• 1
    Epstein M. Derangements of renal water handling in liver disease. Gastroenterology 1985; 89:14151425.MEDLINE
  • 2
    Arroyo V, Clària J, Saló J, Jiménez W. Antidiuretic hormone and the pathogenesis of water retention in cirrhosis with ascites. Semin Liver Dis 1994; 14:4458.MEDLINE
  • 3
    Ginès P, Abraham W, Schrier RW. Vasopressin in pathophysiological states. Semin Nephrol 1994; 14:384397.MEDLINE
  • 4
    Vaamonde CA. Renal water handling in liver disease. In: EpsteinM, ed. The Kidney in Liver Disease, 4th ed. Philadelphia: Hanley & Belfus, Inc., 1996;3374.
  • 5
    Arroyo V, Rodés J, Gutiérrez Lizarraga MA, Revert L. Prognostic value of spontaneous hyponatremia in cirrhosis with ascites. Am J Dig Dis 1976; 21:249256.MEDLINE
  • 6
    Robertson GL, Berl T. Pathophysiology of water metabolism: water retaining disorders. In: BrennerBM, ed. The Kidney, 5th ed. Philadelphia: Saunders, 1996;873928.
  • 7
    Nielsen S, Smith B, Christensen E, Kneppar MA, Agre P. CHIP28 water channel is localized constitutively in water permeable segments of the nephron. J Cell Biol 1993; 120:371383.MEDLINE
  • 8
    Berl T, Schrier RW. Disorders of water metabolism. In: SchrierRW, ed. Renal and Electrolyte Disorders, 5th ed. Boston: Lippincott-Raven, 1997;171.
  • 9
    Teitelbaum I, Kleeman CR, Berl T. The physiology of the renal concentrating and diluting mechanisms. In: NarinsRG, ed. Clinical Disorders of Fluid and Electrolyte Metabolism, 5th ed. New York: McGraw Hill, 1994;101127.
  • 10
    Sands JM, Kokko JP. Countercurrent system. Kidney Int 1990; 38:695699.MEDLINE
  • 11
    Green R, Giebisch G. Refective coefficients and water permeability in rat proximal tubule. Am J Physiol 1989; 257:F658F668.MEDLINE
  • 12
    Schaefer JA, Patlak CS, Troutman SL. Volume reabsorption in the pars recta. II. Hydraulic conductivity coefficient. Am J Physiol 1978; 234:F340F348.MEDLINE
  • 13
    Kokko JP. Sodium chloride and water transport in the descending limb of Henle. J Clin Invest 1970; 49:98389846.
  • 14
    Imai M. Function of the thin ascending limb of Henle of rats and hamsters perfused in vitro. Am J Physiol 1975; 232:F201F209.
  • 15
    Knepper MA, Wade JB, Terris J, Ecelbarger CS, Marples D, Mandon B, Chou CL, et al. Renal aquaporins. Kidney Int 1996; 49:17121717.MEDLINE
  • 16
    Nielsen S, Marples D, Frokiaer J, Knepper M, Agre P. The aquaporin family of water channels in kidney: an update on physiology and pathophysiology of aquaporin-2. Kidney Int 1996; 49:17181723.MEDLINE
  • 17
    King LS, Agre P. Pathophysiology of the aquaporin water channels. Annu Rev Physiol 1996; 58:619648.MEDLINE
  • 18
    Knepper MA. Molecular physiology of urinary concentrating mechanism: regulation of aquaporin water channels by vasopressin. Am J Physiol 1997; 272:F3F12.MEDLINE
  • 19
    Agre P, Preston GM, Smith BL, Jung JS, Raina S, Moon CM, Guggino WB, et al. Aquaporin CHIP: the archetypal molecular water channel. Am J Physiol 1993; 265:F463F476.MEDLINE
  • 20
    Sabolic I, Valent G, Verbavatz J, van Hoek AN, Verkamn AS, Ausiello DA, Brown D. Localization of CHIP28 water channel in rat kidney. Am J Physiol 1992; 203:C1225C1233.
  • 21
    Brown D, Katsura T, Kawashima M, Verkman AS, Sabolic I. Cellular distribution of aquaporins: a family of water channel proteins. Histochem Cell Biol 1995; 104:19.MEDLINE
  • 22
    Maeda Y, Smith B, Agre P, Knepper MA. Quantification of aquaporin CH18 water channel protein in microdissected renal tubules by fluorescence based ELISA. J Clin Invest 1995; 95:422428.MEDLINE
  • 23
    Raymond HK, Stein JH. Efferent limb of volume homeostasis. In: BrennerBM, SteinJH, eds. Contemporary Issues in Nephrology, vol 16. New York: Churchill Livingstone, 1987.
  • 24
    Schuster VL, Kokko JP, Jacobson HR. Angiotensin II directly stimulates sodium transport in rabbit proximal convoluted tubules. J Clin Invest 1984; 73:507515.MEDLINE
  • 25
    Quam A, Baum M. Endogenous production of angiotensin II modulates rat proximal tubule transport. J Clin Invest 1996; 97:28782882.MEDLINE
  • 26
    DiBona G. Neurogenic regulation of renal tubular sodium reabsorption. Am J Physiol 1972; 233:F73F81.
