• 1
    Jelinek DF, Andersson S, Slaughter CA, Russell DW. Cloning and regulation of cholesterol 7 alpha-hydroxylase, the rate-limiting enzyme in bile acid biosynthesis. J Biol Chem 1990; 265:81908197. MEDLINE
  • 2
    Spady DK, Cuthbert JA, Willard MN, Meidell RS. Feedback regulation of hepatic 7alpha-hydroxylase expression by bile salts in the hamster. J Biol Chem 1996; 271:1862318631. MEDLINE
  • 3
    Pandak WM, Vlahcevic ZR, Heuman DM, Redford KS, Chiang JYL, Hylemon PB. Effects of different bile salts on steady-state mRNA levels and transcriptional activity of cholesterol 7α-hydroxylase. Hepatology 1994; 19:941947. MEDLINE
  • 4
    Shefer S, Hauser S, Bekersky I, Mosbach EH. Feedback regulation of bile acid biosynthesis in the rat. J Lipid Res 1969; 10:646655. MEDLINE
  • 5
    Shefer S, Hauser S, Bekersky I, Mosbach EH. Biochemical site of regulation of bile acid biosynthesis in the rat. J Lipid Res 1970; 11:404411. MEDLINE
  • 6
    Botham KM, Lawson ME, Beckett GJ, Percy-Robb IW, Boyd GS. The effect of portal blood bile salt concentrations on bile salt synthesis in rat liver. Studies with isolated hepatocytes. Biochim Biophys Acta 1981; 666:238245. MEDLINE
  • 7
    Kubaska WM, Gurley EC, Hylemon PB, Guzelian PS, Vlahcevic ZR. Absence of negative feedback control of bile acid biosynthesis in cultured rat hepatocytes. J Biol Chem 1985; 260:1345913463. MEDLINE
  • 8
    Davis RA, Highsmith WE, McNeal MM, Schexnayder JA, Kuan JC. Bile acid synthesis by cultured hepatocytes. Inhibition by mevinolin, but not by bile acids. J Biol Chem 1983; 258:40794082. MEDLINE
  • 9
    Pandak WM, Heuman DM, Hylemon PB, Chiang JYL, Vlahcevic ZR. Failure of intravenous infusion of taurocholate to down-reguate cholesterol 7α-hydroxylase in rats with biliary fistulas. Gastroenterology 1995; 108:533544. MEDLINE
  • 10
    Stange EF, Scheibner J, Ditschuneit H. Role of primary and secondary bile acids as feedback inhibitors of bile acid synthesis in the rat in vivo. J Clin Invest 1989; 84:173180. MEDLINE
  • 11
    Davis RA, Musso CA, Malone-McNeal M, Lattier GR, Hyde PM, Archambault-Schexnayder J, Straka M. Examination of bile acid negative feedback regulation in rats. J Lipid Res 1988; 29:202211. MEDLINE
  • 12
    Duane WC, McHale AP, Hamilton JN. Studies of feedback suppression of bile salt synthesis in the bile-fistula rat. J Lipid Res 1988; 29:212214. MEDLINE
  • 13
    Heuman DM, Hylemon PB, Vlahcevic ZR. Regulation of bile acid synthesis. III. Correlation between biliary bile salt hydrophobicity index and the activities of enzymes regulating cholesterol and bile acid synthesis in the rat. J Lipid Res 1989; 30:11611171. MEDLINE
  • 14
    Crestani M, Karam WG, Chiang JY. Effects of bile acids and steroid/thyroid hormones on the expression of cholesterol 7 alpha-hydroxylase mRNA and the CYP7 gene in HepG2 cells. Biochem Biophys Res Commun 1994; 198:546553. MEDLINE
  • 15
    Pandak WM, Stravitz RT, Lucas V, Heuman DM, Chiang JY. Hep G2 cells: a model for studies on regulation of human cholesterol 7alpha-hydroxylase at the molecular level. Am J Physiol 1996; 270:G401G410. MEDLINE
  • 16
    Taniguchi T, Chen J, Cooper AD. Regulation of cholesterol 7 alpha-hydroxylase gene expression in Hep-G2 cells. Effect of serum, bile salts, and coordinate and noncoordinate regulation with other sterol-responsive genes. J Biol Chem 1994; 269:1007110078. MEDLINE
  • 17
    Hall R, Kok E, Javitt NB. Bile acid synthesis: down-regulation by monohydroxy bile acids. FASEB J 1988; 2:152156. MEDLINE
