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Hepatology

Cover image for Hepatology

November 2009

Volume 50, Issue 5

Pages 1325–1682

  1. Special Report

    1. Top of page
    2. Special Report
    3. Master's Perspective
    4. Comments from the Editors
    5. Editorials
    6. Viral Hepatitis
    7. Steatohepatitis/Metabolic Liver Disease
    8. Hepatobiliary Malignancies
    9. Autoimmune, Cholestatic and Biliary Disease
    10. Liver Failure/Cirrhosis/Portal Hypertension
    11. Liver Injury/Regeneration
    12. Liver Biology/Pathobiology
    13. Rapid Communication
    14. Reviews
    15. Hepatology Elsewhere
    16. Image of the Month
    17. Correspondence
    18. Correction
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  2. Master's Perspective

    1. Top of page
    2. Special Report
    3. Master's Perspective
    4. Comments from the Editors
    5. Editorials
    6. Viral Hepatitis
    7. Steatohepatitis/Metabolic Liver Disease
    8. Hepatobiliary Malignancies
    9. Autoimmune, Cholestatic and Biliary Disease
    10. Liver Failure/Cirrhosis/Portal Hypertension
    11. Liver Injury/Regeneration
    12. Liver Biology/Pathobiology
    13. Rapid Communication
    14. Reviews
    15. Hepatology Elsewhere
    16. Image of the Month
    17. Correspondence
    18. Correction
    1. You have free access to this content
  3. Comments from the Editors

    1. Top of page
    2. Special Report
    3. Master's Perspective
    4. Comments from the Editors
    5. Editorials
    6. Viral Hepatitis
    7. Steatohepatitis/Metabolic Liver Disease
    8. Hepatobiliary Malignancies
    9. Autoimmune, Cholestatic and Biliary Disease
    10. Liver Failure/Cirrhosis/Portal Hypertension
    11. Liver Injury/Regeneration
    12. Liver Biology/Pathobiology
    13. Rapid Communication
    14. Reviews
    15. Hepatology Elsewhere
    16. Image of the Month
    17. Correspondence
    18. Correction
    1. You have free access to this content
  4. Editorials

    1. Top of page
    2. Special Report
    3. Master's Perspective
    4. Comments from the Editors
    5. Editorials
    6. Viral Hepatitis
    7. Steatohepatitis/Metabolic Liver Disease
    8. Hepatobiliary Malignancies
    9. Autoimmune, Cholestatic and Biliary Disease
    10. Liver Failure/Cirrhosis/Portal Hypertension
    11. Liver Injury/Regeneration
    12. Liver Biology/Pathobiology
    13. Rapid Communication
    14. Reviews
    15. Hepatology Elsewhere
    16. Image of the Month
    17. Correspondence
    18. Correction
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    2. You have free access to this content
    3. You have free access to this content
      Toward the molecular dissection of primary biliary cirrhosis (pages 1347–1350)

      Gideon M. Hirschfield and Katherine A. Siminovitch

      Article first published online: 29 OCT 2009 | DOI: 10.1002/hep.23252

  5. Viral Hepatitis

    1. Top of page
    2. Special Report
    3. Master's Perspective
    4. Comments from the Editors
    5. Editorials
    6. Viral Hepatitis
    7. Steatohepatitis/Metabolic Liver Disease
    8. Hepatobiliary Malignancies
    9. Autoimmune, Cholestatic and Biliary Disease
    10. Liver Failure/Cirrhosis/Portal Hypertension
    11. Liver Injury/Regeneration
    12. Liver Biology/Pathobiology
    13. Rapid Communication
    14. Reviews
    15. Hepatology Elsewhere
    16. Image of the Month
    17. Correspondence
    18. Correction
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      Impact of pegylated interferon and ribavirin on morbidity and mortality in patients with chronic hepatitis C and normal aminotransferases in France (pages 1351–1359)

      Sylvie Deuffic-Burban, Gérard Babany, Isabelle Lonjon-Domanec, Pierre Deltenre, Valérie Canva-Delcambre, Sébastien Dharancy, Alexandre Louvet, Françoise Roudot-Thoraval and Philippe Mathurin

