• 1
    Ling N, Ying SY, Ueno N, Esch F, Denoroy L, Guillemin R. Isolation and partial characterization of a Mr 32,000 protein with inhibin activity from porcine follicular fluid. Proc Natl Acad Sci U S A 1985; 82: 72177221.
  • 2
    Massagué J. The transforming growth factor-β family. Annu Rev Cell Biol 1990; 6: 597641.
  • 3
    Vale W, Rivier J, Vaughan J, McClintock R, Corrigan A, Woo W, Karr D, Spiess J. Purification and characterization of an FSH releasing protein from porcine ovarian follicular fluid. Nature 1986; 321: 776779.
  • 4
    Ling N, Ying SY, Ueno N, Shimasaki S, Esch F, Hotta M, Guillemin R. Pituitary FSH is released by a heterodimer of the subunits of the two forms of inhibin. Nature 1986; 321: 779782.
  • 5
    Katayama T, Shiota K, Takahashi M. Activin A increases the number of follicle-stimulating hormone cells in anterior pituitary cultures. Mol Cell Endocrinol 1990; 69: 179185.
  • 6
    Mather JP, Attie KM, Woodruff TK, Rice GC, Phillips DM. Activin stimulates spermatogonial proliferation in germ-Sertoli cell cocultures from immature rat testis. Endocrinology 1990; 127: 32063214.
  • 7
    Eto Y, Tsuji T, Takezawa M, Takano S, Yokogawa Y, Shibai H. Purification and characterization of erythroid differentiation factor (EGF) isolated from human leukemia cell line THP-1. Biochem Biophys Res Commun 1987; 142: 10951103.
  • 8
    Smith JC, Price BMJ, Nimmen KV, Huylebroeck D. Identification of a potent Xenopus mesoderm-inducing factor as a homologue of activin A. Nature 1990; 345: 729734.
  • 9
    Mine T, Kojima I, Ogata E. Stimulation of glucose production by activin A in isolated hepatocytes. Endocrinology 1989; 125: 586591.
  • 10
    Yasuda H, Mine T, Shibata H, Eto Y, Hasegawa Y, Takeuchi T, Asano S, Kojima I. Activin A: an autocrine inhibitor of initiation of DNA synthesis in rat hepatocytes. J Clin Invest 1993; 92: 14911496.
  • 11
    Schwall RH, Robbins K, Jardieu P, Chang L, Lai C, Terrell TG. Activin induces cell death in hepatocytes in vivo and in vitro. Hepatology 1993; 18: 347356.
  • 12
    Rojkind M, Greenwel P. The liver as a bioecological system. In: AriasIM, JakobyWB, PopperH, SchachterD, ShafritzDA, eds. The Liver: Biology and Pathobiology. New York: Raven, 1988: 12691285.
  • 13
    Petraglia F, Calza L, Garuti GC, Abrate M, Giardino L, Genazzani AR, Vale W, et al. Presence and synthesis of inhibin subunits in human decidua. J Clin Endocrinol Metab 1990; 71: 487492.
  • 14
    Meunier H, Cajander S, Roberts V, Rivier C, Sawchenko P, Hsueh A, Vale W. Rapid changes in the expression of inhibin alpha-, beta A-, and beta B-subunits in ovarian cell types during the rat estrous cycle. Mol Endocrinol 1988; 2: 13521363.
  • 15
    Rogiers V, Paeme G, Vercruysse A, Bouwens L. Procyclidine metabolism in isolated rat liver cells. In: Van BezooyenC, ed. Pharmacological, Morphological and Physiological Aspects of Liver Ageing. Rijswijk: Eurage, 1984: 121126.
  • 16
    Van Bossuyt H, Bouwens L, Wisse E. Isolation, purification and culture of sinusoidal liver cells. In: Bioulac-SageP, BalabaudC, eds. Sinusoids in Human Liver: Health and Disease. Rijswijk: Kupffer Cell Foundation, 1988: 116.
  • 17
    De Bleser P, Geerts A, Van Eyken P, Vrijsen R, Lazou J, Desmet V, Wisse E. Tenascin synthesis in cultured rat liver fat-storing cells. In: WisseE, KnookD, McCuskeyR, eds. Cells of the Hepatic Sinusoid. Rijswijk: Kupffer Cell Foundation, 1991: 218221.
  • 18
    Chomszynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987; 162: 156159.
  • 19
    Meunier H, Rivier C, Evans RM, Vale W. Gonadal and extragonadal expression of inhibin α, βA, and βB subunits in various tissues predicts diverse functions. Proc Natl Acad Sci U S A 1988; 85: 247251.
