Original Article

You have full text access to this OnlineOpen article

Clinical and histological outcome after hepatitis B e antigen to antibody seroconversion in children with chronic hepatitis B

Mercedes Ruiz-Moreno¹,
Manuela Otero¹,
Antonio Millán¹,
Inmaculada Castillo²,
María Cabrerizo²,
F. Javier Jiménez³,
Horacio Oliva⁴,
Santiago Ramón y Cajal⁵,
Vicente Carreño M.D.^2,*

Article first published online: 30 DEC 2003

DOI: 10.1002/hep.510290230

Issue

Hepatology

Volume 29, Issue 2, pages 572–575, February 1999

Additional Information

How to Cite

Ruiz-Moreno, M., Otero, M., Millán, A., Castillo, I., Cabrerizo, M., Jiménez, F. J., Oliva, H., Ramón y Cajal, S. and Carreño, V. (1999), Clinical and histological outcome after hepatitis B e antigen to antibody seroconversion in children with chronic hepatitis B. Hepatology, 29: 572–575. doi: 10.1002/hep.510290230

Author Information

¹
Department of Paediatrics, Clínica Puerta de Hierro, Madrid, Spain
²
Department of Hepatology, Clínica Puerta de Hierro, Madrid, Spain
³
Department of Research, Clínica Puerta de Hierro, Madrid, Spain
⁴
Department of Pathology, Fundación Jiménez Díaz; Clínica Puerta de Hierro, Madrid, Spain
⁵
Department of Deptartment of Pathology, Clínica Puerta de Hierro, Madrid, Spain

Email: Vicente Carreño M.D. (vcarreno@uni.fjd.es)

^*Department of Hepatology, Fundación Jiménez Díaz, Avda. Reyes Católicos, 2, 28040 Madrid, Spain. fax: +34-91-544-92-28

Publication History

Issue published online: 30 DEC 2003
Article first published online: 30 DEC 2003
Manuscript Accepted: 1 OCT 1998
Manuscript Received: 17 APR 1998

Funded by

Fundación para el Estudio de las Hepatitis Virales, Madrid, Spain

ARTICLE TOOLS

Abstract
References
Cited By

Get PDF (78K)

