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References

  • 1
    Bucher N. Regeneration of mammalian liver. Int Rev Cytol 1963; 15: 245300.
  • 2
    Fausto N, Laird AD, Webber EM. Liver regeneration. 2. Role of growth factors and cytokines in hepatic regeneration. FASEB J 1995; 9: 15271536.
  • 3
    Stöcker E, Schultze B, Heine WD, Liebscher H. Wachstum und regeneration in parenchymatösen organen der ratte. Z Zellforsch Mikr Anat 1972; 125: 306331.
  • 4
    Uryvaeva IV, Factor VM. Liver growth fraction, its composition with regard to cell ploidy and changes with aging. Soviet J Dev Biol 1975; 6: 396401.
  • 5
    Fry M, Silber J, Loeb LA, Martin GM. Delayed and reduced cell replication and diminishing levels of DNA polymerase-α in regenerating liver of aging mice. J Cell Physiol 1984; 118: 225232.
  • 6
    Brodsky VY, Uryvaeva IV. Cell polyploidy: its relation to tissue growth and function. Int Rev Cytol 1977; 50: 275332.
  • 7
    Carriere R. The growth of liver parenchymal nuclei and its endocrine regulation. Int Rev Cytol 1969; 25: 201277.
  • 8
    Gerlyng P, Abyholm A, Grotmol T, Erikstein B, Huitfeldt HS, Stokke T, Seglen PO. Binucleation and polyploidization patterns in developmental and regenerative liver growth. Cell Prolif 1993; 26: 557565.
  • 9
    Brodsky VY, Uryvaeva IV. Genome multiplication in growth and development. Biology of Polyploid and Polytene Cells. Cambridge: Cambridge University Press, 1985: 305.
  • 10
    Harman D. The aging process. Proc Natl Acad Sci U S A 1981; 78: 71247128.
  • 11
    Ames BN, Gold LS. Endogenous mutagens and the causes of aging and cancer. Mutat Res 1991; 250: 316.
  • 12
    Mullaart E, Lohman PHM, Berends F, Vijg J. DNA damage metabolism and aging. Mutat Res 1990; 237: 189210.
  • 13
    Holmes GE, Bernstein C, Bernstein H. Oxidative and other DNA damages as the basis of aging: a review. Mutat Res 1992; 275: 305315.
  • 14
    Curtis HJ. Biological mechanisms underlying the aging process. Science 1963; 141: 686694.
  • 15
    Edwards JL, Klein RE. Cell renewal in adult tissue. Am J Pathol 1961; 38: 437451.
  • 16
    MacDonald RA. “Lifespan” of liver cells. Arch Intern Med 1961; 107: 7987.
  • 17
    Uryvaeva IV. Biological significance of liver cell polyploidy. J Theor Biol 1981; 89: 557571.
  • 18
    Anatskaya OV, Vinogradov AE, Kudryavtsev BN. Hepatocyte polyploidy and metabolism/life-history testing. J Theor Biol 1994; 168: 191199.
  • 19
    Michalopoulos GK. Liver regeneration: molecular mechanisms of growth control. FASEB J 1990; 4: 176187.
  • 20
    Francavilla A, Polimeno L, Barone M, Startzl TE. Hepatic regeneration and growth factors. J Surg Oncol 1993; 3 (suppl): 17.
  • 21
    Diehl AM, Rai RM. Regulation of signal transduction during liver regeneration. FASEB J 1996; 10: 215227.
  • 22
    Luetteke NS, Lee DC. Transforming growth factor α: expression, regulation and biological action of its integral membrane precursor. Semin Cancer Biol 1990; 1: 265276.
  • 23
    Mead JE, Braun L, Martin DA, Fausto N. Induction of replicative competence (“priming”) in normal liver. Cancer Res 1990; 50: 70237030.
  • 24
    Webber EM, Godowski PJ, Fausto N. In vivo response of hepatocytes to growth factors requires an initial priming stimulus. Hepatology 1994; 19: 489497.
  • 25
    Taub R. Liver regeneration 4: transcriptional control of liver regeneration. FASEB J 1996; 10: 413427.