  • 20
    Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 227: 680685.
  • 21
    Vaughan JM, Rivier J, Corrigan AZ, McClintock R, Campen CA, Jolley D, Voglmayr JK, et al. Detection and purification of inhibin using anti-sera generated against synthetic peptide fragments. Methods Enzymol 1989; 168: 588617.
  • 22
    Sawchenko PE, Plotsky PM, Pfeiffer SW. Inhibin in central neural pathways involved in the control of the oxytocin secretion. Nature 1988; 334: 615618.
  • 23
    Roberts VJ, Meunier H, Vaughan J. Production and regulation of inhibin subunits in pituitary gonadotropes. Endocrinology 1989; 124: 552554.
  • 24
    Schirmacher P, Geerts A, Pietrangelo A, Rogler CE. Analysis of hepatocyte growth factor/hepatopoietin A expression in rat liver. Hepatology 1992; 15: 511.
  • 25
    Zarnegar R, Michalopoulos G. Purification and biological characterization of human hepatopoietin A, a polypeptide growth factor for hepatocytes. Cancer Res 1989; 49: 33143320.
  • 26
    Bullough WS. Control of mitotic activity in adult mammalian tissues. Biol Rev Camb Philos Soc 1962; 37: 307342.
  • 27
    Strain AJ. Transforming growth factor-β: the elusive hepatic chalone? Hepatology 1992; 16: 269270.
  • 28
    Sakai R, Shiozaki M, Tabuchi M, Eto Y. The measurement of activin/ EDF in mouse serum: evidence for extragonadal production. Biochem Biophys Res Commun 1992; 188: 921926.
  • 29
    Kim S, Park P, Koeller D, Kim KY, Wakefield LM, Sporn MB, Roberts AB. Posttranscriptional regulation of the human transforming growth factor-β1 gene. J Biol Chem 1992; 267: 1370213707.
  • 30
    Assoian RK, Fleurdelys BE, Stevenson HC, Miller PJ, Madtes DK, Raines EW, Ross R. Expression and secretion of type b transforming growth factor by activated human macrophages. Proc Natl Acad Sci U S A 1987; 84: 60206024.
  • 31
    Nakatsukasa H, Nagy P, Evarts RP, Hsia C, Marsden E, Thorgeirsson S. Cellular distribution of transforming growth factor-b1 and procollagen types I, III, and IV transcripts in carbon tetrachloride-induced rat liver fibrosis. J Clin Invest 1990; 85: 18331843.
  • 32
    Oberhammer FA, Pavelka M, Sharma S, Tietenbacher R, Purchio AF, Bursch W, Schulte-Hermann R. Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor b1. Proc Natl Acad Sci U S A 1992; 89: 54085412.
  • 33
    Vale W, Bilezikjian LM, Rivier C. Reproductive and other roles of inhibins and activins. In: KnobilE, NeillJD, eds. The Physiology of Reproduction. New York: Raven, 1994: 18611878.
  • 34
    Wijsman JH, Jonker RR, Keijzer R, Velde CJHVD, Cornelisse CJ. A new method to detect apoptosis in paraffin sections: in situ end-labeling of fragmented DNA. J Histochem Cytochem 1993; 41: 712.
  • 35
    Gold R, Schmied M, Giegerich G, Breitschoph H, Hartung HP, Toyka KV. Differentiation between cellular apoptosis and necrosis by the combined use of in situ tailing and nick translation techniques. Lab Invest 1994; 71: 219225.
  • 36
    Woodruff TK, Krummen LA, Chen S, DeGuzman G, Lyon R, Baly DL, Allison DE, et al. Pharmacokinetic profile of recombinant human (rh) inhibin A and activin A in the immature rat. I. Serum profile of rh-inhibin A and rh-activin A in the immature female rat. Endocrinology 1993; 132: 715724.
  • 37
    Schneyer AL, Rzucidlo DA, Sluss PM, Crowley WE. Characterization of unique binding kinetics of follistatin and activin or inhibin in serum. Endocrinology 1994; 135: 667674.
  • 38
    Tuuri T, Eramaa M, Hilden K, Ritvos O. The tissue distribution of activin βA- and βB-subunit and follistatin messenger ribonucleic acids suggests multiple sites of action for the activin-follistatin system during human development. J Clin Endocrinol Metab 1994; 78: 15211524.
  • 39
    Kanzaki M, Zhang YQ, Yasuda H, Mine T, Kojima I. Stimulation of production of follistatin by epidermal growth factor in cultured rat hepatocytes. Biochem Biophys Res Commun 1994; 202: 422428.