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Hepatology

Cover image for Hepatology

April 2008

Volume 47, Issue 4

Pages 1103–1430

  1. Comments from the Editors

    1. Top of page
    2. Comments from the Editors
    3. Editorial
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury and Regeneration
    10. Liver Biology and Pathobiology
    11. Special Article
    12. Reviews
    13. Meeting Report
    14. Hepatology Elsewhere
    15. Correspondence
    16. Correction
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  2. Editorial

    1. Top of page
    2. Comments from the Editors
    3. Editorial
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury and Regeneration
    10. Liver Biology and Pathobiology
    11. Special Article
    12. Reviews
    13. Meeting Report
    14. Hepatology Elsewhere
    15. Correspondence
    16. Correction
    1. You have free access to this content
      Screening for biliary atresia: A ray of hope (pages 1105–1107)

      Benjamin L. Shneider

      Article first published online: 25 MAR 2008 | DOI: 10.1002/hep.22302

  3. Viral Hepatitis

    1. Top of page
    2. Comments from the Editors
    3. Editorial
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury and Regeneration
    10. Liver Biology and Pathobiology
    11. Special Article
    12. Reviews
    13. Meeting Report
    14. Hepatology Elsewhere
    15. Correspondence
    16. Correction
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      Health-related quality of life in chronic hepatitis B patients (pages 1108–1117)

      Siew Chin Ong, Belinda Mak, Myat Oo Aung, Shu-Chuen Li and Seng-Gee Lim

      Article first published online: 3 MAR 2008 | DOI: 10.1002/hep.22138

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      Steatohepatitis: Risk factors and impact on disease severity in human immunodeficiency virus/hepatitis C virus coinfection (pages 1118–1127)

      Richard K. Sterling, Melissa J. Contos, Paula G. Smith, R. Todd Stravitz, Velimir A. Luketic, Michael Fuchs, Mitchell L. Shiffman and Arun J. Sanyal

      Article first published online: 7 JAN 2008 | DOI: 10.1002/hep.22134

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      Changing trends in hepatitis C–related mortality in the United States, 1995-2004 (pages 1128–1135)

      Matthew Wise, Stephanie Bialek, Lyn Finelli, Beth P. Bell and Frank Sorvillo

      Article first published online: 19 DEC 2007 | DOI: 10.1002/hep.22165

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      Potential contribution of tumor suppressor p53 in the host defense against hepatitis C virus (pages 1136–1149)

      Narayan Dharel, Naoya Kato, Ryosuke Muroyama, Hiroyoshi Taniguchi, Motoyuki Otsuka, Yue Wang, Amarsanaa Jazag, Run-Xuan Shao, Jin-Hai Chang, Mark K. Adler, Takao Kawabe and Masao Omata

      Article first published online: 19 DEC 2007 | DOI: 10.1002/hep.22176

  4. Steatohepatitis/Metabolic Liver Disease

    1. Top of page
    2. Comments from the Editors
    3. Editorial
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury and Regeneration
    10. Liver Biology and Pathobiology
    11. Special Article
    12. Reviews
    13. Meeting Report
    14. Hepatology Elsewhere
    15. Correspondence
    16. Correction
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      Limitations of conventionally derived chronic liver disease mortality rates: Results of a comprehensive assessment (pages 1150–1157)

      M. Michele Manos, Wendy A. Leyden, Rosemary C. Murphy, Norah A. Terrault and Beth P. Bell

      Article first published online: 20 DEC 2007 | DOI: 10.1002/hep.22181

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      Health-related fitness and physical activity in patients with nonalcoholic fatty liver disease (pages 1158–1166)

      Joanne B. Krasnoff, Patricia L. Painter, Janet P. Wallace, Nathan M. Bass and Raphael B. Merriman

      Article first published online: 11 FEB 2008 | DOI: 10.1002/hep.22137

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      Adiponectin gene polymorphisms modulate acute adiponectin response to dietary fat: Possible pathogenetic role in NASH (pages 1167–1177)

      Giovanni Musso, Roberto Gambino, Franco De Michieli, Marilena Durazzo, Gianfranco Pagano and Maurizio Cassader

      Article first published online: 29 FEB 2008 | DOI: 10.1002/hep.22142

  5. Hepatobiliary Malignancies

    1. Top of page
    2. Comments from the Editors
    3. Editorial
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury and Regeneration
    10. Liver Biology and Pathobiology
    11. Special Article
    12. Reviews
    13. Meeting Report
    14. Hepatology Elsewhere
    15. Correspondence
    16. Correction
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      A novel “patient-like” model of cholangiocarcinoma progression based on bile duct inoculation of tumorigenic rat cholangiocyte cell lines (pages 1178–1190)

