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Hepatology

Cover image for Vol. 47 Issue 6

June 2008

Volume 47, Issue 6

Pages 1799–2149

  1. Comments from the Editors

    1. Top of page
    2. Comments from the Editors
    3. Public Policy
    4. Editorials
    5. Viral Hepatitis
    6. Steatohepatitis/Metabolic Liver Disease
    7. Hepatobiliary Malignancies
    8. Autoimmune, Cholestatic and Biliary Disease
    9. Liver Failure/Cirrhosis/Portal Hypertension
    10. Liver Injury/Regeneration
    11. Liver Biology/Pathobiology
    12. AASLD Practice Guidelines
    13. Reviews
    14. Hepatology Elsewhere
    15. Correspondence
    16. Corrections
    1. You have free access to this content
  2. Public Policy

    1. Top of page
    2. Comments from the Editors
    3. Public Policy
    4. Editorials
    5. Viral Hepatitis
    6. Steatohepatitis/Metabolic Liver Disease
    7. Hepatobiliary Malignancies
    8. Autoimmune, Cholestatic and Biliary Disease
    9. Liver Failure/Cirrhosis/Portal Hypertension
    10. Liver Injury/Regeneration
    11. Liver Biology/Pathobiology
    12. AASLD Practice Guidelines
    13. Reviews
    14. Hepatology Elsewhere
    15. Correspondence
    16. Corrections
    1. You have free access to this content
  3. Editorials

    1. Top of page
    2. Comments from the Editors
    3. Public Policy
    4. Editorials
    5. Viral Hepatitis
    6. Steatohepatitis/Metabolic Liver Disease
    7. Hepatobiliary Malignancies
    8. Autoimmune, Cholestatic and Biliary Disease
    9. Liver Failure/Cirrhosis/Portal Hypertension
    10. Liver Injury/Regeneration
    11. Liver Biology/Pathobiology
    12. AASLD Practice Guidelines
    13. Reviews
    14. Hepatology Elsewhere
    15. Correspondence
    16. Corrections
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      Addendum (pages 1805–1806)

      J. Donald Ostrow and D. Montgomery Bissell

      Article first published online: 28 MAY 2008 | DOI: 10.1002/hep.22313

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  4. Viral Hepatitis

    1. Top of page
    2. Comments from the Editors
    3. Public Policy
    4. Editorials
    5. Viral Hepatitis
    6. Steatohepatitis/Metabolic Liver Disease
    7. Hepatobiliary Malignancies
    8. Autoimmune, Cholestatic and Biliary Disease
    9. Liver Failure/Cirrhosis/Portal Hypertension
    10. Liver Injury/Regeneration
    11. Liver Biology/Pathobiology
    12. AASLD Practice Guidelines
    13. Reviews
    14. Hepatology Elsewhere
    15. Correspondence
    16. Corrections
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      A randomized, prospective trial of ribavirin 400 mg/day versus 800 mg/day in combination with peginterferon alfa-2a in hepatitis C virus genotypes 2 and 3 (pages 1816–1823)

      Peter Ferenci, Harald Brunner, Hermann Laferl, Thomas-Matthias Scherzer, Andreas Maieron, Michael Strasser, Gabriele Fischer, Harald Hofer, Martin Bischof, Rudolf Stauber, Michael Gschwantler, Petra Steindl-Munda, Katharina Staufer and Karin Löschenberger

      Article first published online: 4 FEB 2008 | DOI: 10.1002/hep.22262

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      Virological and immunological determinants of intrahepatic virus-specific CD8+ T-cell failure in chronic hepatitis C virus infection (pages 1824–1836)

      Christoph Neumann-Haefelin, Jörg Timm, Hans Christian Spangenberg, Natalie Wischniowski, Natalja Nazarova, Nadine Kersting, Michael Roggendorf, Todd M. Allen, Hubert E. Blum and Robert Thimme

      Article first published online: 31 JAN 2008 | DOI: 10.1002/hep.22242

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      Randomized comparison of 12 or 24 weeks of peginterferon α-2a and ribavirin in chronic hepatitis C virus genotype 2/3 infection (pages 1837–1845)

      Martin Lagging, Nina Langeland, Court Pedersen, Martti Färkkilä, Mads Rauning Buhl, Kristine Mørch, Amar P. Dhillon, Åsa Alsiö, Kristoffer Hellstrand, Johan Westin and Gunnar Norkrans

      Article first published online: 1 FEB 2008 | DOI: 10.1002/hep.22253

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      Polyclonal immunoglobulins from a chronic hepatitis C virus patient protect human liver–chimeric mice from infection with a homologous hepatitis C virus strain (pages 1846–1855)