  • 27
    DiBona GF, Kopp VC. Neural control of renal function. Physiol Rev 1977; 77:75197.
  • 28
    Rocha AS, Kokko JP. Sodium chloride and water transport in the medullary thick ascending limb of Henle. Evidence for active chloride transport. J Clin Invest 1973; 52:612623.MEDLINE
  • 29
    Ellison DM. Diuretic drugs and the treatment of edema: from clinic to bench and back again. Am J Kidney Dis 1994; 23:623.MEDLINE
  • 30
    Gillin AG, Sands JM. Urea transport in the kidney. Semin Nephrol 1993; 13:146154.MEDLINE
  • 31
    Smith CP, Shakayul C, You G, Lee WS, Martial S, Mackenzie HS, Sands JM, et al. Cloning and regulation of the rat kidney urea transporter (rUT2). J Clin Invest 1995; 96:15561563.MEDLINE
  • 32
    Shakayul C, Steel CA, Hediger MA. Molecular cloning and characterization of the vasopressin-regulated urea transporter of rat kidney collecting duct. J Clin Invest 1996; 98:25802587.MEDLINE
  • 33
    Promeneur D, Rousselet G, Bankir L, Bailly P, Cartron JP, Ripoche P, Trinh-Trang-Tan MM. Evidence for distinct vascular and tubular urea transporters in the rat kidney. J Am Soc Nephrol 1996; 7:852860.MEDLINE
  • 34
    Sands JM, Trimmer RT, Gunn RB. Urea transporters in kidney and erythrocytes. Am J Physiol 1997; 42:F321F339.
  • 35
    Couriaud C, Ripoche P, Rousselet G. Cloning and functional characterization of a rat urea transporter: expression in the brain. Biochim Biophys Acta 1996; 1309:197199.MEDLINE
  • 36
    Tsukaguchi H, Shayakul C, Berger UV, Tokui T, Brown D, Hediger MA. Cloning and characterization of the urea transporter UT3. Localization in rat kidney and testis. J Clin Invest 1997; 99:15061515.MEDLINE
  • 37
    Hebert R, Jacobson H, Breyer MD. PGE2 inhibits AVP induced water flow in cortical collecting duct by protein kinase C activation. Am J Physiol 1990; 259:F318F325.MEDLINE
  • 38
    Nadler SP, Zimpelman JA, Hebert RL. Endothelin inhibits vasopressin stimulated water permeability in rat terminal inner medullary collecting duct. J Clin Invest 1992; 95:14581466.
  • 39
    Snyder HM, Fredin DM, Breyer MD. Muscarinic receptor activation inhibits AVP induced water flow in rabbit cortical collecting ducts. Am J Physiol 1991; 260:F929F936.MEDLINE
  • 40
    Breyer MD, Jacobson HR, Breyer JA. Epidermal growth factor inhibits the hydroosmotic effect of vasopressin in isolated rabbit cortical collecting tubule. J Clin Invest 1988; 82:13131320.MEDLINE
  • 41
    Breyer MD. Regulation of water and salt transport in collecting duct through calcium dependent signalling mechanisms. Am J Physiol 1991; 260:F1F11.MEDLINE
  • 42
    Teitelbaum I. Cyclic AMP and diacylglycerol: mutually inhibitory second messengers in cultured rat inner medullary collecting tubule cells. J Clin Invest 1990; 86:4651.MEDLINE
  • 43
    Heasley LE, Senkfor SI, Winitz A, Strasheim A, Teitelbaum I, Berl T. Hormonal regulation of MAP kinase in cultured rat inner medullary collecting tubule cells. Am J Physiol 1994; 267:F366F373.MEDLINE
  • 44
    Wong R, Heasley L, Ao L, Berl T. Expression of GTPase deficient Ras inhibits vasopressin signaling in cultured cortical collecting duct cells. J Clin Invest 1995; 96:597601.MEDLINE
  • 45
    Bichet DG. Posterior pituitary. In: MelmedS, ed. The pituitary. Cambridge, MA: Blackwell Scientific Publications, Inc., 1995;277306.
  • 46
    Kalogeras KT, Nieman LN, Friedman TC, Doppman JL, Cutler GB, Chrousos GP, Wilder RL, et al. Inferior petrosal sinus sampling in healthy human subjects reveals a unilateral corticotropin-releasing hormone-induced arginine vasopressin release associated with ipsilateral adrenocorticotropin secretion. J Clin Invest 1996; 97:20452050.MEDLINE
  • 47
    Richter D, Schmale H. Molecular aspects of the expression of the vasopressin gene. In: CzernichowP, RobinsonAG, eds. Frontiers of Hormone Research, Vol 13, Diabetes Insipidus in Man. Basel: Karger, 1985;3741.
