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Hepatology

Cover image for Hepatology

April 2009

Volume 49, Issue 4

Pages 1061–1401

  1. Comments from the Editors

    1. Top of page
    2. Comments from the Editors
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. AASLD Practice Guidelines
    12. Rapid Communication
    13. Hepatology Elsewhere
    14. Image of the Month
    15. Correspondence
    1. You have free access to this content
  2. Editorials

    1. Top of page
    2. Comments from the Editors
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. AASLD Practice Guidelines
    12. Rapid Communication
    13. Hepatology Elsewhere
    14. Image of the Month
    15. Correspondence
    1. You have free access to this content
    2. You have free access to this content
      Antiangiogenic therapy: Not just for cancer anymore? (pages 1066–1068)

      Vijay H. Shah and Jordi Bruix

      Version of Record online: 2 FEB 2009 | DOI: 10.1002/hep.22872

  3. Viral Hepatitis

    1. Top of page
    2. Comments from the Editors
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. AASLD Practice Guidelines
    12. Rapid Communication
    13. Hepatology Elsewhere
    14. Image of the Month
    15. Correspondence
    1. You have free access to this content
      Hepatitis C virus drug resistance and immune-driven adaptations: Relevance to new antiviral therapy (pages 1069–1082)

      Silvana Gaudieri, Andri Rauch, Katja Pfafferott, Eleanor Barnes, Wendy Cheng, Geoff McCaughan, Nick Shackel, Gary P. Jeffrey, Lindsay Mollison, Ross Baker, Hansjakob Furrer, Huldrych F. Günthard, Elizabeth Freitas, Isla Humphreys, Paul Klenerman, Simon Mallal, Ian James, Stuart Roberts, David Nolan and Michaela Lucas

      Version of Record online: 8 DEC 2008 | DOI: 10.1002/hep.22773

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      Factors of accuracy of transient elastography (fibroscan) for the diagnosis of liver fibrosis in chronic hepatitis C (pages 1083–1089)

      Damien Lucidarme, Juliette Foucher, Brigitte Le Bail, Julien Vergniol, Laurent Castera, Clotilde Duburque, Gérard Forzy, Bernard Filoche, Patrice Couzigou and Victor de Lédinghen

      Version of Record online: 19 NOV 2008 | DOI: 10.1002/hep.22748

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      HBV superinfection in HCV chronic carriers: A disease that is frequently severe but associated with the eradication of HCV (pages 1090–1097)

      Evangelista Sagnelli, Nicola Coppola, Mariantonietta Pisaturo, Addolorata Masiello, Gilda Tonziello, Caterina Sagnelli, Vincenzo Messina and Pietro Filippini

      Version of Record online: 23 DEC 2008 | DOI: 10.1002/hep.22794

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      Differential microRNA expression between hepatitis B and hepatitis C leading disease progression to hepatocellular carcinoma (pages 1098–1112)

      Shunsuke Ura, Masao Honda, Taro Yamashita, Teruyuki Ueda, Hajime Takatori, Ryuhei Nishino, Hajime Sunakozaka, Yoshio Sakai, Katsuhisa Horimoto and Shuichi Kaneko

      Version of Record online: 19 NOV 2008 | DOI: 10.1002/hep.22749

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      Viral dynamics of hepatitis B virus DNA in human immunodeficiency virus-1–hepatitis B virus coinfected individuals: Similar effectiveness of lamivudine, tenofovir, or combination therapy (pages 1113–1121)

      Sharon R. Lewin, Ruy M. Ribeiro, Anchalee Avihingsanon, Scott Bowden, Gail Matthews, Pip Marks, Stephen A. Locarnini, Kiat Ruxrungtham, Alan S. Perelson and Gregory J. Dore

      Version of Record online: 25 NOV 2008 | DOI: 10.1002/hep.22754

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      Liver X receptor mediates hepatitis B virus X protein–induced lipogenesis in hepatitis B virus–associated hepatocellular carcinoma (pages 1122–1131)

      Tae-Young Na, Young Kee Shin, Kyung Jin Roh, Shin-Ae Kang, Il Hong, Sae Jin Oh, Je Kyung Seong, Cheol Keun Park, Yoon La Choi and Mi-Ock Lee

      Version of Record online: 13 NOV 2008 | DOI: 10.1002/hep.22740

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      Hepatitis B virus suppresses toll-like receptor–mediated innate immune responses in murine parenchymal and nonparenchymal liver cells (pages 1132–1140)

      Jun Wu, Zhongji Meng, Min Jiang, Rongjuan Pei, Martin Trippler, Ruth Broering, Agnes Bucchi, Jan-Peter Sowa, Ulf Dittmer, Dongliang Yang, Michael Roggendorf, Guido Gerken, Mengji Lu and Joerg F. Schlaak

