• 1
    Eggink H-F, Huthoff HJ, Huhema S, Gips CH, Poppema S. Cellular and humoral immune reactions in chronic active liver diseases. Lymphocyte subsets in liver biopsies of patients with untreated idiopathic autoimmune hepatitis, chronic active hepatitis B and primary biliary cirrhosis. Clin Exp Immunol 1982; 50: 1724.
  • 2
    Tiegs G, Hentschel J, Wendel A. A T cell-dependent experimental liver injury in mice inducible by concanavalin A. J Clin Invest 1992; 90: 196203.
  • 3
    Mizuhara H, O'Neill E, Seki N, Ogawa T, Kusunoki C, Otsuka K, Satoh S, et al. T cell activation-associated hepatic injury: mediation by tumor necrosis factors and protection by interleukin-6. J Exp Med 1994; 179: 15291537.
  • 4
    Galanos C, Freudenberg MA, Reutter W. Galactosamine-induced sensitization to the lethal effects of endotoxin. Proc Natl Acad Sci USA 1979; 76: 59395943.
  • 5
    Nagakawa J, Hishinuma I, Hirota K, Miyamoto K, Yamanaka T, Tsukidate K, Katayama K, et al. Involvement of tumor necrosis factor-α in the pathogenesis of activated macrophage-mediated hepatitis in mice. Gastroenterology 1990; 99: 758765.
  • 6
    Gantner F, Leist M, Lohse AW, Germann PG, Tiegs G. Concanavalin A-induced T-cell-mediated hepatic injury in mice: the role of tumor necrosis factor. Hepatology 1995; 21: 190198.
  • 7
    Mizuhara H, Uno M, Seki N, Yamashita M, Yamaoka M, Ogawa T, Kaneda K, et al. Critical involvement of interferon gamma in the pathogenesis of T-cell activation-associated hepatitis and regulatory mechanisms of hepatitis. Hepatology 1996; 23: 16081615.
  • 8
    Küsters S, Gantner F, Künstle G, Tiegs G. Interferon gamma plays a critical role in T cell-dependent liver injury in mice initiated by concanavalin A. Gastroenterology 1996; 111: 462471.
  • 9
    Trinchieri G. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptative immunity. Annu Rev Immunol 1995; 13: 251276.
  • 10
    Tanaka Y, Takahashi A, Watanabe K, Takayama K, Yahata T, Habu S, Nishimura T. A pivotal role of IL-12 in Th1-dependent mouse liver injury. Int Immunol 1996; 8: 569576.
  • 11
    de VriesJE, de Waal MalefytR., eds. Interleukin-10. Austin TX: R.G. Lan-des, 1995.
  • 12
    Taga K, Tosata G. IL-10 inhibits human T cell proliferation and IL-2 production. J Immunol 1992; 148: 11431148.
  • 13
    Donckier V, Flament V, Gerard C, Abramowicz D, Vandenabeele P, Wissing M, Delvaux A, et al. Modulation of the release of cytokines and reduction of the shock syndrome induced by anti-CD3 monoclonal antibody in mice by interleukin-10. Transplantation 1994; 57: 14361439.
  • 14
    Florquin S, Amraoui Z, Abramowicz D, Goldman M. Systemic release and protective role of IL-10 in staphylococcal enterotoxin B-induced shock in mice. J Immunol 1994; 153: 26182623.
  • 15
    van der Poll T, Marchant A, Buurman W, Berman L, Keogh CV, Lazarus DD, Nguyen L, et al. Endogenous IL-10 protects mice from death during septic peritonitis. J Immunol 1995; 155: 53975401.
  • 16
    Standiford TJ, Strieter RM, Lukacs NW, Kunkel SL. Neutralization of IL-10 increases lethality in endotoxemia. J Immunol 1995; 155: 22222229.
  • 17
    Le Moine O, Marchant A, Durand F, Ickx B, Pradier O, Belghiti J, Abramowicz D, et al. Systemic release of interleukin-10 during orthotopic liver transplantation. Hepatology 1994; 20: 889892.
  • 18
    Knolle P, Sclaak J, Uhrig A, Kempf P, Meyer zum Büschenfelde K-H, Gerken G. Human Küpffer cells secrete IL-10 in response to lipopolysaccharide (LPS) challenge. J Hepatol 1995; 22: 226229.