      Article first published online: 7 JUL 2009 | DOI: 10.1002/hep.23159

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      Coffee intake is associated with lower rates of liver disease progression in chronic hepatitis C (pages 1360–1369)

      Neal D. Freedman, James E. Everhart, Karen L. Lindsay, Marc G. Ghany, Teresa M. Curto, Mitchell L. Shiffman, William M. Lee, Anna S. Lok, Adrian M. Di Bisceglie, Herbert L. Bonkovsky, John C. Hoefs, Jules L. Dienstag, Chihiro Morishima, Christian C. Abnet, Rashmi Sinha and HALT-C Trial Group

      Article first published online: 13 JUL 2009 | DOI: 10.1002/hep.23162

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      Calpain activation by hepatitis C virus proteins inhibits the extrinsic apoptotic signaling pathway (pages 1370–1379)

      Yannick Simonin, Olivier Disson, Hervé Lerat, Etienne Antoine, Fabien Binamé, Arielle R. Rosenberg, Solange Desagher, Patrice Lassus, Paulette Bioulac-Sage and Urszula Hibner

      Article first published online: 20 JUL 2009 | DOI: 10.1002/hep.23169

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      Hepatitis B virus as a gene delivery vector activating foreign antigenic T cell response that abrogates viral expression in mouse models (pages 1380–1391)

      Qiang Deng, Maryline Mancini-Bourgine, Xiaoming Zhang, Marie-Christine Cumont, Ren Zhu, Yu-Chun Lone and Marie-Louise Michel

      Article first published online: 7 JUL 2009 | DOI: 10.1002/hep.23150

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  6. Steatohepatitis/Metabolic Liver Disease

    1. Top of page
    2. Special Report
    3. Master's Perspective
    4. Comments from the Editors
    5. Editorials
    6. Viral Hepatitis
    7. Steatohepatitis/Metabolic Liver Disease
    8. Hepatobiliary Malignancies
    9. Autoimmune, Cholestatic and Biliary Disease
    10. Liver Failure/Cirrhosis/Portal Hypertension
    11. Liver Injury/Regeneration
    12. Liver Biology/Pathobiology
    13. Rapid Communication
    14. Reviews
    15. Hepatology Elsewhere
    16. Image of the Month
    17. Correspondence
    18. Correction
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      Ultrasonographic hepatic steatosis increases prediction of mortality risk from elevated serum gamma-glutamyl transpeptidase levels (pages 1403–1411)

      Robin Haring, Henri Wallaschofski, Matthias Nauck, Marcus Dörr, Sebastian E. Baumeister and Henry Völzke

      Article first published online: 19 JUN 2009 | DOI: 10.1002/hep.23135

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      Immature myeloid cells induced by a high-fat diet contribute to liver inflammation (pages 1412–1420)

      Zhong-bin Deng, Yuelong Liu, Cunren Liu, Xiaoyu Xiang, Jianhua Wang, Ziqiang Cheng, Spandan V. Shah, Shuangyin Zhang, Liming Zhang, Xiaoying Zhuang, Sue Michalek, William E. Grizzle and Huang-Ge Zhang

      Article first published online: 2 JUL 2009 | DOI: 10.1002/hep.23148

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      Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis (pages 1421–1430)

      Rafal P. Witek, W. Carl Stone, F. Gamze Karaca, Wing-Kin Syn, Thiago A. Pereira, Kolade M. Agboola, Alessia Omenetti, Youngmi Jung, Vanessa Teaberry, Steve S. Choi, Cynthia D. Guy, John Pollard, Peter Charlton and Anna Mae Diehl

      Article first published online: 13 JUL 2009 | DOI: 10.1002/hep.23167

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      Modulation of glycosphingolipid metabolism significantly improves hepatic insulin sensitivity and reverses hepatic steatosis in mice (pages 1431–1441)

      Nora Bijl, Milka Sokolović, Carlos Vrins, Mirjam Langeveld, Perry D. Moerland, Roelof Ottenhoff, Cindy P. A. A. van Roomen, Nike Claessen, Rolf G. Boot, Jan Aten, Albert K. Groen, Johannes M. F. G. Aerts and Marco van Eijk

      Article first published online: 20 JUL 2009 | DOI: 10.1002/hep.23175

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      Long-term exclusive zinc monotherapy in symptomatic Wilson disease: Experience in 17 patients (pages 1442–1452)