      Version of Record online: 19 NOV 2008 | DOI: 10.1002/hep.22751

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      Hepatitis B virus surface antigen levels: A guide to sustained response to peginterferon alfa-2a in HBeAg-negative chronic hepatitis B (pages 1141–1150)

      Maurizia Rossana Brunetto, Francesco Moriconi, Ferruccio Bonino, George K. K. Lau, Patrizia Farci, Cihan Yurdaydin, Teerha Piratvisuth, Kangxian Luo, Yuming Wang, Stephanos Hadziyannis, Eva Wolf, Philip McCloud, Richard Batrla and Patrick Marcellin

      Version of Record online: 2 DEC 2008 | DOI: 10.1002/hep.22760

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      Early serum HBsAg drop: A strong predictor of sustained virological response to pegylated interferon alfa-2a in HBeAg-negative patients (pages 1151–1157)

      Rami Moucari, Vincent Mackiewicz, Olivier Lada, Marie-Pierre Ripault, Corinne Castelnau, Michelle Martinot-Peignoux, Agnes Dauvergne, Tarik Asselah, Nathalie Boyer, Pierre Bedossa, Dominique Valla, Michel Vidaud, Marie-Hélène Nicolas-Chanoine and Patrick Marcellin

      Version of Record online: 19 NOV 2008 | DOI: 10.1002/hep.22744

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  4. Steatohepatitis/Metabolic Liver Disease

    1. Top of page
    2. Comments from the Editors
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. AASLD Practice Guidelines
    12. Rapid Communication
    13. Hepatology Elsewhere
    14. Image of the Month
    15. Correspondence
    1. You have free access to this content
      Abrogation of hepatic ATP-citrate lyase protects against fatty liver and ameliorates hyperglycemia in leptin receptor-deficient mice (pages 1166–1175)

      Qiong Wang, Lei Jiang, Jue Wang, Shoufeng Li, Yue Yu, Jia You, Rong Zeng, Xiang Gao, Liangyou Rui, Wenjun Li and Yong Liu

      Version of Record online: 8 DEC 2008 | DOI: 10.1002/hep.22774

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      Unsaturated fatty acids inhibit the expression of tumor suppressor phosphatase and tensin homolog (PTEN) via microRNA-21 up-regulation in hepatocytes (pages 1176–1184)

      Manlio Vinciguerra, Antonino Sgroi, Christelle Veyrat-Durebex, Laura Rubbia-Brandt, Leo H. Buhler and Michelangelo Foti

      Version of Record online: 13 NOV 2008 | DOI: 10.1002/hep.22737

  5. Hepatobiliary Malignancies

    1. Top of page
    2. Comments from the Editors
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. AASLD Practice Guidelines
    12. Rapid Communication
    13. Hepatology Elsewhere
    14. Image of the Month
    15. Correspondence
    1. You have free access to this content
      Radiologic–pathologic correlation of hepatocellular carcinoma treated with internal radiation using yttrium-90 microspheres (pages 1185–1193)

      Ahsun Riaz, Laura Kulik, Robert J. Lewandowski, Robert K. Ryu, Georgia Giakoumis Spear, Mary F. Mulcahy, Michael Abecassis, Talia Baker, Vanessa Gates, Ritu Nayar, Frank H. Miller, Kent T. Sato, Reed A. Omary and Riad Salem

      Version of Record online: 19 NOV 2008 | DOI: 10.1002/hep.22747

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      MicroRNA-101 regulates expression of the v-fos FBJ murine osteosarcoma viral oncogene homolog (FOS) oncogene in human hepatocellular carcinoma (pages 1194–1202)

      Shuai Li, Hanjiang Fu, Yulan Wang, Yi Tie, Ruiyun Xing, Jie Zhu, Zhixian Sun, Lixin Wei and Xiaofei Zheng

      Version of Record online: 25 NOV 2008 | DOI: 10.1002/hep.22757

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      Hepatitis B virus X protein shifts human hepatic transforming growth factor (TGF)-β signaling from tumor suppression to oncogenesis in early chronic hepatitis B (pages 1203–1217)

      Miki Murata, Koichi Matsuzaki, Katsunori Yoshida, Go Sekimoto, Yoshiya Tahashi, Shigeo Mori, Yoshiko Uemura, Noriko Sakaida, Junichi Fujisawa, Toshihito Seki, Kazuki Kobayashi, Koutaro Yokote, Kazuhiko Koike and Kazuichi Okazaki