      Alphonse E. Sirica, Zichen Zhang, Guan-Hua Lai, Toru Asano, Xue-Ning Shen, Deanna J. Ward, Arvind Mahatme and Jennifer L. DeWitt

      Article first published online: 14 DEC 2007 | DOI: 10.1002/hep.22088

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      Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice (pages 1191–1199)

      M. Luz Martínez-Chantar, Mercedes Vázquez-Chantada, Usue Ariz, Nuria Martínez, Marta Varela, Zigmund Luka, Antonieta Capdevila, Juan Rodríguez, Ana M. Aransay, Rune Matthiesen, Heping Yang, Diego F. Calvisi, Manel Esteller, Mario Fraga, Shelly C. Lu, Conrad Wagner and José M. Mato

      Article first published online: 19 DEC 2007 | DOI: 10.1002/hep.22159

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      Integration of genomic analysis and in vivo transfection to identify sprouty 2 as a candidate tumor suppressor in liver cancer (pages 1200–1210)

      Susie A. Lee, Coral Ho, Ritu Roy, Cynthia Kosinski, Mohini A. Patil, Aaron D. Tward, Jane Fridlyand and Xin Chen

      Article first published online: 19 DEC 2007 | DOI: 10.1002/hep.22169

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      Sulfatase 2 up-regulates glypican 3, promotes fibroblast growth factor signaling, and decreases survival in hepatocellular carcinoma (pages 1211–1222)

      Jin-Ping Lai, Dalbir S. Sandhu, Chunrong Yu, Tao Han, Catherine D. Moser, Kenard K. Jackson, Ruben Bonilla Guerrero, Ileana Aderca, Hajime Isomoto, Megan M. Garrity-Park, Hongzhi Zou, Abdirashid M. Shire, David M. Nagorney, Schuyler O. Sanderson, Alex A. Adjei, Ju-Seog Lee, Snorri S. Thorgeirsson and Lewis R. Roberts

      Article first published online: 7 JAN 2008 | DOI: 10.1002/hep.22202

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      MicroRNA gene expression profile of hepatitis C virus–associated hepatocellular carcinoma (pages 1223–1232)

      Heike Varnholt, Uta Drebber, Falko Schulze, Inga Wedemeyer, Peter Schirmacher, Hans-Peter Dienes and Margarete Odenthal

      Article first published online: 19 DEC 2007 | DOI: 10.1002/hep.22158

  6. Autoimmune, Cholestatic and Biliary Disease

    1. Top of page
    2. Comments from the Editors
    3. Editorial
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury and Regeneration
    10. Liver Biology and Pathobiology
    11. Special Article
    12. Reviews
    13. Meeting Report
    14. Hepatology Elsewhere
    15. Correspondence
    16. Correction
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      Universal screening for biliary atresia using an infant stool color card in Taiwan (pages 1233–1240)

      Cheng-Hui Hsiao, Mei-Hwei Chang, Huey-Ling Chen, Hung-Chang Lee, Tzee-Chung Wu, Chieh-Chung Lin, Yao-Jong Yang, An-Chyi Chen, Mao-Meng Tiao, Beng-Huat Lau, Chia-Hsiang Chu and Ming-Wei Lai

      Article first published online: 20 DEC 2007 | DOI: 10.1002/hep.22182

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      Mortality attributable to cholestatic liver disease in the United States (pages 1241–1247)

      Flavia D. Mendes, W. Ray Kim, Rachel Pedersen, Terry Therneau and Keith D. Lindor

      Article first published online: 19 DEC 2007 | DOI: 10.1002/hep.22178

  7. Liver Failure/Cirrhosis/Portal Hypertension

    1. Top of page
    2. Comments from the Editors
    3. Editorial
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury and Regeneration
    10. Liver Biology and Pathobiology
    11. Special Article
    12. Reviews
    13. Meeting Report
    14. Hepatology Elsewhere
    15. Correspondence
    16. Correction
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      Increased oxidative stress in cirrhotic rat livers: A potential mechanism contributing to reduced nitric oxide bioavailability (pages 1248–1256)

      Jorge Gracia-Sancho, Bàrbara Laviña, Aina Rodríguez-Vilarrupla, Héctor García-Calderó, Mercedes Fernández, Jaume Bosch and Joan-Carles García-Pagán

      Article first published online: 10 DEC 2007 | DOI: 10.1002/hep.22166

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      Oxygen desaturation during sleep in hepatopulmonary syndrome (pages 1257–1263)

      David T. Palma, George M. Philips, Miguel R. Arguedas, Susan M. Harding and Michael B. Fallon

