• 1
    Wilson JM, Jefferson DM, Chowdury J Roy, Novikoff PM, Johnston DM, Mulligan RC. Retrovirus mediated transduction of adult hepatocytes. Proc Natl Acad Sci U S A 1988; 85: 30143018.
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    Ali M, Lemoine NR, Ring CJA. The use of DNA viruses as vectors for gene therapy. Gene Therapy 1994; 1: 367384.
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    Prevec L, Schneider M, Rosenthal KL, Belbeck LW, Derbyshire JB, Graham FL. Use of human adenovirus-based vectors for antigen expression in animals. J Gen Virol 1989; 70: 429434.
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    Yang Y, Li Q, Ertl HCJ, Wilson JM. Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses. J Virol 1995; 67: 20042015.
  • 8
    Yang Y, Nunes FA, Berencsi K, Gonczol E, Engelhardt JF, Wilson JM. Inactivation of E2a in recombinant adenoviruses improves the prospect for gene therapy in cystic fibrosis. Nat Genet 1994; 7: 362369.
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    Wilson JM, Engelhardt JF, Grossman M, Simon RH, Yang Y. Gene therapy for cystic fibrosis using Er deleted adenovirus. Hum Gene Ther 1994; 4: 501519.
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    Dai Y, Schwarz EM, Gu D, Zhang WW, Sarvetnick N. Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: tolerization to factor IX adenovirus vector antigens allows for long-term expression. Proc Natl Acad Sci U S A 1995; 92: 14011405.
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    Takahashi M, Ilan Y, Sengupta K, Chowdury N Roy, Guida J, Horwitz MS, Chowdhury J. Roy Long-term correction of bilirubin UDP-glucuronosyltransferase deficiency in Gunn rats by administration of a recombinant adenovirus during the neonatal period. J Biol Chem 1996; 271: 2653426536.
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    Kass-Eisler A, Falch-Pederson E, Elfenbein DH, Alvira M, Buttrick PM, Leinwand LA. The impact of developmental stage, route of admission and the immune system on adenovirus-mediated gene transfer. Gene Ther 1994; 1: 395402.
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    Ilan Y, Attavar P, Takahashi M, Ogridson A, Horwitz MS, Chowdhury N Roy, Chowdhury J. Roy Induction of central tolerance by intrathymic inoculation of adenoviral antigens into the host thymus permits long-term gene therapy in Gunn rats. J Clin Invest 1996; 98: 26402647.
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    Ilan Y, Prakash R, Davidson A, Jona V, Droguett G, Horwitz MS, Chowdhury N Roy, Chowdhury J. Roy Oral tolerization to adenoviral antigens permits long-term gene expression using recombinant adenoviral vectors. J Clin Invest 1997; 99: 10981106.
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    Chowdhury N Roy, Kondapalli R, Chowdhury J. Roy The Gunn rat: an animal model for inherited deficiency of bilirubin glucuronidation. In: CorneliusCE, ed. Animal Models in Liver Research. New York: Academic Press, 1993: 150175.
  • 16
    Crigler JF, Najjar VA. Congenital familial nonhemolytic jaundice with kernicterus. Pediatrics 1952; 10: 169180.
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    Bosnia PJ, Chowdhury N Roy, Goldhoom BG, Hofker MH, Elferink TPJO, Jansen PIK, Chowdury J. Roy Sequence of exons and the flanking regions of human bilirubin UDP –glucuronosyltransferase gene complex and identification of a genetic mutation in a patient with Crigler-Najjar syndrome, type 1. Hepatology 1992; 155: 941947.
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    Platt T, Muller-Hill B, Miller JH. Assay of β-galactosidase. In: MillerJH, ed. Experiments in Molecular Genetics. Cold Spring Harbor: Cold Spring Harbor Laboratory, 1972: 352355.
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    Chowdhury J Roy, Chowdhury N Roy, Wu G, Shouval R, Arias I. Bilirubin mono and diglucuronide formation by human liver in vitro: assay by high pressure liquid chromatography. Hepatology 1981; 1: 622627.
  • 20
    Trotman BW, Chowdhury J Roy, Wirt GD. Azodipyroles of unconjugated and conjugated bilirubin using diazotized ethyl anthranilate in dimethyl sulfoxide. Anal Biochem 1982; 121: 175180.
  • 21
    Fang B, Eisensmith RC, Wang H, Kay MA, Cross RI, Gordon G, Bellinger DA, et al. Gene therapy for hemophilia B: host immunosuppression prolongs the therapeutic effect of adenovirus-mediated factor IX expression. Hum Gene Ther 1995; 6: 10391044.
  • 22
    Vilquin JT, Guerette B, Kinoshito I, Roy B, Goulet M, Gravel C, Roy A, et al. FK506 immunosuppression to control the immune reactions triggered by first-generation adenovirus-mediated gene transfer. Hum Gene Ther 1995; 6: 13911401.
  • 23
    Ilan Y, Droguett G, Chowdhury N Roy, Li Y, Sengupta K, Thummala NR, Davidson A, et al. Insertion of the adenoviral E3 region into a recombinant viral vector prevents antiviral humoral and cellular immune responses and permits long-term gene expression. Proc Natl Acad Sci USA, 1997; 94: 25872592.
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    Engelhardt JF, Ye X, Doranz B, Wilson JM. Ablation of E2A in recombinant adenoviruses improves transgene-persistence and decreases inflammatory response in mouse liver. Proc Natl Acad Sci USA 1994; 91: 61966200.
  • 25
    Engelhardt JF, Litzky L, Wilson JM. Prolonged transgene expression in cotton rat lung with recombinant adenoviruses defective in E2a. Hum Gene Ther 1994; 5: 12171229.
  • 26
    Armentano D, Thompson AR, Darlington G, Woo SL. Expression of human factor IX in dog hepatocytes by retrovirus-mediated gene transfer: potential for gene therapy of human hemophilia B. Proc Natl Acad Sci U S A 1990; 87: 61416145.
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    Kay MA, Holterman AX, Meuse L, Gown A, Ochs HD, Linsley PS, Wilson GB. Long term hepatic adenovirus mediated gene expression in mice following CTLA4Ig administration. Nat Genet 1995; 11: 191197.
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    McDiarmid SV, Busutil RW, Ascher NL, Burdick J, Anthony M, D'Alessandro C, Esquivel C, et al. FK 506 compared with cyclosporine for primary immunosuppression after pediatric liver transplantation. Transplantation 1995; 59: 530536.
  • 29
    Schreiber SL. Chemistry and biology of immunophilins and their immu-nosuppressive ligands. Science 1991; 251: 283287.
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    Suzuki S, Toledo-Pereyra LH, Rodriguez FJ, Cejalvo D. Neutrophil infiltration as an important factor in liver ischemia and reperfusion injury. Modulating effects of FK 506 and cyclosporine. Transplantation 1993; 55: 12651272.
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    Schreiber SL, Tree GR. Crab The mechanism of action of cyclosporine and FK 506. Immunol Today 1992; 35: 112132.
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    Lochmuller H, Petrof BJ, Allen C, Prescott B, Massie B, Karpati G. Immunosuppression by FK 506 markedly prolongs expression of adenovirus delivered transgene in skeletal muscles of adult dystrophic mice. Biochem Biophys Res Commun 1995; 213: 569574.
  • 33
    Ilan Y, Chowdhury N Roy, Sauter B, Davidson A, Horwitz MS, Chowdhury J. Roy Effective adenovirus-mediated gene therapy in the presence of anti-adenovirus immune response by oral tolerization of the host [Abstract]. Gastroenterology 1997: in press.