      Thomas Vanwolleghem, Jens Bukh, Philip Meuleman, Isabelle Desombere, Jean-Christophe Meunier, Harvey Alter, Robert H. Purcell and Geert Leroux-Roels

      Article first published online: 31 JAN 2008 | DOI: 10.1002/hep.22244

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      Increased risk of hepatocellular carcinoma among patients with hepatitis C cirrhosis and diabetes mellitus (pages 1856–1862)

      Bart J. Veldt, Wendong Chen, E. Jenny Heathcote, Heiner Wedemeyer, Juerg Reichen, W. Peter Hofmann, Robert J. de Knegt, Stefan Zeuzem, Michael P. Manns, Bettina E. Hansen, Solko W. Schalm and Harry L. A. Janssen

      Article first published online: 1 FEB 2008 | DOI: 10.1002/hep.22251

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      Safety, efficacy, and pharmacokinetics of adefovir dipivoxil in children and adolescents (age 2 to <18 years) with chronic hepatitis B (pages 1863–1871)

      Maureen M. Jonas, Deirdre Kelly, Henry Pollack, Jacek Mizerski, Jeff Sorbel, David Frederick, Elsa Mondou, Franck Rousseau and Etienne Sokal

      Article first published online: 1 FEB 2008 | DOI: 10.1002/hep.22250

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      The hepatitis B virus X protein induces paracrine activation of human hepatic stellate cells (pages 1872–1883)

      Samuel Martín-Vílchez, Paloma Sanz-Cameno, Yolanda Rodríguez-Muñoz, Pedro L. Majano, Francisca Molina-Jiménez, Manuel López-Cabrera, Ricardo Moreno-Otero and Enrique Lara-Pezzi

      Article first published online: 4 FEB 2008 | DOI: 10.1002/hep.22265

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      Rapid virological response and treatment duration for chronic hepatitis C genotype 1 patients: A randomized trial (pages 1884–1893)

      Ming-Lung Yu, Chia-Yen Dai, Jee-Fu Huang, Chang-Fu Chiu, Yi-Hsin C. Yang, Nai-Jen Hou, Li-Po Lee, Ming-Yen Hsieh, Zu-Yau Lin, Shinn-Cherng Chen, Ming-Yuh Hsieh, Liang-Yen Wang, Wen-Yu Chang and Wan-Long Chuang

      Article first published online: 28 MAY 2008 | DOI: 10.1002/hep.22319

  5. Steatohepatitis/Metabolic Liver Disease

    1. Top of page
    2. Comments from the Editors
    3. Public Policy
    4. Editorials
    5. Viral Hepatitis
    6. Steatohepatitis/Metabolic Liver Disease
    7. Hepatobiliary Malignancies
    8. Autoimmune, Cholestatic and Biliary Disease
    9. Liver Failure/Cirrhosis/Portal Hypertension
    10. Liver Injury/Regeneration
    11. Liver Biology/Pathobiology
    12. AASLD Practice Guidelines
    13. Reviews
    14. Hepatology Elsewhere
    15. Correspondence
    16. Corrections
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      Disturbed hepatic carbohydrate management during high metabolic demand in medium-chain acyl–CoA dehydrogenase (MCAD)–deficient mice (pages 1894–1904)

      Hilde Herrema, Terry G. J. Derks, Theo H. van Dijk, Vincent W. Bloks, Albert Gerding, Rick Havinga, Uwe J. F. Tietge, Michael Müller, G. Peter A. Smit, Folkert Kuipers and Dirk-Jan Reijngoud

      Article first published online: 5 MAY 2008 | DOI: 10.1002/hep.22284

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      Prevention of free fatty acid–induced hepatic lipotoxicity by 18β-glycyrrhetinic acid through lysosomal and mitochondrial pathways (pages 1905–1915)

      Xudong Wu, Luyong Zhang, Emily Gurley, Elaine Studer, Jing Shang, Tao Wang, Cuifen Wang, Ming Yan, Zhenzhou Jiang, Phillip B. Hylemon, Arun J. Sanyal, William M. Pandak Jr and Huiping Zhou

      Article first published online: 31 JAN 2008 | DOI: 10.1002/hep.22239

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      A clinical scoring system for predicting nonalcoholic steatohepatitis in morbidly obese patients (pages 1916–1923)

      Guilherme M. Campos, Kiran Bambha, Eric Vittinghoff, Charlotte Rabl, Andrew M. Posselt, Ruxandra Ciovica, Umesh Tiwari, Linda Ferrel, Mark Pabst, Nathan M. Bass and Raphael B. Merriman