  • 26
    Webber EM, Wu JC, Wang L, Merlino G, Fausto N. Overexpression of transforming growth factor-alpha causes liver enlargement and increased hepatocyte proliferation in transgenic mice. Am J Pathol 1994; 145: 398408.
  • 27
    Shiota G, Wang TC, Nakamura T, Schmidt EV. Hepatocyte growth factor in transgenic mice: effects on hepatocyte growth, liver regeneration and gene expression. Hepatology 1994; 19: 962972.
  • 28
    Shiota G, Kawasaki H, Nakamura T, Schmidt EV. Down-regulation of c-myc mRNA after completion of liver regeneration in transgenic mice expressing hepatocyte growth factor in liver. Res Commun Mol Pathol Pharmacol 1995; 89: 259268.
  • 29
    Sakata H, Takayama H, Sharp R, Rubin JS, Merlino G, LaRochelle WJ. Hepatocyte growth factor/scatter factor Overexpression induces growth, abnormal development, and tumor formation in transgenic mouse livers. Cell Growth Differ 1996; 17: 15131523.
  • 30
    Sandgren EP, Quaife CJ, Pinkert CA, Palmiter RD, Brinster RL. Oncogene-induced liver neoplasia in transgenic mice. Oncogene 1989; 4: 715724.
  • 31
    Jhappan C, Stahle C, Harkins RN, Fausto N, Smith GH, Merlino GT. TGF alpha overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas. Cell 1990; 61: 11371146.
  • 32
    Lee GH, Merlino G, Fausto N. Development of liver tumors in transforming growth factor alpha transgenic mice. Cancer Res 1992; 52: 51625170.
  • 33
    Takagi H, Sharp R, Hammermeister C, Goodrow T, Bradley MO, Fausto N, Merlino G. Molecular and genetic analysis of liver oncogenesis in transforming growth factor alpha transgenic mice. Cancer Res 1992; 52: 51715177.
  • 34
    Liu P, Terradillos O, Renard CA, Feldmann G, Buendia M-A, Bernuau D. Hepatocarcinogenesis in woodchuck hepatitis virus/c-myc mice: sustained cell proliferation and biphasic activation of insulin-like growth factor II. Hepatology 1997; 25: 874883.
  • 35
    Murakami H, Sanderson ND, Nagy P, Marino PA, Merlino G, Thorgeirsson SS. Transgenic mouse model for synergistic effects of nuclear oncogenes and growth factors in tumorigenesis: interaction of c-myc and transforming growth factor alpha in hepatic oncogenesis. Cancer Res 1993; 53: 17191723.
  • 36
    Sandgren EP, Luetteke NC, Qiu TH, Palmiter RD, Brinster RL, Lee DC. Transforming growth factor alpha dramatically enhances oncogene-induced carcinogenesis in transgenic mouse pancreas and liver. Mol Cell Biol 1993; 13: 320330.
  • 37
    Tönjes RR, Löhler J, O'Sullivan JF, Kay GF, Schmidt GH, Dalemans W, Pavirani A, et al. Autocrine mitogen IgEGF cooperates with c-myc or with the Hcs locus during hepatocarcinogenesis in transgenic mice. Oncogene 1995; 10: 765768.
  • 38
    Santoni-Rugiu E, Nagy P, Jensen MR, Factor VM, Thorgeirsson SS. Evolution of neoplastic development in the liver of transgenic mice co-expressing c-myc and transforming growth factor-alpha. Am J Pathol 1996; 149: 407428.
  • 39
    Sargent LM, Sanderson ND, Thorgeirsson SS. Ploidy and karyotypic alterations associated with early events in the development of hepatocarcinogenesis in transgenic mice harboring c-myc and transforming growth factor alpha transgenes. Cancer Res 1996; 56: 21372142.
  • 40
    Kao CY, Factor VM, Thorgeirsson SS. Reduced growth capacity of hepatocytes from c-myc and c-myc/TGF-alpha transgenic mice in primary culture. Biochem Biophys Res Commun 1996; 222: 6470.
