• 1
    Wood PR, Rikkers LF, Byers BW, Williams L. A review of liver transplantation for gastroenterologists. Am J Gastroenterol 1987; 82: 593606.
  • 2
    Lee D, Holland RK. Improved performance of the isolated rat liver when perfused with purified bovine serum albumin. Transplantation 1979; 27: 384388.
  • 3
    Vladovic-Relja T. Some functional parameters in the isolated calf liver after hypothermic preservation. Cryobiology 1984; 21: 511520.
  • 4
    Turner MD, Alican F. Successful 20-hour storage of the canine liver by continuous hypothermic perfusion. Cryobiology 1970; 6: 293301.
  • 5
    Abouna GM. Pig liver perfusion with human blood: the effect of preparing and flushing the liver with various balanced solutions on its subsequent viability and function. Br J Surg 1970; 55: 761768.
  • 6
    Kamada N, Calne RY, Wright DGD, Lines JG. Orthotopic rat liver transplantation after long term preservation by continuous perfusion with fluorocarbon emulsion. Transplantation 1980; 30: 4348.
  • 7
    Carithers RL Jr, Fairman RP, Mendez-Piron G, Posner MP, Mills AS, Friedenberg T. Postoperative care. In: MaddreyWC, ed. Transplantation of the Liver. Current Topics in Gastroenterology Series. New York: Elsevier, 1988: 111142.
  • 8
    Maddrey WC. Liver transplantation: state of the art. Hepatology 1989; 8: 948959.
  • 9
    Kalayoglu M, Sollinger HW, Stratta RJ. Extended preservation of the liver for clinical transplantation. Lancet 1988; i: 617619.
  • 10
    Iu S, Harvey PRC, Makowa L, Petrunka CN, Ilson RG, Strasberg SM. Markers of allograft viability in the rat. Relationship between transplantation and liver function in the isolated perfused liver. Transplantation 1987; 44: 562569.
  • 11
    Jamieson NV, Sundberg R, Lindell S, Southard HJ, Belzer FO. A comparison of cold storage solutions for hepatic preservation using the isolated perfused rabbit liver. Cryobiology 1988; 25: 300310.
  • 12
    Jamieson NV, Lindell S, Sundberg R, Southard JH, Belzer FO. An analysis of the components in UW solution using the isolated perfused rabbit liver. Transplantation 1988; 46: 512516.
  • 13
    Bowers BA, Branum GD, Rotolo FS, Walters CR, Meyers WC. Bile flow–an index of ischemic injury. J Surg Res 1987; 42: 565569.
  • 14
    Kamiike W, Nakahara M, Nakao K. Correlation between cellular ATP level and bile excretion in the rat liver. Transplantation 1985; 39: 5055.
  • 15
    Vlahcevic ZR, Heumann DM, Hylemon PB. Regulation of bile acid synthesis. Hepatology 1991; 13: 590600.
  • 16
    Cucchiaro G, Branum GD, Farouk M, Mansour G, Kuhn CM, Anthon DC, Meyers WC. The effect of liver denervation on the regulation of hepatic biliary secretion. Transplantation 1992; 54: 129136.
  • 17
    Erlinger, S. Bile flow. In: AriasI, ed. The Liver: Biology and Pathobiology. New York: Raven, 1982: 407425.
  • 18
    Hofmann AF. Bile acid secretion, bile flow, and biliary lipid secretion in humans. Hepatology 1990; 12: 17S25S.
  • 19
    Lenzen R, Hruby VJ, Tavoloni N. Mechanism of glucagon choleresis in guinea pigs. Am J Physiol 1990; 259 (Gastrointest Liver Physiol 22): G736G744.
  • 20
    Lenzen R, Alpini G, Tavoloni N. Secretin stimulates bile ductular secretory activity through the cAMP system. AmJ Physiol 1992; 263 (Gastrointest Liver Physiol 26): G527G532.
  • 21
    Branum GD, Bowers BA, Walters CR, Haebig J, Cucchiaro G, Farouk M, Meyers WC. Biliary response to glucagon in humans. Ann Surg 1991; 213: 335340.
  • 22
    Konturek SJ, Dabrowski A, Adamczyk B. The effect of secretin, gastrin-pentapeptide and histamine on gastric acid and hepatic bile secretion in man. Am J Dig Dis 1969; 14: 900.
  • 23
    Branum GD, Bowers BA, Wallers CR, Cucchiaro G, Meyers WC. Biliary response lo glucagon and insulin following hepalic transplantation in humans. J Surg Res 1990; 49: 121125.
  • 24
    Neuhaus P, Platz KP. Liver transplantation: newer surgical approaches. Clin Gastroenterol 1994; 8: 481493.
  • 25
    Neuhaus P, Bechstein WO, Blumhardt G, Wiens M, Lemmens P, Langrehr JM, Lohmann R, et al. Comparison of quadruple immuno-suppression after liver transplantation with ATG or IL-2 receptor antibody. Transplantation 1993; 55: 13201327.
