SEARCH

SEARCH BY CITATION

References

  • 1
    Forker, EL. Hepatic transport of organic solutes. In: SchultzSG, ForteJG, RaunerBB, eds. Handbook of Physiology. The Gastrointestinal System. Salivary, Gastric, Pancreatic, and Hepatobiliary Secretion. Vol III, sect 6, chapt 34. Bethesda, Am Physiol Soc 1989: 693716.
  • 2
    Meijer DKF, Mol WEM, Muller M, Kurz G. Carrier-mediated transport in the hepatic distribution and elimination of drugs, with special reference to the category of organic cations. J Pharmakinet Biopharm 1990; 18: 3570.
  • 3
    Berk PD, Potter BJ, Stremmel W. Role of plasma membrane ligand-binding proteins in the hepatocellular uptake of albumin-bound organic anions. Hepatology 1987; 7: 165176.
  • 4
    Suchy FJ. Hepatocellular transport of bile acids. Semin Liver Dis 1993; 13: 235247.
  • 5
    Tiribelli C, Lunazzi GC, Sottocasa GL. Biochemical and molecular aspects of the hepatic uptake of organic anions. Biochim Biophys Acta 1990; 1031: 261275.
  • 6
    Berk PD, Bradbury M, Zhou S-L, Stump D, Han N.-I. Characterization of membrane transport processes: Lessons from the study of BSP, bilirubin, and fatty acid uptake. Semin Liver Dis 1996; 16: 107120.
  • 7
    Frimmer M, Ziegler K. The transport of bile acids in liver cells. Biochim Biophys Acta 1988; 947: 7599.
  • 8
    Petzinger E. Transport of organic anions in the liver. An update on bile acid, fatty acid, monocarboxylate, anionic amino acid, cholephilic organic anion, and anionic drug transport. Rev Physiol Biochem Phar-macol 1994; 123: 47211.
  • 9
    Groothuis GMM, Meijer DKF. Drug traffic in the hepatobiliary system. J Hepatol 1996; 24 (Suppl 1): 328.
  • 10
    Bertrams AA, Ziegler K. New substrates of the multispecific bile acid transporter in liver cells: interference of some linear renin-inhibiting peptides with transport protein(s) for bile acids. Biochim Biophys Acta 1991; 1073: 213220.
  • 11
    Eaton DL, Klassen CD. Carrier-mediated transport of ouabain in isolated hepatocytes. J Pharmacol Exp Ther 1978; 205: 480488.
  • 12
    Ishii K, Wolkoff AW. Inhibition of rat hepatocyte organic anion transport by bile acids. Am J Physiol 1994; 267: G458G464.
  • 13
    Okudaira K, Yamazaki M, Sawada Y, Sugiyama Y, Iga T, Hanano M. Correlation between the inhibitory effects of basic drugs on the uptake of cardiac glycosides and taurocholate by isolated rat hepatocytes. Pharm Res 1992; 9: 11521156.
  • 14
    Steen H, Merema M, Meijer DKF. A multispecific uptake system for taurocholate, cardiac glycosides and cationic drugs in liver. Biochem Pharmacol 1992; 44: 23232331.
  • 15
    Torres AM, Galan AI, Tiribelli C. Competition of bile acids on the sulfobromophthalein uptake in basolateral rat liver plasma membrane vesicles. Biochem Pharmacol 1994; 48: 13011304.
  • 16
    Yamazaki M, Suzuki H, Hanano M, Tokui T, Komai T, Sugiyama Y. Na+-independent multispecific anion transporter mediates active transport of pravastatin into rat liver. Am J Physiol 1993; 264: G36G44.
  • 17
    Ziegler K, Stunkel W. Tissue-selective action of pravastatin due to hepatocellular uptake via a sodium-independent bile acid transporter. Biochim Biophys Acta 1992; 1139: 203209.
  • 18
    Zuhlke RD, Zhang HJ, Joho RH. Xenopus oocytes: a system for expression cloning and structure-function studies of ion channels and receptors. Meth Neurosci 1995; 25: 6789.
  • 19
    Boyer JL, Ng OC, Ananthanarayanan M, Hofmann A, Schteingart CD, Hagenbuch B, Stieger B, et al. Expression and characterization of a functional rat liver Na+ bile acid cotransport system in COS-7 cells. Am J Physiol 1994; 266: G382G387.