  • 48
    Schrier RW, Berl T, Anderson RJ. Osmotic and non osmotic control of vasopressin release. Am J Physiol 1979; 236:F321F332.MEDLINE
  • 49
    Oliet SH, Bourque CW. Mechanosensitive channels transduce osmosensitivity in supraoptic neurons. Nature 1993; 364:341343.MEDLINE
  • 50
    Jung JS, Bhat RV, Preston GM, Guggino WB, Baraban JM, Agre P. Molecular characterisation of an aquaporin cDNA from brain: candidate osmoreceptor and regulator of water balance. Proc Natl Acad Sci U S A 1994; 91:1305213056.MEDLINE
  • 51
    Kannan H, Yagi R. Supraoptic neurosecretory neurons: evidence for the existence of converging inputs both from carotid baroreceptors and osmoreceptors. Brain Res 1978; 145:385390.MEDLINE
  • 52
    Anderson RJ, Cadnapaphornchai P, Harbottle JA, McDonald KM, Schrier RW. Mechanism of effect of thoracic inferior vena cava contriction on renal water excretion. J Clin Invest 1974; 54:14731479.MEDLINE
  • 53
    Kim JK, Summer SN, Howard RL, Schrier RW. Vasopressin gene expression in rats with experimental cirrhosis. Hepatology 1993; 17:143147.MEDLINE
  • 54
    Kim JK, Michel JB, Soubrier F, Durr J, Corvol P, Schrier RW. Arginine vasopressin gene expression in chronic cardiac failure in rats. Kidney Int 1990; 38:818822.MEDLINE
  • 55
    Howard RL, Summer S, Rossi N, Kim JK, Schrier RW. Short-term hypothyroidism and vasopressin gene expression in the rat. Am J Kidney Dis 1992; 19:573577.MEDLINE
  • 56
    Pyo HJ, Summer SN, Niederberger M, Kim JK, Schrier RW. Arginine vasopressin gene expression in rats with puromycin-induced nephrotic syndrome. Am J Kidney Dis 1995; 25:5862.MEDLINE
  • 57
    Morel A, O'Carroll A-M, Brownstein MJ, Lolait SJ. Molecular cloning and expression of a rat V1a arginine vasopressin receptor. Nature 1992; 356:523526.MEDLINE
  • 58
    Birnbaumer M, Seibold A, Gilbert S, Ishido M, Barberis C, Antaramian A, Brabet P, et al. Molecular cloning of the receptor for human antidiuretic hormone. Nature 1992; 357:333335.MEDLINE
  • 59
    Lolait SJ, O'Carroll A-M, McBride OW, Konig M, Morel A, Brownstein MJ. Cloning and characterization of a vasopressin V2 receptor and possible link to nephrogenic diabetes insipidus. Nature 1992; 357:336339.MEDLINE
  • 60
    Thibonnier M, Auzan C, Madhun Z, Wilkins P, Berti-Mattera L, Clauser E. Molecular cloning, sequencing, and functional expression of a cDNA encoding the human V1a vasopressin receptor. J Biol Chem 1994; 269:33043310.MEDLINE
  • 61
    Sugimoto T, Saito M, Mochizuki S, Watanabe Y, Hashimoto S, Kawashima H. Molecular cloning and functional expression of a cDNA encoding the human V1b vasopressin receptor. J Biol Chem 1994; 269:2708827092.MEDLINE
  • 62
    de Keyzer Y, Auzan C, Lenne F, Beldjord C, Thibonnier M, Bertagna X, Clauser E. Cloning and characterization of the human V3 pituitary vasopressin receptor. FEBS Lett 1994; 356:215220.MEDLINE
  • 63
    Lolait SJ, O'Carroll A-M, Mahan LC, Felder CC, Button DC, Young WS, Mezey E, et al. Extrapituitary expression of the rat V1b vasopressin receptor gene. Proc Natl Acad Sci U S A 1995; 92:67836787.MEDLINE
  • 64
    Rozen F, Russo C, Banville D, Zingg HH. Structure, characterization, and expression of the rat oxytocin receptor gene. Proc Natl Acad Sci U S A 1995; 92:200204.MEDLINE
  • 65
    Watson S, Arkinstall. The G protein linked receptor. FactsBook Series, London: Academic, 1994.