      Version of Record online: 30 DEC 2008 | DOI: 10.1002/hep.22765

  6. Autoimmune, Cholestatic and Biliary Disease

    1. Top of page
    2. Comments from the Editors
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. AASLD Practice Guidelines
    12. Rapid Communication
    13. Hepatology Elsewhere
    14. Image of the Month
    15. Correspondence
    1. You have free access to this content
      A missense mutation in ABCB4 gene involved in progressive familial intrahepatic cholestasis type 3 leads to a folding defect that can be rescued by low temperature (pages 1218–1227)

      Jean-Louis Delaunay, Anne-Marie Durand-Schneider, Danièle Delautier, Alegna Rada, Julien Gautherot, Emmanuel Jacquemin, Tounsia Aït-Slimane and Michèle Maurice

      Version of Record online: 8 DEC 2008 | DOI: 10.1002/hep.22775

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  7. Liver Failure/Cirrhosis/Portal Hypertension

    1. Top of page
    2. Comments from the Editors
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. AASLD Practice Guidelines
    12. Rapid Communication
    13. Hepatology Elsewhere
    14. Image of the Month
    15. Correspondence
    1. You have free access to this content
      Computer-assisted image analysis of liver collagen: Relationship to Ishak scoring and hepatic venous pressure gradient (pages 1236–1244)

      Vincenza Calvaruso, Andrew Kenneth Burroughs, Richard Standish, Pinelopi Manousou, Federica Grillo, Gioacchino Leandro, Sergio Maimone, Maria Pleguezuelo, Ilias Xirouchakis, Gian Piero Guerrini, David Patch, Dominic Yu, James O'Beirne and Amar Paul Dhillon

      Version of Record online: 19 NOV 2008 | DOI: 10.1002/hep.22745

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      Beneficial effects of sorafenib on splanchnic, intrahepatic, and portocollateral circulations in portal hypertensive and cirrhotic rats (pages 1245–1256)

      Marc Mejias, Ester Garcia-Pras, Carolina Tiani, Rosa Miquel, Jaime Bosch and Mercedes Fernandez

      Version of Record online: 25 NOV 2008 | DOI: 10.1002/hep.22758

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      Detection of novel biomarkers of liver cirrhosis by proteomic analysis (pages 1257–1266)

      Christian Mölleken, Barbara Sitek, Corinna Henkel, Gereon Poschmann, Bence Sipos, Sebastian Wiese, Bettina Warscheid, Christoph Broelsch, Markus Reiser, Scott L. Friedman, Ida Tornøe, Anders Schlosser, Günter Klöppel, Wolff Schmiegel, Helmut E. Meyer, Uffe Holmskov and Kai Stühler

      Version of Record online: 2 DEC 2008 | DOI: 10.1002/hep.22764

  8. Liver Injury/Regeneration

    1. Top of page
    2. Comments from the Editors
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. AASLD Practice Guidelines
    12. Rapid Communication
    13. Hepatology Elsewhere
    14. Image of the Month
    15. Correspondence
    1. You have free access to this content
      Natural killer T cells regulate the homing of chemokine CXC receptor 3-positive regulatory T cells to the liver in mice (pages 1267–1276)

      Tania Santodomingo-Garzon, Jinglan Han, Tai Le, Yang Yang and Mark G. Swain

      Version of Record online: 2 DEC 2008 | DOI: 10.1002/hep.22761

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  9. Liver Biology/Pathobiology

    1. Top of page
    2. Comments from the Editors
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. AASLD Practice Guidelines
    12. Rapid Communication
    13. Hepatology Elsewhere
    14. Image of the Month
    15. Correspondence
    1. You have free access to this content
      Thyroid hormone receptor ligands induce regression of rat preneoplastic liver lesions causing their reversion to a differentiated phenotype (pages 1287–1296)

      Andrea Perra, Marta Anna Kowalik, Monica Pibiri, Giovanna M. Ledda-Columbano and Amedeo Columbano

      Version of Record online: 19 NOV 2008 | DOI: 10.1002/hep.22750

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      Cathepsins B and D drive hepatic stellate cell proliferation and promote their fibrogenic potential (pages 1297–1307)

      Anna Moles, Núria Tarrats, José C. Fernández-Checa and Montserrat Marí

      Version of Record online: 25 NOV 2008 | DOI: 10.1002/hep.22753

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      Ethanol metabolism alters major histocompatibility complex class I–restricted antigen presentation in liver cells (pages 1308–1315)

      Natalia A. Osna, Ronda L. White, Geoffrey M. Thiele and Terrence M. Donohue Jr.