  • 20
    Stieger B, Hagenbuch B, Landmann L, Höchli M, Schroeder A, Meier PJ. In situ localization of the hepatocytic Na+/taurocholate cotransporting polypeptide in rat liver. Gastroenterology 1994; 107: 17811787.
  • 21
    Shi X, Bai S, Ford AC, Burk RD, Jacquemin E, Hagenbuch B, Meier PJ, et al. Stable inducible expression of a functional rat liver organic anion transport protein in HeLa cells. J Biol Chem 1995; 270: 2559125599.
  • 22
    Platte HD, Honscha W, Schuh K, Petzinger E. Functional characterization of the hepatic sodium-dependent taurocholate transporter stably transfected into an immortalized liver-derived cell line and V79 fibroblasts. Eur J Cell Biol 1996; 70: 5460.
  • 23
    Von Dippe P, Amoui M, Stellwagen RH, Levy D. The functional expression of sodium-dependent bile acid transport in Madin Canine Kidney Cells transfected with the cDNA for microsomal epoxide hydrolase. J Biol Chem 1996; 271: 1817618180.
  • 24
    Meier PJ. Hepatocellular transport systems: from carrier identification in membrane vesicles to cloned proteins. J Hepatol 1996; 24 (suppl 1): 2935.
  • 25
    Nathanson MH, Boyer JL. Mechanisms and regulation of bile secretion. Hepatology 1991; 14: 551566.
  • 26
    Elferink RPJ Oude, Meijer DKF, Kuipers F, Jansen PLM, Groen AK, Groothuis GMM. Hepatobiliary secretion of organic compounds; molecular mechanisms of membrane transport. Biochim Biophys Acta 1995; 1241: 215268.
  • 27
    Meier PJ. Molecular mechanisms of hepatic bile salt transport from sinusoidal blood into bile. Am J Physiol 1995; 269: G801G812.
  • 28
    Tiribelli C, Reichen J, Meijer DKF, eds. The Hochhausen Experience: Report of a European Research Network on Hepatobiliary Transport. J Hepatol 1996; 24 (Suppl 1): 3134.
  • 29
    Rotschild MA, Berk PD, Gollan JL, eds. The molecular basis of hepatic transport. Semin Liver Dis 1996; 16: 107229.
  • 30
    WehnerF, PetzingerE, eds. Cell Biology and Molecular Basis of Liver Transport. Second International Ringberg Conference on Hepatic Transport. Projekt Verlag, Dortmund, Germany, 1995: 3267.
  • 31
    Wehner F, Kinne RKH, Petzinger E. Second International Ringberg Conference: Cell biology and molecular basis of liver transport. Hepatology 1996; 24: 259267.
  • 32
    Arias IM. The biology of hepatic endothelial cell fenestrae. Prog Liver Dis 1990; 9: 1126.
  • 33
    Weisiger RA. The role of albumin binding in hepatic organic anion trnasport. In: TavoloniN, BerkPD, eds. Hepatic Transport and Bile Secretion: Physiology and Pathophysiology. New York: Raven, 1993: 171196.
  • 34
    Sorrentino D, Zifroni A, van Ness K, Berk PD. Unbound ligand drives hepatocyte taurocholate and BSP uptake at physiological albumin concentration. Am J Physiol 1994; 266: G425G432.
  • 35
    Van Dyke RW, Stephens JE, Scharschmidt BF. Bile acid transport in cultured hepatocytes. Am J Physiol 1982; 243: G484G492.
  • 36
    Yamazaki M, Suzuki H, Hanano M, Sugiyama Y. Different relationships between cellular ATP and hepatic uptake among taurocholate, cholate, and organic anions. Am J Physiol 1993; 264: G693G701.
  • 37
    Anwer MS, Hegner D. Effect of Na+ on bile acid uptake by isolated rat hepatocytes. Hoppe-Seylers Z Physiol Chem 1978; 359: 10271030.
  • 38
    Boelsterli UA, Zimmerli B, Meier PJ. Identification and characterization of a basolateral dicarboxylate/cholate antiport system in rat hepatocytes. Am J Physiol 1995; 268: G797G805.
  • 39
    Fitz JG. Cellular mechanisms of bile secretion. In: ZakimD, BoyerTD, eds. Hepatology. A Textbook of Liver Disease, Vol I. Philadelphia: Saunders, 1996: 362376.
