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Hepatology

Cover image for Vol. 48 Issue 1

July 2008

Volume 48, Issue 1

Pages 1–352

  1. Comments from the Editors

    1. Top of page
    2. Comments from the Editors
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. Reviews
    12. Hepatology Elsewhere
    13. Correspondence
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      The need for better clinical trials (pages 1–3)

      Patrick S. Kamath

      Version of Record online: 16 APR 2008 | DOI: 10.1002/hep.22373

  2. Editorials

    1. Top of page
    2. Comments from the Editors
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. Reviews
    12. Hepatology Elsewhere
    13. Correspondence
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      Does retinol-binding protein 4 cause or reflect fatty liver disease? (pages 4–6)

      Matthias Blüher, Anke Tönjes and Michael Stumvoll

      Version of Record online: 20 JUN 2008 | DOI: 10.1002/hep.22426

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      The challenge of diagnosing autoimmune hepatitis: Less is more (pages 10–12)

      Gina Choi and Marion G. Peters

      Version of Record online: 30 MAY 2008 | DOI: 10.1002/hep.22438

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      Portopulmonary hypertension (pages 13–15)

      J.T. Wells, J.R. Runo and M.R. Lucey

      Version of Record online: 18 APR 2008 | DOI: 10.1002/hep.22378

  3. Viral Hepatitis

    1. Top of page
    2. Comments from the Editors
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. Reviews
    12. Hepatology Elsewhere
    13. Correspondence
    1. You have free access to this content
      Morphological changes in intracellular lipid droplets induced by different hepatitis C virus genotype core sequences and relationship with steatosis (pages 16–27)

      Aurélie Piodi, Philippe Chouteau, Hervé Lerat, Christophe Hézode and Jean-Michel Pawlotsky

      Version of Record online: 20 JUN 2008 | DOI: 10.1002/hep.22288

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      Retinol-binding protein 4: A new marker of virus-induced steatosis in patients infected with hepatitis c virus genotype 1 (pages 28–37)

      Salvatore Petta, Calogero Cammà, Vito Di Marco, Nicola Alessi, Francesco Barbaria, Daniela Cabibi, Rosalia Caldarella, Stefania Ciminnisi, Anna Licata, Maria Fatima Massenti, Alessandra Mazzola, Giuseppe Tarantino, Giulio Marchesini and Antonio Craxì

      Version of Record online: 10 MAR 2008 | DOI: 10.1002/hep.22316

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      Sequence variation in hepatitis C virus nonstructural protein 5A predicts clinical outcome of pegylated interferon/ribavirin combination therapy (pages 38–47)

      Ahmed El-Shamy, Motoko Nagano-Fujii, Noriko Sasase, Susumu Imoto, Soo-Ryang Kim and Hak Hotta

      Version of Record online: 24 MAR 2008 | DOI: 10.1002/hep.22339

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      Hepatitis C virus–infected hepatocytes extrinsically modulate dendritic cell maturation to activate T cells and natural killer cells (pages 48–58)

      Takashi Ebihara, Masashi Shingai, Misako Matsumoto, Takaji Wakita and Tsukasa Seya

      Version of Record online: 24 MAR 2008 | DOI: 10.1002/hep.22337

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      Hepatitis C virus replication is inhibited by 22β-methoxyolean-12-ene-3β, 24(4β)-diol (ME3738) through enhancing interferon-β (pages 59–69)

      Yoichi Hiasa, Hiroyuki Kuzuhara, Yoshio Tokumoto, Ichiro Konishi, Nobuyuki Yamashita, Bunzo Matsuura, Kojiro Michitaka, Raymond T. Chung and Morikazu Onji

      Version of Record online: 21 FEB 2008 | DOI: 10.1002/hep.22289

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      Human leukocyte antigen class II associations with hepatitis C virus clearance and virus-specific CD4 T cell response among Caucasians and African Americans (pages 70–79)

      Rebecca A. Harris, Kazushi Sugimoto, David E. Kaplan, Fusao Ikeda, Malek Kamoun and Kyong-Mi Chang

      Version of Record online: 7 JUN 2008 | DOI: 10.1002/hep.22287

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      Obesity and steatosis influence serum and hepatic inflammatory markers in chronic hepatitis C (pages 80–87)

      Julie R. Jonsson, Helen D. Barrie, Peter O'Rourke, Andrew D. Clouston and Elizabeth E. Powell