  • 66
    Ostrowski NL, Young WS, Knepper MA, Lolait ST. Expression of vasopressin V1a and V2 receptor messenger ribonucleic acid in the liver and kidney of embryonic, developing, and adult rats. Endocrinology 1993; 133:18491859.MEDLINE
  • 67
    Ostrowski NL, Lolait SJ, Young WS. Cellular localization of vasopressin V1a receptor messenger ribonucleic acid in adult male rat brain, pineal, and brain vasculature. Endocrinology 1994; 135:15111528.MEDLINE
  • 68
    Grazzini E, Lodboerer AM, Pérez-Martín A, Joubert D, Guillon G. Molecular and functional characterization of V1b vasopressin receptor in rat adrenal medulla. Endocrinology 1996; 137:39063914.MEDLINE
  • 69
    Knepper M, Nielsen S, Chou CL. Mechanism of vasopressin action in the renal collecting duct. Semin Nephrol 1994; 14:302321.MEDLINE
  • 70
    Fushimi K, Uchida S, Hora G. Cloning and expression of apical membrane water channel of rat kidney. Nature 1993; 361:549552.MEDLINE
  • 71
    Brown D. Membrane recycling and epithelial cell function. Am J Physiol 1989; 256:F1F6.MEDLINE
  • 72
    Nielsen S, Chou CL, Marples D, Christensen EI, Kishore BK, Knepper MA. Vasopressin increases water permeability of the kidney collecting duct by inducing translocation of AQP-CD water channels to plasma membrane. Proc Natl Acad Sci U S A 1995; 92:10131017.MEDLINE
  • 73
    DiGiovanni SR, Nielsen S, Christensen EI, Knepper MA. Regulation of collecting duct water channel expression by vasopressin in Brattleboro rat. Proc Natl Acad Sci U S A 1994; 91:89848988.MEDLINE
  • 74
    Uchida S, Sasaki S, Fushimi K, Marumo F. Isolation of human aquaporin-CD gene. J Biol Chem 1994; 269:2345123455.MEDLINE
  • 75
    Rai T, Uchida S, Marumo F, Sasaki S. Cloning of rat and mouse aquaporin-2 gene promoters and identification of a negative cis-regulatory element. Am J Physiol 1997; 273:F263F273.
  • 76
    Hozawa S, Holtzman EJ, Ausiello DA. cAMP motifs regulating transcription in the aquaporin-2 gene. Am J Physiol 1996; 270:C1695C1702.MEDLINE
  • 77
    Yasui M, Zelenin SM, Celsi G, Aperia A. Adenylate cyclase-coupled vasopressin receptor activates AQP2 promoter via a dual effect on CRE and AP1 elements. Am J Physiol 1997; 272:F443F450.MEDLINE
  • 78
    Van Lieburg AB, Verdijk MA, Knoers VV, van Essen Boesman W, Mallmann R, Monnens LA, et al. Patients with autosomal nephrogenic diabetes insipidus homozygous for mutations in the aquaporin 2 water channel gene. Am J Hum Genet 1994; 55:648652.MEDLINE
  • 79
    Marples D, Christensen E, Christensen EI, Ottosen PD, Nielsen S. Lithium induced downregulation of aquaporin 2 water channel expression in rat kidney medulla. J Clin Invest 1995; 95:18381843.MEDLINE
  • 80
    Marples D, Frokiaer J, Dorup M. Hypokalemia induced downregulation of aquaporin-2 water channel expression in rat kidney medulla and cortex. J Clin Invest 1996; 97:19601968.MEDLINE
  • 81
    Sands JM, Naruse N, Jacobs JD. Changes in aquaporin-2 protein contribute to the urine concentrating defect in rats fed a low-protein diet. J Clin Invest 1996; 97:28072814.MEDLINE
  • 82
    Knepper MA. The aquaporin family of molecular water channels. Proc Natl Acad Sci U S A 1994; 91:62556258.MEDLINE
  • 83
    Hediger MA, Smith CP, You G, Lee W-S, Kanai Y, Shayakul C. Structure, regulation and physiological roles of urea transporters. Kidney Int 1996; 49:16151623.MEDLINE
  • 84
    Bichet D, Szatalowicz V, Chaimovitz C, Schrier RW. Role of vasopressin in abnormal water excretion in cirrhotic patients. Ann Intern Med 1982; 96:413417.MEDLINE
  • 85
    Bichet DG, Van Putten VJ, Schrier RW. Potential role of increased sympathetic activity in impaired sodium and water excretion in cirrhosis. N Engl J Med 1982; 307:15521557.MEDLINE
  • 86
    Better OS, Aisenbrey GA, Berl T, Anderson RJ, Handelman WA, Linas SL, Guggenheim SJ, et al. Role of antidiuretic hormone in impaired urinary dilution associated with chronic bile-duct ligation. Clin Sci 1980; 58:493500.MEDLINE
  • 87
    Camps J, Solá J, Arroyo V, Pérez Ayuso RM, Gaya J, Rivera J, Rodés J. Temporal relationship between the impairment of free water excretion and antidiuretic hormone hypersecretion in rats with experimental cirrhosis. Gastroenterology 1987; 93:498505.MEDLINE
  • 88
    Linas SL, Anderson RJ, Guggenheim SJ, Robertson GL, Berl T. Role of vasopressin in impaired water excretion in conscious rats with experimental cirrhosis. Kidney Int 1981; 20:173180.MEDLINE
  • 89
    Clària J, Jiménez W, Arroyo V, Guarner F, López C, La Villa G, Asbert M, et al. Blockade of the hydroosmotic effect of vasopressin normalizes water excretion in cirrhotic rats. Gastroenterology 1989; 97:12941299.MEDLINE
  • 90
    Fujita N, Ishikawa SE, Sasaki S, Fujisawa G, Fushimi K, Marumo F, Saito T. Role of water channel AQP-CD in water retention in SIADH and cirrhotic rats. Am J Physiol 1995; 269:F926F931.MEDLINE
  • 91
    Solis-Herruzo JA, González Gamarra A, Castellano G, Muñoz-Yague MT. Metabolic clearance rate of arginine vasopressin in patients with cirrhosis. Hepatology 1992; 16:974979.MEDLINE
  • 92
    Boyer TD, Zia P, Reynolds TB. Effect of indomethacin and prostaglandin A2 in renal function and plasma renin activity in alcoholic liver disease. Gastroenterology 1979; 77:215222.MEDLINE
  • 93
    Orloff J, Handler FS, Berstrom S. Effect of prostaglandin (PGE1) on the permeability response of toad bladder to vasopressin, theophylline and adenosine 3′,5′- monophosphate. Nature 1965; 205:397398.