  • 40
    Schwarz LR, Burr R, Schwenk M, Pfaff E, Greim H. Uptake of taurocholic acid into isolated rat-liver cells. Eur J Biochem 1975; 55: 617623.
  • 41
    Anwer MS, Kroker R, Hegner D. Effect of albumin on bile acid uptake by isolated rat hepatocytes. Is there a common bile acid carrier. Biochem Biophys Res Commun 1976; 73: 6371.
  • 42
    Minder E, Paumgartner G. Disparate Na+-requirement of taurocholate and indocyanine green uptake by isolated hepatocytes. Experientia 1979; 35: 888890.
  • 43
    Blitzer BL, Ratoosh SL, Donovan CB, Boyer JL. Effects of inhibitors of Na+-coupled ion transport on bile acid uptake by isolated rat hepatocytes. Am J Physiol 1982; 243: G48G53.
  • 44
    Zimmerli B, Valantinas J, Meier PJ. Multispecificity of Na+-dependent taurocholate uptake in basolateral (sinusoidal) rat liver plasma membrane vesicles. J Pharmacol Exp Ther 1989; 250: 301308.
  • 45
    Stacey NH, Kotecka B. Inhibition of taurocholate and ouabain transport in isolated rat hepatocytes by cyclosporin A. Gastroenterology 1988; 95: 780786.
  • 46
    Torchia EC, Shapiro RJ, Agellon LB. Reconstitution of bile acid transport in the rat hepatoma McArdle RH-7777 cell line. Hepatology 1996; 24: 206211.
  • 47
    Green RM, Whiting JF, Rosenbluth AB, Beier D, Gollan JL. Interleukin-6 inhibits hepatocyte taurocholate uptake and sodium-potassium-ad-enotriphosphatase activity. Am J Physiol 1994; 267: G1094G1100.
  • 48
    Ganguly T, Hyde JF, Vore M. Prolactin increases Na+/taurocholate cotransport in isolated hepatocytes from postpartum rats and ovariectomized rats. J Pharmacol Exp Ther 1993; 267: 8287.
  • 49
    Schramm U, Fricker G, Buscher HP, Gerok W, Kurz G. Fluorescent derivatives of bile salts. III. Uptake of 7/3-NBD-NCT into isolated hepatocytes by the transport systems for cholyltaurine. J Lipid Res 1993; 34: 741757.
  • 50
    Von Dippe P, Drain P, Levy D. Synthesis and transport characteristics of photoaffinity probes for the hepatocyte bile acid transport system. J Biol Chem 1983; 258: 88908895.
  • 51
    Follmann W, Petzinger E, Kinne RKH. Alterations of bile acid and bumetanide uptake during culturing of rat hepatocytes. Am J Physiol 1990; 258: C700C712.
  • 52
    Kuhn WF, Gewirtz DA. Stimulation of taurocholate and glycocholate efflux from the rat hepatocyte by arginine vasopressin. Am J Physiol 1988; 254: G732G740.
  • 53
    Sandker GW, Weert B, Olinga P Wolters H, Slooff MJH, Meijer DKF, Groothuis GMM. Characterization of transport in isolated human hepatocytes. A study with the bile acid taurocholic acid, the uncharged ouabain and the organic cations vecuronium and rocuronium. Biochem Pharmacol 1994; 47: 21932200.
  • 54
    Foliot A, Glaise D, Erlinger S, Guguen-Guillouzo C. Long-term maintenance of taurocholate uptake by adult rat hepatocytes co-cultured with a liver epithelial cell line. Hepatology 1985; 5: 215219.
  • 55
    Liang D, Hagenbuch B, Stieger B, Meier PJ. Parallel decrease of Na+-taurocholate cotransport and its encoding mRNA in primary cultures of rat heaptocytes. Hepatology 1993; 18: 11621166.
  • 56
    Von Dippe P, Levy D. Characterization of the bile acid transport system in normal and transformed hepatocytes. Photoaffinity labelling of the taurocholate carrier protein. J Biol Chem 1983; 258: 88968901.
  • 57
    Von Dippe P, Levy D. Expression of the bile acid transport protein during liver development and in hepatoma cells. J Biol Chem 1990; 265: 59425945.
  • 58
    Fricker G, Hugentobler G, Meier PJ, Kurz G, Boyer JL. Identification of a single sinusoidal bile salt uptake system in skate liver. Am J Physiol 1987; 253: G816G822.