      Francisca H. H. Linn, Roderick H. J. Houwen, Jan van Hattum, Stefan van der Kleij and Karel J. van Erpecum

      Article first published online: 20 JUL 2009 | DOI: 10.1002/hep.23182

  7. Hepatobiliary Malignancies

    1. Top of page
    2. Special Report
    3. Master's Perspective
    4. Comments from the Editors
    5. Editorials
    6. Viral Hepatitis
    7. Steatohepatitis/Metabolic Liver Disease
    8. Hepatobiliary Malignancies
    9. Autoimmune, Cholestatic and Biliary Disease
    10. Liver Failure/Cirrhosis/Portal Hypertension
    11. Liver Injury/Regeneration
    12. Liver Biology/Pathobiology
    13. Rapid Communication
    14. Reviews
    15. Hepatology Elsewhere
    16. Image of the Month
    17. Correspondence
    18. Correction
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      Targeting cadherin-17 inactivates Wnt signaling and inhibits tumor growth in liver carcinoma (pages 1453–1463)

      Ling Xiao Liu, Nikki P. Lee, Vivian W. Chan, Wen Xue, Lars Zender, Chunsheng Zhang, Mao Mao, Hongyue Dai, Xiao Lin Wang, Michelle Z. Xu, Terence K. Lee, Irene O. Ng, Yangchao Chen, Hsiang-fu Kung, Scott W. Lowe, Ronnie T.P. Poon, Jian Hua Wang and John M. Luk

      Article first published online: 24 JUN 2009 | DOI: 10.1002/hep.23143

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      Comprehensive analysis of the independent effect of twist and snail in promoting metastasis of hepatocellular carcinoma (pages 1464–1474)

      Muh-Hwa Yang, Chih-Li Chen, Gar-Yang Chau, Shih-Hwa Chiou, Chien-Wei Su, Teh-Ying Chou, Wei-Li Peng and Jaw-Ching Wu

      Article first published online: 10 AUG 2009 | DOI: 10.1002/hep.23221

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      Radiofrequency ablation of hepatocellular carcinoma: Long-term results and prognostic factors in 235 Western patients with cirrhosis (pages 1475–1483)

      Gisèle N'Kontchou, Amel Mahamoudi, Mounir Aout, Nathalie Ganne-Carrié, Véronique Grando, Emmanuelle Coderc, Eric Vicaut, Jean Claude Trinchet, Nicolas Sellier, Michel Beaugrand and Olivier Seror

      Article first published online: 20 JUL 2009 | DOI: 10.1002/hep.23181

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      Myeloperoxidase and superoxide dismutase 2 polymorphisms comodulate the risk of hepatocellular carcinoma and death in alcoholic cirrhosis (pages 1484–1493)

      Pierre Nahon, Angela Sutton, Pierre Rufat, Marianne Ziol, Hassan Akouche, Christelle Laguillier, Nathalie Charnaux, Nathalie Ganne-Carrié, Véronique Grando-Lemaire, Gisèle N'Kontchou, Jean-Claude Trinchet, Liliane Gattegno, Dominique Pessayre and Michel Beaugrand

      Article first published online: 20 JUL 2009 | DOI: 10.1002/hep.23187

  8. Autoimmune, Cholestatic and Biliary Disease

    1. Top of page
    2. Special Report
    3. Master's Perspective
    4. Comments from the Editors
    5. Editorials
    6. Viral Hepatitis
    7. Steatohepatitis/Metabolic Liver Disease
    8. Hepatobiliary Malignancies
    9. Autoimmune, Cholestatic and Biliary Disease
    10. Liver Failure/Cirrhosis/Portal Hypertension
    11. Liver Injury/Regeneration
    12. Liver Biology/Pathobiology
    13. Rapid Communication
    14. Reviews
    15. Hepatology Elsewhere
    16. Image of the Month
    17. Correspondence
    18. Correction
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      Deletion of interleukin-12p40 suppresses autoimmune cholangitis in dominant negative transforming growth factor β receptor type II mice (pages 1494–1500)