      Version of Record online: 3 MAR 2008 | DOI: 10.1002/hep.22311

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      Entecavir therapy for lamivudine-refractory chronic hepatitis B: Improved virologic, biochemical, and serology outcomes through 96 weeks (pages 99–108)

      Morris Sherman, Cihan Yurdaydin, Halis Simsek, Marcelo Silva, Yun-Fan Liaw, Vinod K. Rustgi, Hoel Sette, Naoky Tsai, Daniel J. Tenney, James Vaughan, Bruce Kreter and Robert Hindes

      Version of Record online: 8 JUN 2008 | DOI: 10.1002/hep.22323

  4. Steatohepatitis/Metabolic Liver Disease

    1. Top of page
    2. Comments from the Editors
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. Reviews
    12. Hepatology Elsewhere
    13. Correspondence
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      Tranilast, an antifibrogenic agent, ameliorates a dietary rat model of nonalcoholic steatohepatitis (pages 109–118)

      Masafumi Uno, Seiichiro Kurita, Hirofumi Misu, Hitoshi Ando, Tsuguhito Ota, Naoto Matsuzawa-Nagata, Yuki Kita, Satoko Nabemoto, Hiroshi Akahori, Yoh Zen, Yasuni Nakanuma, Shuichi Kaneko and Toshinari Takamura

      Version of Record online: 24 MAR 2008 | DOI: 10.1002/hep.22338

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      Lifestyle intervention and antioxidant therapy in children with nonalcoholic fatty liver disease: A randomized, controlled trial (pages 119–128)

      Valerio Nobili, Melania Manco, Rita Devito, Vincenzo Di Ciommo, Donatella Comparcola, Maria Rita Sartorelli, Fiorella Piemonte, Matilde Marcellini and Paul Angulo

      Version of Record online: 24 MAR 2008 | DOI: 10.1002/hep.22336

  5. Hepatobiliary Malignancies

    1. Top of page
    2. Comments from the Editors
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. Reviews
    12. Hepatology Elsewhere
    13. Correspondence
    1. You have free access to this content
      Joint effects of coffee consumption and serum gamma-glutamyltransferase on the risk of liver cancer (pages 129–136)

      Gang Hu, Jaakko Tuomilehto, Eero Pukkala, Timo Hakulinen, Riitta Antikainen, Erkki Vartiainen and Pekka Jousilahti

      Version of Record online: 18 MAR 2008 | DOI: 10.1002/hep.22320

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      Trends in mortality from hepatocellular carcinoma in Europe, 1980-2004 (pages 137–145)

      Cristina Bosetti, Fabio Levi, Paolo Boffetta, Franca Lucchini, Eva Negri and Carlo La Vecchia

      Version of Record online: 3 MAR 2008 | DOI: 10.1002/hep.22312

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      Autocrine insulin-like growth factor-II stimulation of tumor cell migration is a progression step in human hepatocarcinogenesis (pages 146–156)

      Tanja Nussbaum, Jana Samarin, Volker Ehemann, Michaela Bissinger, Eduard Ryschich, Akmal Khamidjanov, Xiaolei Yu, Norbert Gretz, Peter Schirmacher and Kai Breuhahn

      Version of Record online: 21 FEB 2008 | DOI: 10.1002/hep.22297

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      CD40ligand-expressing dendritic cells induce regression of hepatocellular carcinoma by activating innate and acquired immunity in vivo (pages 157–168)

      Maria A. Gonzalez-Carmona, Veronika Lukacs-Kornek, Anne Timmerman, Sara Shabani, Miroslaw Kornek, Annabelle Vogt, Yildiz Yildiz, Elisabeth Sievers, Ingo G.H. Schmidt-Wolf, Wolfgang H. Caselmann, Tilman Sauerbruch and Volker Schmitz

      Version of Record online: 21 FEB 2008 | DOI: 10.1002/hep.22296

  6. Autoimmune, Cholestatic and Biliary Disease

    1. Top of page
    2. Comments from the Editors
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. Reviews
    12. Hepatology Elsewhere
    13. Correspondence
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      Simplified criteria for the diagnosis of autoimmune hepatitis (pages 169–176)

      Elke M. Hennes, Mikio Zeniya, Albert. J. Czaja, Albert Parés, George N. Dalekos, Edward L. Krawitt, Paulo L. Bittencourt, Gilda Porta, Kirsten M. Boberg, Harald Hofer, Francesco B. Bianchi, Minoru Shibata, Christoph Schramm, Barbara Eisenmann de Torres, Peter R. Galle, Ian McFarlane, Hans-Peter Dienes and Ansgar W. Lohse