      Article first published online: 31 JAN 2008 | DOI: 10.1002/hep.22241

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      Increased hepatic steatosis and insulin resistance in mice lacking hepatic androgen receptor (pages 1924–1935)

      Hung-Yun Lin, I-Chen Yu, Ruey-Shen Wang, Yei-Tsung Chen, Ning-Chun Liu, Saleh Altuwaijri, Cheng-Lung Hsu, Wen-Lung Ma, Jenny Jokinen, Janet D. Sparks, Shuyuan Yeh and Chawnshang Chang

      Article first published online: 1 FEB 2008 | DOI: 10.1002/hep.22252

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  6. Hepatobiliary Malignancies

    1. Top of page
    2. Comments from the Editors
    3. Public Policy
    4. Editorials
    5. Viral Hepatitis
    6. Steatohepatitis/Metabolic Liver Disease
    7. Hepatobiliary Malignancies
    8. Autoimmune, Cholestatic and Biliary Disease
    9. Liver Failure/Cirrhosis/Portal Hypertension
    10. Liver Injury/Regeneration
    11. Liver Biology/Pathobiology
    12. AASLD Practice Guidelines
    13. Reviews
    14. Hepatology Elsewhere
    15. Correspondence
    16. Corrections
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      MicroRNA profiling in hepatocellular tumors is associated with clinical features and oncogene/tumor suppressor gene mutations (pages 1955–1963)

      Yannick Ladeiro, Gabrielle Couchy, Charles Balabaud, Paulette Bioulac-Sage, Laura Pelletier, Sandra Rebouissou and Jessica Zucman-Rossi

      Article first published online: 1 FEB 2008 | DOI: 10.1002/hep.22256

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      Melittin prevents liver cancer cell metastasis through inhibition of the Rac1-dependent pathway (pages 1964–1973)

      Shujing Liu, Mei Yu, Ying He, Lin Xiao, Fang Wang, Changcheng Song, Shuhan Sun, Changquan Ling and Zhiheng Xu

      Article first published online: 31 JAN 2008 | DOI: 10.1002/hep.22240

  7. Autoimmune, Cholestatic and Biliary Disease

    1. Top of page
    2. Comments from the Editors
    3. Public Policy
    4. Editorials
    5. Viral Hepatitis
    6. Steatohepatitis/Metabolic Liver Disease
    7. Hepatobiliary Malignancies
    8. Autoimmune, Cholestatic and Biliary Disease
    9. Liver Failure/Cirrhosis/Portal Hypertension
    10. Liver Injury/Regeneration
    11. Liver Biology/Pathobiology
    12. AASLD Practice Guidelines
    13. Reviews
    14. Hepatology Elsewhere
    15. Correspondence
    16. Corrections
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      Adoptive transfer of CD8+ T cells from transforming growth factor beta receptor type II (dominant negative form) induces autoimmune cholangitis in mice (pages 1974–1982)

      Guo-Xiang Yang, Zhe-Xiong Lian, Ya-Hui Chuang, Yuki Moritoki, Ruth Y. Lan, Kanji Wakabayashi, Aftab A. Ansari, Richard A. Flavell, William M. Ridgway, Ross L. Coppel, Koichi Tsuneyama, Ian R. Mackay and M. Eric Gershwin

      Article first published online: 21 JAN 2008 | DOI: 10.1002/hep.22226

  8. Liver Failure/Cirrhosis/Portal Hypertension

    1. Top of page
    2. Comments from the Editors
    3. Public Policy
    4. Editorials
    5. Viral Hepatitis
    6. Steatohepatitis/Metabolic Liver Disease
    7. Hepatobiliary Malignancies
    8. Autoimmune, Cholestatic and Biliary Disease
    9. Liver Failure/Cirrhosis/Portal Hypertension
    10. Liver Injury/Regeneration
    11. Liver Biology/Pathobiology
    12. AASLD Practice Guidelines
    13. Reviews
    14. Hepatology Elsewhere
    15. Correspondence
    16. Corrections
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      Nitric oxide promotes caspase-independent hepatic stellate cell apoptosis through the generation of reactive oxygen species (pages 1983–1993)

      Daniel A. Langer, Amitava Das, David Semela, Ningling Kang-Decker, Helen Hendrickson, Steven F. Bronk, Zvonimir S. Katusic, Gregory J. Gores and Vijay H. Shah