      Katsunori Yoshida, Guo-Xiang Yang, Weici Zhang, Masanobu Tsuda, Koichi Tsuneyama, Yuki Moritoki, Aftab A. Ansari, Kazuichi Okazaki, Zhe-Xiong Lian, Ross L. Coppel, Ian R. Mackay and M. Eric Gershwin

      Article first published online: 19 JUN 2009 | DOI: 10.1002/hep.23132

  9. Liver Failure/Cirrhosis/Portal Hypertension

    1. Top of page
    2. Special Report
    3. Master's Perspective
    4. Comments from the Editors
    5. Editorials
    6. Viral Hepatitis
    7. Steatohepatitis/Metabolic Liver Disease
    8. Hepatobiliary Malignancies
    9. Autoimmune, Cholestatic and Biliary Disease
    10. Liver Failure/Cirrhosis/Portal Hypertension
    11. Liver Injury/Regeneration
    12. Liver Biology/Pathobiology
    13. Rapid Communication
    14. Reviews
    15. Hepatology Elsewhere
    16. Image of the Month
    17. Correspondence
    18. Correction
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      Pharmacological inhibition of integrin αvβ3 aggravates experimental liver fibrosis and suppresses hepatic angiogenesis (pages 1501–1511)

      Eleonora Patsenker, Yury Popov, Felix Stickel, Vreni Schneider, Monika Ledermann, Hans Sägesser, Gerald Niedobitek, Simon L. Goodman and Detlef Schuppan

      Article first published online: 2 JUL 2009 | DOI: 10.1002/hep.23144

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      Inhibition of extracellular signal-regulated kinase 1 by adenovirus mediated small interfering RNA attenuates hepatic fibrosis in rats (pages 1524–1536)

      Wei Zhong, Wei-Feng Shen, Bei-Fang Ning, Ping-Fang Hu, Yong Lin, Hai-Yan Yue, Chuan Yin, Jun-Liang Hou, Yue-Xiang Chen, Jun-Ping Zhang, Xin Zhang and Wei-Fen Xie

      Article first published online: 22 JUL 2009 | DOI: 10.1002/hep.23189

  10. Liver Injury/Regeneration

    1. Top of page
    2. Special Report
    3. Master's Perspective
    4. Comments from the Editors
    5. Editorials
    6. Viral Hepatitis
    7. Steatohepatitis/Metabolic Liver Disease
    8. Hepatobiliary Malignancies
    9. Autoimmune, Cholestatic and Biliary Disease
    10. Liver Failure/Cirrhosis/Portal Hypertension
    11. Liver Injury/Regeneration
    12. Liver Biology/Pathobiology
    13. Rapid Communication
    14. Reviews
    15. Hepatology Elsewhere
    16. Image of the Month
    17. Correspondence
    18. Correction
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      CD4 T cells promote tissue inflammation via CD40 signaling without de novo activation in a murine model of liver ischemia/reperfusion injury (pages 1537–1546)

      Xiuda Shen, Yue Wang, Feng Gao, Feng Ren, Ronald W. Busuttil, Jerzy W. Kupiec-Weglinski and Yuan Zhai

      Article first published online: 7 JUL 2009 | DOI: 10.1002/hep.23153

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      The strength of the Fas ligand signal determines whether hepatocytes act as type 1 or type 2 cells in murine livers (pages 1558–1566)

      Sven Schüngel, Laura Elisa Buitrago-Molina, Padmavathi devi Nalapareddy, Margitta Lebofsky, Michael P. Manns, Hartmut Jaeschke, Atan Gross and Arndt Vogel

      Article first published online: 20 JUL 2009 | DOI: 10.1002/hep.23176

  11. Liver Biology/Pathobiology

    1. Top of page
    2. Special Report
    3. Master's Perspective
    4. Comments from the Editors
    5. Editorials
    6. Viral Hepatitis
    7. Steatohepatitis/Metabolic Liver Disease
    8. Hepatobiliary Malignancies
    9. Autoimmune, Cholestatic and Biliary Disease
    10. Liver Failure/Cirrhosis/Portal Hypertension
    11. Liver Injury/Regeneration
    12. Liver Biology/Pathobiology
    13. Rapid Communication
    14. Reviews
    15. Hepatology Elsewhere
    16. Image of the Month
    17. Correspondence
    18. Correction
    1. You have free access to this content
      HuR regulates gap junctional intercellular communication by controlling β-catenin levels and adherens junction integrity (pages 1567–1576)