      Version of Record online: 19 MAR 2008 | DOI: 10.1002/hep.22322

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      Telomere shortening in the damaged small bile ducts in primary biliary cirrhosis reflects ongoing cellular senescence (pages 186–195)

      Motoko Sasaki, Hiroko Ikeda, Junpei Yamaguchi, Satoko Nakada and Yasuni Nakanuma

      Version of Record online: 28 MAR 2008 | DOI: 10.1002/hep.22348

  7. Liver Failure/Cirrhosis/Portal Hypertension

    1. Top of page
    2. Comments from the Editors
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. Reviews
    12. Hepatology Elsewhere
    13. Correspondence
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      Clinical risk factors for portopulmonary hypertension (pages 196–203)

      Steven M. Kawut, Michael J. Krowka, James F. Trotter, Kari E. Roberts, Raymond L. Benza, David B. Badesch, Darren B. Taichman, Evelyn M. Horn, Steven Zacks, Neil Kaplowitz, Robert S. Brown Jr. and Michael B. Fallon

      Version of Record online: 19 MAR 2008 | DOI: 10.1002/hep.22275

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      Effects of satavaptan, a selective vasopressin V2 receptor antagonist, on ascites and serum sodium in cirrhosis with hyponatremia: A randomized trial (pages 204–213)

      Pere Ginès, Florence Wong, Hugh Watson, Slobodan Milutinovic, Luis Ruiz del Arbol and Dan Olteanu

      Version of Record online: 21 FEB 2008 | DOI: 10.1002/hep.22293

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      Comorbidity and survival of Danish cirrhosis patients: A nationwide population-based cohort study (pages 214–220)

      Peter Jepsen, Hendrik Vilstrup, Per Kragh Andersen, Timothy L. Lash and Henrik Toft Sørensen

      Version of Record online: 26 MAR 2008 | DOI: 10.1002/hep.22341

  8. Liver Injury/Regeneration

    1. Top of page
    2. Comments from the Editors
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. Reviews
    12. Hepatology Elsewhere
    13. Correspondence
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      Granulocyte-colony stimulating factor induces proliferation of hepatic progenitors in alcoholic steatohepatitis: A randomized trial (pages 221–229)

      Laurent Spahr, Jean-François Lambert, Laura Rubbia-Brandt, Yves Chalandon, Jean-Louis Frossard, Emiliano Giostra and Antoine Hadengue

      Version of Record online: 10 MAR 2008 | DOI: 10.1002/hep.22317

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      Adenosine-dependent activation of hypoxia-inducible factor-1 induces late preconditioning in liver cells (pages 230–239)

      Elisa Alchera, Lorenza Tacchini, Chiara Imarisio, Caterina Dal Ponte, Cristina De Ponti, Elena Gammella, Gaetano Cairo, Emanuele Albano and Rita Carini

      Version of Record online: 1 FEB 2008 | DOI: 10.1002/hep.22249

  9. Liver Biology/Pathobiology

    1. Top of page
    2. Comments from the Editors
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. Reviews
    12. Hepatology Elsewhere
    13. Correspondence
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      The molecular mechanism regulating 24-hour rhythm of CYP2E1 expression in the mouse liver (pages 240–251)

      Naoya Matsunaga, Misaki Ikeda, Takako Takiguchi, Satoru Koyanagi and Shigehiro Ohdo

      Version of Record online: 25 FEB 2008 | DOI: 10.1002/hep.22304

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      Prospero-related homeobox 1 and liver receptor homolog 1 coordinately regulate long-term proliferation of murine fetal hepatoblasts (pages 252–264)

      Akihide Kamiya, Sei Kakinuma, Masafumi Onodera, Atsushi Miyajima and Hiromitsu Nakauchi

      Version of Record online: 25 FEB 2008 | DOI: 10.1002/hep.22303

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      Thirty-kilodalton Tat-interacting protein suppresses tumor metastasis by inhibition of osteopontin transcription in human hepatocellular carcinoma (pages 265–275)

      Jian Zhao, Bin Lu, Hao Xu, Xin Tong, Guobin Wu, Xia Zhang, Anmin Liang, Wenming Cong, Jianxin Dai, Hao Wang, Mengchao Wu and Yajun Guo

