia HL-60 cells. J Biol Chem 1995; 270: 2732627331.
  • 31
    Pages G, Lenormand P, L'Allemain G, Chambard J-C, Meloche S, Pouyssegur J. Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation. Proc Natl Acad Sci U S A 1993; 90: 83198323.
  • 32
    Dbaibo GS, Obeid LM, Hannun YA. Tumor necrosis factor-α (TNF-α) signal transduction through ceramide. J Biol Chem 1993; 268: 1776217766.
  • 33
    Hannun YA. The sphingomyelin cycle and the second messenger function of ceramide. J Biol Chem 1994; 269: 31253128.
  • 34
    Westwick JK, Bielawska AE, Dbaibo G, Hannun Y, Brenner DA. Ceramide activates the stress-activated protein kinases. J Biol Chem 1995; 270: 2268922692.
  • 35
    Kamada N, Calne RY. Orthotopic liver transplantation in the rat. Technique using cuff for portal vein anastomosis and biliary drainage. Transplantation 1979; 28: 47.
  • 36
    Lavery DJ, Schibler U. Circadian transcription of the cholesterol 7-alpha hydroxylase gene may involve the liver-enriched bZIP protein DBP. Genes Dev 1993; 7: 1871.
  • 37
    Hattori M, Tugores A, Karin M, Brenner DA. A simplified method for the preparation of nuclear extracts. DNA 1990; 9: 777.
  • 38
    Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 27: 246254.
  • 39
    Westwick JK, Brenner DA. Methods for analyzing c-Jun kinase. Methods Enzymol 1995; 255: 342359.
  • 40
    Marias R, Wynne J, Treisman R. The SRF accessory protein Elk-1 contains a growth fact or-regulated trans criptional activation domain. Cell 1993; 73: 381393.
  • 41
    Herman B, Nieminen A-L, Gores GJ, Lemasters JJ. Irreversible injury in anoxic hepatocytes precipitated by an abrupt increase in plasma membrane permeability. FASEB J 1988; 2: 146151.
  • 42
    Gores GJ, Flarsheim CE, Dawson TL, Nieminen A-L, Herman B, Lemasters JJ. Swelling, reductive stress, and cell death during chemical hypoxia in hepatocytes. Am J Physiol 1989; 257: C347C354.
  • 43
    Dignam JD, Lebovitz RM, Roeder RG. A simplified method for the preparation of nuclear extracts. Nucleic Acids Res 1983; 11: 14751489.
  • 44
    Westwick JK, Weitzel C, Leffert HL, Brenner DA. Activation of Jun kinase is an early event in hepatic regeneration. J Clin Invest 1995; 95: 803810.
  • 45
    Baeuerle PA, Baltimore D. A 65-kappaD subunit of active NF-kappaB is required for inhibition of NF-kappaB by I-kappaB. Genes Dev 1989; 3: 16891698.
  • 46
    Hattori MA, Tugores A, Westwick JK, Veloz L, Leffert HL, Karin M, Brenner DA. Activation of activating protein 1 during hepatic acute phase response. Am J Physiol 1993; 264: G95G103.
  • 47
    Chirgwin JM, Przybyla AE, MacDonald RJ, Rutter WJ. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 1979; 18:5294.
  • 48
    Jayadev S, Liu B, Bielawska AE, Lee JY, Nazaire F, Pushkareva MY, Obeid LM, et al. Role for ceramide in cell cycle arrest. J Biol Chem 1995; 270: 20472052.
  • 49
    Sabbadini R, McNutt W, Jenkins G, Betto R, Salviati G. Sphingosine is endogenous to cardiac and skeletal muscle. Biochem Biophys Res Commun 1993; 193: 752758.
  • 50
    Crofford L, Sano H, Karalis K, Webster EL, Goldmuntz EA, Chrousos GP, Wilder RL. Local secretion of corticotropin-releasing hormone in the joints of Lewis rats with inflammatory arthritis. J Clin Invest 1992; 90: 25552564.
  • 51
    Kwon J, Chung I, Benveniste E. Cloning and sequence analysis of the rat tumor necrosis factor-encoding genes. Gene 1993; 132: 227236.
  • 52
    Lange-Carter CA, Pleiman CM, Gardner AM, Blumer KJ, Johnson GL. A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf. Science 1993; 260: 315319.