  • 59
    Fricker G, Dubost V, Finsterwald K, Boyer JL. Characteristics of bile salt uptake into skate hepatocytes. Biochem J 1994; 299: 665670.
  • 60
    Rabergh CMI, Ziegler K, Isomaa B, Lipsky MM, Eriksson JE. Uptake of taurocholic acid and cholic acid in isolated hepatocytes from rainbow trout. Am J Physiol 1994; 267: G380G386.
  • 61
    Gartung C, Ananthanarayanan M, Rahman MA, Schuele S, Nundy S, Soroka CJ, Stolz A, et al. Down-regulation of expression and function of the rat liver Na+/bile acid cotransporter in extrahepatic cholestasis. Gastroenterology 1996; 110: 199209.
  • 62
    Green RM, Beier D, Gollan JL. Regulation of hepatocyte bile salt transporters by endotoxin and inflammatory cytokines in rodents. Gastroenterology 1996; 111: 193198.
  • 63
    Dumaswala R, Berkowitz D, Setchell KDR, Heubi JE. Effect of fasting on the enterohepatic circulation of bile acids in rats. Am J Physiol 1994; 267: G836G842.
  • 64
    Wieland T, Nassal M, Kramer W, Fricker G, Bickel U, Kurz G. Identity of hepatic membrane transport systems for bile salts, phalloidin, and antamanide by photoaffinity labeling. Proc Natl Acad Sci USA 1984; 81: 52325236.
  • 65
    Fricker G, Dubost V, Schwab D, Bruns C, Thiele C. Heterogeneity in hepatic transport of somatostatin analog octapeptide. Hepatology 1994; 120: 191200.
  • 66
    Moseley R, Johnson TR, Morrisette JM. Inhibition of bile acid transport by cyclosporin A in rat liver plasma membrane vesicles. J Pharmacol Exp Ther 1990; 253: 974980.
  • 67
    Petzinger E, Föllmann W, Blumrich M, Schermuly R, Schulz S, Hahnen J, Feit PW. Interaction of bumetanide derivatives with hepatocellular bile acid uptake. Am J Physiol 1993; 265: G942G954.
  • 68
    Eaton DL, Richards JA. Kinetic evaluation of carrier-mediated transport of ouabain and taurocholic acid in isolated rat hepatocytes. Evidence for independent transport systems. Biochem Pharmacol 1986; 35: 27212725.
  • 69
    Ohkuma S, Kuriyama K. Uptake of cholic acid by freshly isolated rat hepatocytes: presence of a common carrier for bile acid transport. Steroids 1982; 39: 719.
  • 70
    Zimmerli B, O'Neill B, Meier PJ. Identification of sodium-dependent and sodium-independent dicarboxylate transport systems in rat liver basolateral membrane vesicles. Pflüg Arch Europ J Physiol 1992; 421: 329335.
  • 71
    Caflisch C, Zimmerli B, Reichen J, Meier PJ. Cholate uptake in basolateral rat liver plasma membrane vesicles and in liposomes. Biochim Biophys Acta 1990; 1021: 7076.
  • 72
    Boyer JL, Graf J, Meier PJ. Hepatic transport systems regulating pHi, cell volume, and bile secretion. Annu Rev Physiol 1992; 54: 415438.
  • 73
    Hugentobler G, Meier PJ. Multispecific anion exchange in basolateral (sinusoidal) rat liver plasma membrane vesicles. Am J Physiol 1986; 251: G656G664.
  • 74
    Cole SPC, Bhardwaj G, Gerlach JH, Mackie JE, Grant CE, Almquist KC, Stewart A, et al. Overexpression of a transporter gene in a multidrug-resistant human cancer cell line. Science 1992: 258: 16501654.
  • 75
    Mayer R, Kartenbeck J, Buchler M, Jedlitschky G, Leier I, Keppler D. Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes. J Cell Biol 1995; 131: 137150.
  • 76
    Kartenbeck J, Leuschner U, Mayer R, Keppler D. Absence of the canalicular isoform of the MRP gene-encoded conjugate export pump from the hepatocytes in Dubin-Johnson syndrome. Hepatology 1996; 23: 10611066.
  • 77
    Paulusma CC, Bosnia PJ, Zaman GJR, Bakker CTM, Otter M, Scheffer GL, Scheper R, et al. Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene. Science 1996; 271: 11261128.