  • 26
    Steffen R, Reinhartz O, Blumhardt G, Bechstein WO, Raakow R, Langrehr JM, Rossaint R, et al. Bacterial and fungal colonization and infections using oral selective bowel decontamination in ortholopic liver transplantations. Transplant Int 1994; 7: 101108.
  • 27
    Neuhaus P, Blumhardt G, Bechstein WO, Steffen R, Platz KP, Keck H. Technique and results of biliary reconstruction using side-to-side choledochocholedochostomy in 300 orthotopic liver transplants. Ann Surg 1994; 219: 426434.
  • 28
    Boyer JL, Bloomer JR. Canalicular bile secrelion in man. Sludies utilizing the biliary clearance of 14C mannitol. J Clin Invesl 1974; 54: 773781.
  • 29
    Rundle FF, Cass MH, Robson B, Middleton M. Bile drainage after choledochostomy in man with some observations on biliary fistula. Surgery 1955; 37: 903910.
  • 30
    Erlinger S, Farges O, Gigou M, Touchard D, Dumot M, D'Hont C, Adam R, et al. Bile secretion by the human transplanted liver. In: PaumgartnerG, StiehlA, GerokW, eds. Bile Acids and the Hepatobiliary System [Falk Symposium 68]. Dordrecht: Kluwer Academic Publishers, 1993: 184186.
  • 31
    Lenzen R, Bähr A, Bechstein WO, Richter WS, Marschall U, Hampel KE, Neuhaus P. Bile physiology studies in patients after orthotopic liver transplantation are valid using T tube bile. Hepatology 1995; 22: 206A.
  • 32
    Bergmeyer HU. Methoden der enzymatischen Analysen. Weinheim: Verlag Chemie, 1974.
  • 33
    Rick W. Klinische Chemie und Mikroskopie. Berlin: Springer Verlag, 1977.
  • 34
    Dürr HK. The secrelin-pancreozymin (caerulein)-test. Methodological problems. In: GyrKE, SingerMV, SarlesH, eds. Pancreatitis. Amsterdam, New York, Oxford: Excerpta Medica, 1984: 261266.
  • 35
    Snover DC. The pathology of acute rejection. Transplant Proc 1986; 18 (suppl 4): 123127.
  • 36
    Shiffman ML, Carithers RL Jr, Posner MP, Moore EW. Recovery of bile secretion following orthotopic liver transplantation. J Hepatol 1991; 12: 351361.
  • 36a
    Schersten T, Nilsson S, Cahlin E, Filipson M, Brodin-Persson G. Relationship between the biliary excretion of bile acids and excretion of water, lecithin and cholesterol in man. Eur J Clin Invest 1971; 1: 242247.
  • 37
    Haagsma EB, Huizenga JR, Vonk RJ, Albers CJEM, Grond J, Krom RAF, Gips CH. Composition of bile after orthotopic liver transplantation. Scand J Gastroenterol 1987; 22: 10491055.
  • 38
    Loria P, Carulli, Medici G, Tripodi A, Lori R, Rovesti S, Bergomi M, et al. Determinants of bile secretion: effect of bile sail structure on bile flow and biliary cation secretion. Gastroenterology 1989; 96: 11421150.
  • 39
    Wheeler HO, Ramos OL. Determinants of the flow and composition of bile in the unanesthelized dog during constant infusions of sodium taurocholate. J Clin Invest 1960; 39: 161170.
  • 40
    Tavoloni N, Sakozi L, Jones MJT. Choleretic effects of differently structured bile acids in the guinea pig. Proc Soc Exp Biol Med 1985; 178: 6067.
  • 41
    Knyrim K, Vakil N, Pfab R, Classen M. The effects of intraduodenal bile acid administration on biliary secretion of ionized calcium and carbonate in man. Hepatology 1989; 10: 134142.
  • 42
    Zakko SF, Lira M, Clerici C, Lambert K, Gurantz D, Schteingart C, Hofmann AF. Novel metabolism and hypercholeretic effect of nor-ursodeoxycholic acid in man [Abstract]. Gastroenterology 1987; 92: 1792.
  • 43
    Hofmann AF. The cholehepatic circulation of unconjugated bile acids: an update. In: PaumgartnerG, StiehlA, GerokW, eds. Bile Acids and the Hepatobiliary System. Boston: Kluwer Academic Publishers, 1993: 177183.
  • 44
    Boyer JL. New concepts of mechanisms of hepatocyte bile formation. Physiol Rev 1980; 60: 303320.
  • 45
    Lira M, Schleingart CD, Steinbach JH, Lambert K, McRoberts JA, Hofmann AF. Absorption of sugars by the biliary ductular epithelium of the rat: evidence for two transport systems. Gastroenterology 1992; 102: 563571.