References

1
Su I-J, lai M-Y, Hsu H-C, Chen D-S, Yang P-M, Chuang S-, Sung J-L. Diverse virological, histopathological and prognostic implications of seroconversion for hepatitis B e antigen to anti-HBe in chronic hepatitis B virus infection. J Hepatol 1986; 3:182–189.MEDLINE
2
Fattovich G, Rugge M, Brollo L, Pontisso P, Noventa F, Guido M, Alberti A, et al. Clinical, virologic and histologic outcome following seroconversion from HBeAg to anti-HBe in chronic hepatitis type B. Hepatology 1986; 6:167–172.MEDLINE
Direct Link:
3
Korenman J, Baker B, Waggoner J, Everhart JE, Di Bisceglie AM, Hoofnagle JH. Long-term remission of chronic hepatitis B after alpha-interferon therapy. Ann Intern Med 1991; 114:629–634.MEDLINE
4
Carreño V, Castillo I, Molina J, Porres JC, Bartolomé J. Long-term follow-up of hepatitis B chronic carriers who responded to interferon therapy. J Hepatol 1992; 15:102–106.MEDLINE
5
Lok ASF, Chung HT, Liu VW, Ma CCK. Long-term follow-up of chronic hepatitis B patients treated with interferon alfa. Gastroenterology 1993; 105:1833–1838.MEDLINE
6
Fong T-L, Di Bisceglie AM, Gerber A, Waggoner JG, Hoofnagle JH. Persistence of hepatitis B virus DNA in the liver after loss of HBsAg in chronic hepatitis B. Hepatology 1993; 18:1313–1318.MEDLINE
Direct Link:
7
Berninger M, Hammer M, Hoyer B, Gerin JL. An assay for the detection of the DNA genome of hepatitis B virus in serum. J Med Virol 1982; 9:57–68.MEDLINE
Direct Link:
8
López-Alcorocho JM, Moraleda G, Bartolomé J, Castillo I, Cotonat T, Aguilar J, Ortega E, et al. Analysis of hepatitis B precore region in serum and liver of chronic hepatitis B virus carriers. J Hepatol 1994; 21:353–360.MEDLINE
9
Castillo I, Bartolomé J, Navas S, González S, Herrero M, Carreño V. Virological and biochemical long-term follow-up of patients with chronic hepatitis C treated with interferon. Hepatology 1994; 19:1331–1336.MEDLINE
Direct Link:
10
Desmet VJ, Gerber M, Hoofnagle JH, Manns M, Scheuer PJ. Classification of chronic hepatitis: Diagnosis, grading and staging. Hepatology 1994; 19:1513–1520.MEDLINE
Direct Link:
11
Hoofnagle JH, Shafritz DA, Popper H. Chronic type B hepatitis and the “healthy” HBsAg carrier state. Hepatology 1987; 7:758–763.MEDLINE
Direct Link:
12
Hoofnagle JH, Peters G, Mullen KD, Jones DB, Rustgi V, Di Bisceglie AM, Hallahan C, et al. Randomized controlled trial of recombinant human alpha-interferon in patients with chronic hepatitis B. Gastroenterology 1988; 95:1318–1325.MEDLINE
13
Perrillo RP, Schiff ER, Davis GL, Bodenheimer HC, Lindsay K, Payne J, Dienstag JL, et al. A randomized controlled trial of interferon alfa-2b alone and after prednisone withdrawal for the treatment of chronic hepatitis B. N Engl J Med 1990; 323:295–301.MEDLINE
14
Ruiz-Moreno M, Rúa MJ, Molina J, Moraleda G, Moreno A, García-Aguado J, Carreño V. Prospective, randomized controlled trial of interferon alpha in children with chronic hepatitis B. Hepatology 1991; 13:1035–1039.MEDLINE
Direct Link:
15
Lee P-I, Chang M-H, Lee C-Y, Hsu H-Y, Chen J-S, Chen P-J, Chen D-S. Changes of serum hepatitis B virus DNA and aminotransferase levels during the course of chronic hepatitis B virus infection in children. Hepatology 1990; 12:657–660.MEDLINE
Direct Link:
16
Hoofnagle JH, Dusheiko GM, Schafer DF, Jones A, Micetich KC, Young RC, Costa J. Reactivation of chronic hepatitis B virus infection by cancer chemotherapy. Ann Intern Med 1982; 96:447–449.MEDLINE
17
Lok ASF, Liang RHS, Chiu EKW, Wong K-L, Chan T-K, Todd D. Reactivation of hepatitis B virus replication in patients receiving cytotoxic therapy. Gastroenterology 1991; 100:182–108.MEDLINE
18
Payne RJH, Nowak MA, Blumberg BS. The dynamics of hepatitis B virus infection. Proc Natl Acad Sci U S A 1996; 93:6542–6546.MEDLINE
19
Raimondo G, Schneider R, Stemler M, Smedile V, Rodino G, Will H. A new hepatitis B virus variant in a chronic carrier with multiple episodes of viral replication and acute hepatitis. Virology 1990; 179:64–68.MEDLINE
20
Perrillo RP, Brunt EM. Hepatic and immunohistochemical changes in chronic hepatitis B after prolonged clearance of hepatitis B e antigen and hepatitis B surface antigen. Ann Intern Med 1991; 115:113–115.MEDLINE
21
Chang M-H, Hsu H-Y, Hsu H-C, Ni Y-H, Chen J-S, Chen D-S. The significance of spontaneous hepatitis B e antigen seroconversion in childhood: With special emphasis on the clearance of hepatitis B e antigen before 3 years of age. Hepatology 1995; 22:1387–1392.MEDLINE
22
Marcellin P, Martinot-Peignoux M, Loriot MA, Giostra E, Boyer N, Thiers V, Benhaou JP. Persistence of hepatitis B virus DNA demonstrated by polymerase chain reaction in serum and liver after loss of HBsAg induced by antiviral therapy. Ann Intern Med 1990; 112:227–230.MEDLINE
23
Molina J, Bartolomé J, Moraleda G, Ruiz-Moreno M, Rúa MJ, Moreno A, Carreño V. Persistence of hepatitis B virus DNA after reduction of viral replication in serum and liver. J Med Virol 1992; 38:11–15.MEDLINE
Direct Link:
24
Paterlini P, Gerken G, Nakajima E, Terre S, D'Erico A, Giorgini W, Nalpas B, et al. Polymerase chain reaction to detect hepatitis B virus DNA and RNA sequences in primary livers cancers from patients negative for hepatitis B surface antigen. N Engl J Med 1990; 323:80–85.MEDLINE

Get PDF (78K)

JOURNAL TOOLS

JOURNAL MENU

FIND ISSUES

FIND ARTICLES

GET ACCESS

FOR CONTRIBUTORS

ABOUT THIS JOURNAL

SPECIAL FEATURES

Clinical and histological outcome after hepatitis B e antigen to antibody seroconversion in children with chronic hepatitis B

Hepatology

How to Cite

Author Information

Publication History

Funded by

ARTICLE TOOLS

References

More content like this

JOURNAL TOOLS

JOURNAL MENU

FIND ISSUES

FIND ARTICLES

GET ACCESS

FOR CONTRIBUTORS

ABOUT THIS JOURNAL

SPECIAL FEATURES

Clinical and histological outcome after hepatitis B e antigen to antibody seroconversion in children with chronic hepatitis B

Hepatology

How to Cite

Author Information

Publication History

Funded by

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

References

More content like this