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Hepatology

Cover image for Hepatology

November 2008

Volume 48, Issue 5

Pages 1357–1730

  1. Presidential Profile

    1. Top of page
    2. Presidential Profile
    3. Comments from the Editors
    4. Master's Perspective
    5. Editorials
    6. Viral Hepatitis
    7. Steatohepatitis/Metabolic Liver Disease
    8. Hepatobiliary Malignancies
    9. Autoimmune, Cholestatic and Biliary Disease
    10. Liver Failure/Cirrhosis/Portal Hypertension
    11. Liver Injury/Regeneration
    12. Liver Biology/Pathobiology
    13. Meeting Report
    14. Reviews
    15. Hepatology Elsewhere
    16. Rapid Communication
    17. Correspondence
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      Scott L. Friedman, 59th President, AASLD (pages 1357–1358)

      Meena B. Bansal, Simon W. Beaven and Don C. Rockey

      Article first published online: 9 OCT 2008 | DOI: 10.1002/hep.22669

  2. Comments from the Editors

    1. Top of page
    2. Presidential Profile
    3. Comments from the Editors
    4. Master's Perspective
    5. Editorials
    6. Viral Hepatitis
    7. Steatohepatitis/Metabolic Liver Disease
    8. Hepatobiliary Malignancies
    9. Autoimmune, Cholestatic and Biliary Disease
    10. Liver Failure/Cirrhosis/Portal Hypertension
    11. Liver Injury/Regeneration
    12. Liver Biology/Pathobiology
    13. Meeting Report
    14. Reviews
    15. Hepatology Elsewhere
    16. Rapid Communication
    17. Correspondence
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  3. Master's Perspective

    1. Top of page
    2. Presidential Profile
    3. Comments from the Editors
    4. Master's Perspective
    5. Editorials
    6. Viral Hepatitis
    7. Steatohepatitis/Metabolic Liver Disease
    8. Hepatobiliary Malignancies
    9. Autoimmune, Cholestatic and Biliary Disease
    10. Liver Failure/Cirrhosis/Portal Hypertension
    11. Liver Injury/Regeneration
    12. Liver Biology/Pathobiology
    13. Meeting Report
    14. Reviews
    15. Hepatology Elsewhere
    16. Rapid Communication
    17. Correspondence
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  4. Editorials

    1. Top of page
    2. Presidential Profile
    3. Comments from the Editors
    4. Master's Perspective
    5. Editorials
    6. Viral Hepatitis
    7. Steatohepatitis/Metabolic Liver Disease
    8. Hepatobiliary Malignancies
    9. Autoimmune, Cholestatic and Biliary Disease
    10. Liver Failure/Cirrhosis/Portal Hypertension
    11. Liver Injury/Regeneration
    12. Liver Biology/Pathobiology
    13. Meeting Report
    14. Reviews
    15. Hepatology Elsewhere
    16. Rapid Communication
    17. Correspondence
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    2. You have free access to this content
    3. You have free access to this content
  5. Viral Hepatitis

    1. Top of page
    2. Presidential Profile
    3. Comments from the Editors
    4. Master's Perspective
    5. Editorials
    6. Viral Hepatitis
    7. Steatohepatitis/Metabolic Liver Disease
    8. Hepatobiliary Malignancies
    9. Autoimmune, Cholestatic and Biliary Disease
    10. Liver Failure/Cirrhosis/Portal Hypertension
    11. Liver Injury/Regeneration
    12. Liver Biology/Pathobiology
    13. Meeting Report
    14. Reviews
    15. Hepatology Elsewhere
    16. Rapid Communication
    17. Correspondence
    1. You have free access to this content
    2. You have free access to this content
      Fatty acid synthase is up-regulated during hepatitis C virus infection and regulates hepatitis C virus entry and production (pages 1396–1403)

      Wei Yang, Brian L. Hood, Sara L. Chadwick, Shufeng Liu, Simon C. Watkins, Guangxiang Luo, Thomas P. Conrads and Tianyi Wang

      Article first published online: 9 JUL 2008 | DOI: 10.1002/hep.22508

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      Placebo-controlled trial of 400 mg amantadine combined with peginterferon alfa-2a and ribavirin for 48 weeks in chronic hepatitis C virus-1 infection (pages 1404–1411)

      Michael von Wagner, Wolf Peter Hofmann, Gerlinde Teuber, Thomas Berg, Tobias Goeser, Ulrich Spengler, Holger Hinrichsen, Hans Weidenbach, Guido Gerken, Michael Manns, Peter Buggisch, Eva Herrmann and Stefan Zeuzem

