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Therapy of hepatitis C: Interferon alfa-2a trials
Article first published online: 30 DEC 2003
DOI: 10.1002/hep.510260716
Copyright © 1997 by the American Association for the Study of Liver Diseases
Issue
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Hepatology
Supplement: Management of Hepatitis C: 2002
Volume 26, Issue Supplement 3, pages 89S–95S, December 1997
Additional Information
How to Cite
Lee, W. M. (1997), Therapy of hepatitis C: Interferon alfa-2a trials. Hepatology, 26: 89S–95S. doi: 10.1002/hep.510260716
Publication History
- Issue published online: 30 DEC 2003
- Article first published online: 30 DEC 2003
References
- 1. Usefulness of interferon for treatment of hepatitis C. J Hepatol 1995; 22 (suppl 1): 101–109.
- 2, . Human interferon-alphaA, -alpha2, and -alpha2 (Arg) genes in genomic DNA. J Biol Chem 1993; 268: 12565–12569.
- 3, , , , . Final study report: results from serial HCV RNA determinations using a quantitative PCR method. Roche Research Report N. B-154.142, 1995.
- 4, , , , , , , et al. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology 1981; 1: 431–435.
- 5, , , , , , , et al. Treatment with interferon(s) of community-acquired chronic hepatitis and cirrhosis type C. J Hepatol 1993; 17 (suppl 3): S123–126.
- 6, , , , , , , et al. Randomized trial comparing three different regimens of alpha-2a-interferon in chronic hepatitis C. Hepatology 1995; 22: 700–706.
- 7, , , , , , , et al. A prospective, randomized trial comparing lympho-blastoid to recombinant interferon alfa 2a as therapy for chronic hepatitis C. Hepatology 1996; 24: 1366–1370.
- 8, , , , , , , et al. Treatment of chronic hepatitis C with recombinant human interferon-alfa 2a: results of a randomized controlled clinical trial. Hepatology 1994; 19: 1–5.
- 9, , , , , , , et al. Interferon therapy in chronic hepatitis C virus: evidence of different outcome with respect to different viral strains. J Med Virol 1995; 45: 445–450.
- 10, , , , . Treatment of type C chronic active hepatitis with interferon alfa-2a. Treatment duration does not influence biochemical remission but does decrease relapse rate. J Clin Gastroenterol 1994; 19: 214–216.
- 11, , , , , , , et al. Continuous versus intermittent therapy for chronic hepatitis C with recombinant interferon alfa-2a. Gastroenterology 1994; 107: 479–485.
- 12, , , , , . Virological and biochemical long-term follow-up of patients with chronic hepatitis C treated with interferon. Hepatology 1994; 19: 1342–1346.
- 13, , , , , , , et al. Randomized controlled trial of recombinant alpha-2a-interferon for chronic hepatitis C. Dig Dis Sci 1993; 38: 601–607.
- 14, , , , , , , et al. Prevention of relapse in patients with chronic non-A, non-B/ C hepatitis who respond to alpha-interferon. A controlled multicenter trial of low-dose maintenance therapy. J Hepatol 1994; 21: 774–778.
- 15, , , . Clinical outcomes after transfusion-associated hepatitis C. N Engl J Med 1995; 332: 1463–1466.
- 16, , , , . Viral and host factors that contribute to efficacy of interferon-alfa 2a therapy in patients with chronic hepatitis C. Dig Dis Sci 1994; 39: 1273–1280.
- 17, , , , , , , et al. Treatment with recombinant interferon-alfa-2 for patients with chronic hepatitis C: predictive factors for biochemical and virological response. Scand J Gastroenterol 1996; 31: 1021–1026.
- 18, , , , , , , et al. Predictors of sustained response, relapse and no response in patients with chronic hepatitis C treated with interferon alfa. J Viral Hepatitis 1995; 2: 91–96.
- 19, , , , , , , et al. Relationship between serum HCV markers and response to interferon therapy in chronic hepatitis C. Dig Dis Sci 1994; 39: 2497–2502.
- 20, , , , , , , et al. Interferon antibodies in patients with chronic hepatitis C infection treated with recombinant interferon alpha-2a. J Hepatol 1994; 20: 416–420.
- 21, , , , , , . Serum markers of hepatic fibrogenesis in chronic hepatitis type C treated with alfa-2A interferon. Liver 1994; 14: 257–264.
- 22, , , , , , et al. Normalization of depressed natural killer cell activ-ity after interferon-alfa therapy is associated with a low frequency of relapse in patients with chronic hepatitis C. Int J Tiss Reac 1993; 15: 11–16.
- 23, , , , , , . Long-term carriage of hepatitis C virus with normal aminotransferase after interferon treatment in patients with chronic hepatitis C. J Med Virol 1993; 41: 65–70.
- 24, , , , , , , et al. Persistent hepatitis C viremia predicts late relapse after sustained response to interferon-alpha in chronic hepatitis C. Ann Intern Med 1996; 124: 1058–1060.
- 25, , , , , , , et al. Recombinant interferon-alfa and ursodeoxycholic acid versus interferon-alfa alone in the treatment of chronic hepatitis C: a randomized clinical trial with long-term follow-up. Am J Gastroenterol 1995; 90: 263–269.
- 26, , , , , , , et al. Long-term efficacy of ribavirin plus interferon alfa in the treatment of chronic hepatitis C. Gastroenterology 1996; 111: 1307–1312.
- 27, , , , , , , et al. Controlled randomized comparative study of the efficacy of interferon alpha-2b and interferon alpha-2a in the treatment of chronic hepatitis C. Gastroenterologia Y Hepatologia 1995; 18: 22–28.

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