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References

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    Saavedra JE, Billiar TR, Williams DL, Kim YM, Watkins SC, Keefer LK. Targeting nitric oxide (NO) delivery in vivo. Design of a liver- selective NO donor prodrug that blocks tumor necrosis factor-alpha- induced apoptosis and toxicity in the liver. J Med Chem 1997; 40:19471954.MEDLINE
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    Ou J, Carlos TM, Watkins SC, Saavedra JE, Keefer LK, Kim YM et al. Differential effects of nonselective nitric oxide synthase (NOS) and selective inducible NOS inhibition on hepatic necrosis, apoptosis, ICAM- 1 expression, and neutrophil accumulation during endotoxemia. Nitric Oxide 1997; 1:404416.MEDLINE
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    Sass G, Koerber K, Bang R, Guehring H, Tiegs G. Inducible nitric oxide synthase is critical for immune-mediated liver injury in mice. J Clin Invest 2001; 107:439447.MEDLINE
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    Lee VG, Johnson M, Baust J, Laubach V, Watkins S, Billiar TR. The roles of iNOS in liver ischemia-reperfusion injury. Shock 2001 (in press).
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    Kim YM, de Vera ME, Watkins SC, Billiar TR. Nitric oxide protects cultured rat hepatocytes from tumor necrosis factor-alpha-induced apoptosis by inducing heat shock protein 70 expression. J Biol Chem 1997; 272:14021411.MEDLINE
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    Kim YM, Talanian RV, Billiar TR. Nitric oxide inhibits apoptosis by preventing increases in caspase-3- like activity via two distinct mechanisms. J Biol Chem 1997; 272:3113831148.MEDLINE
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    Li J, Yang S, Billiar TR. Cyclic nucleotides suppress tumor necrosis factor alpha-mediated apoptosis by inhibiting caspase activation and cytochrome c release in primary hepatocytes via a mechanism independent of Akt activation. J Biol Chem 2000; 275:1302613034.MEDLINE
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    Kim YM, Chung HT, Simmons RL, Billiar TR. Cellular non-heme iron content is a determinant of nitric oxide- mediated apoptosis, necrosis, and caspase inhibition. J Biol Chem 2000; 275:1095410961.MEDLINE