1527-3350/asset/olbannerleft.gif?v=1&s=4b2409f9534ed500d3c8da1940a23842e2b9932d)
1527-3350/asset/olbannerright.gif?v=1&s=141b9a8485298533c3e2016e937b0404f7d933e1)
Original Article
You have full text access to this OnlineOpen article
Mitosis and apoptosis in the liver of interleukin-6–deficient mice after partial hepatectomy
Article first published online: 30 DEC 2003
DOI: 10.1002/hep.510290244
Copyright © 1999 American Association for the Study of Liver Diseases
1527-3350/asset/cover.gif?v=1&s=3cd983af6575c8dbfd6b47a63ffa95415ace15f8 "Hepatology")
Additional Information
How to Cite
Sakamoto, T., Liu, Z., Murase, N., Ezure, T., Yokomuro, S., Poli, V. and Demetris, A. J. (1999), Mitosis and apoptosis in the liver of interleukin-6–deficient mice after partial hepatectomy. Hepatology, 29: 403–411. doi: 10.1002/hep.510290244
Publication History
- Issue published online: 30 DEC 2003
- Article first published online: 30 DEC 2003
- Manuscript Accepted: 12 OCT 1998
- Manuscript Received: 22 JUN 1998
Funded by
- NIH. Grant Number: RO1-DK49615-02
References
- 1. Rous Whipple Award Lecture. Atherosclerosis: a defense mechanism gone awry. Am J Pathol 1993; 143:987–1002.MEDLINE
- 2. Immunopathology of the human biliary tree. In: SiricaAE, LongneckerDS, eds. Biliary and Pancreatic Ductal Epithelia. Pathobiology and Pathophysiology. New York: Dekker. 1997;127–180.
- 3, , . Liver regeneration. 2. Role of growth factors and cytokines in hepatic regeneration. FASEB J 1995; 9:1527–1536.MEDLINE
- 4, , , , , . Kupffer cell depletion by gadolinium chloride enhances liver regeneration after partial hepatectomy in rats. Am J Physiol 1996; 270:G909–G918.MEDLINE
- 5
- 6
- 7, , , , . Human biliary epithelial cells secrete and respond to cytokines and hepatocyte growth factors in vitro: interleukin-6, hepatocyte growth factor and epidermal growth factor promote DNA synthesis in vitro. Hepatology 1994; 20:376–382.MEDLINE
- 8, , , , . Interleukin-6 functions as an autocrine growth factor in a cholangiocarcinoma cell line. J Gastroenterol Hepatol 1994; 9:462–467.MEDLINE
- 9, , , , , , , et al. Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion. EMBO J 1994; 13:1189–1196.MEDLINE
- 10, . Experimental pathology of the liver. I. Restoration of the liver of the white rat following partial surgical removal. Arch Pathol 1931; 12:186–202.
- 11, , , , , , , et al. Molecular and functional heterogeneity of cholangiocytes from rat liver after bile duct ligation. Am J Physiol 1997; 272(2 Pt 1):G289–G297.MEDLINE
- 12, , . Dose response of hepatic and renal DNA synthetic rates to continuous exposure of bromodeoxyuridine (BrdU) via slow-release pellets or osmotic minipumps in male B6C3F1 mice. J Histochem Cytochem 1991; 39:177–84.MEDLINE
- 13, , . Importance of and approaches to quantification of hepatocyte apoptosis. Toxicol Pathol 1996; 24:24–35.MEDLINE
- 14, , , , , , . Role of lipopolysaccharide (LPS), interleukin-1, interleukin-6, tumor necrosis factor, and dexamethasone in regulation of LPS-binding protein expression in normal hepatocytes and hepatocytes from LPS-treated rats. Infect Immun 1995; 63:2435–2442.MEDLINE
- 15, . Gluconeogenesis in perfused livers of genetically obese-hyperglycemic (ob/ob) mice. Horm Metab Res 1979; 11:9–14.MEDLINE
- 16, , , , , . Genomic DNA from mice: a comparison of recovery methods and tissue sources. Biochem Mol Med 1997; 62:197–202.MEDLINE
- 17, , , , , , . High-level expression of a biologically active human interleukin-6 mutein. J Biotechnol 1994; 34:79–86.MEDLINE
- 18, , . Cellular injury and cellular death. In: CotranRS, KumarV, RobbinsSL, eds. Pathologic Basis of Disease. 5th ed. Philadelphia: Saunders. 1994;1–34.
- 19, , . Apoptosis and hepatocarcinogenesis. In: JirtleRL, ed. Liver Regeneration and Carcinogenesis. Molecular and Cellular Mechanisms. San Diego, CA: Academic Press. 1995;141–178.
- 20, , , , , , , et al. Effect of human recombinant interleukin-6 on the proliferation of mouse hepatocytes in the primary culture. Immunobiology 1990; 180:235–242.MEDLINE
- 21
- 22, . Effects of IL-11 on the growth of intestinal epithelial cells in vitro. Cell Prolif 1995; 28:581–594.MEDLINE
- 23, , . Interferon-gamma and interleukin-6 inhibit proliferation in human melanoma cells by different signalling pathways. Melanoma Res 1998; 8:24–30.MEDLINE
- 24, , , , . Relationship between cAMP induced inhibition of human meningioma cell proliferation and autocrine secretion of interleukin-6. Life Sci 1996; 58:1323–1329.MEDLINE
- 25, . Interleukin-6 undergoes transition from paracrine growth inhibitor to autocrine stimulator during human melanoma progression. J Cell Biol 1993; 120:1281–1288.MEDLINE
- 26, , . Regulation of apoptosis-associated genes in the regenerating liver. Semin Liver Dis 1998; 18:123–140.MEDLINE
- 27
- 28
- 29
- 30, , , , , . Modulation of apoptosis-associated genes bcl-2, bcl-x, and bax during rat liver regeneration. Cell Growth Differ 1996; 7:1633–1642.MEDLINE
- 31, , . Expression of Bcl-2 family during liver regeneration and identification of Bcl-x as a delayed early response gene. Am J Pathol 1997; 150:1985–1995.MEDLINE
- 32, , , , , . Interleukin-6 and uncompensated cirrhosis [Abstract]. Hepatology 1998; 28:525A.
- 33, , , , . Interleukin-6 protects liver against warm ischemia/reperfusion injury and promotes hepatocyte proliferation in the rodent. Hepatology 1997; 26:1513–1520.MEDLINE
- 34, , , . Dexamethasone inhibits the proliferation of hepatocytes and oval cells but not bile duct cells in rat liver. Hepatology 1998; 28:423–429.MEDLINE
- 35. Interleukin-6. In: ThomsonAW, ed. The Cytokine handbook. 2nd ed. San Diego: Academic Press. 1994;145–168.
- 36, , , , , . Serum interleukin 6 concentrations in chronic hepatitis C patients before and after interferon-alpha treatment. Int J Clin Pharmacol Ther 1997; 35:385–388.MEDLINE
- 37, . Mechanisms of liver tumor promotion. In: JirtleRL, ed. Liver Regeneration and Carcinogenesis. Molecular and Cellular Mechanisms. San Diego, CA: Academic Press. 1995;199–226.