  • 78
    Buchler M, Konig J, Brom M, Kartenbeck J, Spring H, Hories T, Keppler D. cDNA cloning of the hepatocyte canalicular isoform of the multi-drug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats. J Biol Chem 1996; 271: 1509115098.
  • 79
    Gatmaitan ZC, Arias IM. ATP-dependent transport systems in the canalicular membrane of the hepatocyte. Physiol Rev 1995; 75: 261275.
  • 80
    Kast C, Stieger B, Winterhalter KH, Meier PJ. Hepatocellular transport of bile acids. Evidence for distinct subcellular localizations of electro-genie and ATP-dependent taurocholate transport in rat hepatocytes. J Biol Chem 1994; 269: 51795186.
  • 81
    Fernandez-Checa JC, Yi J, Ruiz CG, Ookhtens M, Kaplowitz N. Plasma membrane and mitochondrial transport of hepatic reduced glutathione. Semin Liver Dis 1996; 16: 147158.
  • 82
    Hagenbuch B, Meier PJ. Sinusoidal (basolateral) bile salt uptake systems of hepatocytes. Semin Liver Dis 1996; 16: 129136.
  • 83
    Anwer MS, Hegner D. Effect of organic anions on bile acid uptake by isolated rat hepatocytes. Hoppe-Seylers Z Physiol Chem 1978; 359: 10271030.
  • 84
    Petzinger E, Fischer K. Transport functions of the liver. Lack of correlation between hepatocellular ouabain uptake and binding to (Na+K+)-ATPase. Biochim Biophys Acta 1985; 815: 334340.
  • 85
    Schwenk M, Wiedmann T, Remmer H. Uptake, accumulation and release of ouabain by isolated rat hepatocytes. Naunyn-Schmiedeberg Arch Pharmacol 1981; 316: 334340.
  • 86
    Ziegler K, Lins W, Frimmer M. Hepatocellular transport of cyclosomatostatins: Evidence for a carrier system related to the multispecific bile acid transporter. Biochim Biophys Acta 1991; 1061: 287296.
  • 87
    Eckhardt U, Stüber W, Dickneite G, Reers M, Petzinger E. First-pass elimination of a peptidomimetic thrombin inhibitor is due to carrier-mediated uptake by the liver. Interaction with bile acid transport systems. Biochem Pharmacol 1996; 52: 8596.
  • 88
    Kontaxi M, Eckhardt U, Hagenbuch B, Stieger B, Meier PJ, Petzinger E. Hepatocellular uptake of the mycotoxin Ochratoxin A occurs via the cloned organic anion transporting polypeptide in liver cells. J Pharmacol Exp Ther 1996; 279: 15071513.
  • 89
    Torres AM, Lunazzi GC, Stremmel W, Tiribelli C. Bilitranslocase and sulfobromophthalein/bilirubin-binding protein are both involved in the hepatic uptake of organic anions. Proc Natl Acad Sci USA 1993; 90: 81368139.
  • 90
    Potter BJ, Ni JZ, Wolfe K, Stump D, Berk PD. Induction of a dose-related increase in sulfobromophthalein uptake velocity in freshly isolated rat hepatocytes by phenobarbital. Hepatology 1994; 20: 10781085.
  • 91
    Wolkoff AW. Hepatocellular sinusoidal membrane organic anion transport and transporters. Semin Liver Dis 1996; 16: 121127.
  • 92
    Goeser T, Nakata R, Braly LF, Sosiak A, Campell CG, Dermietzel R, NoviRoff PM, et al. The rat hepatocyte plasma membrane organic anion binding protein is immunologically related to the mitochondrial Fl adenosine triphosphatase b-subunit. J Clin Invest 1990; 86: 220227.
  • 93
    Wolkoff AW, Samuelson AC, Johansen KL, Nakata R, Withers DM, Sosiak A. Influence of Cl- on organic anion transport in short-term cultured rat hepatocytes and isolated perfused rat liver. J Clin Invest 1987; 79: 12591268.
  • 94
    Schwenk M, Burr R, Schwarz L, Pfaff E. Uptake of bromosulfophthalein by isolated liver cells. Eur J Biochem 1976; 64: 189197.
  • 95
    Schwarz LR, Götz R, Klaassen CD. Uptake of sulfobromophthalein-glutathione conjugate by isolated hepatocytes. AmJ Physiol 1980; 239: C118C123.