  • 94
    Anderson RJ, Berl T, Mc Donald KM, Schrier RW. Evidence for an in vivo antagonism between vasopressin and prostaglandin in the mammalian kidney. J Clin Invest 1975; 56:420426.MEDLINE
  • 95
    Walker LA, Frohlich JC. Dose-dependent-stimulation of renal prostaglandin synthesis by deamino-8-d-arginine vasopressin in rats with hereditary diabetes insipidus. J Pharmacol Exp Ther 1981; 217:8791.MEDLINE
  • 96
    Pérez Ayuso RM, Arroyo V, Camps J, Rimola A, Gaya J, Costa J, Rivera F, et al. Evidence that renal prostaglandins are involved in renal water metabolism in cirrhosis. Kidney Int 1984; 26:7280.MEDLINE
  • 97
    Angeli P, De Bei E, Dalla M. Effects of amiloride on renal sodium handling in non-azotemic ascitic cirrhotics. Hepatology 1992; 15:651654.MEDLINE
  • 98
    Epstein M. Atrial natriuretic factor and liver disease. In: EpsteinM, eds. The Kidney in Liver Disease, 4th ed. Philadelphia: Hanley & Belfus Inc., 1996;339358.
  • 99
    Abraham WT, Lauwaars ME, Kim JK, Pena RL, Schrier RW. Reversal of atrial natriuretic peptide resistance by increasing distal tubular sodium delivery in patients with decompensated cirrhosis. Hepatology 1995; 22:737743.MEDLINE
  • 100
    Shear L, Hall PW, Gabuzda GJ. Renal failure in patients with cirrhosis of the liver. II. Factors influencing maximal urinary flow rate. Am J Med 1966; 39:199209.
  • 101
    Anderson RJ, Cronin RE, Mc Donald KM, Schrier RW. Mechanisms of portal hypertension-induced alterations in renal hemodynamics renal water excretion and renin secretion. J Clin Invest 1976; 58:964970.MEDLINE
  • 102
    Schrier RW, Arroyo V, Bernardi M, Epstein M, Henriksen JH, Rodés J. Peripheral arterial vasodilation hypothesis: a proposal for the initiation of renal sodium and water retention in cirrhosis. Hepatology 1988; 8:11511157.MEDLINE
  • 103
    Bichet DG, Groves BM, Schrier RW. Mechanisms of improvement of water and sodium excretion by immersion in decompensated cirrhotic patients. Kidney Int 1983; 24:788794.MEDLINE
  • 104
    Shapiro MD, Nicholls KM, Groves BM, Kluge R, Chung HM, Bichet DG, Schrier RW. Interrelationship between cardiac output and vascular resistance as determinants of effective arterial blood volume in cirrhotic patients. Kidney Int 1985; 28:206211.MEDLINE
  • 105
    Clària J, Jiménez W, Arroyo V, La Villa G, López C, Asbert M, Castro A, et al. Effect of V1-vasopressin receptor blockade on arterial pressure in conscious rats with cirrhosis and ascites. Gastroenterology 1991; 100:494501.MEDLINE
  • 106
    Sieber CC, López-Talavera JC, Groszmann RJ. Role of nitric oxide in the in vitro splanchnic vascular hyporeactivity in ascitic cirrhotic rats. Gastroenterology 1993; 104:17501754.MEDLINE
  • 107
    Niederberger M, Ginès P, Tsai P, Martin PY, Weigert A, Morris K, McMurtry Y, et al. Increased aortic cyclic guanosine monophosphate concentration in experimental cirrhosis in rats: evidence for a role of nitric oxide in the pathogenesis of arterial vasodilation in cirrhosis. Hepatology 1995; 21:16251631.MEDLINE
  • 108
    Clària J, Jiménez W, Ros J, Asbert M, Castro A, Arroyo V, Rivera F, et al. Pathogenesis of arterial hypotension in cirrhotic rats with ascites: role of endogenous nitric oxide. Hepatology 1992; 15:343349.MEDLINE
  • 109
    Campillo B, Chabrier PE, Pelle G, Sediame G, Atlan G, Fouet P, Adnot S. Inhibition of nitric oxide synthesis in the forearm arterial bed of patients with advanced cirrhosis. Hepatology 1995; 22:14231429.MEDLINE
  • 110
    Laffi G, Foschi M, Masini E, Simoni A, Mugnai L, La Villa G, Barletta G, et al. Increased production of nitric oxide by neutrophils and monocytes from cirrhotic patients with ascites and hyperdynamic circulation. Hepatology 1995; 22:16631673.