      Niloofar Ale-Agha, Stefanie Galban, Christiane Sobieroy, Kotb Abdelmohsen, Myriam Gorospe, Helmut Sies and Lars-Oliver Klotz

      Article first published online: 2 JUL 2009 | DOI: 10.1002/hep.23146

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      The niche of stellate cells within rat liver (pages 1617–1624)

      Iris Sawitza, Claus Kordes, Sven Reister and Dieter Häussinger

      Article first published online: 20 JUL 2009 | DOI: 10.1002/hep.23184

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      Chronically inflamed livers up-regulate expression of inhibitory B7 family members (pages 1625–1637)

      Rachel Kassel, Michael W. Cruise, Julia C. Iezzoni, Nicholas A. Taylor, Timothy L. Pruett and Young S. Hahn

      Article first published online: 8 SEP 2009 | DOI: 10.1002/hep.23173

  12. Rapid Communication

    1. Top of page
    2. Special Report
    3. Master's Perspective
    4. Comments from the Editors
    5. Editorials
    6. Viral Hepatitis
    7. Steatohepatitis/Metabolic Liver Disease
    8. Hepatobiliary Malignancies
    9. Autoimmune, Cholestatic and Biliary Disease
    10. Liver Failure/Cirrhosis/Portal Hypertension
    11. Liver Injury/Regeneration
    12. Liver Biology/Pathobiology
    13. Rapid Communication
    14. Reviews
    15. Hepatology Elsewhere
    16. Image of the Month
    17. Correspondence
    18. Correction
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      Cyclosporine A inhibits hepatitis C virus nonstructural protein 2 through cyclophilin A (pages 1638–1645)

      Sandra Ciesek, Eike Steinmann, Heiner Wedemeyer, Michael P. Manns, Johann Neyts, Norbert Tautz, Vanesa Madan, Ralf Bartenschlager, Thomas von Hahn and Thomas Pietschmann

      Article first published online: 9 SEP 2009 | DOI: 10.1002/hep.23281

  13. Reviews

    1. Top of page
    2. Special Report
    3. Master's Perspective
    4. Comments from the Editors
    5. Editorials
    6. Viral Hepatitis
    7. Steatohepatitis/Metabolic Liver Disease
    8. Hepatobiliary Malignancies
    9. Autoimmune, Cholestatic and Biliary Disease
    10. Liver Failure/Cirrhosis/Portal Hypertension
    11. Liver Injury/Regeneration
    12. Liver Biology/Pathobiology
    13. Rapid Communication
    14. Reviews
    15. Hepatology Elsewhere
    16. Image of the Month
    17. Correspondence
    18. Correction
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      Experimental models for hepatitis C viral infection (pages 1646–1655)

      Andre Boonstra, Luc J. W. van der Laan, Thomas Vanwolleghem and Harry L. A. Janssen

      Article first published online: 24 JUN 2009 | DOI: 10.1002/hep.23138

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  14. Hepatology Elsewhere

    1. Top of page
    2. Special Report
    3. Master's Perspective
    4. Comments from the Editors
    5. Editorials
    6. Viral Hepatitis
    7. Steatohepatitis/Metabolic Liver Disease
    8. Hepatobiliary Malignancies
    9. Autoimmune, Cholestatic and Biliary Disease
    10. Liver Failure/Cirrhosis/Portal Hypertension
    11. Liver Injury/Regeneration
    12. Liver Biology/Pathobiology
    13. Rapid Communication
    14. Reviews
    15. Hepatology Elsewhere
    16. Image of the Month
    17. Correspondence
    18. Correction
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    2. You have free access to this content
  15. Image of the Month

    1. Top of page
    2. Special Report
    3. Master's Perspective
    4. Comments from the Editors
    5. Editorials
    6. Viral Hepatitis
    7. Steatohepatitis/Metabolic Liver Disease
    8. Hepatobiliary Malignancies
    9. Autoimmune, Cholestatic and Biliary Disease
    10. Liver Failure/Cirrhosis/Portal Hypertension
    11. Liver Injury/Regeneration
    12. Liver Biology/Pathobiology
    13. Rapid Communication
    14. Reviews
    15. Hepatology Elsewhere
    16. Image of the Month
    17. Correspondence
    18. Correction
    1. You have free access to this content
      Autosomal dominant polycystic disease (pages 1671–1672)