  • 53
    Westwick JK, Cox AD, Der CJ, Cobb MH, Hibi M, Karin M, Brenner DA. Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases. Proc Natl Acad Sci USA 1994; 91: 60306034.
  • 54
    Chen R-H, Sarnecki C, Blenis J. Nuclear Localization and regulation of erk- and rsk-encoded protein kinases. Mol Cell Biol 1992; 12: 915927.
  • 55
    Seth A, Gonzalez FA, Gupta S, Raden DL, Davis RJ. Signal transduction within the nucleus by mitogen-activated protein kinase. J Biol Chem 1992; 267: 2479624804.
  • 56
    Cavigelli M, Dolfi F, Claret F-X, Karin M. Induction of c-fos expression through JNK-mediated TCF/Elk phosphorylation. EMBO J 1995; 14: 59575964.
  • 57
    Kim M-Y, Linardic C, Obeid L, Hannun Y. Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor α and γ-interferon:specific role in differentiation. J Biol Chem 1991; 266: 484489.
  • 58
    Kyriakis JM, Bannerjee P, Nikolakaki E, Dai T, Rubi EA, Ahmad MF, Avruch J, et al. The stress-activated protein kinase subfamily of c-Jun kinases. Nature 1994; 369: 156160.
  • 59
    Pombo CM, Bonventre JV, Avruch J, Woodgett JR, Kyriakis JM, Force T. The stress-activated protein kinases are major c-jun amino-terminal kinases activated by ischemia and reperfusion. J Biol Chem 1994; 269: 2654626551.
  • 60
    Knight RJ, Buxton DB. Stimulation of c-Jun kinase and mitogen-activated protein kinase by ischemia and reperfusion in the perfused rat heart. Biochem Biophys Res Commun 1996; 218: 8388.
  • 61
    Morooka H, Bonventre JV, Pombo CM, Kyriakis JM, Force T. Ischemia and reperfusion enhance ATF-2 and c-Jun binding to cAMP response elements and to an AP-1 binding site from the c-jun promoter. J Biol Chem 1995; 270: 3008430092.
  • 62
    Bogoyevitch MA, Ketterman AJ, Snugden PH. Cellular stresses differentially activate c-Jun N-terminal protein kinases and extracellular signal-regulated protein kinases in cultured ventricular myocytes. J Biol Chem 1995; 270: 2971029717.
  • 63
    Bradham CA, Qian T, Lemasters JJ, Brenner DA. Manuscript in preparation.
  • 64
    Schreck R, Rieber P, Baeuerle PA. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-KB transcription factor and HIV-1. EMBO J 1991; 10: 22472258.
  • 65
    Goossens V, Grooten J, De Vos K, Fiers W. Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity. Proc Natl Acad Sci U S A 1995; 92: 81158119.
  • 66
    Exton JH. Phosphatidylcholine breakdown and signal transduction. Biochim Biophys Acta 1994; 1212: 2642.
  • 67
    Olivera A, Spiegel S. Sphingosine-1-phosphate as a second messenger in cell proliferation induced by PDGF and FCS mitogens. Nature 1993; 365: 557560.
  • 68
    Takei Y, Marzi I, Gao W, Gores GJ, Lemasters JJ, Thurman RG. Leukocyte adhesion and cell death following orthotopic liver transplantation in the rat. Transplantation 1991; 51: 959965.
  • 69
    Obeid LM, Linardic CM, Karolak LA, Hannun Y. Programmed cell death induced by ceramide. Science 1993; 259: 17691771.
  • 70
    Brach MA, Gruss H-J, Scott C, Herrmann F. The mitogenic response to tumor necrosis factor alpha requires c-Jun/AP-1. Mol Cell Biol 1993; 13: 42844290.
  • 71
    Olivera A, Buckley NE, Spiegel S. Sphingomyelinase and cell-permeable ceramide analogs stimulate cellular proliferation in quiescent swiss 3T3 fibroblasts. J Biol Chem 1992; 267: 2612126127.
  • 72
    Diehl AM, Yin M, Fleckenstein J, Yang SQ, Lin HZ, Brenner DA, Westwick J, et al. Tumor necrosis factor-α induces c-jun during the regenerative response to liver injury. Am J Physiol 1994; 267: G552G561.