      Version of Record online: 19 FEB 2008 | DOI: 10.1002/hep.22280

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      An inducible autocrine cascade regulates rat hepatocyte proliferation and apoptosis responses to tumor necrosis factor-α (pages 276–288)

      Benjamin D. Cosgrove, Connie Cheng, Justin R. Pritchard, Donna B. Stolz, Douglas A. Lauffenburger and Linda G. Griffith

      Version of Record online: 24 MAR 2008 | DOI: 10.1002/hep.22335

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  10. Reviews

    1. Top of page
    2. Comments from the Editors
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. Reviews
    12. Hepatology Elsewhere
    13. Correspondence
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      Host neutralizing responses and pathogenesis of hepatitis C virus infection (pages 299–307)

      Mirjam B. Zeisel, François-Loïc Cosset and Thomas F. Baumert

      Version of Record online: 29 FEB 2008 | DOI: 10.1002/hep.22307

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  11. Hepatology Elsewhere

    1. Top of page
    2. Comments from the Editors
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. Reviews
    12. Hepatology Elsewhere
    13. Correspondence
    1. You have free access to this content
      Cell-specific location of Hfe: It is the 'cyte that matters (pages 336–338)

      Darrell H. G. Crawford, Linda M. Fletcher and Gregory J. Anderson

      Version of Record online: 20 JUN 2008 | DOI: 10.1002/hep.22427

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      Closing the door on hepatitis B (pages 338–341)

      C.-Thomas Bock and Joseph Torresi

      Version of Record online: 9 JUN 2008 | DOI: 10.1002/hep.22447

  12. Correspondence

    1. Top of page
    2. Comments from the Editors
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. Reviews
    12. Hepatology Elsewhere
    13. Correspondence
    1. You have free access to this content
      Possible determinants of rapid virological response suggesting shorter courses of combination therapy for hepatitis C virus genotype 2 (page 342)

      Chia-Yen Dai, Wan-Long Chuang, Jee-Fu Huang, Ming-Yen Hsieh and Ming-Lung Yu

      Version of Record online: 19 DEC 2007 | DOI: 10.1002/hep.22173

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      Effects of adjuvant therapy on the outcomes of surgical management of extrahepatic biliary atresia (pages 342–343)

      Carlo Pulitanò, Akihiko Kobayashi and Luca Aldrighetti

      Version of Record online: 3 JUN 2008 | DOI: 10.1002/hep.22144

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      Management of gastric fundal varices (pages 343–344)

      Akio Matsumoto

      Version of Record online: 27 MAY 2008 | DOI: 10.1002/hep.22157

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      Tauroursodeoxycholic acid: Relieving the pathogenesis of HFE C282Y hereditary hemochromatosis (pages 344–345)

      Matthew W. Lawless, Arun K. Mankan, Anthony W. Ryan and Suzanne Norris

      Version of Record online: 17 JAN 2008 | DOI: 10.1002/hep.22155

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      Antiviral effects of silymarin against hepatitis C: The jury is still out (pages 345–346)

      Stephen J. Polyak, Chihiro Morishima and Roy Hawke

      Version of Record online: 28 MAY 2008 | DOI: 10.1002/hep.22235

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      Implicaton of tetraspanin-enriched microdomains (TEMs) in hepatitis C virus (pages 346–348)

      Paloma Sanz-Cameno, Samuel Martín-Vílchez, Yolanda Rodriguez-Muñoz and Ricardo Moreno-Otero

      Version of Record online: 2 JUN 2008 | DOI: 10.1002/hep.22318

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      Impact of cyclosporine-based immunosuppressive therapy on liver histology of hepatitis C virus–infected renal transplant patients (pages 348–349)

      Leonardo L. Schiavon, Roberto J. Carvalho-Filho, Janaína L. Narciso-Schiavon, Denize V. Barbosa, Valéria P. Lanzoni, Maria Lucia G. Ferraz and Antonio Eduardo B. Silva

      Version of Record online: 2 JUN 2008 | DOI: 10.1002/hep.22331

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      Reply: (page 350)

      Massimo Pinzani, Umberto Arena and Francesco Vizzutti

      Version of Record online: 20 JUN 2008 | DOI: 10.1002/hep.22388

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      Reply: (pages 351–352)

      Eric Delwart

      Version of Record online: 7 JUN 2008 | DOI: 10.1002/hep.22398

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