  • 41
    Michalopoulos GK, DeFrances MC. Liver regeneration. Science 1997; 276: 6066.
  • 42
    Higgins GM, Anderson RM. Experimental pathology of the liver. 1. Restoration of the liver of the white rat following partial surgical removal. Arch Pathol 1931; 12: 186202.
  • 43
    Bisgaard HC, Nagy P, Santoni-Rugiu E, Thorgeirsson SS. Proliferation, apoptosis, and induction of hepatic transcription factors are characteristics of the early response of biliary epithelial (oval) cells to chemical carcinogens. Hepatology 1996; 23: 6270.
  • 44
    Schweizer JL, Goerttler K. Synthesis in vitro of keratin polypeptides directed by mRNA isolated from newborn and adult mouse epidermis. Eur J Biochem 1980; 112: 243249.
  • 45
    Albrecht JH, Hoffman JS, Kren BT, Steer CJ. Cyclin and cyclin-dependent kinase 1 mRNA expression in models of regenerating liver and human liver diseases. Am J Physiol 1993; 265: G857G864.
  • 46
    Cornell RP, Liljequist BL, Bartizal KF. Depressed liver regeneration after partial hepatectomy in germ-free, athymic and lipopolysaccharide-resistant mice. Hepatology 1990; 11: 916922.
  • 47
    Loyer P, Glaaise D, Cariou S, Baffet G, Meijer L, Guguen-Guillouzo C. Expression and activation of cdk (1 and 2) and cyclins in the cell cycle progression during liver regeneration. J Biol Chem 1994; 269: 24912500.
  • 48
    Alexandrow MG, Moses HL. Transforming growth factor β and cell cycle regulation. Cancer Res 1995; 55: 14521457.
  • 49
    Barbason H, Rassenfosse C, Betz EH. Promotion mechanism of phenobarbital and partial hepatectomy in DENA hepatocarcinogenesis cell kinetics effects. Br J Cancer 1983; 47: 517525.
  • 50
    Jirtle RL, Meyer SA. Liver tumor promotion: effects of phenobarbital on EGF and protein kinase c signal transduction and transforming growth factor-β1 expression. Dig Dis Sci 1991; 36: 659668.
  • 51
    Stein GH, Drullinger LF, Robetorye RS, Pereira-Smith OM, Smith JR. Senescent cells fail to express cdc2, cycA and cycB in response to mitogen stimulation. Proc Natl Acad Sci U S A 1991; 88: 1101211016.
  • 52
    Ohkubo Y, Kishimoto T, Nakata T, Yasuda H, Endo T. SV40 large T antigen reinduces the cell cycle in terminally differentiated miotubes through inducing cdk2, cdc2 and their partner cyclins. Exp Cell Res 1994; 214: 270278.
  • 53
    Dulic V, Drullinger LF, Lees E, Reed SI, Stein GH. Altered regulation of G1 cyclins in senescent human diploid fibroblasts: accumulation of inactive cyclin E-Cdk2 and cyclin D1-Cdk2 complexes. Proc Natl Acad Sci U S A 1993; 90: 1103411038.
  • 54
    Goldstein S. Replicative senescence: the human fibroblasts comes of age. Science 1990; 249: 11291133.
  • 55
    Campisi J, Dimri G, Hara E. Control of replicative senescence. In: Handbook of the Biology of Aging, 4th ed. New York: Academic, 1996: 121149.
  • 56
    Smith JR, Pereira-Smith OM. Replicative senescence: implications for in vivo aging and tumor suppression. Science 1996; 273: 6367.
  • 57
    Stöcker E. Der proliferationsmodus in niere und leber. Verh Dtsch Ges Path 1968; 50: 5374.
  • 58
    Fabrikant JI. Size of proliferating pools in regenerating liver. Exp Cell Res 1969; 55: 277279.
  • 59
    Rabes HM, Wizsching R, Tuczek HV, Iseler G. Analysis of cell cycle compartments of hepatocytes after partial hepatectomy. Cell Tissue Kinet 1976; 9: 517532.