  • 18
    Redinger RN. The economy of the enterohepatic circulation of bile acids in the baboon. 2. Regulation of bile acid synthesis by enterohepatic circulation of bile acids. J Lipid Res 1984; 25:437447. MEDLINE
  • 19
    Tauber G, Empen K, Scheibner J, Fuchs M, Stange EF. Feedback regulation of bile acid synthesis measured by stable isotope kinetics in humans. Eur J Gastroenterol Hepatol 1996; 8:2331. MEDLINE
  • 20
    Bertolotti M, Abate N, Loria P, Dilengite M, Carubbi F, Pinetti A, Digrisolo A, et al. Regulation of bile acid synthesis in humans: effect of treatment with bile acids, cholestyramine or simvastatin on cholesterol 7α-hydroxylation rates in vivo. Hepatology 1991; 14:830837. MEDLINE
  • 21
    Pandak WM, Heuman DM, Hylemon PB, Vlahcevic ZR. Regulation of bile acid synthesis. IV. Interrelationship between cholesterol and bile acid biosynthesis pathways. J Lipid Res 1990; 31:7990. MEDLINE
  • 22
    Jones MP, Pandak WM, Heuman DM, Chiang JYL, Hylemon PB, Vlahcevic ZR. Cholesterol 7α-hydroxylase: evidence for transcriptional regulation by cholesterol or metabolic products of cholesterol in the rat. J Lipid Res 1993; 34:885892. MEDLINE
  • 23
    Vlahcevic ZR, Pandak WM, Hylemon PB, Heuman DM. Role of newly synthesized cholesterol or its metabolites on the regulation of bile acid biosynthesis after short-term biliary diversion in the rat. Hepatology 1993; 18:660668. MEDLINE
  • 24
    Pandak WM, Vlahcevic ZR, Heuman DM, Hylemon PB. Regulation of bile acid synthesis. V. Inhibition of conversion of 7-dehydrocholesterol to cholesterol is associated with down-regulation of cholesterol 7α-hydroxylase activity and inhibition of bile acid synthesis. J Lipid Res 1990; 31:21492158. MEDLINE
  • 25
    Mitchell JC, Stone BG, Logan GM, Duane WC. Role of cholesterol synthesis in regulation of bile acid synthesis and biliary cholesterol secretion in humans. J Lipid Res 1991; 32:11431149. MEDLINE
  • 26
    Hylemon PB, Gurley EC, Stravitz RT, Litz JS, Pandak WM, Chiang JY, Vlahcevic ZR. Hormonal regulation of cholesterol 7 alpha-hydroxylase mRNA levels and transcriptional activity in primary rat hepatocyte cultures. J Biol Chem 1992; 267:1686616871. MEDLINE
  • 27
    Adrian TE, Ballantyne GH, Longo WE, Bilchik AJ, Graham S, Basson MD, Tierney RP, et al. Deoxycholate is an important releaser of peptide YY and enteroglucagon from the human colon. Gut 1993; 34:12191224. MEDLINE
  • 28
    Dakka T, Dumoulin V, Chayvialle JA, Cuber JC. Luminal bile salts and neurotensin release in the isolated vascularly perfused rat jejuno-ileum. Endocrinology 1994; 134:603607. MEDLINE
  • 29
    Akerlund JE, Björkhem I. Studies on the regulation of cholesterol 7α-hydroxylase and HMG-CoA reductase in rat liver: effects of lymphatic drainage and ligation of the lymph duct. J Lipid Res 1990; 31:21592166. MEDLINE
  • 30
    Schoenfield LJ, Bonorris GG, Ganz P. Induced alterations in the rate-limiting enzymes of hepatic cholesterol and bile acid synthesis in the hamster. J Lab Clin Med 1973; 82:858868. MEDLINE
  • 31
    Goldstein LI, Bonorris GG, Coyne MJ, Schoenfield LJ. Persistent effects of chenodeoxycholic acid on biliary lipids in the hamster. J Lab Clin Med 1975; 85:10321041. MEDLINE
  • 32
    Princen HMG, Meijer P, Wolthers BG, Vonk RJ, Kuipers F. Cyclosporin A blocks bile acid synthesis in cultured hepatocytes by specific inhibition of chenodeoxycholic acid synthesis. Biochem J 1991; 275:501505. MEDLINE
  • 33