  • 96
    Laperche Y, Preaux AM, Berthelot P. Two systems are involved in the sulfobromophthalein uptake by rat liver cells: one is shared with bile salts. Biochem Pharmacol 1981; 30: 13331336.
  • 97
    Stremmel W, Berk PD. Hepatocellular uptake of sulfobromophthalein and bilirubin is selectively inhibited by an antibody to the liver plasma membrane sulfobromophthalein/bilirubin binding protein. J Clin Invest 1986; 78: 822826.
  • 98
    Persico M, Bellentani S, Marchegiano P, Orzes N, Lunazzi GC, Sot-tocasa GL, Tiribelli C. Sex steroid modulation of the hepatic uptake of organic anions in rat. J Hepatol 1988; 6: 343349.
  • 99
    Sorrentino D, Bartoli E. Hepatocellular sulfobromophthalein uptake at physiologic albumin concentrations: kinetic evidence for a high affinity/low capacity sinusoidal membrane system. J Hepatol 1996; 25: 178182.
  • 100
    Potter BJ, Blades BB, Shepard MD, Thung SM, Berk PD. The kinetics of sulfobromophthalein uptake by rat liver sinusoidal vesicles. Biochim Biophys Acta 1987; 898: 159171.
  • 101
    Min AD, Goeser T, Campbell CG, Novikoff PM, Wolkoff AW. Organic anion transport in HepG2 cells: absence of the high-affinity, chloride-dependent transporter. Hepatology 1991; 14: 12171223.
  • 102
    Schwenk M, del Pino V. Lopez Uptake of estrone sulfate by isolated rat liver cells. J Steroid Biochem 1980; 13: 669673.
  • 103
    Brouwer KL, Durham S, Vore M. Multiple carriers for uptake of 3H-estradiol-17β-glucuronide in isolated rat hepatocytes. Mol Pharmacol 1987; 32: 519523.
  • 104
    Vore M, Hoffmann T. Carrier-mediated electrogenic transport of estra-diol-17β-glucuronide in rat liver BMV. Am J Physiol 1994; 267: G546G551.
  • 105
    Von Dippe P, Amoui M, Alves C, Levy D. Na+-dependent bile acid transport by hepatocytes is mediated by a protein similar to micro-somal epoxide hydrolase. Am J Physiol 1993; 264: G528G534.
  • 106
    Hagenbuch B, Lübbert H, Stieger B, Meier PJ. Expression of the hepatocyte Na+/bile acid cotransporter in Xenopus laevis oocytes. J Biol Chem 1990; 265: 53575360.
  • 107
    Hagenbuch B, Stieger B, Foguet M, Lübbert H, Meier PJ. Functional expression cloning and characterization of the hepatocyte Na+/bile acid cotransport system. Proc Natl Acad Sci U S A 1991; 88: 1062910633.
  • 108
    Ananthanarayanan M, Ng OC, Boyer JL, Suchy FJ. Characterization of the cloned rat liver Na+-bile acid cotransporter using peptide and fusion protein antibodies. Am J Physiol 1994; 267: G637G643.
  • 109
    Cohn MA, Rounds DJ, Karpen SJ, Ananthanarayanan M, Suchy FJ. Assignment of a rat liver Na+/bile acid cotransporter gene to chromosome 6q24. Mamm Genome 1995; 6: 6061.
  • 110
    Karpen SJ, Sun AQ, Kudish B, Hagenbuch B, Meier PJ, Ananthanarayanan M, Suchy FJ. Multiple factors regulate the rat basolateral sodium-dependent bile acid cotransporter gene promoter. J Biol Chem 1996; 271: 1521115221.
  • 111
    Wong MH, Oelkers P, Craddock AL, Dawson PA. Expression cloning and characterization of the hamster ileal sodium-dependent bile acid transporter. J Biol Chem 1994; 269: 13401347.
  • 112
    Shneider BL, Dawson PA, Christie DM, Hardikar W, Wong MH, Suchy FJ. Cloning and molecular characterization of the ontogeny of a rat ileal sodium-dependent bile acid transporter. J Clin Invest 1995; 95: 745754.
  • 113
    Simon FR, Fortune J, Iwahashi M, Gartung C, Wolkoff A, Sutherland E. Ethinyl estradiol induced cholestasis involves alterations in the expression of liver sinusoidal membrane transporters. Am J Physiol 1996; 34: G1043G1052.