  • 111
    Sogni P, Garnier P, Gadano A, Moreau R, Dall'Ava-Santucci J, Dinh-Xuan AT, Lebrec D. Endogenous pulmonary nitric oxide production measured from exhaled air is increased in patients with severe cirrhosis. J Hepatol 1995; 23:471473.MEDLINE
  • 112
    Castro A, Jiménez W, Clària J, Ros J, Martínez JM, Bosch M, Arroyo V, et al. Impaired responsiveness to angiotensin II in experimental cirrhosis: role of nitric oxide. Hepatology 1993; 18:367372.MEDLINE
  • 113
    Weigert AL, Martin PY, Niederberger M, Ginès P, Higa EMS, McMurtry I, Schrier RW. Endothelium-dependent vascular hyporesponsiveness without detection of nitric oxide synthase induction in aorta of cirrhotic rats. Hepatology 1995; 22:18561862.MEDLINE
  • 114
    Niederberger M, Martin PY, Ginès P, Morris K, Tsai P, Xu DL, McMurtry I, et al. Normalization of nitric oxide production corrects arterial vasodilation and hyperdynamic circulation in cirrhotic rats. Gastroenterology 1995; 109:16241630.MEDLINE
  • 115
    Martin PY, Ohara M, Ginès P, Xu DL, St John J, Niederberger M, Schrier RW. Nitric oxide synthase (NOS) inhibition for one week improves renal sodium and water excretion in cirrhotic rats with ascites. J Clin Invest 1998; 101:235242.MEDLINE
  • 116
    Ota M, Grofton JT, Festavan GT, Share L. Evidence that nitric oxide can act centrally to stimulate vasopressin release. Neuroendocrinology 1993; 57:955959.MEDLINE
  • 117
    Slizgi GR, Ludens JH. Studies on the nature and mechanism of the diuretic activity of the opioid analgesic ethylketocyclazocine. J Pharmacol Exp Ther 1982; 220:585591.MEDLINE
  • 118
    Mansour A, Khachaturian H, Lewis ME, Akil H, Watson SJ. Anatomy of CNS opioid receptors. Trends Neur Sci 1988; 11:308314.
  • 119
    Hamon G, Jouquey S. Kappa agonists and vasopressin secretion. Horm Res 1990; 34:129132.MEDLINE
  • 120
    Kinter LB, Huffman WF, Stassen FL. Antagonists of the antidiuretic activity of vasopressin. Am J Physiol 1988; 254:F165F177.MEDLINE
  • 121
    Manning M, Sawyer WH. Discovery, development, and some uses of vasopressin and oxytocin antagonists. J Lab Clin Med 1989; 114:617632.MEDLINE
  • 122
    Laszlo FA, Laszlo F, DeWied D. Pharmacology and clinical perspectives of vasopressin antagonists. Pharmacol Rev 1991; 43:73108.MEDLINE
  • 123
    Yamamura Y, Ogawa H, Yamashita H, Chichara T, Miyamoto H, Nakamura S, Onogawa T, et al. Characterization of a novel aquaretic agent, OPC-31260, as an orally effective, nonpeptide vasopressin V2-receptor antagonist. Br J Pharmacol 1992; 105:787791.MEDLINE
  • 124
    Pérez Ayuso RM, Arroyo V, Camps J, Jiménez W, Rodamilans M, Rimola A, Gaya J, et al. Effect of demeclocycline on renal function and urinary prostaglandin E2 and kallikrein in hyponatremic cirrhotics. Nephron 1984; 36:3037.MEDLINE
  • 125
    De Bodo RC. The antidiuretic action of morphine and its mechanism. J Pharmacol Exp Ther 1994; 82:7585.
  • 126
    Giarman NJ, Mattie LR, Stephenson WF. Studies on the antidiuretic action of morphine. Science 1953; 117:225226.
  • 127
    Kamoi K, White K, Robertson GL. Opiates elevate the osmotic threshold for vasopressin release in rats. Clin Res 1979; 27:254A.
  • 128
    Van Wimersma Greidanus TB, Thody TJ, Verspaget H, de Rotte GA, Goedemans HJ, Croiset G, et al. Effects of morphine and β-endorphin on basal and elevated plasma levels of α-MSH and vasopressin. Life Sci 1979; 24:570585.
