• 1
    Nanji AA, Zakim D. Alcoholic liver disease. In: ZakimD, BoyerTD, eds. Hepatology: a textbook of liver disease. Ed 3. Philadelphia: Saunders, 1996: 891961.
  • 2
    Nanji AA, Mendenhall CL, French SW. Beef fat prevents alcoholic liver disease in the rat. Alcohol Clin Exp Res 1989; 13: 1519.
  • 3
    Nanji AA, French SW. Dietary linoleic acid is required for development of experimental alcoholic liver disease. Life Sci 1989; 44: 223227.
  • 4
    Nanji AA, Zhao S, Sadrzadeh SMH, Dannenberg AJ, Tahan SR, Waxman DJ. Markedly enhanced cytochrome P450 2E1 induction and lipid per-oxidation is associated with severe liver injury in fish oil-ethanol fed rats. Alcohol Clin Exp Res 1994; 18: 12801285.
  • 5
    Morimoto M, Zern MA, Hagbjork AL, Ingelman-Sundberg M, French SW. Fish oil, alcohol and liver pathology: role of cytochrome P450 2E1. Proc Soc Exp Biol Med 1994; 207: 197205.
  • 6
    Nanji AA, Sadrzadeh SMH, Yang EK, Fogt F, Meydani M, Dannenberg AJ. Dietary saturated fatty acids: a novel treatment for alcoholic liver disease. Gastroenterology 1995; 109: 547554.
  • 7
    Nanji AA, Yang EK, Fogt F, Sadrzadeh SMH, Dannenberg AJ. Medium chain triglycerides and vitamin E reduce the severity of established experimental alcoholic liver disease. J Pharmacol Exp Ther 1996; 277: 16941700.
  • 8
    Nanji AA, French SW. Dietary factors and alcoholic cirrhosis. Alcohol Clin Exp Res 1986; 10: 271273.
  • 9
    Nanji AA, Khwaja S, Tahan SR, Sadrzadeh SMH. Plasma levels of a novel noncyclooxygenase-derived prostanoid (8-isoprostane) correlate with severity of liver injury in experimental alcoholic liver disease. J Pharmacol Exp Ther 1994; 269: 12801285.
  • 10
    Morimoto M, Hagbjork AL, Nanji AA, Ingelman-Sundberg M, Lindros KO, Fu PC, Albano E, French SW. Role of cytochrome P450 2E1 in alcoholic liver disease. Alcohol 1993; 10: 459464.
  • 11
    Nanji AA, Zhao S, Lamb RG, Dannenberg AJ, Sadrzadeh SMH, Waxman DJ. Changes in cytochromes P450, 2E1, 2B1 and 4A and phospholipases A and C in the intragastric feeding rat model for alcoholic liver disease: relationship to dietary fats and pathologic liver injury. Alcohol Clin Exp Res 1994; 18: 902908.
  • 12
    Nanji AA, Khettry U, Sadrzadeh SMH, Yamanaka T. Severity of liver injury in experimental alcoholic liver disease: correlation with plasma endotoxin, prostaglandin E2, leukotriene B4 and thromboxane B2. Am J Pathol 1993; 142: 367373.
  • 13
    Nanji AA, Sadrzadeh SMH, Thomas P, Yamanaka T. Eicosanoid profile and evidence for endotoxin-tolerance in chronic ethanol-fed rats. Life Sci 1994; 55: 611620.
  • 14
    Feng L, Xia Y, Garcia GE, Hwang D, Wilson CB. Involvement of reactive oxygen intermediates in cyclooxygenase-2 expression induced by in-terleukin-1, tumor necrosis factor-α and lipopolysaccharide. J Clin Invest 1995; 96: 16691675.
  • 15
    Hempel SL, Monick MM, Yano T, Hunninghake GW. Synthesis of prostaglandin H synthase-2 by human alveolar macrophages in response to lipopolysaccharide is inhibited by decreased cell oxidant tone. J Biol Chem 1994; 269: 3297932984.
  • 16
    Nanji AA, Khettry U, Sadrzadeh SMH. Lactobacillus feeding reduces endotoxemia and severity of experimental alcoholic liver disease. Proc Soc Exp Biol Med 1994; 205: 243247.
  • 17
    Adachi Y, Moore LE, Bradford BU, Gao W, Thurman RG. Antibiotics prevent liver injury in rats following long-term exposure to ethanol. Gastroenterology 1995; 108: 218224.
  • 18
    Nanji AA, Griniuviene B, Yacoub LK, Fogt F, Tahan SR. Intercellular adhesion molecule-1 expression in experimental alcoholic liver disease: relationship to endotoxemia and TNFα messenger RNA. Exp Mol Pathol 1995; 62: 4251.
  • 19
    Hempel SL, Monick MM, Hunninghake GW. Lipopolysaccharide induces prostaglandin H synthase-2 protein and mRNA in human alveolar macrophages and blood monocytes. J Clin Invest 1994; 93: 391396.
  • 20
    Hla T, Ristimaki A, Appleby S, Barriocanal JG. Cyclooxygenase gene expression in inflammation and angiogenesis. Ann NY Acad Sci 1993; 696: 197204.