      Version of Record online: 11 DEC 2008 | DOI: 10.1002/hep.22787

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      Blockade of four-transmembrane L6 family member 5 (TM4SF5)-mediated tumorigenicity in hepatocytes by a synthetic chalcone derivative (pages 1316–1325)

      Sin-Ae Lee, Hyung Won Ryu, Young Mee Kim, Suyong Choi, Mi Ji Lee, Tae Kyoung Kwak, Hyeon Jung Kim, Moonjae Cho, Ki Hun Park and Jung Weon Lee

      Version of Record online: 8 DEC 2008 | DOI: 10.1002/hep.22777

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      An early complement-dependent and TLR-4–independent phase in the pathogenesis of ethanol-induced liver injury in mice (pages 1326–1334)

      Sanjoy Roychowdhury, Megan R. McMullen, Michele T. Pritchard, Amy G. Hise, Nico van Rooijen, M. Edward Medof, Abram B. Stavitsky and Laura E. Nagy

      Version of Record online: 8 DEC 2008 | DOI: 10.1002/hep.22776

  10. AASLD Practice Guidelines

    1. Top of page
    2. Comments from the Editors
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. AASLD Practice Guidelines
    12. Rapid Communication
    13. Hepatology Elsewhere
    14. Image of the Month
    15. Correspondence
    1. You have free access to this content
      Diagnosis, management, and treatment of hepatitis C: An update (pages 1335–1374)

      Marc G. Ghany, Doris B. Strader, David L. Thomas and Leonard B. Seeff

      Version of Record online: 2 DEC 2008 | DOI: 10.1002/hep.22759

  11. Rapid Communication

    1. Top of page
    2. Comments from the Editors
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. AASLD Practice Guidelines
    12. Rapid Communication
    13. Hepatology Elsewhere
    14. Image of the Month
    15. Correspondence
    1. You have free access to this content
      Differential expression of lumican and fatty acid binding protein-1: New insights into the histologic spectrum of nonalcoholic fatty liver disease (pages 1375–1384)

      Michael Charlton, Kimberly Viker, Anuradha Krishnan, Schuyler Sanderson, Bart Veldt, A. J. Kaalsbeek, Michael Kendrick, Geoffrey Thompson, Florencia Que, James Swain and Michael Sarr

      Version of Record online: 3 MAR 2009 | DOI: 10.1002/hep.22927

  12. Hepatology Elsewhere

    1. Top of page
    2. Comments from the Editors
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. AASLD Practice Guidelines
    12. Rapid Communication
    13. Hepatology Elsewhere
    14. Image of the Month
    15. Correspondence
    1. You have free access to this content
      Advanced chronic hepatitis C: How to handle if you cannot halt? (pages 1385–1387)

      Wolf Peter Hofmann and Stefan Zeuzem

      Version of Record online: 27 MAR 2009 | DOI: 10.1002/hep.22903

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  13. Image of the Month

    1. Top of page
    2. Comments from the Editors
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. AASLD Practice Guidelines
    12. Rapid Communication
    13. Hepatology Elsewhere
    14. Image of the Month
    15. Correspondence
    1. You have free access to this content
      A woman with chronic anemia and cholestatic liver disease (pages 1390–1391)

      M. Isabel Fiel and Thomas Schiano

      Version of Record online: 2 FEB 2009 | DOI: 10.1002/hep.22873

  14. Correspondence

    1. Top of page
    2. Comments from the Editors
    3. Editorials
    4. Viral Hepatitis
    5. Steatohepatitis/Metabolic Liver Disease
    6. Hepatobiliary Malignancies
    7. Autoimmune, Cholestatic and Biliary Disease
    8. Liver Failure/Cirrhosis/Portal Hypertension
    9. Liver Injury/Regeneration
    10. Liver Biology/Pathobiology
    11. AASLD Practice Guidelines
    12. Rapid Communication
    13. Hepatology Elsewhere
    14. Image of the Month
    15. Correspondence
    1. You have free access to this content
      Histological changes in hepatitis C virus antibody–positive, hepatitis C virus RNA–negative subjects suggest persistent virus infection (page 1392)

      Isabelle Moreau, Elizabeth Kenny-Walsh, Orla Crosbie and Liam J. Fanning

      Version of Record online: 30 DEC 2008 | DOI: 10.1002/hep.22799

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      Reply: (pages 1392–1393)

      Matthew Hoare and Graeme Alexander

      Version of Record online: 4 MAR 2009 | DOI: 10.1002/hep.22830

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      Reply: (pages 1393–1394)

      Pedro Zapater, Rubén Francés and Jose Such

      Version of Record online: 27 MAR 2009 | DOI: 10.1002/hep.22829

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      Reply: (pages 1394–1395)

      Salvatore Petta, Calogero Cammà and Antonio Craxì

      Version of Record online: 23 JAN 2009 | DOI: 10.1002/hep.22854

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      Reply: (page 1396)

      Peter Ferenci

      Version of Record online: 27 MAR 2009 | DOI: 10.1002/hep.22876

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