      Carlo Pedrolli and Emanuele Cereda

      Article first published online: 29 OCT 2009 | DOI: 10.1002/hep.23254

  16. Correspondence

    1. Top of page
    2. Special Report
    3. Master's Perspective
    4. Comments from the Editors
    5. Editorials
    6. Viral Hepatitis
    7. Steatohepatitis/Metabolic Liver Disease
    8. Hepatobiliary Malignancies
    9. Autoimmune, Cholestatic and Biliary Disease
    10. Liver Failure/Cirrhosis/Portal Hypertension
    11. Liver Injury/Regeneration
    12. Liver Biology/Pathobiology
    13. Rapid Communication
    14. Reviews
    15. Hepatology Elsewhere
    16. Image of the Month
    17. Correspondence
    18. Correction
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      Coffee intake and chronic hepatitis C (page 1673)

      Tugrul Purnak and Ersan Ozaslan

      Article first published online: 29 OCT 2009 | DOI: 10.1002/hep.23243

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      Reply: (page 1673)

      Neal D. Freedman, Teresa M. Curto and James E. Everhart

      Article first published online: 9 SEP 2009 | DOI: 10.1002/hep.23284

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      Hepatic congestion plays a role in liver stiffness (pages 1674–1675)

      Nora Frulio, Hervé Laumonier, Charles Balabaud, Hervé Trillaud and Paulette Bioulac-Sage

      Article first published online: 10 AUG 2009 | DOI: 10.1002/hep.23109

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      The myth of occult hepatitis C infection (page 1675)

      Philippe Halfon, Michele Martinot-Peignoux and Patrice Cacoub

      Article first published online: 8 JUN 2009 | DOI: 10.1002/hep.23113

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      Binge drinking–induced liver injury (page 1676)

      Napoleon Waszkiewicz, Sławomir Dariusz Szajda, Anna Zalewska, Beata Konarzewska, Agata Szulc, Alina Kȩpka and Krzysztof Zwierz

      Article first published online: 20 JUL 2009 | DOI: 10.1002/hep.23178

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      Reply: (pages 1677–1679)

      Michael W. Fried, Peter Button, Teerha Piratvisuth, George K. K. Lau, Patrick Marcellin, Wan-Cheng Chou, Graham Cooksley, Kang-Xian Luo, Seung Woon Paik, Yun-Fan Liaw and Matei Popescu

      Article first published online: 13 OCT 2009 | DOI: 10.1002/hep.23366

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      Quantification of genotype 4 hepatitis C virus RNA by the COBAS AmpliPrep/COBAS TaqMan hepatitis C virus test (pages 1679–1680)

      Jeffrey J. Germer, Carl E. Bommersbach, Dana M. Schmidt, Jordan L. Bendel and Joseph D. C. Yao

      Article first published online: 9 SEP 2009 | DOI: 10.1002/hep.23282

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      Underestimation of hepatitis C virus genotype 4 RNA levels by the Cobas AmpliPrep/Cobas TaqMan assay (page 1681)

      Stéphane Chevaliez, Jenna Fix, Alexandre Soulier and Jean-Michel Pawlotsky

      Article first published online: 29 SEP 2009 | DOI: 10.1002/hep.23349

  17. Correction

    1. Top of page
    2. Special Report
    3. Master's Perspective
    4. Comments from the Editors
    5. Editorials
    6. Viral Hepatitis
    7. Steatohepatitis/Metabolic Liver Disease
    8. Hepatobiliary Malignancies
    9. Autoimmune, Cholestatic and Biliary Disease
    10. Liver Failure/Cirrhosis/Portal Hypertension
    11. Liver Injury/Regeneration
    12. Liver Biology/Pathobiology
    13. Rapid Communication
    14. Reviews
    15. Hepatology Elsewhere
    16. Image of the Month
    17. Correspondence
    18. Correction
    1. You have free access to this content
      Correction (page 1682)

      Article first published online: 8 SEP 2009 | DOI: 10.1002/hep.23244

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