      Article first published online: 29 FEB 2008 | DOI: 10.1002/hep.22143

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      Hemodynamic effects of urotensin II and its specific receptor antagonist palosuran in cirrhotic rats (pages 1264–1276)

      Jonel Trebicka, Ludger Leifeld, Martin Hennenberg, Erwin Biecker, Andreas Eckhardt, Nicolas Fischer, Andrea Schulze Pröbsting, Christoph Clemens, Frank Lammert, Tilman Sauerbruch and Jörg Heller

      Article first published online: 19 DEC 2007 | DOI: 10.1002/hep.22170

  8. Liver Injury and Regeneration

    1. Top of page
    2. Comments from the Editors
    3. Editorial
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury and Regeneration
    10. Liver Biology and Pathobiology
    11. Special Article
    12. Reviews
    13. Meeting Report
    14. Hepatology Elsewhere
    15. Correspondence
    16. Correction
    1. You have free access to this content
      Pregnane X receptor is essential for normal progression of liver regeneration (pages 1277–1287)

      Guoli Dai, Lin He, Pengli Bu and Yu-Jui Yvonne Wan

      Article first published online: 31 DEC 2007 | DOI: 10.1002/hep.22129

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      Expansion of liver cancer stem cells during aging in methionine adenosyltransferase 1A–deficient mice (pages 1288–1297)

      C. Bart Rountree, Shantha Senadheera, Jose M. Mato, Gay M. Crooks and Shelly C. Lu

      Article first published online: 31 DEC 2007 | DOI: 10.1002/hep.22141

  9. Liver Biology and Pathobiology

    1. Top of page
    2. Comments from the Editors
    3. Editorial
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury and Regeneration
    10. Liver Biology and Pathobiology
    11. Special Article
    12. Reviews
    13. Meeting Report
    14. Hepatology Elsewhere
    15. Correspondence
    16. Correction
    1. You have free access to this content
      Ciliary neurotrophic factor receptor α subunit–modulated multiple downstream signaling pathways in hepatic cancer cell lines and their biological implications (pages 1298–1308)

      Xin Hu, Yingjun Zhao, Xianghuo He, Jinjun Li, Tao Wang, Weiping Zhou, Dafang Wan, Hongyang Wang and Jianren Gu

      Article first published online: 19 DEC 2007 | DOI: 10.1002/hep.22163

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    3. You have free access to this content
      TRAIL mediates liver injury by the innate immune system in the bile duct–ligated mouse (pages 1317–1330)

      Alisan Kahraman, Fernando J. Barreyro, Steven F. Bronk, Nathan W. Werneburg, Justin L. Mott, Yuko Akazawa, Howard C. Masuoka, Charles L. Howe and Gregory J. Gores

      Article first published online: 10 JAN 2008 | DOI: 10.1002/hep.22136

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      Activation of liver X receptor sensitizes mice to gallbladder cholesterol crystallization (pages 1331–1342)

      Hirdesh Uppal, Yonggong Zhai, Archana Gangopadhyay, Shaheen Khadem, Songrong Ren, James A. Moser and Wen Xie

      Article first published online: 19 DEC 2007 | DOI: 10.1002/hep.22175

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      Dendritic cells are required for effective cross-presentation in the murine liver (pages 1343–1351)

      George Plitas, Bryan M. Burt, Jennifer A. Stableford, Hoang M. Nguyen, Alexander P. Welles and Ronald P. DeMatteo

      Article first published online: 19 DEC 2007 | DOI: 10.1002/hep.22167

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      Systemic transmigration of allosensitizing donor dendritic cells to host secondary lymphoid organs after rat liver transplantation (pages 1352–1362)

      Hisashi Ueta, Changde Shi, Nobutomo Miyanari, Xue-Dong Xu, Shu Zhou, Masaki Yamashita, Taichi Ezaki and Kenjiro Matsuno

      Article first published online: 25 JAN 2008 | DOI: 10.1002/hep.22161

  10. Special Article

    1. Top of page
    2. Comments from the Editors
    3. Editorial
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury and Regeneration
    10. Liver Biology and Pathobiology
    11. Special Article
    12. Reviews
    13. Meeting Report
    14. Hepatology Elsewhere
    15. Correspondence
    16. Correction
    1. You have free access to this content
      Serum activity of alanine aminotransferase (ALT) as an indicator of health and disease (pages 1363–1370)

      W. Ray Kim, Steven L. Flamm, Adrian M. Di Bisceglie and Henry C. Bodenheimer

      Article first published online: 7 JAN 2008 | DOI: 10.1002/hep.22109

  11. Reviews

    1. Top of page
    2. Comments from the Editors
    3. Editorial
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury and Regeneration
    10. Liver Biology and Pathobiology
    11. Special Article
    12. Reviews
    13. Meeting Report
    14. Hepatology Elsewhere
    15. Correspondence
    16. Correction
    1. You have free access to this content
      Hepatitis C genotype 4: What we know and what we don't yet know (pages 1371–1383)