  • 21
    Feng L, Sun W, Xia Y, Tang WW, Chanmugam P, Soyooka E, Wilson CB, Hwang D. Cloning two isoforms of rat Cyclooxygenase: differential regulation of their expression. Arch Biochem Biophys 1993; 307: 361368.
  • 22
    Otto JC, Smith WL. Prostaglandin endoperoxide synthases-1 and -2. J Lipid Medial Cell Signal 1995; 12: 139156.
  • 23
    Dinchuk JE, Car BD, Focht RJ, Johnston JJ, Jaffee BD, Covington MB, Contel NR, et al. Renal abnormalities and an altered inflammatory response in mice lacking Cyclooxygenase II. Nature 1995; 378: 406409.
  • 24
    Nanji AA, Miao L, Thomas P, Rahemtulla A, Khwaja S, Zhao S, Peters D, Tahan SR, Dannenberg AJ. Enhanced cyclooxygenase-2 gene expression in alcoholic liver disease in the rat. Gastroenterology 1997; 112: 943951.
  • 25
    Tsukamoto H, Gaal K, French SW. Insight into the pathogenesis of alcoholic liver necrosis and fibrosis. Hepatology 1990; 12: 599608.
  • 26
    French SW, Miyamoto K, Tsukamoto H. Ethanol-induced hepatic fibrosis in the rat: role of the amount of dietary fat. Alcohol Clin Exp Res 1986; 10: 13S19S.
  • 27
    French SW, Wong K, Jui L, Albano E, Hagbjork AL, Ingelman-Sundberg M. Effect of ethanol on cytochrome P450 2E1 (CYP 2E1), lipid peroxidation and serum protein in adduct formation in relation to liver pathology pathogenesis. Exp Mol Pathol 1993; 58: 6175.
  • 28
    Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987; 162: 156159.
  • 29
    Nanji AA, Zhao S, Sadrzadeh SMH, Waxman DJ. Use of reverse-transcription polymerase chain reaction to evaluate in-vivo cytokine gene expression in rats fed ethanol for long periods. Hepatology 1994; 19: 1481487.
  • 30
    Mendenhall CL, Tosch T, Weesner RE, Garcia-Pont P, Goldberg SJ, Kiernan T, Seeff LB, Sorrell M, et al. VA cooperative study on alcoholic hepatitis II: prognostic significance of protein calorie malnutrition. Am J Clin Nutr 1986; 43: 213218.
  • 31
    Mendenhall CL, Anderson S, Garcia-Point P, Goldberg S, Kiernan T, Seeff LB, Sorrell M, Tamburro C, et al. Short-term and long-term survival in patients with alcoholic hepatitis treated with oxandrolone and prednisolone. N Engl J Med 1984; 311: 14641470.
  • 32
    Lieber CS, Robins SJ, Li J, DeCarli LM, Mak KM, Fasulo JM, Leo MA. Phosphatidylcholine protects against fibrosis and cirrhosis in the baboon. Gastroenterology 1994; 106: 257259.
  • 33
    Liu P, Vonder-Fecht SL, McGuire GM, Fisher MA, Farhood A, Jaeschke H. The 21-aminosteroid tirilazad mesylate protects against endotoxin shock and acute liver failure in rats. J Pharmacol Exp Ther 1994; 271: 438445.
  • 34
    McClain CJ, Cohen DA. Increased tumor necrosis factor production by monocytes in alcoholic hepatitis. Hepatology 1989; 9: 349351.
  • 35
    Felver ME, Mezey E, McGurie M, Mitchell MC, Herlong EH, Veech GA, Veech RL. Plasma tumor necrosis factor-a predicts decreased long-term survival in severe alcoholic hepatitis. Alcohol Clin Exp Res 1990; 14: 255259.
  • 36
    McClain CJ, Hill D, Schmidt J, Diehl AM. Cytokines and alcoholic liver disease. Semin Liver Dis 1993; 13: 170182.
  • 37
    Hewett JA, Jean PA, Kunkel SL, Roth RA. Relationship between tumor necrosis factor-α and neutrophils in endotoxin-induced liver injury. Am J Physiol 1993; 265: G10111015.
  • 38
    Hansen J, Cherwitz DL, Allen JI. The role of tumor necrosis factor-α in acute endotoxin-induced hepatotoxicity in ethanol-fed rats. Hepatology 1994; 20: 461474.
  • 39
    Masferrer JL, Isakson PC, Seibert K. Cyclooxygenase-2 inhibitors. Gas-troenterol Clin North Am 1996; 25: 363372.
  • 40
    Pairet M, Engelhardt G. Distinct isoforms (Cox-1 and Cox-2) of cyclooxygenase: possible physiologic and therapeutic implications. Fun-dam Clin Pharmacol 1996; 10: 115.
  • 41
    Kurumbail RG, Stevens AM, Gierse JK, McDonald JJ, Stegman RA, Pak JY, Gildehaus D, et al. Structural basis for selective inhibition of cycloox-ygenase-2 by anti-inflammatory agents. Nature 1996; 384: 644648.
  • 42
    Mestre JR, Subbaramaiah K, Sacks PG, Schantz SP, Tanabe T, Inoue H, Dannenberg AJ. Retinoids suppress phorbol ester-mediated induction of cyclooxygenase-2. Cancer Res 1997; 57: 10811085.