  • 46
    Brunner H, Northfield TC, Hofmann AF, Go VLW, Summerskill WHJ. Gastric emptying and secretion of bile acids, cholesterol, and pancreatic enzymes during digestion: duodenal perfusion studies in healthy subjects. Mayo Clin Proc 1974; 49: 851860.
  • 47
    Northfield TC, Hofmann AF. Biliary lipid output during three meals and an overnight fast. I. Relationship to bile acid pool size and cholesterol saturation of bile in gallstone and control subjects. Gut 1975; 16: 111.
  • 48
    van Berge Henegouwen GP, Hofmann AF. Nocturnal gallbladder storage and emptying in gallstone patients and healthy subjects. Gastroenterology 1978; 75: 879885
  • 49
    McCashland TM, Donovan JP, Amelsberg A, Rossi SS, Hofmann AF, Shaw BW Jr, Quigley EMM. Bile acid metabolism and biliary secretion in patients receiving orthotopic liver transplants: differing effects of cyclosporine and FK 506. Hepatology 1994; 19: 13811389.
  • 50
    Hofmann AF. Current concepts of biliary secretion. Dig Dis Sci 1989; 34: S16S20.
  • 51
    Carulli N, Loria P, Bertolotti M, de Leon M Ponz, Menozzi D, Medici G, Piccagli I. Effects of acute changes of bile acid pool composition on biliary lipid secretion. J Clin Invest 1984; 74: 614624.
  • 52
    Hardison WGM, Wood CA. Importance of bicarbonate in bile salt independent fraction of bile flow. Am J Physiol 1972; 235: E158E164.
  • 53
    Anwer MS, Hegner D. Role of inorganic electrolytes in bile acid–independent canalicular bile formation. Am J Physiol 1983; 244: G116G124.
  • 54
    Meier PJ, Knickelbein R, Moseley RH, Dobbins JW, Boyer JL. Evidence for carrier-mediated chloride/bicarbonate exchange in canalicular rat liver plasma membrane vesicles. J Clin Invest 1985; 75: 12561263.
  • 55
    Fitz JG, Scharschmidt BF. Intracellular chloride activity in intact rat liver: relationship to membrane potential and bile flow. Am J Physiol 1987; 252: G699G706.
  • 56
    Ballatori N, Truong AT. Relation between biliary glutathione secretion and bile-acid-independent bile flow. Am J Physiol 1989; 256 (Gastrointest Liver Physiol 19): G22G30.
  • 57
    Ballatori N, Truong AT. Glutathione as a primary osmotic driving force in hepatic bile formation. Am J Physiol 1992; 263 (Gastrointest Liver Physiol 26): G617G624.
  • 58
    Simon FR, Sutherland EM, Gonzales M. Stimulation of hepatic sodium and potassium-activated adenosine triphosphatase activity by phenobarbital: its possible role in regulation of bile flow. J Clin Invest 1982; 70: 401411.
  • 59
    Macarol V, Morris RQ, Baker KJ, Bradley SE. Hydrocortisone choleresis in the dog. J Clin Invest 1970; 49: 17141723.
  • 60
    Zsigmond G, Solymoss B. Increased canalicular bile production induced by pregnenolone-16a-carbonitrile, spironolactone and cortisol in rats. Proc Soc Exp Biol Med 1974; 145: 631635.
  • 61
    Balabaud C, Kron KA, Gumucio JJ. The assessment of the bile salt-nondependent fraction of canalicular bile water in the rat. J Lab Clin Med 1977; 89: 393399.
  • 62
    Forker EL. Two sites of bile formation as determined by mannitol and erythritol clearance in the guinea pig. J Clin Invest 1967; 46: 11891195.
  • 63
    Boyer JL. Canalicular bile formation in the isolated perfused rat liver. Am J Physiol 1971; 221: 11561163.
  • 64
    Tavoloni N. Biliary clearance of inert carbohydrates. Expectations and reality. Gastroenterology 1988; 94: 217228.
  • 65
    Lowe P, Miyai K, Steinbach JH, Hardison WGM. Hormonal regulation of hepatocyte tight junctional permeability. Am J Physiol 1988; 255 (Gastrointest Liver Physiol 18): G454G461.
  • 66
    Garberoglio CA, Richter HA, Henarejos A, Moossa AR, Baker AL. Pharmacological and physiological doses of insulin and determinants of bile flow in dogs. Am J Physiol 1983; 245: G157G163.
  • 67
    Garberoglio CA, Bickerstaff KI, Baker AL, Moossa AR. Is glucagon a choleretic hormone at physiologic blood levels? Am J Surg 1982; 143: 6166.
  • 68
    Schirmer BD, Kortz WJ, Miller RJ, Christian KG, Hayes E, Jones RS. Glucagon lowers canine biliary cholesterol output at physiologic doses. Dig Dis Sci 1986; 31: 297300.
  • 69
    Kaminski DL, Deshpande Y, Seinfeld MC. Effect of stimulation of endogenous glucagon secretion by amino acid administration on canine hepatic bile flow. Dig Dis Sci 1987; 32: 401406.