      Sanaa M. Kamal and Imad A. Nasser

      Article first published online: 28 JAN 2008 | DOI: 10.1002/hep.22127

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      Thrombosis and anticoagulation in liver disease (pages 1384–1393)

      Dominique Charles Valla

      Article first published online: 7 JAN 2008 | DOI: 10.1002/hep.22192

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  12. Meeting Report

    1. Top of page
    2. Comments from the Editors
    3. Editorial
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury and Regeneration
    10. Liver Biology and Pathobiology
    11. Special Article
    12. Reviews
    13. Meeting Report
    14. Hepatology Elsewhere
    15. Correspondence
    16. Correction
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      Acute liver failure: Summary of a workshop (pages 1401–1415)

      William M. Lee, Robert H. Squires Jr, Scott L. Nyberg, Edward Doo and Jay H. Hoofnagle

      Article first published online: 19 DEC 2007 | DOI: 10.1002/hep.22177

  13. Hepatology Elsewhere

    1. Top of page
    2. Comments from the Editors
    3. Editorial
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury and Regeneration
    10. Liver Biology and Pathobiology
    11. Special Article
    12. Reviews
    13. Meeting Report
    14. Hepatology Elsewhere
    15. Correspondence
    16. Correction
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      Efficient postexposure prophylaxis by hepatitis A vaccine (pages 1416–1418)

      Samira Fafi-Kremer, Françoise Stoll-Keller and Thomas F. Baumert

      Article first published online: 7 FEB 2008 | DOI: 10.1002/hep.22274

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  14. Correspondence

    1. Top of page
    2. Comments from the Editors
    3. Editorial
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury and Regeneration
    10. Liver Biology and Pathobiology
    11. Special Article
    12. Reviews
    13. Meeting Report
    14. Hepatology Elsewhere
    15. Correspondence
    16. Correction
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      Role of probiotic bacteria in sepsis (page 1422)

      Tetsuji Fujita

      Article first published online: 25 MAR 2008 | DOI: 10.1002/hep.22111

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      Reply: (pages 1422–1423)

      Karen Madsen

      Article first published online: 2 APR 2008 | DOI: 10.1002/hep.22255

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      Reply: (page 1424)

      Valérie Eschwège, Olivier Chazouillières and Annie Robert

      Article first published online: 27 FEB 2008 | DOI: 10.1002/hep.22062

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      To define virological response in hepatitis B e antigen–negative patients (page 1425)

      Resat Ozaras, Hakan Leblebicioglu and Cafer Eroglu

      Article first published online: 5 MAR 2008 | DOI: 10.1002/hep.22233

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      Reply: (pages 1425–1426)

      Jinlin Hou, Nathaniel Brown and JiDong Jia

      Article first published online: 5 MAR 2008 | DOI: 10.1002/hep.22277

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      Development of novel agents for the treatment of hepatitis C virus (page 1426)

      Tracy Swan and Raymond T. Chung

      Article first published online: 5 MAR 2008 | DOI: 10.1002/hep.22248

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      WIN-R revisited: Response to editorial (page 1427)

      Ira M. Jacobson and Robert S. Brown Jr

      Article first published online: 6 MAR 2008 | DOI: 10.1002/hep.22208

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      Practice variation in treatment of primary biliary cirrhosis and effect on clinical outcomes (page 1428)

      Jayant A. Talwalkar and Andrea A. Gossard

      Article first published online: 25 MAR 2008 | DOI: 10.1002/hep.22080

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      Somatostatin or its analogs and terlipressin: Different evidence levels, Same recommendations? (page 1428)

      Yu Bai, Jun Gao, Duo-Wu Zou and Zhao-Shen Li

      Article first published online: 6 MAR 2008 | DOI: 10.1002/hep.21999

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      The optimal interval of endoscopic variceal ligation (page 1429)

      Gin-Ho Lo and Kwok-Hung Lai

      Article first published online: 6 MAR 2008 | DOI: 10.1002/hep.22051

  15. Correction

    1. Top of page
    2. Comments from the Editors
    3. Editorial
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury and Regeneration
    10. Liver Biology and Pathobiology
    11. Special Article
    12. Reviews
    13. Meeting Report
    14. Hepatology Elsewhere
    15. Correspondence
    16. Correction
    1. You have free access to this content
      Correction (page 1430)

      Article first published online: 25 MAR 2008 | DOI: 10.1002/hep.22120

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