      Article first published online: 5 MAY 2008 | DOI: 10.1002/hep.22285

  9. Liver Injury/Regeneration

    1. Top of page
    2. Comments from the Editors
    3. Public Policy
    4. Editorials
    5. Viral Hepatitis
    6. Steatohepatitis/Metabolic Liver Disease
    7. Hepatobiliary Malignancies
    8. Autoimmune, Cholestatic and Biliary Disease
    9. Liver Failure/Cirrhosis/Portal Hypertension
    10. Liver Injury/Regeneration
    11. Liver Biology/Pathobiology
    12. AASLD Practice Guidelines
    13. Reviews
    14. Hepatology Elsewhere
    15. Correspondence
    16. Corrections
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      The hepatic stem cell niche: Identification by label-retaining cell assay (pages 1994–2002)

      Reiichiro Kuwahara, Alexander V. Kofman, Charles S. Landis, E. Scott Swenson, Els Barendswaard and Neil D. Theise

      Article first published online: 21 JAN 2008 | DOI: 10.1002/hep.22218

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      Relationship between daily dose of oral medications and idiosyncratic drug-induced liver injury: Search for signals (pages 2003–2009)

      Craig Lammert, Stefan Einarsson, Chandan Saha, Anna Niklasson, Einar Bjornsson and Naga Chalasani

      Article first published online: 7 FEB 2008 | DOI: 10.1002/hep.22272

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      Metron factor-1 prevents liver injury without promoting tumor growth and metastasis (pages 2010–2025)

      Terumi Takahara, Feng Xue, Massimiliano Mazzone, Yutaka Yata, Kazunobu Nonome, Masami Kanayama, Kengo Kawai, Alberto M. Pisacane, Shiro Takahara, Xiao-Kang Li, Paolo M. Comoglio, Toshiro Sugiyama and Paolo Michieli

      Article first published online: 31 JAN 2008 | DOI: 10.1002/hep.22243

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      Hepatocyte-specific inhibitor-of-kappaB-kinase deletion triggers the innate immune response and promotes earlier cell proliferation during liver regeneration (pages 2036–2050)

      Yann Malato, Leif E. Sander, Christian Liedtke, Malika Al-Masaoudi, Frank Tacke, Christian Trautwein and Naiara Beraza

      Article first published online: 4 FEB 2008 | DOI: 10.1002/hep.22264

  10. Liver Biology/Pathobiology

    1. Top of page
    2. Comments from the Editors
    3. Public Policy
    4. Editorials
    5. Viral Hepatitis
    6. Steatohepatitis/Metabolic Liver Disease
    7. Hepatobiliary Malignancies
    8. Autoimmune, Cholestatic and Biliary Disease
    9. Liver Failure/Cirrhosis/Portal Hypertension
    10. Liver Injury/Regeneration
    11. Liver Biology/Pathobiology
    12. AASLD Practice Guidelines
    13. Reviews
    14. Hepatology Elsewhere
    15. Correspondence
    16. Corrections
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      Capacitative calcium entry and transient receptor potential canonical 6 expression control human hepatoma cell proliferation (pages 2068–2077)

      Charbel El Boustany, Gabriel Bidaux, Antoine Enfissi, Philippe Delcourt, Natalia Prevarskaya and Thierry Capiod

      Article first published online: 4 FEB 2008 | DOI: 10.1002/hep.22263

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      Defective DNA strand break repair causes chromosomal instability and accelerates liver carcinogenesis in mice (pages 2078–2088)

      Narci C. Teoh, Yock Young Dan, Karen Swisshelm, Stacey Lehman, Jocelyn H. Wright, Jamil Haque, Yansong Gu and Nelson Fausto

      Article first published online: 7 JAN 2008 | DOI: 10.1002/hep.22194

  11. AASLD Practice Guidelines

    1. Top of page
    2. Comments from the Editors
    3. Public Policy
    4. Editorials
    5. Viral Hepatitis
    6. Steatohepatitis/Metabolic Liver Disease
    7. Hepatobiliary Malignancies
    8. Autoimmune, Cholestatic and Biliary Disease
    9. Liver Failure/Cirrhosis/Portal Hypertension
    10. Liver Injury/Regeneration
    11. Liver Biology/Pathobiology
    12. AASLD Practice Guidelines
    13. Reviews
    14. Hepatology Elsewhere
    15. Correspondence
    16. Corrections
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  12. Reviews

    1. Top of page
    2. Comments from the Editors
    3. Public Policy
    4. Editorials
    5. Viral Hepatitis
    6. Steatohepatitis/Metabolic Liver Disease
    7. Hepatobiliary Malignancies
    8. Autoimmune, Cholestatic and Biliary Disease
    9. Liver Failure/Cirrhosis/Portal Hypertension
    10. Liver Injury/Regeneration
    11. Liver Biology/Pathobiology
    12. AASLD Practice Guidelines
    13. Reviews
    14. Hepatology Elsewhere
    15. Correspondence
    16. Corrections
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      Coordinate regulation of gallbladder motor function in the gut-liver axis (pages 2112–2126)