      Article first published online: 19 JUN 2008 | DOI: 10.1002/hep.22483

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      Interpretation of positive transcription-mediated amplification test results from polymerase chain reaction–negative samples obtained after treatment of chronic hepatitis C (pages 1412–1419)

      Chihiro Morishima, Timothy R. Morgan, James E. Everhart, Elizabeth C. Wright, Minjun C. Apodaca, David R. Gretch, Mitchell L. Shiffman, Gregory T. Everson, Karen L. Lindsay, William M. Lee, Anna S. F. Lok, Jules L. Dienstag, Marc G. Ghany, Teresa M. Curto and HALT-C Trial Group

      Article first published online: 9 JUL 2008 | DOI: 10.1002/hep.22487

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      Heme oxygenase-1 suppresses hepatitis C virus replication and increases resistance of hepatocytes to oxidant injury (pages 1430–1439)

      Zhaowen Zhu, Anne T. Wilson, M. Meleah Mathahs, Feng Wen, Kyle E. Brown, Bruce A. Luxon and Warren N. Schmidt

      Article first published online: 16 JUL 2008 | DOI: 10.1002/hep.22491

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      Intrahepatic levels of CXCR3-associated chemokines correlate with liver inflammation and fibrosis in chronic hepatitis C (pages 1440–1450)

      Marija Zeremski, Lydia M. Petrovic, Luis Chiriboga, Queenie B. Brown, Herman T. Yee, Milan Kinkhabwala, Ira M. Jacobson, Rositsa Dimova, Marianthi Markatou and Andrew H. Talal

      Article first published online: 8 JUL 2008 | DOI: 10.1002/hep.22500

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      Is there a meaningful serum hepatitis B virus DNA cutoff level for therapeutic decisions in hepatitis B e antigen–negative chronic hepatitis B virus infection? (pages 1451–1459)

      George V. Papatheodoridis, Emanuel K. Manesis, Spilios Manolakopoulos, Ioannis S. Elefsiniotis, John Goulis, John Giannousis, Antonios Bilalis, Georgia Kafiri, Dimitrios Tzourmakliotis and Athanasios J. Archimandritis

      Article first published online: 10 JUL 2008 | DOI: 10.1002/hep.22518

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      Hepatitis B virus X protein affects S phase progression leading to chromosome segregation defects by binding to damaged DNA binding protein 1 (pages 1467–1476)

      Silvia Martin-Lluesma, Céline Schaeffer, Eva Isabelle Robert, Pieter Cornelis van Breugel, Olivier Leupin, Olivier Hantz and Michel Strubin

      Article first published online: 24 JUL 2008 | DOI: 10.1002/hep.22542

  6. Steatohepatitis/Metabolic Liver Disease

    1. Top of page
    2. Presidential Profile
    3. Comments from the Editors
    4. Master's Perspective
    5. Editorials
    6. Viral Hepatitis
    7. Steatohepatitis/Metabolic Liver Disease
    8. Hepatobiliary Malignancies
    9. Autoimmune, Cholestatic and Biliary Disease
    10. Liver Failure/Cirrhosis/Portal Hypertension
    11. Liver Injury/Regeneration
    12. Liver Biology/Pathobiology
    13. Meeting Report
    14. Reviews
    15. Hepatology Elsewhere
    16. Rapid Communication
    17. Correspondence
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      Alpha-lipoic acid decreases hepatic lipogenesis through adenosine monophosphate-activated protein kinase (AMPK)-dependent and AMPK-independent pathways (pages 1477–1486)

      Keun-Gyu Park, Ae-Kyung Min, Eun Hee Koh, Hyoun Sik Kim, Mi-Ok Kim, Hye-Sun Park, Yong-Deuk Kim, Tae-Seung Yoon, Byoung Kuk Jang, Jae Seok Hwang, Jae Bum Kim, Hueng-Sik Choi, Joong-Yeol Park, In-Kyu Lee and Ki-Up Lee

      Article first published online: 16 JUL 2008 | DOI: 10.1002/hep.22496

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      Alterations in hepatic glucose and energy metabolism as a result of calorie and carbohydrate restriction (pages 1487–1496)

      Jeffrey D. Browning, Brian Weis, Jeannie Davis, Santhosh Satapati, Matthew Merritt, Craig R. Malloy and Shawn C. Burgess

      Article first published online: 9 OCT 2008 | DOI: 10.1002/hep.22504

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  7. Hepatobiliary Malignancies

