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IDIBAPS: Institut d'Investigacions Biomèdiques August Pi i Sunyer
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Original Article
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Transarterial embolization versus symptomatic treatment in patients with advanced hepatocellular carcinoma: Results of a randomized, controlled trial in a single institution
Article first published online: 30 DEC 2003
DOI: 10.1002/hep.510270617
Copyright © 1998 American Association for the Study of Liver Diseases
Additional Information
How to Cite
Bruix, J., Llovet, J. M., Castells, A., Montañá, X., Brú, C., Ayuso, M. D. C., Vilana, R. and Rodés, J. (1998), Transarterial embolization versus symptomatic treatment in patients with advanced hepatocellular carcinoma: Results of a randomized, controlled trial in a single institution. Hepatology, 27: 1578–1583. doi: 10.1002/hep.510270617
Publication History
- Issue published online: 30 DEC 2003
- Article first published online: 30 DEC 2003
- Manuscript Accepted: 24 MAR 1998
- Manuscript Received: 5 FEB 1998
Funded by
- Fondo de Investigaciones Sanitarias. Grant Number: FIS 93/00544
REFERENCES
- 1
- 2, . Treatment of hepatocellular carcinoma in patients with cirrhosis. J Hepatol 1997; 27:756–765.MEDLINE
- 3, , , , , , , et al. A randomized trial of hepatic arterial chemoembolization in patients with unresectable hepatocellular carcinoma. J Hepatol 1990; 11:181–184.MEDLINE
- 4Group d'Etude et de Traitement de Carcinome Hepatocellulaire. A comparison of lipiodol chemoembolization and conservative treatment for unresectable hepatocellular carcinoma. N Engl J Med 1995; 332:1256–1261.MEDLINE
- 5, , , . Treatment of hepatocellular carcinoma: a systematic review of randomized controlled trials. Ann Oncol 1997; 8:117–136.MEDLINE
- 6, , , , , , , et al. Phase II study of transarterial embolization in European patients with hepatocellular carcinoma: need for controlled trials. Hepatology 1994; 20:643–650.MEDLINE
- 7, , , , , , . Prognostic factors of hepatocellular carcinoma in the West: a multivariate analysis in 206 patients. Hepatology 1990; 12:753–760.MEDLINE
- 8, , , , , , , et al. Treatment of small hepatocellular carcinoma in cirrhotic patients: a cohort study comparing surgical resection and percutaneous ethanol injection. Hepatology 1993; 18:1121–1126.MEDLINE
- 9, , , , , , , . Treatment of hepatocellular carcinoma with tamoxifen: a double-blind placebo-controlled trial in 120 patients. Gastroenterology 1995; 109:917–922.MEDLINE
- 10, , , , , , , et al. Surgical resection of hepatocellular carcinoma in cirrhotic patients. Prognostic value of preoperative portal pressure. Gastroenterology 1996; 111:1018–1022.MEDLINE
- 11, , , , , , , et al. Natural history of hepatocellular carcinoma and prognosis in relation to treatment. Cancer 1985; 56:918–928.MEDLINE
- 12, , , . Performance status assessment in cancer patients. An inter-observer variability study. Br J Cancer 1993; 67:773–775.MEDLINE
- 13
- 14, , , , . Transection of the oesophagus for bleeding oesophageal varices. Br J Surg 1973; 60:646–664.MEDLINE
- 15, , , . Renal function abnormalities, prostaglandins, and effects of nonsteroidal anti-inflammatory drugs in cirrhosis with ascites. Am J Med 1986; 81:104–122.MEDLINE
- 16, , , , . Intraarterial adriamycin and lipiodol for inoperable hepatocellular carcinoma: a comparison with intravenous adriamycin. J Hepatol 1990; 11:349–353.MEDLINE
- 17, , , , , , , et al. Prospective and randomized clinical trial for treatment of hepatocellular carcinoma. A comparison of lipiodol-transcatheter arterial embolization with and without adiamycin (first cooperative study). The Cooperative Study Group for Liver Cancer Treatment of Japan. Cancer Chemother Pharmacol 1992; 31(Suppl:S1–S6.MEDLINE
- 18, , , , . Transcatheter arterial embolization with or without cisplatin treatment of hepatocellular carcinoma. A randomized controlled study. Cancer 1994; 74:2449–2453.MEDLINE
- 19. Structure and function of the p53 tumor supressor gene: clues for rational cancer therapeutic strategies. J Natl Cancer Inst 1996; 88:1442–1455.MEDLINE
- 20, , , , , , , et al. Bile duct necrosis: complication of transcatheter arterial embolization. Radiology 1985; 156:331–334.MEDLINE
- 21, , , , . Transcatheter oil chemoembolization in the management of advanced hepatocellular carcinoma in cirrhosis: results of a Western comparative study in 60 patients. Hepatology 1991; 13:427–433.MEDLINE
- 22, , , , , , . Chemoembolization for hepatocellular carcinoma. J Clin Oncol 1990; 8:1108–1114.MEDLINE
- 23, , , , . Treatment of hepatocellular carcinoma using doxorubicin ethiodized oil gelatin powder chemoembolization. Cancer 1993; 72:3202–3209.MEDLINE
- 24, , , , , , , et al. Hepatic artery embolization for inoperable hepatocellular carcinoma: prognosis and risk factors. Cancer Chemother Pharmacol 1989; 23(Suppl:S123–S125.MEDLINE
- 25, , , , , , , et al. Transarterial oil chemoembolization for the treatment of hepatocellular carcinoma: a multivariate analysis of prognostic factors. Hepatology 1994; 19:1115–1123.MEDLINE
- 26, , , , , , . Primary treatment of hepatocellular carcinoma by arterial chemoembolization. Am J Surg 1992; 163:387–394.MEDLINE
- 27, , , , . Effect of repeated transcatheter arterial embolization on the survival time in patients with hepatocellular carcinoma. Cancer 1991; 68:2150–2154.MEDLINE
- 28, , , , , , , et al. Changes in hepatic functional reserve after transcatheter embolization of hepatocellular carcinoma. Assessment by maximal removal of indocyanine green. J Hepatol 1988; 6:332–336.MEDLINE
- 29, , , , , , , et al. Spontaneous and iatrogenic spreading of liver-derived cells into peripheral blood of patients with primary liver cancer. Hepatology 1997; 26:998–1005.MEDLINE
- 30, , , , , , . Circulating mRNA for alpha-fetoprotein in patients with hepatocellular carcinoma. Evidence of tumor dissemination after transarterial embolization. Hepatology 1996; 24:349A.
- 31, , , , . Hepatocellular carcinoma cells during anoxia by preventing phospholipase-mediated calpain activation. J Cell Physiol 1996; 167:434–442.MEDLINE
- 32, , , . Interactive effects of p53 tumor suppressor gene and hepatitis B virus in hepatocellular carcinoma. In: ArroyoV, BoschJ, BrugueraM, Rodés J, eds. Therapy in Liver Diseases. The Pathophysiological Basis of Therapy. Barcelona: Masson, 1997:471–478.