• 1
    Alter HJ. To C or not to C: these are the questions. Blood 1995; 85:16811695. MEDLINE
  • 2
    Missale G, Bertoni R, Lamonaca V, Valli A, Massari M, Mori C, Rumi MG, et al. Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune response. J Clin Invest 1996; 98:706714. MEDLINE
  • 3
    Diepolder HM, Zachoval R, Hoffman RM, Wierenga E, Santantonio T, Jung MC, Elchenlaub D, et al. Possible mechanism involving T-lymphocyte response to non-structural protien 3 in viral clearance in acute hepatitis C virus infection. Lancet 1995; 346:10061007. MEDLINE
  • 4
    Tsai SL, Liaw YF, Chen MH, Huang CY, Kuo GC. Detection of type 2-like T-helper cells in hepatitis C virus infection: implications for hepatitis C virus chronicity. Hepatology 1997; 25:449458. MEDLINE
  • 5
    Ferrari C, Valli A, Galati L, Penna A, Scaccaglia P, Giuberti T, Schianchi C, et al. T-cell response to structural and nonstructural hepatitis C virus antigens in persistent and self-limited hepatitis C virus infections. Hepatology 1994; 19:286295. MEDLINE
  • 6
    Chomczynski P, Sacchi N. Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162: 286295.
  • 7
    Struyver L, Rossau R, Wyseur A, Duhamel M, Vanderborght B, Van Heuverswyn H, Maertens G. Typing of HCV isolates and characterization of new (sub)types using a line probe assay. J Gen Virol 1993; 74:10931102. MEDLINE
  • 8
    Altschul SF, Madden TL, Schaffer AA, Zhang J, Zhang Z, Miller W, Lipman DJ. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 1997; 25:33893402. MEDLINE
  • 9
    Penna A, Del Prete G, Cavalli A, Bertoletti A, D'Elios MM, Sorrentino R, D'Amato M, et al. Predominant T helper 1 cytokine profile of hepatitis B virus nucleocapsid-specific T cells in acute self-limited hepatitis B. Hepatology 1997; 25:10221027. MEDLINE
  • 10
    Buyse I, Decorte R, Baens M, Cuppens H, Semana G, Emonds MP, Marynen P, et al. Rapid DNA typing of class II HLA antigens using the polymerase chain reaction and reverse dot blot hybridization. Tissue Antigens 1993; 41:114. MEDLINE
  • 11
    Southwood S, Sidney J, Kondo A, Del Guercio M-F, Appella E, Hoffman S, Kubo RT, et al. Several common HLA-DR types share largely overlapping peptide binding repertoires. J Immunol 1998; 160:33633373. MEDLINE
  • 12
    Sidney J, Southwood S, Oseroff C, Del Guercio M-F, Sette A, Grey HM. Measurement fo MHC/peptide interactions by gel filtration. Current Protocols in Immunology 1998;
  • 13
    Sette A, Buus S, Colon SM, Miles C, Grey HM. Structural analysis of peptides capable of binding to more than one Ia antigen. J Immunol 1989; 142:35. MEDLINE
  • 14
    Gorga JC, Horejsi V, Johnson DR, Raghupathy R, Strominger JL. Purification and characterization of class II histocompatibility antigens from a homozygous human B cell line. J Biol Chem 1998; 262:16087.
  • 15
    Imanishi T, Akaza T, Kimura A, Tokunaga K, Gojobori T. Allele and haplotype frequencies for HLA and complement loci in various ethnic groups. In: Tsuji K, Aizaqua M, Sasazuki T, eds. HLA Proceedings of the Eleventh International Histocompatibility Workshop and Conference. Tokyo: Oxford University Press, 1991; 1065.
  • 16
    Diepolder HM, Gerlach JT, Zachoval R, Hoffmann RM, Jung MC, Wierenga EA, Scholz S, et al. Immunodominant CD4+ T-cell epitope within nonstructural protein 3 in acute hepatitis C virus infection. J Virol 1997; 71:60116019. MEDLINE
  • 17
    Simmonds P. Variability of hepatitis C virus. Hepatology 1995; 21:570581. MEDLINE
  • 18
    Bertoletti A, D'Elios MM, Boni C, De Carli M, Zignego AL, Durazzo M, Missale G, et al. Different cytokine profiles of intrahepatic T cells in chronic hepatitis B and hepatitis C virus infections. Gastroenterology 1997; 112:193199. MEDLINE
  • 19
    Paul WE, Seder RA. Lymphocyte responses and cytokines. Cell 1994; 76:241251. MEDLINE
  • 20
    Sher A, Coffman RL. Regulation of immunity to parasites by T cells and T-cell derived cytokines. Annu Rev Immunol 1992; 10:385409. MEDLINE
  • 21
    Maggi E, Mazzetti M, Ravina A, Annunziato F, De Carli M, Piccinni MP, Manetti R, et al. Ability of HIV to promote a Th1 to Th0 shift and to replicate preferentially in Th2 and Th0 cells. Science 1994; 265:244248. MEDLINE
  • 22
    Clerici M, Hakin FT, Venzon DJ, Blatt S, Hendrix CW, Wynn TW, Shearer GM. Changes in interleukin-2 and interleukin-4 production in asymptomatic, human immunodeficiency virus-seropositive individuals. J Clin Invest 1993; 91:759765. MEDLINE
  • 23
    Hill AV, Elvin J, Willis AC, Aidoo M, Allsopp CE, Gotch FM, Gao XM, et al. Molecular analysis of the association of HLA-B53 and resistance to severe malaria. Nature 1992; 360:434439. MEDLINE
  • 24
    Davenport MP, Quin CL, Chicz RM, Green BN, Willis AC, Lane WS, Bell JI, et al. Naturally processed peptides from two disease-resistance associated HLA DR13 alleles show related sequence motifs and the effects of the dimorphism at position 86 of the HLA-DRb chain. Proc Nat Acad Sci U S A 1995; 92:65676571.
  • 25
    Sinigaglia F, Guttinger M, Kilgus J, Doran DM, Matile H, Etlinger H, Trzeciak A, et al. A malaria T cell epitope recognized in association with most mouse and human MHC class II molecules. Nature 1988; 336:778780. MEDLINE
  • 26
    Panina P, Tan A, Termijtelen A, Demotz S, Corradin G, Lanzavecchia A. Universally immunogenic T cell epitopes: promiscuous binding to human class II and promiscuous recognition by T cells. Eur J Immunol 1989; 19:22372242. MEDLINE
  • 27
    Hammer J, Valsasnini P, Tolba K, Bolin D, Higelin J, Takacs B, Sinigaglia F. Promiscuous and allele-specific anchors in HLA-DR binding peptides. Cell 1993; 74:197203. MEDLINE
  • 28
    Sette A, Sidney J, Oseroff C, Del Guercio M-F, Southwood S, Arrhenious T, Powell M, et al. HLA DR4w4-binding motifs illustrate the biochemical basis of degeneracy and specificity in peptide-DR interactions. J Immunol 1993; 151:31633170. MEDLINE
  • 29
    O'Sullivan DT, Arrhenius T, Sidney J, Del Guercio M-F, Albertson M, Wall M, Southwood S, et al. On the interaction of promiscuous antigenic peptides with different DR alleles: identification of common structural motifs. J Immunol 1991; 147:2663. MEDLINE