  • 129
    Lutz-Bucher B, Koch B. Evidence for a direct inhibitory effect of morphine on the secretion of posterior pituitary hormones. Eur J Pharmacol 1980; 66:375378.MEDLINE
  • 130
    Patterson SJ, Robson LE, Kosterlitz HW. Classification of opioid receptors. Br Med Bull 1983; 39:3136.MEDLINE
  • 131
    Leander JD. Evidence that nalorphine, butorphanol and oxilorphan are partial agonists at a κ-opioid receptor. Eur J Pharmacol 1983; 86:467470.MEDLINE
  • 132
    Leander JD, Hart JC, Zerbe RL. Diuresis and suppression of vasopressin by kappa-opioids: comparison with mu- and delta-opioids and clonidine. J Pharmacol Exp Ther 1985; 234:463469.MEDLINE
  • 133
    Leander JD. A kappa opioid effect: increased urination in the rat. J Pharmacol Exp Ther 1983; 224:8994.MEDLINE
  • 134
    Leander JD. Further study of kappa opioids on increased urination. J Pharmacol Exp Ther 1983; 227:3541.MEDLINE
  • 135
    Von Voigtlander PF, Lahti RA, Ludens JH. U-50,488 H: A selective and structurally novel non-mu (kappa) opioid agonist. J Pharmacol Exp Ther 1983; 224:712.MEDLINE
  • 136
    Leander JD, Hart JC, Zerbe RL. Kappa agonist–induced diuresis: evidence for steroselectivity, strain differences, independence of hydration variables and a result of decreased plasma vasopressin levels. J Pharmacol Exp Ther 1987; 242:3339.MEDLINE
  • 137
    Peters GR, Ward NJ, Antal EG, Lai PY, deMaar EW. Diuretic actions in man of a selective kappa opioid agonist: U-62,066 E. J Pharmacol Exp Ther 1987; 240:128131.MEDLINE
  • 138
    Ohnishi A, Mihara M, Yasuda S, Tomono Y, Hasegawa J, Tanaka T. Aquaretic effect of the stable dynorphin-A analog E2078 in the human. J Pharmacol Exp Ther 1994; 270:342347.MEDLINE
  • 139
    Bellissant E, Denolle M, Sinnassamy P, Bichet DG, Giudicelli JF, Lecoz F, Gandon JM, et al. Systemic and regional hemodynamic and biological effect of a new κ-opioid agonist, niravoline, in healthy volunteers. J Pharmacol Exp Ther 1996; 278:232242.MEDLINE
  • 140
    Richards ML, Sadee W. In vivo binding of benzomorphans to mu, delta and kappa opioid receptors: comparison with urine output in the rat. J Pharmacol Exp Ther 1985; 233:425432.MEDLINE
  • 141
    Slizgi GR, Ludens JH. Displacement of 3H-EKC binding by opioids in the rat kidney: a correlate to diuretic activity. Life Sci 1985; 36:21892193.MEDLINE
  • 142
    Huidobro-Toro JP, Parada S. k-opiates and urination: Pharmacological evidence for an endogenous role of the κ-opioid receptor in fluid and electrolyte balance. Eur J Pharmacol 1985; 107:110.
  • 143
    Yamada K, Imai M, Yoshida S. Mechanism of diuretic action of U-62,066E, a κ opioid receptor agonist. Eur J Pharmacol 1989; 160:229237.MEDLINE
  • 144
    Blackburn TP, Borkowski KR, Friend J, Rauce MJ. On the mechanisms of κ-opioid–induced diuresis. Br J Pharmacol 1986; 89:593598.MEDLINE
  • 145
    Slizgi GR, Taylor CJ, Ludens JH. Effects of the highly selective kappa opioid, U-50,488, on renal function in the anesthetized dog. J Pharmacol Exp Ther 1984; 230:641645.MEDLINE
  • 146
    Hamon G, Clemence F, Fortin M, Le Martret O, Jouquey S, Vincent JC, Petif F, et al. Niravoline hydrochloride, a novel selective kappa agonist with marked aquaretic properties but low analgesic potency. Br J Pharmacol 1995; 114:310P.
  • 147
    Salas SP, Roblero J, Ureta H, Huidobro-Toro JP. Diuretic effect of bremazocine, a kappa-opioid with central and peripheral sites of action. J Pharmacol Exp Ther 1989; 250:992999.MEDLINE
  • 148
    Salas SP, Roblero J, Ureta H, Huidobro-Toro JP. (N-methyl-Tyr1, N-methyl-Arg7-d-Leu8)-dynorphin-A-(1–8) ethylamide, a stable dynorphin analog, produces diuresis by kappa-opiate receptor activation in the rat. J Pharmacol Exp Ther 1992; 262:979986.MEDLINE
  • 149
    Slizgi GR, Ludens JH. Role of ADH in ethylketocyclazocine-induced diuresis: studies in the Brattleboro rat. Life Sci 1986; 38:24372440.MEDLINE
  • 150
    Oiso Y, Iwasaki Y, Kondo K, Takatsuki K, Tomita A. Effect of the opioid kappa-receptor agonist U-50, 488 H on the secretion of arginine vasopressin. Neuroendocrinology 1988; 48:658662.MEDLINE
  • 151
    Hamon G, Fortin M, Le Martret O, Jouquey S, Vincent JC, Bichet DG. Pharmacological profile of niravoline a new aquaretic compound. J Am Soc Nephrol 1994; 5:272.