  • 60
    Sawada N, Ishikawa T. Reduction of potential for replicative but not unscheduled DNA synthesis in hepatocytes isolated from aged as compared to young rats. Cancer Res 1988; 48: 16181622.
  • 61
    Gerlyng P, Grotmol T, Erikstein B, Stokke T, Seglen PO. Reduced proliferative activity of polyploid cells in primary hepatocellular carcinoma. Carcinogenesis 1992; 13: 17951801.
  • 62
    Mossin L, Blankson H, Huitfeldt H, Seglen PO. Ploidy-dependent growth and binucleation in cultured rat hepatocytes. Exp Cell Res 1994; 214: 551560.
  • 63
    Pendergrass WR, Li Y, Jiang D, Wolf N. Decrease in cellular replicative potential in “giant” mice transfected with the bovine growth hormone gene correlates to shortened life span. J Cell Physiol 1993; 156: 96103.
  • 64
    Asakura S, Sawada S, Daimon H, Fukuda T, Ogura K, Yamatsu K, Furihata T. Effects of dietary restriction on induction of unscheduled DNA synthesis (UDS) and replicative DNA synthesis (RDS) in rat liver. Mutat Res 1994; 322: 257264.
  • 65
    Chou MW, Shaddock JG, Kong J, Hart RW, Casciano DA. Effect of dietary restriction on partial hepatectomy-induced liver regeneration of aged F344 rats. Cancer Lett 1995; 91: 191197.
  • 66
    Himeno Y, Engelman RW, Good RA. Influence of calorie restriction on oncogene expression and DNA synthesis during liver regeneration. Proc Natl Acad Sci U S A 1992; 89: 54975501.
  • 67
    Kaufmann WK, Paules RS. DNA damage and cell cycle checkpoints. FASEB J 1996; 10: 238247.
  • 68
    Sanchez A, Alvarez AM, Benito M, Fabregat I. Apoptosis induced by transforming growth factor-β in fetal hepatocyte primary cultures. J Cell Biol 1996; 271: 74167422.
  • 69
    Rosenberger RF, Gounaris E, Kolettas E. Mechanisms responsible for the limited lifespan and immortal phenotypes in cultured mammalian cells. J Theor Biol 1991; 148: 383392.
  • 70
    Norwood TH, Gray M. The role of DNA damage in cellular aging: is it time for a reassessment? Exp Geront 1996; 31: 6168.
  • 71
    McWhir J, Harrison DJ, Squires S, Melton DW. Mice with DNA repair gene (ERCC-1) deficiency have elevated levels of p53, liver nuclear abnormalities and die before weaning. Nat Genet 1993; 5: 217224.
  • 72
    Adachi M, Suematsu S, Kondo T, Ogasawara J, Tanaka T, Yoshida N, Nagata S. Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver. Nat Genet 1995; 11: 294300.
  • 73
    Sandgren EP, Schroeder JA, Qui TH, Palmiter RD, Brinster RL, Lee DC. Inhibition of mammary gland involution is associated with transforming growth factor alpha but not c-myc-induced tumorigenesis in transgenic mice. Cancer Res 1995; 55: 39153927.
  • 74
    Smith GH, Sharp R, Kordon EC, Jhappan C, Merlino G. Transforming growth factor-alpha promotes mammary tumorigenesis through selective survival and growth of secretory epithelial cells. Am J Pathol 1995; 147: 10811096.
  • 75
    Amundadottir LT, Johnson MD, Merlino G, Smith GH, Dickson RB. Synergistic interaction of transforming growth factor alpha and c-myc in mouse mammary and salivary gland tumorigenesis. Cell Growth Differ 1995; 6: 737748.
  • 76
    Dice JF. Cellular and molecular mechanisms of aging. Physiol Rev 1993; 73: 149159.
  • 77
    Factor VM, Kao CJ, Jensen MR, Woitach JT, Thorgeirsson SS. Replicative senescence: relationship to hepatic neoplasia [Abstract]. Proceedings of the American Association for Cancer Research 1997; 38: 585A.