  • 19
    Alfrey EJ, Most D, Wang X, Lee LK, Holm B, Krieger NR, Sibley RK, et al. Interferon-gamma and interleukin-10 messenger RNA are up-regulated after orthotopic liver transplantation in tolerant rats: evidence for cytokine-mediated immune dysregulation. Surgery 1995; 118: 399405.
  • 20
    Arai T, Hiromatsu K, Kobayashi N, Takano M, Ishida H, Nimura Y, Yoshikai Y. IL-10 is involved in the protective effect of dibutyryl cyclic adenosine monophosphate on en do toxin-induced inflammatory liver injury. J Immunol 1995; 155: 57435749.
  • 21
    Gazzinelli RT, Wysocka M, Hieny S, Scharton-Kersten T, Cheever A, Kühn R, Müller W, et al. In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-γ, and TNF-α. J Immunol 1996; 157: 798805.
  • 22
    Santucci L, Fiorucci S, Chiorean M, Brunori PM, Di Matteo FM, Sidoni A, Migliorati G, et al. Interleukin-10 reduces lethality and hepatic injury induced by lipopolysaccharide in galactosamine-sensitized mice. Gastroenterology 1996; 111: 736744.
  • 23
    Louis H, Le Moine O, Peny M-O, Gulbis B, Nisol F, Goldman M, Devière J. Hepatoprotective role of interleukin-10 in galactosamine/lipopolysac-charide mouse liver injury in mice. Gastroenterology 1997; 112: 939942.
  • 24
    Marchant A, Bruyns C, Vandenabeele P, Ducarme M, Gerard C, Delvaux A, De Groote D, et al. Interleukin-10 controls interferon-γ and tumor necrosis factor production during experimental endotoxemia. Eur J Immunol 1994; 24: 11671171.
  • 25
    Mosmann TR, Scumacher JH, Florentine DF, Leverah J, Moore K, Bond MW. Isolation of monoclonal antibodies specific for IL-4, IL-5, IL-6, and a new Th2 specific cytokine (IL-10), cytokine synthesis inhibitory factor, by using a solid phase radioimmunoadsorbent assay. J Immunol 1990; 145: 29382945.
  • 26
    Gerard C, Bruyns C, Marchant A, Abramowicz D, Vandenabeele P, Delvaux A, Fiers W, et al. Interleukin-10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia. J Exp Med 1993; 177: 547550.
  • 27
    Billiau A. Interferon-γ: biology and role in pathogenesis. Adv Immunol 1996; 62: 61130
  • 28
    Napoli J, Bishop GA, McCaughan GW. Intrahepatic messenger RNA expression of interleukins 2, 6 and 8 in human cirrhosis. Gastroenterology 1994; 107: 789798.
  • 29
    Ferrari C, Mondelli MU, Penna A, Fiaccadori F, Chisari FV. Functional characterization of cloned intrahepatic, hepatitis B virus nucleoprotein-specific helper T cell lines. J Immunol 1987; 139: 539544.
  • 30
    Löhr HF, Schlaak JF, Gerken G, Fleisher B, Dienes HP, Meyer zum Büschenfelde KH. Phenotypical analysis and cytokine release of liver-infiltrating and peripheral blood T lymphocytes from patients with chronic hepatitis of different etiology. Liver 1994; 14: 161166.
  • 31
    Tilg H, Vogel W, Aulitzky WE, Herold M, Königsrainer A, Margreiter R, Huber C. Evaluation of cytokines and cytokine-induced secondary messages in sera of patients after liver transplantation. Transplantation 1990; 49: 10741080.
  • 32
    Ando K, Moriyama T, Guidotti LG, Wirth S, Schreiber RD, Schlicht HJ, Huang S, et al. Mechanisms of class I restricted immunopathology. A transgenic mouse model of fulminant hepatitis. J Exp Med 1993; 178: 15411554.
  • 33
    Toyonaga T, Hino O, Sugai S, Wakasugi S, Abe K, Shishiri M, Yamamura K. Chronic active hepatitis in transgenic mice expressing interferon-y in the liver. Proc Natl Acad Sci U S A 1994; 91: 614618.
  • 34
    Kissi JL, Deiss LP, Bayewitch, Raveh T, Khaspekov G, Kimchi A. Isolation of DAP3, a novel mediator of interferon γ-induced cell death. J Biol Chem 1995; 270: 2793227936.