  • 152
    Rossi NF, Brooks DP. κ-Opioid agonist inhibition of osmotically induced AVP release: preferential action at hypothalamic sites. Am J Physiol 1996; 270:E367E372.MEDLINE
  • 153
    Pumford KM, Russel JA, Leng G. Effects of the selective kappa-opioid agonist U-50,488 upon the electrical activity of supraoptic neurones in morphine-tolerant and morphine-naive rats. Exp Brain Res 1993; 94:237246.MEDLINE
  • 154
    Grudt TJ, Williams JT. κ-Opioid receptors also increase potassium conductance. Proc Natl Acad Sci U S A 1993; 90:1142911432.MEDLINE
  • 155
    Tallent M, Dichter MA, Bell GI, Reisine T. The cloned kappa opioid receptor couples to an N-type calcium current in undifferentiated PC-12 cells. Neuroscience 1994; 63:10331040.MEDLINE
  • 156
    McDonald RL, Werz MA. Dynorphin A decreases voltage-dependent calcium conductance of mouse dorsal root ganglion neurones. J Physiol 1986; 377:237249.MEDLINE
  • 157
    Yamamura Y, Ogawa H, Chichara T, Kondo K, Onogawa T, Nakamura S, Mori T, et al. OPC-21268, an orally effective, nonpeptide vasopressin-V1 receptor antagonist. Science 1991; 252:572574.MEDLINE
  • 158
    Serradeil-le Gal C, Lacour C, Valette G, Garcia G, Foulon L, Galindo G, Bankir L, et al. Characterization of SR 121463A, a highly potent and selective, orally active vasopressin V2 receptor antagonist. J Clin Invest 1996; 98:27292738.MEDLINE
  • 159
    Albright JD, Chan PS. Recent advances in the discovery and development of vasopressin antagonists: peptide and nonpeptide V(1a) and V2 receptor antagonists. Curr Pharm Des 1997; 3:615632.
  • 160
    Coupet J, Mazandarani H, Albright JD, Dusza JP. Characterization of VPA-985 as a specific nonpeptide vasopressin V2 antagonist. Proceedings of the World Congress of Neurohypophysial Hormones, Montreal, 1998:181A.
  • 161
    Tanikella TK, Park CH, Lock YW, Ning X, Coupet J, Dusza JP, Albright JD. Evaluation of VPA-985, a selective vasopressin V2 antagonist, in cloned human receptors. Proceedings of the World Congress of Neurohypophysial Hormones, Montreal, 1998:182A.
  • 162
    Chan PS, Ru X, Bailey T. Aquaretic effects of VPA-985, a potent orally active nonpeptide AVP V2 receptor antagonist. Proceedings of the World Congress of Neurohypophysial Hormones, Montreal, 1998:180A.
  • 163
    Yamashita T, Yamamura Y, Chihara T, Nakamura S, Ogonawa T, Yamada Y, Mori T, et al. Effect of OPC-31260, vasopressin V2 antagonist, on renal function in anesthetized dogs. Jpn J Pharmacol 61 (Suppl 1):615632.
  • 164
    Ohnishi A, Orita Y, Okahara R, Fujihara H, Inoue T, Yamamura Y, Yabuuchi Y, et al. Potent aquaretic agent—a novel nonpeptide selective vasopressin 2 antagonist (OPC-31260) in men. J Clin Invest 1993; 92:26532659.MEDLINE
  • 165
    Ohnishi A, Orita Y, Takagi N, Fujita T, Toyoki T, Ihara Y, Yamamura Y, et al. Aquaretic effect of a potent, orally active, nonpeptide V2 antagonist in men. J Pharmacol Exp Ther 1995; 272:546551.MEDLINE
  • 166
    Shimizu K. Aquaretic effects of a nonpeptide V2 antagonist OPC-31260 in hydropenic humans. Kidney Int 1995; 48:220226.MEDLINE
  • 167
    Jiménez W, Clària J, Arroyo V. Experimental cirrhosis and pathogenesis of ascites formation in chronic liver disease. In: HolstegeA, SchölmerichJ, HahnEG, eds. Portal Hypertension. London: Kluwer Academic Publishers, 1995;1532.
  • 168
    Tsuboi Y, Ishikawa SE, Fujisawa G, Okada K, Saito T. Therapeutic efficacy of the non-peptide AVP antagonist OPC-31260 in cirrhotic rats. Kidney Int 1994; 46:237244.MEDLINE
  • 169
    Bosch Marcé M, Jiménez W, Angeli P, Leivas A, Claria J, Graziotto A, Arroyo V, et al. Aquaretic effect of the κ-opioid agonist, RU 51599 in cirrhotic rats with ascites and water retention. Gastroenterology 1995; 109:217223.MEDLINE
  • 170
    Hamon G, Jouquey S. Effects of subchronic administration of niravoline, a novel aquaretic compound, on water and electrolyte renal excretion in cirrhotic rats. Br J Pharmacol 1996; 117(Suppl 2):24P.
  • 171
    Inoue T, Ohnishi A, Matsuo A, Kawai B, Harada M, Okada K, Yamamura Y, et al. Aquaretic effect of a potent, orally active, nonpeptide V2 antagonist in cirrhosis. Hepatology 1996; 23:26T.
  • 172
    Gadano A, Moreau R, Trombino C, Giuily N, Valla D, Augustin M, Sinnassamy P, et al. Aquaretic effects of niravoline in patients with cirrhosis. Hepatology 1996; 24:448A.