    Vlahcevic ZR, Stravitz RT, Heuman DM, Hylemon PB, Pandak WM. Quantitative estimations of the contribution of different bile acid pathways to total bile acid synthesis in the rat [Comments]. Gastroenterology 1997; 113:19491957. MEDLINE
  • 34
    Schwarz M, Lund EG, Setchell KDR, Kayden HJ, Zerwekh JE, Bjorkhem I, Herz J, et al. Disruption of cholesterol 7alpha-hydroxylase gene in mice. II. Bile acid deficiency is overcome by induction of oxysterol 7alpha-hydroxylase. J Biol Chem 1996; 271:1802418031. MEDLINE
  • 35
    Shefer S, Kren BT, Salen G, Steer CJ, Nguyen LB, Chen T, Tint GS, et al. Regulation of bile acid synthesis by deoxycholic acid in the rat: different effects on cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase. Hepatology 1995; 22:12151221. MEDLINE
  • 36
    Vlahcevic ZR, Jairath SK, Heuman DM, Stravitz RT, Hylemon PB, Avadhani NG, Pandak WM. Transcriptional regulation of hepatic sterol 27-hydroxylase by bile acids. Am J Physiol 1996; 270:G646G652. MEDLINE
  • 37
    Twisk J, Hoekman MF, Muller LM, IIda T, Tamaru T, Ijzerman A, Mager WH, et al. Structural aspects of bile acids involved in the regulation of cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase. Eur J Biochem 1995; 228:596604. MEDLINE
  • 38
    Twisk J, de Wit EC, Princen HM. Suppression of sterol 27-hydroxylase mRNA and transcriptional activity by bile acids in cultured rat hepatocytes. Biochem J 1995; 305:505511. MEDLINE
  • 39
    Araya Z, Sjoberg H, Wikvall K. Different effects on the expression of CYP7 and CYP27 in rabbit liver by cholic acid and cholestyramine. Biochem Biophys Res Commun 1995; 216:868873. MEDLINE
  • 40
    Fuchs M, Scheibner J, Hörmann E, Tauber G, Stange EF. Enterohepatic circulation in hamsters with an extracorporeal bile duct. J Lipid Res 1992; 33:13831392. MEDLINE
  • 41
    Dietschy JM, Spady DK. Measurement of rates of cholesterol synthesis using tritiated water. J Lipid Res 1984; 25:14691476. MEDLINE
  • 42
    Scheibner J, Fuchs M, Schiemann M, Stange EF. Deoxycholate and cholate modulate the source of cholesterol substrate for bile acid synthesis in the rat. Hepatology 1995; 21:529538. MEDLINE
  • 43
    Stange EF, Scheibner J, Lutz Ch, Ditschuneit H. Feedback regulation of bile acid synthesis in the rat by dietary vs. intravenous cholate or taurocholate. Hepatology 1988; 8:879886. MEDLINE
  • 44
    Scheibner J, Fuchs M, Hörmann E, Tauber G, Stange EF. Biliary cholesterol secretion and bile acid formation in the hamster: the role of newly synthesized cholesterol. J Lipid Res 1994; 35:690697. MEDLINE
  • 45
    Scheibner J, Fuchs M, Schiemann M, Tauber G, Hörmann E, Stange EF. Bile acid synthesis from newly synthesized vs. preformed cholesterol precursor pools in the rat. Hepatology 1993; 17:10951102. MEDLINE
  • 46
    Swobodnik W, Klüppelberg U, Wechsler JG, Volz M, Normandin G, Ditschuneit H. Rapid and accurate reversed-phase high-performance liquid chromatographic determination of conjugated bile acids in human bile for routine clincal applications. J Chromatogr 1985; 339:263271. MEDLINE
  • 47
    Turley SD, Dietschy JM. The contribution of newly synthesized cholesterol to biliary cholesterol in the rat. J Biol Chem 1981; 256:24382446. MEDLINE
  • 48
    Stange EF, Spady DK, Dietschy JM. Characterization of the cholesterol precursor pools used for bile acid synthesis in the rat. In: PaumgartnerG, StiehlA, GerokW, eds. Enterohepatic Circulation of Bile Acids and Sterol Metabolism Falk Symposium 42. Lancaster, PA: MTP Press Ltd., 1985; 2936.