  • 114
    Schroeder A, Hagenbuch B, Stieger B, Tynes R, Schteingart CD, Hof-mann AF, Meier PJ. The rat hepatocyte Na+/taurocholate cotransport-ing polypeptide (Ntcp) mediates multispecific substrate transport in stably transfected Chinese hamster ovary (CHO) cells [Abstract]. Gastroenterology 1994; 106: 979A.
  • 115
    Hagenbuch B, Jacquemin E, Meier PJ. Na+-dependent and Na+-inde-pendent bile acid uptake systems in the liver. Cell Physiol Biochem 1994; 4: 198205.
  • 116
    Honscha W, Schulz K, Müller D, Petzinger E. Two different mRNAs from rat liver code for the transport of bumetanide and taurocholate in Xenopus laevis oocytes. Eur J Pharmacol 1993; 246: 227232.
  • 117
    Green RM, Gollan JL, Hagenbuch B, Meier PJ, Beier DR. Regulation of hepatocyte bile salt transporters during hepatic regeneration. Am J Pysiol 1997; 36: 86218627.
  • 118
    Suchy FJ, Bucuvalas JC, Goodrich AL, Moyer MS, Blitzer BL. Taurocholate transport and Na+-K+-ATPase activity in fetal and neonatal rat liver plasma membrane vesicles. Am J Physiol 1986; 251: G665G673.
  • 119
    Hardikar W, Ananthanarayanan M, Suchy FJ. Differential ontogenic regulation of basolateral and canalicular bile acid transport proteins in rat liver. J Biol Chem 1995; 270: 2084120846.
  • 120
    Suchy FJ, Courchene SM, Blitzer BL. Taurocholate transport by basolateral plasma membrane vesicles isolated from developing rat liver. Am J Physiol 1985; 248: G648G654.
  • 121
    Ganguly TC, Liu Y, Hyde JF, Hagenbuch B, Meier PJ, Vore M. Prolactin increases hepatic Na+/taurocholate co-transport activity and messenger RNA post partum. Biochem J 1994; 303: 3336.
  • 122
    Meier PJ. More Na+/bile acid cotransporters in hepatocytes? Lessons from obstructive cholestasis Hepatology 1996; 24: 971972.
  • 123
    Hardison WGM, Bellentani S, Heasley V, Shellhamer D. Specificity of an Na+-dependent taurocholate transport site in isolated rat hepatocytes. Am J Physiol 1984; 246: G477G483.
  • 124
    Bellentani S, Hardison WGM, Marchegiano P, Zanasi G, Manenti F. Bile acid inhibition of taurocholate uptake by rat hepatocytes: role of OH groups. Am J Physiol 1987; 252: G339G344.
  • 125
    Hardison WGM, Heasley VL, Shellhamer DF. Specificity of the hepatocyte Na+-dependent taurocholate transporter: Influence of side chain length and charge. Hepatology 1991; 13: 6872.
  • 126
    Hagenbuch B, Meier PJ. Molecular cloning, chromosomal localization, and functional characterization of a human liver Na+/bile acid cotrans-porter. J Clin Invest 1994; 93: 13261331.
  • 127
    Novak DA, Ryckman FC, Suchy FJ. Taurocholate transport by basolateral plasma membrane vesicles isolated from human liver. Hepatology 1989; 10: 447453.
  • 128
    Hofmann AF. Overview of bile secretion. In: SchultzSG, ForteJG, RaunerBB, eds. Handbook of Physiology. The Gastrointestinal System. Salivary, Gastric, Pancreatic, and Hepatobiliary Secretion. Vol III, sect 6, chapt 28. Bethesda, Am Physiol Soc 1989: 549596.
  • 129
    Clark RF, Cruts M, Korenblat KM, He C, Talbot C, Van Broeckhoven C, Geate AM. A yeast artificial chromosome contiguity from human chromosme 14q24 spanning the Alzheimers disease locus AD3. Hum Mol Genet 1995; 8: 13471354.
  • 130
    Ananthanarayanan M, von Dippe P, Levy D. Identification of the hepatocyte Na+-dependent bile acid transport protein using monoclonal antibodies. J Biol Chem 1988; 263: 83388343.
  • 131
    Von Dippe P, Levy D. Reconstitution of the immunopurified 49-kDa sodium-dependent bile acid transport protein derived from hepatocyte sinusoidal plasma membranes. J Biol Chem 1990; 265: 1481214816.