  • 35
    Morita M, Watanabe Y, Akaike T. Protective effect of hepatocyte growth factor on interferon-gamma-induced cytotoxicity in mouse hepatocytes. Hepatology 1995; 21: 15851593.
  • 36
    Watanabe Y, Morita M, Akaike T. Concanavalin A induces perforin-mediated but not Fas-mediated hepatic injury. Hepatology 1996; 24: 702710.
  • 37
    Hishinuma I, Nagakawa J, Hirota K, Miyamoto K, Tsukidate K, Yamanaka T, Katayama K, et al. Involvement of tumor necrosis factor-α in development of hepatic injury in galactosamine-sensitized mice. Hepatology 1990; 12: 11871191.
  • 38
    Nagaki M, Muto Y, Ohnishi H, Yasuda S, Sano K, Naito T, Maeda T, et al. Hepatic injury and lethal shock in galactosamine-sensitized mice induced by the superantigen staphylococcal enterotoxin B. Gastroenterology 1994; 106: 450458.
  • 39
    Gantner F, Leist M, Jilg S, Germann PG, Freudenberg MA, Tiegs G. Tumor necrosis factor-induced hepatic DNA fragmentation as an early marker of T cell-dependent liver injury in mice. Gastroenterology 1995; 109: 166176.
  • 40
    Feinman R, Henriksen-De Stefano D, Tsujimoto M, Vilcek J. Tumor necrosis factor is an important mediator of tumor cell killing by human monocytes. J Immunol 1987; 138: 635640.
  • 41
    Chan SH, Kobayashi M, Santoli D, Perussia B, Trinchieri G. Mechanisms of IFN-γ induction by natural killer cell stimulatory factor (NKCSF/IL-12). J Immunol 1992; 148: 9298.
  • 42
    Heinzel FP, Rerko RM, Ling P, Hakimi J, Schoenhaut DS. Interleukin-12 is produced in vivo during endotoxemia and stimulates synthesis of gamma interferon. Infect Immun 1994; 62: 42444249.
  • 43
    D'Andrea A, Aste-Amezaga M, Valiente NM, Ma X, Kubin M, Trinchieri G. Interleukin-10 (IL-10) inhibits human lymphocyte interferon γ-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. J Exp Med 1993; 178: 10411048.
  • 44
    Moore K, O'Garra A, de Waal Malefyt R, Vieira P, Mosmann T. Interleu-kin-10. Annu Rev Immunol 1993; 11: 165190.
  • 45
    Marchant A, Amraoui Z, Gueydan C, Bruyns C, Le Moine O, Vandenabeele P, Fiers W, et al. Methylprednisolone differentially regulates IL-10 and tumor necrosis factor (TNF) production during murine endotoxemia. Clin Exp Immunol 1996; 106: 9196.
  • 46
    Marchant A, Vincent J-L, Goldman M. Interleukin-10 as a protective cytokine produced during sepsis. In: MorrisonDC, RyanJL, eds. Novel Therapeutic Strategies in the Treatment of Sepsis. New York: Dekker, 1996: 301311.
  • 47
    Shimozato T, Iwata M, Tamura N. Suppression of tumor necrosis factor alpha production by a human immunoglobulin preparation for intravenous use. Infect Immun 1990; 58: 13841390.
  • 48
    Andersson J, Skansen-Saphir U, Sparrelid E, Andersson U. Intravenous immune globulin affects cytokine production in T lymphocytes and monocytes/macrophages. Clin Exp Immunol 1996; 104 (suppl 1): 1020.
  • 49
    Cassatella MA, Meda L, Bonora S, Ceska M, Constantin G. Interleukin-10 (IL-10) inhibits the release of pro inflammatory cytokines from human polymorphonuclear leukocytes. Evidence for an autocrine role of tumor necrosis factor and IL-1β in mediating the production of IL-8 triggered by lipopoysaccharide. J Exp Med 1993; 178: 22072211.
  • 50
    Willems F, Marchant A, Delville JP, Gerard C, Delvaux A, Velu T, de Boer M, et al. Interleukin-10 inhibits B7 and intercellular adhesion molecule-1 expression on human monocytes. Eur J Immunol 1994; 24: 10071009.