  • 49
    Andersen JM, Dietschy JM. Absolute rates of cholesterol synthesis in extrahepatic tissues measured with 3H-labeled water and 14C-labeled substrates. J Lipid Res 1979; 20:740752. MEDLINE
  • 50
    Xu G, Salen G, Shefer S, Tint GS, Kren BT, Nguyen LB, Steer CJ, et al. Increased bile acid pool inhibits cholesterol 7 alpha-hydroxylase in cholesterol-fed rabbits. Gastroenterology 1997; 113:19581965. MEDLINE
  • 51
    Xu G, Salen G, Shefer S, Ness GC, Nguyen LB, Parker TS, Chen TS, et al. Unexpected inhibition of cholesterol 7 alpha-hydroxylase by cholesterol in New Zealand white and Watanabe heritable hyperlipidemic rabbits. J Clin Invest 1995; 95:14971504. MEDLINE
  • 52
    Rudel L, Deckelman C, Wilson M, Scobey M, Anderson R. Dietary cholesterol and downregulation of cholesterol 7 alpha-hydroxylase and cholesterol absorption in African green monkeys. J Clin Invest 1994; 93:24632472. MEDLINE
  • 53
    Horton JD, Cuthbert JA, Spady DK. Regulation of hepatic 7 alpha-hydroxylase expression and response to dietary cholesterol in the rat and hamster. J Biol Chem 1995; 270:53815387. MEDLINE
  • 54
    Bjorkhem I, Lund E, Rudling M. Coordinate regulation of cholesterol 7 alpha-hydroxylase and HMG-CoA reductase in the liver. Subcell Biochem 1997; 28:2355. MEDLINE
  • 55
    Turley SD, Spady DK, Dietschy JM. Alteration of the degree of biliary cholesterol saturation in the hamster and rat by manipulation of the pools of preformed and newly synthesized cholesterol. Gastroenterology 1983; 84:253264. MEDLINE
  • 56
    Bandsma RH, Stellaard F, Vonk RJ, Nagel GT, Neese RA, Hellerstein MK, Kuipers F. Contribution of newly synthesized cholesterol to rat plasma and bile determined by mass isotopomer distribution analysis: bile-salt flux promotes secretion of newly synthesized cholesterol into bile. Biochem J 1998; 329:699703. MEDLINE
  • 57
    Empen K, Lange K, Stange EF, Scheibner J. Newly synthesized cholesterol in human bile and plasma: quantification by mass isotopomer distribution analysis. Am J Physiol 1997; 272:G367G373. MEDLINE
  • 58
    Spady DK, Stange EF, Bilhartz LE, Dietschy JM. Bile acids regulate hepatic low density lipoprotein receptor activity in the hamster by altering cholesterol flux across the liver. Proc Natl Acad Sci U S A 1986; 83:19161920. MEDLINE
  • 59
    Xu G, Salen G, Batta AK, Shefer S, Nguyen LB, Niemann W, Chen TS, et al. Glycocholic acid and glycodeoxycholic acid but not glycoursocholic acid inhibit bile acid synthesis in the rabbit. Gastroenterology 1992; 102:17171723. MEDLINE
  • 60
    Cohen BI, Raicht RF, Mosbach EH. Sterol metabolism studies in the rat. Effects of primary bile acids (sodium taurochenodeoxycholate and sodium taurocholate) on sterol metabolism. J Lipid Res 1977; 18:223231. MEDLINE
  • 61
    Sama C, LaRusso NF. Effect of deoxycholic, chenodeoxycholic, and cholic acids on intestinal absorption of cholesterol in humans. Mayo Clin Proc 1982; 57:4450. MEDLINE
  • 62
    Martin KO, Budai K, Javitt NB. Cholesterol and 27-hydroxycholesterol 7α-hydroxylation: evidence for two different enzymes. J Lipid Res 1993; 34:581588. MEDLINE
  • 63
    Javitt NB. Bile acid synthesis from cholesterol: regulatory and auxiliary pathways. FASEB J 1994; 8:13081311. MEDLINE
  • 64
    Stroup D, Crestani M, Chiang JY. Identification of a bile acid response element in the cholesterol 7 alpha-hydroxylase gene CYP7A. Am J Physiol 1997; 273:G50817. MEDLINE
  • 65
    Twisk J, Hoekman MF, Mager WH, Moorman AF, de Boer PA, Scheja L, Princen HM, et al. Heterogeneous expression of cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase genes in the rat liver lobulus. J Clin Invest 1995; 95:12351243. MEDLINE
  • 66
    Ugele B, Kempen HJM, Gebhardt R, Meijer P, Burger HJ, Princen HMG. Heterogeneity of rat liver parenchyma in cholesterol 7α-hydroxylase and bile acid synthesis. Biochem J 1991; 276:7377. MEDLINE