    1. Top of page
    2. Presidential Profile
    3. Comments from the Editors
    4. Master's Perspective
    5. Editorials
    6. Viral Hepatitis
    7. Steatohepatitis/Metabolic Liver Disease
    8. Hepatobiliary Malignancies
    9. Autoimmune, Cholestatic and Biliary Disease
    10. Liver Failure/Cirrhosis/Portal Hypertension
    11. Liver Injury/Regeneration
    12. Liver Biology/Pathobiology
    13. Meeting Report
    14. Reviews
    15. Hepatology Elsewhere
    16. Rapid Communication
    17. Correspondence
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      The angiogenic makeup of human hepatocellular carcinoma does not favor vascular endothelial growth factor/angiopoietin-driven sprouting neovascularization (pages 1517–1527)

      Wenjiao Zeng, Annette S.H. Gouw, Marius C. van den Heuvel, Peter J. Zwiers, Pieter E. Zondervan, Sibrand Poppema, Nong Zhang, Inge Platteel, Koert P. de Jong and Grietje Molema

      Article first published online: 16 JUL 2008 | DOI: 10.1002/hep.22490

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      Differentiation therapy of hepatocellular carcinoma in mice with recombinant adenovirus carrying hepatocyte nuclear factor-4α gene (pages 1528–1539)

      Chuan Yin, Yong Lin, Xin Zhang, Yue-Xiang Chen, Xin Zeng, Hai-Yan Yue, Jun-Liang Hou, Xing Deng, Jun-Ping Zhang, Ze-Guang Han and Wei-Fen Xie

      Article first published online: 8 JUL 2008 | DOI: 10.1002/hep.22510

  8. Autoimmune, Cholestatic and Biliary Disease

    1. Top of page
    2. Presidential Profile
    3. Comments from the Editors
    4. Master's Perspective
    5. Editorials
    6. Viral Hepatitis
    7. Steatohepatitis/Metabolic Liver Disease
    8. Hepatobiliary Malignancies
    9. Autoimmune, Cholestatic and Biliary Disease
    10. Liver Failure/Cirrhosis/Portal Hypertension
    11. Liver Injury/Regeneration
    12. Liver Biology/Pathobiology
    13. Meeting Report
    14. Reviews
    15. Hepatology Elsewhere
    16. Rapid Communication
    17. Correspondence
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      Prediction of clinical outcomes in primary biliary cirrhosis by serum enhanced liver fibrosis assay (pages 1549–1557)

      Marlyn J. Mayo, Julie Parkes, Beverley Adams-Huet, Burton Combes, A. S. Mills, Rodney S. Markin, Raphael Rubin, Donald Wheeler, Melissa Contos, A. B. West, Sandra Saldana, Yonas Getachew, Robert Butsch, Velimir Luketic, Marion Peters, Adrian Di Bisceglie, Nathan Bass, John Lake, Thomas Boyer, Enrique Martinez, James Boyer, Guadalupe Garcia-Tsao, David Barnes and William M. Rosenberg

      Article first published online: 9 JUL 2008 | DOI: 10.1002/hep.22517

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  9. Liver Failure/Cirrhosis/Portal Hypertension

    1. Top of page
    2. Presidential Profile
    3. Comments from the Editors
    4. Master's Perspective
    5. Editorials
    6. Viral Hepatitis
    7. Steatohepatitis/Metabolic Liver Disease
    8. Hepatobiliary Malignancies
    9. Autoimmune, Cholestatic and Biliary Disease
    10. Liver Failure/Cirrhosis/Portal Hypertension
    11. Liver Injury/Regeneration
    12. Liver Biology/Pathobiology
    13. Meeting Report
    14. Reviews
    15. Hepatology Elsewhere
    16. Rapid Communication
    17. Correspondence
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      Evaluation of previously nonscreened hereditary hemorrhagic telangiectasia patients shows frequent liver involvement and early cardiac consequences (pages 1570–1576)

      Rodica Gincul, Gaetan Lesca, Bénédicte Gelas-Dore, Nathalie Rollin, Martine Barthelet, Sophie Dupuis-Girod, Franck Pilleul, Sophie Giraud, Henri Plauchu and Jean-Christophe Saurin

      Article first published online: 9 JUL 2008 | DOI: 10.1002/hep.22514

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  10. Liver Injury/Regeneration