  • 132
    Stasiecki P, Oesch F, Bruder G, Jarasch ED, Franke WW. Distribution of enzymes involved in metabolism of polycyclic aromatic hydrocarbons among rat liver endomembranes and plasma membranes. Fur J Cell Biol 1980; 21: 7992.
  • 133
    Honscha W, Platte HD, Oesch F, Friedberg T. Relationship between the microsomal epoxide hydrolase and the hepatocellular transport of bile acids and xenobiotics. Biochem J 1995; 311: 975979.
  • 134
    Jacquemin E, Hagenbuch B, Stieger B, Wolkoff AW, Meier PJ. Expression of the hepatocellular chloride-dependent sulfobromophthalein uptake system in Xenopus laevis oocytes. J Clin Invest 1991; 88: 21462149.
  • 135
    Jacquemin E, Hagenbuch B, Stieger B, Wolkoff AW, Meier PJ. Expression cloning of a rat liver Na+-independent organic anion transporter. Proc Natl Acad Sci U S A 1994; 91: 133137.
  • 136
    Bergwerk AJ, Shi X, Ford AC, Kanai N, Jacquemin E, Burk RD, Bai S, et al. Immunologic distribution of an organic anion transport protein in rat liver and kidney. Am J Physiol 1996; 271: G231G238.
  • 137
    Angeletti RH, Novikoff PM, Juuvadi SR, Fritschy JM, Meier PJ, Wolkoff AW. The choroid plexus epithelium is the site of the organic anion transport protein in the brain. Proc Natl Acad Sci U S A 1997; 94: 283286.
  • 138
    Kanai N, Lu R, Satriano JA, Bao Y, Wolkoff AW, Schuster VL. Identification and characterization of a prostaglandin transporter. Science 1995; 268: 866869.
  • 139
    Lu R, Kanai N, Bao Y, Schuster VL. Cloning, in vitro expression, and tissue distribution of a human prostaglandin transporter cDNA (hPGT). J Clin Invest 1996; 98: 11421149.
  • 140
    Saito H, Masuda S, Inui K. Cloning and functional characterization of a novel rat organic anion transporter mediating basolateral uptake of methotrexate in the kidney. J Biol Chem 1996; 271: 2071920724.
  • 141
    Noé B, Hagenbuch B, Stieger B, Meier PJ. Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain. Proc Natl Acad Sci U S A 1997; 94: 1034610350.
  • 142
    Kullak-Ublick GA, Hagenbuch B, Stieger B, Wolkoff AW, Meier PJ. Functional characterization of the basolateral rat liver organic anion transporting polypeptide. Hepatology 1994; 20: 411416.
  • 143
    Kanai N, Lu R, Bao Y, Wolkoff AW, Vore M, Schuster VL. Estradiol 17β-D-glucuronide is a high-affinity substrate for oatp organic anion transporter. Am J Physiol 1996; 270: F326F331.
  • 144
    Bossuyt X, Müller M, Hagenbuch B, Meier PJ. Polyspecific drug and steroid clearance by an organic anion transporter of mammalian liver. J Pharm Exp Ther 1996; 276: 891896.
  • 145
    Eckhardt U, Horz JA, Petzinger E, Stüber W, Reers M, Dickneite G, Daniel H, et al. The peptide based thrombin inhibitor CRC 220 is a new substrate of the basolateral rat liver organic anion transporting polypeptide. Hepatology 1996; 24: 380384.
  • 146
    Kullak-Ublick GA, Hagenbuch B, Stieger B, Schteingart CD, Hofmann AF, Wolkoff AW, Meier PJ. Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver. Gastroenterology 1995; 109: 12741282.
  • 147
    Bossuyt X, Müller M, Meier PJ. Multispecific amphipathic substrate transport by an organic anion transporter of human liver. J Hepatol 1996; 25: 733738.
  • 148
    Kullak-Ublick GA, Beuers U, Meier PJ, Domdey H, Paumgartner G. Assignment of the human organic anion transporting polypeptide (OATP) gene to chromosome 12pl2 by fluorescence in situ hybridization. J Hepatol 1996; 25: 985987.
  • 149
    Kullak-Ublick GA, Beuers U, Fahney C, Hagenbuch B, Meier PJ, Paumgartner G. Identification and functional characterization of the promoter region of the human organic anion transporting polypeptide gene. Hepatology 1997; 26: 991997.