      Piero Portincasa, Agostino Di Ciaula, Helen H. Wang, Giuseppe Palasciano, Karel J. van Erpecum, Antonio Moschetta and David Q.-H. Wang

      Article first published online: 7 JAN 2008 | DOI: 10.1002/hep.22204

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      Hepatitis C virus infection: Molecular pathways to metabolic syndrome (pages 2127–2133)

      Muhammad Y. Sheikh, Jinah Choi, Ishtiaq Qadri, Jacob E. Friedman and Arun J. Sanyal

      Article first published online: 7 FEB 2008 | DOI: 10.1002/hep.22269

  13. Hepatology Elsewhere

    1. Top of page
    2. Comments from the Editors
    3. Public Policy
    4. Editorials
    5. Viral Hepatitis
    6. Steatohepatitis/Metabolic Liver Disease
    7. Hepatobiliary Malignancies
    8. Autoimmune, Cholestatic and Biliary Disease
    9. Liver Failure/Cirrhosis/Portal Hypertension
    10. Liver Injury/Regeneration
    11. Liver Biology/Pathobiology
    12. AASLD Practice Guidelines
    13. Reviews
    14. Hepatology Elsewhere
    15. Correspondence
    16. Corrections
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    3. You have free access to this content
  14. Correspondence

    1. Top of page
    2. Comments from the Editors
    3. Public Policy
    4. Editorials
    5. Viral Hepatitis
    6. Steatohepatitis/Metabolic Liver Disease
    7. Hepatobiliary Malignancies
    8. Autoimmune, Cholestatic and Biliary Disease
    9. Liver Failure/Cirrhosis/Portal Hypertension
    10. Liver Injury/Regeneration
    11. Liver Biology/Pathobiology
    12. AASLD Practice Guidelines
    13. Reviews
    14. Hepatology Elsewhere
    15. Correspondence
    16. Corrections
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      Transient elastography, liver stiffness values, and acute hepatopathy (page 2140)

      George Panos, Paul Holmes, Sara Valero, Michael Anderson, Brian Gazzard and Mark Nelson

      Article first published online: 28 MAY 2008 | DOI: 10.1002/hep.22314

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      Reply: (pages 2140–2141)

      Francesco Vizzutti, Umberto Arena and Massimo Pinzani

      Article first published online: 28 MAY 2008 | DOI: 10.1002/hep.22324

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      A grapefruit a day for patients infected with hepatitis C? (pages 2141–2142)

      Peter N. Morcos, Barbara Brennan and Patrick F. Smith

      Article first published online: 28 MAY 2008 | DOI: 10.1002/hep.22308

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      Reply: (pages 2142–2143)

      Yaakov Nahmias, Martin L. Yarmush and Raymond T. Chung

      Article first published online: 26 MAR 2008 | DOI: 10.1002/hep.22340

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      Hypothyroidism in patients with hepatocellular carcinoma treated by transarterial chemoembolization (page 2144)

      Felix Flohr, Jan Harder, Jochen Seufert, Hubert E. Blum and Hans C. Spangenberg

      Article first published online: 5 MAY 2008 | DOI: 10.1002/hep.22347

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      Biopsy diagnosis of hepatocellular carcinoma (page 2145)

      Eugenio Caturelli and Ilario de Sio

      Article first published online: 28 MAY 2008 | DOI: 10.1002/hep.22282

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      Reply: (pages 2146–2147)

      Alejandro Forner and Jordi Bruix

      Article first published online: 28 MAY 2008 | DOI: 10.1002/hep.22329

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      Autoimmune hepatitis: Of host and pathogen (pages 2147–2148)

      Eirini I. Rigopoulou and George N. Dalekos

      Article first published online: 5 MAY 2008 | DOI: 10.1002/hep.22002

  15. Corrections

    1. Top of page
    2. Comments from the Editors
    3. Public Policy
    4. Editorials
    5. Viral Hepatitis
    6. Steatohepatitis/Metabolic Liver Disease
    7. Hepatobiliary Malignancies
    8. Autoimmune, Cholestatic and Biliary Disease
    9. Liver Failure/Cirrhosis/Portal Hypertension
    10. Liver Injury/Regeneration
    11. Liver Biology/Pathobiology
    12. AASLD Practice Guidelines
    13. Reviews
    14. Hepatology Elsewhere
    15. Correspondence
    16. Corrections
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