    1. Top of page
    2. Presidential Profile
    3. Comments from the Editors
    4. Master's Perspective
    5. Editorials
    6. Viral Hepatitis
    7. Steatohepatitis/Metabolic Liver Disease
    8. Hepatobiliary Malignancies
    9. Autoimmune, Cholestatic and Biliary Disease
    10. Liver Failure/Cirrhosis/Portal Hypertension
    11. Liver Injury/Regeneration
    12. Liver Biology/Pathobiology
    13. Meeting Report
    14. Reviews
    15. Hepatology Elsewhere
    16. Rapid Communication
    17. Correspondence
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      Functional alterations of liver innate immunity of mice with aging in response to CpG-oligodeoxynucleotide (pages 1586–1597)

      Toshinobu Kawabata, Manabu Kinoshita, Akihito Inatsu, Yoshiko Habu, Hiroyuki Nakashima, Nariyoshi Shinomiya and Shuhji Seki

      Article first published online: 16 JUL 2008 | DOI: 10.1002/hep.22489

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      Inhibition of Kupffer cell-mediated early proinflammatory response with carbon monoxide in transplant-induced hepatic ischemia/reperfusion injury in rats (pages 1608–1620)

      Koji Tomiyama, Atsushi Ikeda, Shinya Ueki, Atsunori Nakao, Donna B. Stolz, Yasushi Koike, Amin Afrazi, Chandrashekhar Gandhi, Daisuke Tokita, David A. Geller and Noriko Murase

      Article first published online: 29 OCT 2008 | DOI: 10.1002/hep.22482

  11. Liver Biology/Pathobiology

    1. Top of page
    2. Presidential Profile
    3. Comments from the Editors
    4. Master's Perspective
    5. Editorials
    6. Viral Hepatitis
    7. Steatohepatitis/Metabolic Liver Disease
    8. Hepatobiliary Malignancies
    9. Autoimmune, Cholestatic and Biliary Disease
    10. Liver Failure/Cirrhosis/Portal Hypertension
    11. Liver Injury/Regeneration
    12. Liver Biology/Pathobiology
    13. Meeting Report
    14. Reviews
    15. Hepatology Elsewhere
    16. Rapid Communication
    17. Correspondence
    1. You have free access to this content
      Insulin induces calcium signals in the nucleus of rat hepatocytes (pages 1621–1631)

      Michele A. Rodrigues, Dawidson A. Gomes, Viviane A. Andrade, M. Fatima Leite and Michael H. Nathanson

      Article first published online: 27 MAY 2008 | DOI: 10.1002/hep.22424

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      Farnesoid X receptor antagonizes nuclear factor κB in hepatic inflammatory response (pages 1632–1643)

      Yan-Dong Wang, Wei-Dong Chen, Meihua Wang, Donna Yu, Barry M. Forman and Wendong Huang

      Article first published online: 10 JUL 2008 | DOI: 10.1002/hep.22519

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      Translocation of iron from lysosomes into mitochondria is a key event during oxidative stress-induced hepatocellular injury (pages 1644–1654)

      Akira Uchiyama, Jae-Sung Kim, Kazuyoshi Kon, Hartmut Jaeschke, Kenichi Ikejima, Sumio Watanabe and John J. Lemasters

      Article first published online: 8 JUL 2008 | DOI: 10.1002/hep.22498

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      Cell fusion is a physiological process in mouse liver (pages 1655–1664)

      Francesca Faggioli, Maria Grazia Sacco, Lucia Susani, Cristina Montagna and Paolo Vezzoni

      Article first published online: 8 JUL 2008 | DOI: 10.1002/hep.22488

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      Rab4 facilitates cyclic adenosine monophosphate–stimulated bile acid uptake and Na+-taurocholate cotransporting polypeptide translocation (pages 1665–1670)

      Christopher M. Schonhoff, Krishna Thankey, Cynthia R.L. Webster, Yoshiyuki Wakabayashi, Allan W. Wolkoff and M. Sawkat Anwer

      Article first published online: 16 JUL 2008 | DOI: 10.1002/hep.22495

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      Alcohol-induced alterations in hepatic microtubule dynamics can be explained by impaired histone deacetylase 6 function (pages 1671–1679)

      Blythe D. Shepard, Rohan A. Joseph, George T. Kannarkat, Tara M. Rutledge, Dean J. Tuma and Pamela L. Tuma

