• 1
    Kim PKM, Zamora R, Petrosko P, Billiar TR. The regulatory role of nitric oxide in apoptosis. Int Immunopharmacol 2001; 1:14211441.
  • 2
    Saavedra JE, Billiar TR, Williams DL, Kim YM, Watkins SC, Keefer LK. Targeting nitric oxide (NO) delivery in vivo. Design of a liver- selective NO donor prodrug that blocks tumor necrosis factor-alpha- induced apoptosis and toxicity in the liver. J Med Chem 1997; 40:19471954.MEDLINE
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    Ou J, Carlos TM, Watkins SC, Saavedra JE, Keefer LK, Kim YM et al. Differential effects of nonselective nitric oxide synthase (NOS) and selective inducible NOS inhibition on hepatic necrosis, apoptosis, ICAM- 1 expression, and neutrophil accumulation during endotoxemia. Nitric Oxide 1997; 1:404416.MEDLINE
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    Sass G, Koerber K, Bang R, Guehring H, Tiegs G. Inducible nitric oxide synthase is critical for immune-mediated liver injury in mice. J Clin Invest 2001; 107:439447.MEDLINE
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    Hierholzer C, Harbrecht B, Menezes JM, Kane J, MacMicking J, Nathan CF, Peitzman AB, et al. Essential role of induced nitric oxide in the initiation of the inflammatory response after hemorrhagic shock. J Exp Med 1998; 187:917928.MEDLINE
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    Lee VG, Johnson M, Baust J, Laubach V, Watkins S, Billiar TR. The roles of iNOS in liver ischemia-reperfusion injury. Shock 2001 (in press).
  • 7
    Rai RM, Lee FY, Rosen A, Yang SQ, Lin HZ, Koteish A, Liew FY, et al. Impaired liver regeneration in inducible nitric oxide synthase deficient mice. Proc Natl Acad Sci U S A 1998; 95:1382913834.MEDLINE
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    Kim YM, de Vera ME, Watkins SC, Billiar TR. Nitric oxide protects cultured rat hepatocytes from tumor necrosis factor-alpha-induced apoptosis by inducing heat shock protein 70 expression. J Biol Chem 1997; 272:14021411.MEDLINE
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    Kim YM, Talanian RV, Billiar TR. Nitric oxide inhibits apoptosis by preventing increases in caspase-3- like activity via two distinct mechanisms. J Biol Chem 1997; 272:3113831148.MEDLINE
  • 10
    Li J, Yang S, Billiar TR. Cyclic nucleotides suppress tumor necrosis factor alpha-mediated apoptosis by inhibiting caspase activation and cytochrome c release in primary hepatocytes via a mechanism independent of Akt activation. J Biol Chem 2000; 275:1302613034.MEDLINE
  • 11
    Kim YM, Chung HT, Simmons RL, Billiar TR. Cellular non-heme iron content is a determinant of nitric oxide- mediated apoptosis, necrosis, and caspase inhibition. J Biol Chem 2000; 275:1095410961.MEDLINE