• Please log in or register to access this feature.

Hepatology Elsewhere

You have full text access to this OnlineOpen article

Ask(1) and you shall receive: A new link between antioxidants and cell death signaling

  1. Mark J. Czaja M.D.

Article first published online: 30 DEC 2003

DOI: 10.1002/hep.510380132

Issue

Hepatology

Hepatology

Volume 38, Issue 1, pages 252–254, July 2003

Additional Information

How to Cite

Czaja, M. J. (2003), Ask(1) and you shall receive: A new link between antioxidants and cell death signaling. Hepatology, 38: 252–254. doi: 10.1002/hep.510380132

Author Information

  1. Department of Medicine and Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY

Publication History

  1. Issue published online: 30 DEC 2003
  2. Article first published online: 30 DEC 2003

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

Get PDF (95K)

References

  • 1
    Yu ZW, Quinn PJ. Dimethyl sulphoxide: a review of its applications in cell biology. Biosci Rep 1994; 14:259–281.
  • 2
    Isom HC, Secott T, Georgoff I, Woodworth C, Mummaw J. Maintenance of differentiated rat hepatocytes in primary culture. Proc Natl Acad Sci U S A 1985; 82:3252–3256.
  • 3
    Park Y, Smith RD, Combs AB, Kehrer JP. Prevention of acetaminophen-induced hepatotoxicity by dimethyl sulfoxide. Toxicology 1988; 52:165–175.
  • 4
    Bruck R, Aeed H, Shirin H, Matas Z, Zaidel L, Avni Y, Halpern Z. The hydroxyl radical scavengers dimethylsulfoxide and dimethylthiourea protect rats against thioacetamide-induced fulminant hepatic failure. J Hepatol 1999; 31:27–38.
  • 5
    Bruck R, Shirin H, Aeed H, Matas Z, Hochman A, Pines M, Avni Y. Prevention of hepatic cirrhosis in rats by hydroxyl radical scavengers. J Hepatol 2001; 35:457–464.
  • 6
    Czaja MJ. The future of GI and liver research: editorial perspectives III. JNK/AP-1 regulation of hepatocyte death. Am J Physiol 2003; 284:G875–G879.
  • 7
    Schwabe RF, Bradham CA, Uehara T, Hatano E, Bennett BL, Schoonhoven R, Brenner DA. c-Jun N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration. Hepatology 2003; 37:824–832.
    Direct Link:
  • 8
    Qiao L, Han SI, Fang Y, Park JS, Gupta S, Gilfor D, Amorino G, et al. Bile acid regulation of C/EBPβ, CREB, and c-Jun function, via the extracellular signal-regulated kinase and c-Jun NH2-terminal kinase pathways, modulates the apoptotic response of hepatocytes. Mol Cell Biol 2003; 23:3052–3066.
  • 9
    Hatai T, Matsuzawa A, Inoshita S, Mochida Y, Kuroda T, Sakamaki K, Kuida K, et al. Execution of apoptosis signal-regulating kinase 1 (ASK1)-induced apoptosis by the mitochondria-dependent caspase activation. J Biol Chem 2000; 275:26576–26581.
  • 10
    Hayes JD, Pulford DJ. The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Crit Rev Biochem Mol Biol 1995; 30:445–600.
  • 11
    Cho SG, Lee YH, Park HS, Ryoo K, Kang KW, Park J, Eom SJ, et al. Glutathione S-transferase mu modulates the stress-activated signals by suppressing apoptosis signal-regulating kinase 1. J Biol Chem 2001; 276:12749–12755.
  • 12
    Dorion S, Lambert H, Landry J. Activation of the p38 signaling pathway by heat shock involves the dissociation of glutathione S-transferase Mu from Ask1. J Biol Chem 2002; 277:30792–30797.
  • 13
    Saitoh M, Nishitoh H, Fujii M, Takeda K, Tobiume K, Sawada Y, Kawabata M, et al. Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK)1. EMBO J 1998; 17:2596–2606.
  • 14
    Park HS, Cho SG, Kim CK, Hwang HS, Noh KT, Kim MS, Hub SH, et al. Heat shock protein hsp72 is a negative regulator of apoptosis signal-regulating kinase 1. Mol Cell Biol 2002; 22:7721–7730.
  • 15
    Tobiume K, Matsuzawa A, Takahashi T, Nishitoh H, Morita K-I, Takeda K, Minowa O, et al. ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis. EMBO Rep 2001; 2:222–228.
  • 16
    Adler V, Yin Z, Fuchs SY, Benezra M, Rosario L, Tew KD, Pincus MR, et al. Regulation of JNK signaling by GSTp. EMBO J 1999; 18:1321–1334.
  • 17
    Wang T, Arifoglu P, Ronai Z, Tew KD. Glutathione S-transferase P1-1 (GSTP1-1) inhibits c-Jun N-terminal kinase (JNK1) signaling through interaction with the C terminus. J Biol Chem 2001; 276:20999–21003.
Get PDF (95K)