      Article first published online: 19 JUN 2008 | DOI: 10.1002/hep.22481

  12. Meeting Report

    1. Top of page
    2. Presidential Profile
    3. Comments from the Editors
    4. Master's Perspective
    5. Editorials
    6. Viral Hepatitis
    7. Steatohepatitis/Metabolic Liver Disease
    8. Hepatobiliary Malignancies
    9. Autoimmune, Cholestatic and Biliary Disease
    10. Liver Failure/Cirrhosis/Portal Hypertension
    11. Liver Injury/Regeneration
    12. Liver Biology/Pathobiology
    13. Meeting Report
    14. Reviews
    15. Hepatology Elsewhere
    16. Rapid Communication
    17. Correspondence
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      Using controlled clinical trials to learn more about acute drug-induced liver injury (pages 1680–1689)

      Paul B. Watkins, Paul J. Seligman, John S. Pears, Mark I. Avigan and John R. Senior

      Article first published online: 13 OCT 2008 | DOI: 10.1002/hep.22633

  13. Reviews

    1. Top of page
    2. Presidential Profile
    3. Comments from the Editors
    4. Master's Perspective
    5. Editorials
    6. Viral Hepatitis
    7. Steatohepatitis/Metabolic Liver Disease
    8. Hepatobiliary Malignancies
    9. Autoimmune, Cholestatic and Biliary Disease
    10. Liver Failure/Cirrhosis/Portal Hypertension
    11. Liver Injury/Regeneration
    12. Liver Biology/Pathobiology
    13. Meeting Report
    14. Reviews
    15. Hepatology Elsewhere
    16. Rapid Communication
    17. Correspondence
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    2. You have free access to this content
  14. Hepatology Elsewhere

    1. Top of page
    2. Presidential Profile
    3. Comments from the Editors
    4. Master's Perspective
    5. Editorials
    6. Viral Hepatitis
    7. Steatohepatitis/Metabolic Liver Disease
    8. Hepatobiliary Malignancies
    9. Autoimmune, Cholestatic and Biliary Disease
    10. Liver Failure/Cirrhosis/Portal Hypertension
    11. Liver Injury/Regeneration
    12. Liver Biology/Pathobiology
    13. Meeting Report
    14. Reviews
    15. Hepatology Elsewhere
    16. Rapid Communication
    17. Correspondence
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  15. Rapid Communication

    1. Top of page
    2. Presidential Profile
    3. Comments from the Editors
    4. Master's Perspective
    5. Editorials
    6. Viral Hepatitis
    7. Steatohepatitis/Metabolic Liver Disease
    8. Hepatobiliary Malignancies
    9. Autoimmune, Cholestatic and Biliary Disease
    10. Liver Failure/Cirrhosis/Portal Hypertension
    11. Liver Injury/Regeneration
    12. Liver Biology/Pathobiology
    13. Meeting Report
    14. Reviews
    15. Hepatology Elsewhere
    16. Rapid Communication
    17. Correspondence
    1. You have free access to this content
      Extrahepatic cholestasis increases liver stiffness (FibroScan) irrespective of fibrosis (pages 1718–1723)

      Gunda Millonig, Frank M. Reimann, Stephanie Friedrich, Hamidreza Fonouni, Arianeb Mehrabi, Markus W. Büchler, Helmut Karl Seitz and Sebastian Mueller

      Article first published online: 14 AUG 2008 | DOI: 10.1002/hep.22577

  16. Correspondence

    1. Top of page
    2. Presidential Profile
    3. Comments from the Editors
    4. Master's Perspective
    5. Editorials
    6. Viral Hepatitis
    7. Steatohepatitis/Metabolic Liver Disease
    8. Hepatobiliary Malignancies
    9. Autoimmune, Cholestatic and Biliary Disease
    10. Liver Failure/Cirrhosis/Portal Hypertension
    11. Liver Injury/Regeneration
    12. Liver Biology/Pathobiology
    13. Meeting Report
    14. Reviews
    15. Hepatology Elsewhere
    16. Rapid Communication
    17. Correspondence
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      Reply: (pages 1725–1726)

      Salvatore Petta, Calogero Cammà and Antonio Craxfi

      Article first published online: 29 OCT 2008 | DOI: 10.1002/hep.22574

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      Reply: (pages 1727–1728)

      Morris Sherman

      Article first published online: 29 OCT 2008 | DOI: 10.1002/hep.22566

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      Nonalcoholic steatohepatitis is frequently accompanied by metabolic diseases (page 1728)

      Teoman Dogru, Cemal Nuri Ercin, Gokhan Erdem, Ilker Tasci, Alper Sonmez and Serkan Tapan

      Article first published online: 29 OCT 2008 | DOI: 10.1002/hep.22562

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      Reply: (page 1729)

      David van der Poorten and Jacob George

      Article first published online: 29 OCT 2008 | DOI: 10.1002/hep.22568

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